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PE20091346A1 - Compuestos tretraciclicos como moduladores de un receptor aminergico acoplado a la proteina g - Google Patents

Compuestos tretraciclicos como moduladores de un receptor aminergico acoplado a la proteina g

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Publication number
PE20091346A1
PE20091346A1 PE2008001834A PE2008001834A PE20091346A1 PE 20091346 A1 PE20091346 A1 PE 20091346A1 PE 2008001834 A PE2008001834 A PE 2008001834A PE 2008001834 A PE2008001834 A PE 2008001834A PE 20091346 A1 PE20091346 A1 PE 20091346A1
Authority
PE
Peru
Prior art keywords
hydroxyl
alkyl
receptor
compounds
modulators
Prior art date
Application number
PE2008001834A
Other languages
English (en)
Inventor
David T Hung
Andrew Asher Protter
Rajendra Parasmal Jain
Sundeep Dugar
Sarvajit Chakravarty
Sergey Olegovich Bachurin
Anatoly Konstantinovich Ustinov
Bogdan Konstantinovich Beznosko
Elena Feofanovna Shevtsova
Vladimir Viktorovich Grigoriev
Original Assignee
Medivation Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivation Technologies Inc filed Critical Medivation Technologies Inc
Publication of PE20091346A1 publication Critical patent/PE20091346A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Psychiatry (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Pain & Pain Management (AREA)
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  • Transplantation (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDO A UN COMPUESTO TRETRACICLICO DE FORMULA E, DONDE R1 ES H, HIDROXILO, NITRO, ENTRE OTROS, R2a Y R2b SON CADA UNO, H, ALQUILO C1-C8 SUSTITUIDO O NO, HALO, HIDROXILO, ENTRE OTROS, R3a Y R3b SON CADA UNO, H, ALQUILO C1-C8 SUSTITUIDO O NO, HALO, ENTRE OTROS, X7, X8, X9 Y X10 SON CADA UNO N O CR4, R4 ES H, HIDROXILO, NITRO, ENTRE OTROS, m Y q SON CADA UNO 0 O 1, R8a, R8b, R8c, R8d, R8e Y R8f SON CADA UNO H, HIDROXILO, ALQUILO C1-C8, ENTRE OTROS, R10a Y R10b SON CADA UNO H, ALQUILO C1-C8 SUSTITUIDO O NO, HALO, ENTRE OTROS, Q ES ARILO, HETEROARILO, CICLOALQUILO SUSTITUIDOS O NO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2,3,4,5-TETRAHIDRO-2,8-DIMETIL-1H-PIRIDO[4,3-b] INDOL, 8-BROMO-2,3,4,5-TETRAHIDRO-2-METIL-1H-PIRIDO[4,3-b]INDOL, 8-CLORO-2,3,4,5-TETRAHIDRO-2-METIL-1H-PIRIDO[4,3-b]INDOL. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE UN RECEPTOR AMINERGICO ACOPLADO A LA PROTEINA G, TAL COMO UN RECEPTOR ADRENERGICO ( 1D, 2A Y/O 2B), UN RECEPTOR DE SEROTONINA (5-HT2A, 5-HT2B, 5-HT6 Y/O 5-HT7), UN RECEPTOR DE DOPAMINA (D2L) O UN RECEPTOR DE HISTAMINA (H1, H2 Y/O H3), SIENDO UTILES PARA EL TRATAMIENTO DE ENFERMEDAD DE ALZHEIMER, MAL DE PARKINSON, AUTISMO, ESCLEROSIS MULTIPLE, ESQUIZOFRENIA, TRASTORNO BIPOLAR, ENTRE OTROS
PE2008001834A 2007-10-25 2008-10-27 Compuestos tretraciclicos como moduladores de un receptor aminergico acoplado a la proteina g PE20091346A1 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US98267807P 2007-10-25 2007-10-25
US98267907P 2007-10-25 2007-10-25
RU2007139634/04A RU2007139634A (ru) 2007-10-25 2007-10-25 Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения
US6233208P 2008-01-25 2008-01-25
US6233108P 2008-01-25 2008-01-25
US3375408P 2008-03-04 2008-03-04
US3375708P 2008-03-04 2008-03-04

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PE20091346A1 true PE20091346A1 (es) 2009-09-23

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US (6) US8338408B2 (es)
EP (1) EP2217598A1 (es)
JP (1) JP5665543B2 (es)
CN (2) CN101952284A (es)
AU (1) AU2008316560B2 (es)
BR (1) BRPI0816582A2 (es)
CA (1) CA2704008A1 (es)
PE (1) PE20091346A1 (es)
RU (1) RU2007139634A (es)
UY (1) UY31436A1 (es)
WO (1) WO2009055828A1 (es)

Families Citing this family (80)

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Publication number Priority date Publication date Assignee Title
UA98324C2 (ru) * 2007-04-05 2012-05-10 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1H-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
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US9034880B2 (en) 2015-05-19
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CN106188043A (zh) 2016-12-07
US8999978B2 (en) 2015-04-07
US8338408B2 (en) 2012-12-25
US20150182509A1 (en) 2015-07-02
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US20130190304A1 (en) 2013-07-25

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