[go: up one dir, main page]

PE20120006A1 - Compuestos derivados de pirimidina como inhibidores de la quinasa aurora - Google Patents

Compuestos derivados de pirimidina como inhibidores de la quinasa aurora

Info

Publication number
PE20120006A1
PE20120006A1 PE2011001452A PE2011001452A PE20120006A1 PE 20120006 A1 PE20120006 A1 PE 20120006A1 PE 2011001452 A PE2011001452 A PE 2011001452A PE 2011001452 A PE2011001452 A PE 2011001452A PE 20120006 A1 PE20120006 A1 PE 20120006A1
Authority
PE
Peru
Prior art keywords
pyrimidine
methyl
inhibitors
cyclopentilamine
benzamide
Prior art date
Application number
PE2011001452A
Other languages
English (en)
Inventor
Stephan Karl Zahn
Bojan Bister
Guido Boehmelt
Ulrich Gurtler
Andres Mantoulidis
Ulrich Reiser
Andreas Schoop
Flavio Solca
Ulrike Tontsch-Grunt
Matthias Treu
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37102115&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120006(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20120006A1 publication Critical patent/PE20120006A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRIMIDINA SIENDO PREFERIDOS LOS SIGUIENTES COMPUESTOS: 4-[4-((1R,2S)-2-ISOPROPILCARBAMOIL-CICLOPENTILAMINA)-5-TRIFLUOROMETIL-PIRIMIDIN-2-IL-AMINA]-N-METIL-N-(1,2,2,6,6-PENTAMETIL-PIPERIDIN-4-IL)-BENZAMIDA; N-(1-ETIL-PIPERIDIN-4-IL)-4-[4-((1R,2S)-2-ISOPROPILCARBAMOIL-CICLOPENTILAMINA)-5-TRIFLUOROMETIL-PIRIMIDINA-2-IL-AMINA]-N-METIL-BENZAMIDA; N-METIL-4-[4-((1R,2S)-2-METILCARBAMOIL-CICLOPENTILAMINA)-5-TRIFLUOROMETIL-PIRIMIDIN-2-ILAMINA]-N-(1-METIL-PIPERIDIN-4-IL)-BENZAMIDA; 4-{4-[(1R,3S)-3-(CICLOPROPILMETIL-CARBAMOIL)-CICLOPENTILAMINA]-5-TRIFLUOROMETIL-PIRIMIDINA-2-IL-AMINA}-N-METIL-N-(1-METIL-PIPERIDIN-4-IL)-BENZAMIDA; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE LA QUINASA AURORA SIENDO UTILES EN EL TRATAMIENTO DE SARCOMA DE KAPOSI, ARTRITIS, LEUCEMIA, PSORIASIS
PE2011001452A 2006-05-15 2007-05-11 Compuestos derivados de pirimidina como inhibidores de la quinasa aurora PE20120006A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06113967 2006-05-15

Publications (1)

Publication Number Publication Date
PE20120006A1 true PE20120006A1 (es) 2012-02-02

Family

ID=37102115

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2007000569A PE20080068A1 (es) 2006-05-15 2007-05-11 Compuestos derivados de pirimidina como inhibidores de la quinasa aurora
PE2011001452A PE20120006A1 (es) 2006-05-15 2007-05-11 Compuestos derivados de pirimidina como inhibidores de la quinasa aurora

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2007000569A PE20080068A1 (es) 2006-05-15 2007-05-11 Compuestos derivados de pirimidina como inhibidores de la quinasa aurora

Country Status (21)

