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PE20120061A1 - Derivados de pirimidina como antagonistas del receptor ccr2 - Google Patents

Derivados de pirimidina como antagonistas del receptor ccr2

Info

Publication number
PE20120061A1
PE20120061A1 PE2011001236A PE2011001236A PE20120061A1 PE 20120061 A1 PE20120061 A1 PE 20120061A1 PE 2011001236 A PE2011001236 A PE 2011001236A PE 2011001236 A PE2011001236 A PE 2011001236A PE 20120061 A1 PE20120061 A1 PE 20120061A1
Authority
PE
Peru
Prior art keywords
antagonists
alkyl
pyrimidine derivatives
ccr2 receptor
alkylene
Prior art date
Application number
PE2011001236A
Other languages
English (en)
Inventor
Heiner Ebel
Sara Franttini
Riccardo Giovannini
Christoph Hoenke
Thomas Trieselmann
Patrick Tielmann
Stefan Scheuerer
Silke Hobbie
Frank Buettner
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42049604&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120061(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20120061A1 publication Critical patent/PE20120061A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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Abstract

REFERIDA A UN COMPUESTO DERIVADO DE PIRIMIDINA DE FORMULA (I), DONDE R1 ES -L1-R7; L1 ES UN ENLACE, ALQUILENO C1-C2, ALQUENILENO C1-C2, ENTRE OTROS; R7 ES CICLOALQUILO C3-C8, HETEROARILO C5-C10, ARILO C5-C10, ENTRE OTROS; R2 ES H, HALOGENO, CN, O-ALQUILO C1-C4, ENTRE OTROS; R3 ES H, METILO, ETILO, PROPILO, ENTRE OTROS; R4 Y R5 SON UN PAR DE ELECTRONES, H, ALQUILO C1-C6, NH2, ENTRE OTROS; R6 ES H, ALQUILO C1-C4, OH, HALOGENO, ENTRE OTROS; A ES UN ENLACE SENCILLO, =CH, CH2, O, NH; Z ES C O N; n ES 1, 2 O 3. SON COMPUESTOS PREFERIDOS: (a), (b), ENTRE OTROS. DICHOS COMPUESTOS SON ANTAGONISTAS DE CCR2 (RECEPTOR 2 DE QUIMIOQUINA CC) Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES PULMONARES, NEUROLOGICAS, RELACIONADAS CON EL SISTEMA INMUNE, ENTRE OTRAS
PE2011001236A 2008-12-19 2009-12-17 Derivados de pirimidina como antagonistas del receptor ccr2 PE20120061A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08172336 2008-12-19
EP09160416 2009-05-15

Publications (1)

Publication Number Publication Date
PE20120061A1 true PE20120061A1 (es) 2012-02-19

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PE2011001236A PE20120061A1 (es) 2008-12-19 2009-12-17 Derivados de pirimidina como antagonistas del receptor ccr2

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US (3) US20120053164A1 (es)
EP (2) EP2379525B1 (es)
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KR (1) KR101754698B1 (es)
CN (2) CN102256963B (es)
AR (1) AR074814A1 (es)
AU (1) AU2009327127C1 (es)
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CA (1) CA2747677C (es)
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PE (1) PE20120061A1 (es)
PL (1) PL2379525T3 (es)
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Families Citing this family (58)

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Publication number Priority date Publication date Assignee Title
EP2155689B1 (en) 2007-05-31 2015-07-08 Boehringer Ingelheim International GmbH Ccr2 receptor antagonists and uses thereof
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
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