PE20121552A1 - Anticuerpos monoclonales anti cea humanizados de afinidad madura - Google Patents
Anticuerpos monoclonales anti cea humanizados de afinidad maduraInfo
- Publication number
- PE20121552A1 PE20121552A1 PE2012000266A PE2012000266A PE20121552A1 PE 20121552 A1 PE20121552 A1 PE 20121552A1 PE 2012000266 A PE2012000266 A PE 2012000266A PE 2012000266 A PE2012000266 A PE 2012000266A PE 20121552 A1 PE20121552 A1 PE 20121552A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- monoclonal antibodies
- humanized anti
- heavy chain
- light chain
- Prior art date
Links
- 230000002494 anti-cea effect Effects 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UNA MOLECULA DE UNION A ANTIGENO (ABM) TAL COMO UN ANTICUERPO QUE COMPRENDE UN DOMINIO DE UNION A ANTIGENO QUE SE UNE AL ANTIGENO CARCINOEMBRIONARIO HUMANO (CEA) UNIDO A MEMBRANA, EL CUAL COMPRENDE A) UNA REGION VARIABLE DE CADENA PESADA QUE COMPRENDE i) UNA CDR1 DE CADENA PESADA QUE CONSISTE EN LAS SEC ID Nº 1, 2, 3, 5, 6, 7, 8, 9, 10 O 12, ii) UNA CDR2 DE CADENA PESADA QUE CONSISTE EN LAS SEC ID Nº 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, ENTRE OTROS, iii) UNA CDR3 DE CADENA PESADA QUE CONSISTE EN LAS SEC ID Nº 25, 26, 27, 28, 29, 30, 31, 32, 33, 34 O 35; Y B) UNA REGION VARIABLE DE CADENA LIGERA QUE COMPRENDE i) UNA CDR1 DE CADENA LIGERA QUE CONSISTE EN LAS SEC ID Nº 36, 37, 38, 39, 40, 41, 42, 43, 44 O 45, ii) UNA CDR2 DE CADENA LIGERA QUE CONSISTE EN LAS SEC ID Nº 46, 47, 48, 49, 50, 51, 52, 53, 54 O 55, iii) UNA CDR3 DE CADENA LIGERA QUE CONSISTE EN LA SEC ID Nº 56. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA UTIL EN EL TRATAMIENTO DE CANCER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23850509P | 2009-08-31 | 2009-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20121552A1 true PE20121552A1 (es) | 2012-11-26 |
Family
ID=42985489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000266A PE20121552A1 (es) | 2009-08-31 | 2010-08-27 | Anticuerpos monoclonales anti cea humanizados de afinidad madura |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9068008B2 (es) |
| EP (1) | EP2473532B1 (es) |
| JP (1) | JP5744872B2 (es) |
| KR (1) | KR101528013B1 (es) |
| CN (1) | CN102741293B (es) |
| AR (1) | AR078111A1 (es) |
| AU (1) | AU2010288469A1 (es) |
| BR (1) | BR112012003983A2 (es) |
| CA (1) | CA2770174A1 (es) |
| CL (1) | CL2012000551A1 (es) |
| CO (1) | CO6491105A2 (es) |
| CR (1) | CR20120087A (es) |
| EC (1) | ECSP12011698A (es) |
| IL (1) | IL218038A0 (es) |
| MA (1) | MA33536B1 (es) |
| MX (1) | MX339608B (es) |
| PE (1) | PE20121552A1 (es) |
| RU (1) | RU2570554C2 (es) |
| SG (1) | SG178567A1 (es) |
| TW (1) | TW201121994A (es) |
| WO (1) | WO2011023787A1 (es) |
| ZA (1) | ZA201200954B (es) |
Families Citing this family (43)
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| JPS5992710A (ja) * | 1982-11-16 | 1984-05-29 | 関西電力株式会社 | 直接水冷線路の立坑部の布設方法 |
| CA2838062C (en) | 2001-08-03 | 2015-12-22 | Roche Glycart Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| CN105440123B (zh) | 2011-02-10 | 2020-10-09 | 罗切格利卡特公司 | 突变体白介素-2多肽 |
| JP2014511147A (ja) | 2011-02-10 | 2014-05-12 | ロシュ グリクアート アーゲー | 改善された免疫療法 |
| AU2012222463B9 (en) | 2011-03-02 | 2017-05-25 | Roche Glycart Ag | CEA antibodies |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| NO2748201T3 (es) | 2011-08-23 | 2018-05-12 | ||
| KR101681818B1 (ko) | 2011-08-23 | 2016-12-01 | 로슈 글리카트 아게 | T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법 |
| RU2650775C2 (ru) | 2011-08-23 | 2018-04-17 | Рош Гликарт Аг | Биспецифические антигенсвязывающие молекулы |
| WO2013054320A1 (en) * | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