Country Link
US (1) US8623887B2 (es)
EP (2) EP2027107B1 (es)
JP (1) JP5247681B2 (es)
KR (1) KR20090018955A (es)
CN (1) CN101443325A (es)
AR (1) AR060890A1 (es)
AT (1) ATE545641T1 (es)
AU (1) AU2007251553A1 (es)
BR (1) BRPI0712400A2 (es)
CA (1) CA2647238A1 (es)
EA (1) EA200802214A1 (es)
EC (1) ECSP088905A (es)
IL (1) IL195218A0 (es)
MX (1) MX2008014500A (es)
NO (1) NO20083845L (es)
NZ (1) NZ573506A (es)
PE (2) PE20080068A1 (es)
TW (1) TW200815392A (es)
UA (1) UA94944C2 (es)
WO (1) WO2007132010A1 (es)
ZA (1) ZA200807581B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2109605B1 (en) * 2006-12-22 2013-02-20 Boehringer Ingelheim International GmbH 2- [(phenylamino) -pyrimidin-4ylamin0] -cyclopentane carboxamide derivatives and related compounds as inhibitors of kinases of the cell cycle for the treatment of cancer
CL2008001943A1 (es) 2007-07-02 2009-09-11 Boehringer Ingelheim Int Compuestos derivados de fenil-triazol, inhibidores de enzimas de señales especificas que participan del control de la proliferacion celular; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer, infecciones, enfermedades inflamatorias y autoinmunes.
EP2268621A1 (en) * 2008-03-20 2011-01-05 Boehringer Ingelheim International GmbH Regioselective preparation of substituted pyrimidines
UY31714A (es) * 2008-03-20 2009-11-10 Boehringer Ingelheim Int Preparación selectiva de pirimidinas sustituidas
CL2009000600A1 (es) * 2008-03-20 2010-05-07 Bayer Cropscience Ag Uso de compuestos de diaminopirimidina como agentes fitosanitarios; compuestos de diaminopirimidina; su procedimiento de preparacion; agente que los contiene; procedimiento para la preparacion de dicho agente; y procedimiento para combatir plagas de animales y/u hongos dañinos patogenos de plantas.
MX2011003292A (es) 2008-09-29 2011-04-21 Boehringer Ingelheim Int Compuestos antiproliferativos.
US20110071158A1 (en) * 2009-03-18 2011-03-24 Boehringer Ingelheim International Gmbh New compounds
US8410126B2 (en) 2009-05-29 2013-04-02 Boehringer Ingelheim International Gmbh Pyrimidine inhibitors of PKTK2
EP2464633A1 (en) 2009-08-14 2012-06-20 Boehringer Ingelheim International GmbH Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US8933227B2 (en) 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
US8466155B2 (en) * 2009-10-02 2013-06-18 Boehringer Ingelheim International Gmbh Pyrimidines
EP2552907B1 (en) 2010-03-26 2014-10-22 Boehringer Ingelheim International GmbH Pyridyltriazoles
US20120107304A1 (en) 2010-04-27 2012-05-03 Boehringer Ingelheim International Gmbh Combination therapy in treatment of oncological and fibrotic diseases
CN105837519A (zh) 2010-06-04 2016-08-10 霍夫曼-拉罗奇有限公司 作为lrrk2调节剂的氨基嘧啶衍生物
WO2012059932A1 (en) * 2010-11-01 2012-05-10 Aurigene Discovery Technologies Limited 2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors
CN103313978B (zh) 2010-11-10 2015-04-15 霍夫曼-拉罗奇有限公司 作为lrrk2调节剂的吡唑氨基嘧啶衍生物
US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
CN105793251B (zh) * 2013-12-05 2018-10-12 豪夫迈·罗氏有限公司 具有亲电子官能性的杂芳基吡啶酮和氮杂-吡啶酮化合物
RU2016129380A (ru) * 2013-12-20 2018-01-25 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Замещенные диаминопиримидильные соединения, их композиции и способы лечения с их участием

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69933680T2 (de) 1998-08-29 2007-08-23 Astrazeneca Ab Pyrimidine verbindungen
BRPI9915552B8 (pt) * 1998-11-10 2021-05-25 Janssen Pharmaceutica Nv pirimidinas inibidoras da reprodução do hiv
GB9828511D0 (en) * 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB0007371D0 (en) 2000-03-28 2000-05-17 Astrazeneca Uk Ltd Chemical compounds
GB0016877D0 (en) 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
PL367130A1 (en) * 2001-05-29 2005-02-21 Schering Aktiengesellschaft Cdk inhibiting pyrimidines, production thereof and their use as medicaments
DK1534286T3 (da) 2002-07-29 2010-04-26 Rigel Pharmaceuticals Inc Fremgangsmåder til behandling eller forebyggelse af autoimmune sygdomme med 2,4-pyrimidindiamin-forbindelser
JP4634367B2 (ja) 2003-02-20 2011-02-16 スミスクライン ビーチャム コーポレーション ピリミジン化合物
GB0305929D0 (en) 2003-03-14 2003-04-23 Novartis Ag Organic compounds
ATE506953T1 (de) * 2003-08-07 2011-05-15 Rigel Pharmaceuticals Inc 2,4-pyrimidindiamin-verbindungen und verwendungen als antiproliferative mittel
EP1763514A2 (en) * 2004-05-18 2007-03-21 Rigel Pharmaceuticals, Inc. Cycloalkyl substituted pyrimidinediamine compounds and their uses
EP1598343A1 (de) 2004-05-19 2005-11-23 Boehringer Ingelheim International GmbH 2-Arylaminopyrimidine als PLK Inhibitoren
US7521457B2 (en) 2004-08-20 2009-04-21 Boehringer Ingelheim International Gmbh Pyrimidines as PLK inhibitors
US20070032514A1 (en) 2005-07-01 2007-02-08 Zahn Stephan K 2,4-diamino-pyrimidines as aurora inhibitors

