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PE20091435A1 - Compuestos de 2,3,4,5-tetrahidro-1h-pirido[4,3-b]indol como moduladores del receptor de histamina - Google Patents

Compuestos de 2,3,4,5-tetrahidro-1h-pirido[4,3-b]indol como moduladores del receptor de histamina

Info

Publication number
PE20091435A1
PE20091435A1 PE2009000103A PE2009000103A PE20091435A1 PE 20091435 A1 PE20091435 A1 PE 20091435A1 PE 2009000103 A PE2009000103 A PE 2009000103A PE 2009000103 A PE2009000103 A PE 2009000103A PE 20091435 A1 PE20091435 A1 PE 20091435A1
Authority
PE
Peru
Prior art keywords
tetrahydro
cyane
halo
alkyl
receptor modulators
Prior art date
Application number
PE2009000103A
Other languages
English (en)
Inventor
David T Hung
Andrew Asher Protter
Sarvajit Chakravarty
Rajendra Parasmal Jain
Original Assignee
Medivation Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40901464&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091435(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medivation Technologies Inc filed Critical Medivation Technologies Inc
Publication of PE20091435A1 publication Critical patent/PE20091435A1/es

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    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
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Abstract

REFERIDA A UN DERIVADO DE INDOL DE FORMULA (E), DONDE R1 ES H, OH, NITRO, CIANO, HALO, ENTRE OTROS; R2a Y R2b SON H, ALQUILO C1-C8, OH, CIANO, ENTRE OTROS; R3a Y R3b SON H, ALQUILO C1-C8, HALO, CIANO, ENTRE OTROS; X7, X8, X9 Y X10 SON N O CR4; m, q Y n SON 0 O 1; R4 ES H, OH, NITRO, CIANO, HALO, ENTRE OTROS; R8a, R8b, R8c, R8d, R8e Y R8f SON H, OH, ALQUILO C1-C8, ENTRE OTROS; R10a Y R10b SON H, ALQUILO C1-C8, HALO, OH; ENTRE OTROS; Q ES ACILAMINO ACICLICO O CICLICO, CARBONILALCOXI, AMINOACILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-(1,2,3,4-TETRAHIDRO-2,8-DIMETILPIRIDO[4,3-b]INDOL-5-IL)PROPANOATO DE ETILO, 4-(1,2,3,4-TETRAHIDRO-2,8-DIMETILPIRIDO[4,3-b]INDOL-5-IL)BUTANOATO DE ETILO, 2-(8-CLORO-1,2,3,4-TETRAHIDRO-2-METILPIRIDO[4,3-b]INDOL-5-IL)ACETATO DE ETILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR DE HISTAMINA Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS PSICOTICOS, COGNITIVOS, TRASNTORNOS NEURONALES, ENTRE OTROS
PE2009000103A 2008-01-25 2009-01-26 Compuestos de 2,3,4,5-tetrahidro-1h-pirido[4,3-b]indol como moduladores del receptor de histamina PE20091435A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6239408P 2008-01-25 2008-01-25
US6243008P 2008-01-25 2008-01-25
RU2008102993/04A RU2544856C2 (ru) 2008-01-25 2008-01-25 НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ

Publications (1)

Publication Number Publication Date
PE20091435A1 true PE20091435A1 (es) 2009-10-14

Family

ID=40901464

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PE2009000103A PE20091435A1 (es) 2008-01-25 2009-01-26 Compuestos de 2,3,4,5-tetrahidro-1h-pirido[4,3-b]indol como moduladores del receptor de histamina

Country Status (13)

Country Link
US (3) US9115137B2 (es)
EP (1) EP2244708B1 (es)
JP (1) JP2011510932A (es)
CN (1) CN101983059B (es)
AR (1) AR072042A1 (es)
AU (1) AU2009206246C1 (es)
BR (1) BRPI0905783A2 (es)
CA (1) CA2713997A1 (es)
CL (1) CL2009000161A1 (es)
PE (1) PE20091435A1 (es)
RU (1) RU2544856C2 (es)
UY (1) UY31614A1 (es)
WO (1) WO2009094668A1 (es)

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