| GB201213858D0 (en) | 2012-08-03 | 2012-09-19 | Mab Design Ltd | Method |
| CA2872195A1 (en) | 2012-08-07 | 2014-02-13 | Roche Glycart Ag | Composition comprising two antibodies engineered to have reduced and increased effector function |
| EP2904016B1 (en) | 2012-10-08 | 2018-11-14 | Roche Glycart AG | Fc-free antibodies comprising two fab-fragments and methods of use |
| MX2015010843A (es) | 2013-02-26 | 2016-04-04 | Roche Glycart Ag | Moleculas biespecificas de union al antigeno que activan celulas t. |
| KR20180023035A (ko) | 2013-02-26 | 2018-03-06 | 로슈 글리카트 아게 | 이중특이적 t 세포 활성화 항원 결합 분자 |
| EP3444278A1 (en) | 2013-02-26 | 2019-02-20 | Roche Glycart AG | Bispecific t cell activating antigen binding molecules |
| BR112016024972B1 (pt) | 2014-04-27 | 2024-02-20 | Ccam Biotherapeutics Ltd | Anticorpo monoclonal humanizado, polinucleotídeo isolado,plasmídeo, composições farmacêutica e de disgnóstico, usos do dito anticorpo monoclonal humanizado e método in vitro para determinar a expressão de ceacam1 |
| US11427647B2 (en) | 2014-04-27 | 2022-08-30 | Famewave Ltd. | Polynucleotides encoding humanized antibodies against CEACAM1 |
| DK3177643T3 (da) | 2014-08-04 | 2019-07-15 | Hoffmann La Roche | Bispecifikke T-celle-aktiverende antigenbindende molekyler |
| DK4141032T3 (da) | 2014-11-20 | 2024-08-05 | Hoffmann La Roche | Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler og PD-1-aksebindende antagonister |
| DK3221357T3 (da) | 2014-11-20 | 2020-08-10 | Hoffmann La Roche | Fælles letkæder og fremgangsmåder til anvendelse |
| DK3221356T3 (da) | 2014-11-20 | 2020-11-02 | Hoffmann La Roche | T-celleaktiverende, bispecifikke, antigenbindende molekyler mod folr1 og cd3 |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| KR20180073561A (ko) | 2015-10-02 | 2018-07-02 | 에프. 호프만-라 로슈 아게 | 이중특이적 항-ceaxcd3 t 세포 활성화 항원 결합 분자 |
| KR102850929B1 (ko) | 2015-12-09 | 2025-08-27 | 에프. 호프만-라 로슈 아게 | 항-약물 항체의 형성을 감소시키기 위한 ii형 항-cd20 항체 |
| ES2837428T3 (es) | 2016-01-08 | 2021-06-30 | Hoffmann La Roche | Procedimientos de tratamiento de cánceres positivos para CEA usando antagonistas de unión al eje PD-1 y anticuerpos biespecíficos anti-CEA/anti-CD3 |
| JP7015244B2 (ja) | 2016-03-22 | 2022-02-02 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | プロテアーゼ活性化ｔ細胞二重特異性分子 |
| CN107663240B (zh) * | 2016-07-29 | 2021-01-12 | 中国人民解放军第四军医大学 | 高度糖基化cea特异性结合的单链抗体及其在检测和治疗上的应用 |
| ES2897217T3 (es) | 2016-09-30 | 2022-02-28 | Hoffmann La Roche | Anticuerpos biespecíficos frente a p95HER2 |
| CN118772288A (zh) | 2018-02-08 | 2024-10-15 | 豪夫迈·罗氏有限公司 | 双特异性抗原结合分子和使用方法 |
| TWI804572B (zh) | 2018-02-09 | 2023-06-11 | 日商小野藥品工業股份有限公司 | 雙特異性抗體 |
| CN113906053B (zh) * | 2019-06-26 | 2022-10-25 | 江苏恒瑞医药股份有限公司 | 抗cea抗体及其应用 |
| BR112021026293A2 (pt) | 2019-06-26 | 2022-03-03 | Hoffmann La Roche | Moléculas de ligação, anticorpos humanizados, ácido nucleico isolado, célula hospedeira, métodos para produzir a molécula de ligação ao antígeno, para tratar um indivíduo e suprarregular ou prolongar a atividade de células t citotóxicas, composição farmacêutica e uso da molécula |
| CN110713539B (zh) * | 2019-09-23 | 2021-04-16 | 华道(上海)生物医药有限公司 | 一种抗癌胚抗原的抗体及其制备方法和用途 |
| CN110862456B (zh) * | 2019-09-23 | 2021-04-09 | 华道(上海)生物医药有限公司 | 一种抗癌胚抗原的抗体及其制备方法和用途 |
| BR112022025856A2 (pt) | 2020-06-19 | 2023-01-10 | Hoffmann La Roche | Anticorpo que se liga a cd3 e cd19, polinucleotídeo isolado, célula hospedeira, método de produção de um anticorpo que se liga a cd3 e cd19, composição farmacêutica, uso do anticorpo, método para tratar uma doença em um indivíduo e invenção |
| EP4097486A4 (en) | 2020-08-20 | 2023-09-06 | A2 Biotherapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATMENT OF POSITIVE CANCERS AT CEACAM |