Also Published As

Publication number Publication date
CN101443325A (zh) 2009-05-27
EP2357181A1 (de) 2011-08-17
US20090163467A1 (en) 2009-06-25
CA2647238A1 (en) 2007-11-22
EP2027107B1 (de) 2012-02-15
JP5247681B2 (ja) 2013-07-24
MX2008014500A (es) 2008-11-27
PE20080068A1 (es) 2008-03-17
EA200802214A1 (ru) 2009-06-30
NZ573506A (en) 2011-12-22
NO20083845L (no) 2008-12-11
TW200815392A (en) 2008-04-01
BRPI0712400A2 (pt) 2012-10-16
AR060890A1 (es) 2008-07-23
EP2027107A1 (de) 2009-02-25
UA94944C2 (ru) 2011-06-25
WO2007132010A1 (de) 2007-11-22
US8623887B2 (en) 2014-01-07
ZA200807581B (en) 2010-05-26
ATE545641T1 (de) 2012-03-15
ECSP088905A (es) 2008-12-30
IL195218A0 (en) 2009-09-22
KR20090018955A (ko) 2009-02-24
AU2007251553A1 (en) 2007-11-22
JP2009537485A (ja) 2009-10-29

Similar Documents

Publication Publication Date Title
PE20120006A1 (es) Compuestos derivados de pirimidina como inhibidores de la quinasa aurora
CL2004001834A1 (es) Compuesto 4-{4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenoxi}-piridin-2-metilamida, inhibidor de la raf, vegfr, p38 y pdgfr quinasas, sus sales; composiicon farmaceutica; combinacion farmaceutica; y su uso para tratar trastornos hiperprol
CY1109854T1 (el) Παραγωγα αζαδικυκλο(3.1.0)εξανιου χρησιμα ως ρυθμιστες υποδοχεων d3 ντοπαμινης
PE20121050A1 (es) Compuestos de n-(1-(4-(1h-pirazol-5-il)ftalazin-1-il)piperidin-4-il)-benzamida sustituidos como antagonistas de la trayectoria hedgehog
BR0313330A (pt) Piperidina-ftalazonas substituìdas com pirrolidinadiona como inibidores de pde4
EA201070238A1 (ru) Соединения пиримидина
NO20093200L (no) Tiazolidinderivater
NO20075624L (no) Nye histamin H3-reseptorligander og deres terapeutiske anvendelser
EA201000396A1 (ru) Новые фунгициды
PE20080768A1 (es) Compuestos de isoindolina 5-sustituidos
ZA201102735B (en) Antagonists of the vanilloid receptor subtype 1(vr1) and uses thereof
EA201000395A1 (ru) Фунгицидные производные 2-алкилтио-2-хинолинилоксиацетамида
PE20142355A1 (es) 1-pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il)ureas como inhibidores de proteinas cinasas activadas por mitogeno p38
ATE493386T1 (de) Trans-3-aza-bicyclo-ä3.1.0ü-hexan-derivate
PE20110433A1 (es) Antagonistas de la via hedgehog de ftalazina disustituida
DK2114933T3 (da) Piperidin-GPCR-agonister
MX2007005933A (es) Compuestos de acetamida como fungicidas.
PE20150463A1 (es) HETEROCICLOS DE 5 MIEMBROS QUE CONTIENEN NITROGENO SUSTITUIDOS POR CARBOXAMIDA O SULFONAMIDA COMO MODULADORES PARA EL RECEPTOR NUCLEAR HUERFANO RORgamma
EA200870489A1 (ru) Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1
EA201000269A1 (ru) Новые гербициды
IS2696B (is) Setin 2-amínótetralín fyrir meðhöndlunina á geðdeyfð
ATE477256T1 (de) Thienylverbindungen
EA200801608A1 (ru) Производные бензимидазолонкарбоновой кислоты
CR8350A (es) 4-anilino-3-quinolincarbonitrilos para el tratamiento de leucemia mielogenica cronica
UY28200A1 (es) Acidos carboxílicos de heteroarilo condensado como agonistas del ppar

Legal Events

Date Code Title Description
FA Abandonment or withdrawal