| MX2023002041A (es) | 2020-08-20 | 2023-04-27 | A2 Biotherapeutics Inc | Composiciones y métodos para tratar cánceres positivos para mesotelina. |
| EP4330282A1 (en) | 2021-04-30 | 2024-03-06 | F. Hoffmann-La Roche AG | Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate |
| JP2025504667A (ja) * | 2022-01-27 | 2025-02-14 | ヤンセン バイオテツク，インコーポレーテツド | 増強されたタンパク質組成物 |
| MX2024011519A (es) | 2022-03-23 | 2024-09-24 | Synaffix Bv | Conjugados de anticuerpos para el direccionamiento contra tumores que expresan el antigeno carcinoembrionario. |
| TW202506733A (zh) | 2023-06-12 | 2025-02-16 | 美商安進公司 | 淋巴毒素β受體促效劑結合蛋白 |
| WO2025257185A1 (en) * | 2024-06-11 | 2025-12-18 | Abcely | Humanized anti-human-carcinoembryonic antigen antibody |
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-
2010
- 2010-08-27 AU AU2010288469A patent/AU2010288469A1/en not_active Abandoned
- 2010-08-27 PE PE2012000266A patent/PE20121552A1/es not_active Application Discontinuation
- 2010-08-27 EP EP10745651.9A patent/EP2473532B1/en active Active
- 2010-08-27 RU RU2012112340/10A patent/RU2570554C2/ru active
- 2010-08-27 JP JP2012526072A patent/JP5744872B2/ja not_active Expired - Fee Related
- 2010-08-27 CN CN201080048622.1A patent/CN102741293B/zh not_active Expired - Fee Related
- 2010-08-27 WO PCT/EP2010/062527 patent/WO2011023787A1/en not_active Ceased
- 2010-08-27 MX MX2012002461A patent/MX339608B/es active IP Right Grant
- 2010-08-27 BR BR112012003983-0A patent/BR112012003983A2/pt not_active Application Discontinuation
- 2010-08-27 SG SG2012013306A patent/SG178567A1/en unknown
- 2010-08-27 CA CA2770174A patent/CA2770174A1/en not_active Abandoned
- 2010-08-27 KR KR1020127008265A patent/KR101528013B1/ko not_active Expired - Fee Related
- 2010-08-30 AR ARP100103166A patent/AR078111A1/es not_active Application Discontinuation
- 2010-08-30 TW TW099129130A patent/TW201121994A/zh unknown
- 2010-08-31 US US12/872,908 patent/US9068008B2/en active Active
-
2012
- 2012-01-30 CO CO12014021A patent/CO6491105A2/es not_active Application Discontinuation
- 2012-02-08 ZA ZA2012/00954A patent/ZA201200954B/en unknown
- 2012-02-09 IL IL218038A patent/IL218038A0/en unknown
- 2012-02-20 CR CR20120087A patent/CR20120087A/es unknown
- 2012-02-27 MA MA34650A patent/MA33536B1/fr unknown
- 2012-02-28 EC ECSP12011698 patent/ECSP12011698A/es unknown
- 2012-02-29 CL CL2012000551A patent/CL2012000551A1/es unknown
-
2015
- 2015-05-26 US US14/721,795 patent/US20160075795A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110104148A1 (en) | 2011-05-05 |
| EP2473532A1 (en) | 2012-07-11 |
| CN102741293B (zh) | 2015-04-01 |
| SG178567A1 (en) | 2012-04-27 |
| KR101528013B1 (ko) | 2015-06-16 |
| CN102741293A (zh) | 2012-10-17 |
| RU2570554C2 (ru) | 2015-12-10 |
| US9068008B2 (en) | 2015-06-30 |
| CO6491105A2 (es) | 2012-07-31 |
| RU2012112340A (ru) | 2013-10-10 |
| MX339608B (es) | 2016-05-31 |
| US20160075795A1 (en) | 2016-03-17 |
| JP2013502913A (ja) | 2013-01-31 |
| MX2012002461A (es) | 2012-03-14 |
| AR078111A1 (es) | 2011-10-12 |
| CL2012000551A1 (es) | 2012-10-12 |
| CA2770174A1 (en) | 2011-03-03 |
| BR112012003983A2 (pt) | 2021-09-14 |
| KR20120060874A (ko) | 2012-06-12 |
| MA33536B1 (fr) | 2012-08-01 |
| HK1176951A1 (en) | 2013-08-09 |
| ECSP12011698A (es) | 2012-03-30 |
| CR20120087A (es) | 2012-03-22 |
| WO2011023787A1 (en) | 2011-03-03 |
| AU2010288469A1 (en) | 2012-03-01 |
| EP2473532B1 (en) | 2017-06-21 |
| TW201121994A (en) | 2011-07-01 |
| IL218038A0 (en) | 2012-04-30 |
| ZA201200954B (en) | 2014-07-30 |
| JP5744872B2 (ja) | 2015-07-08 |
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| FD | Application declared void or lapsed |