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PE20091673A1 - Nuevos derivados de carbazol, inhibidores de hsp90, composiciones que los contienen y utilizacion - Google Patents

Nuevos derivados de carbazol, inhibidores de hsp90, composiciones que los contienen y utilizacion

Info

Publication number
PE20091673A1
PE20091673A1 PE2009000368A PE2009000368A PE20091673A1 PE 20091673 A1 PE20091673 A1 PE 20091673A1 PE 2009000368 A PE2009000368 A PE 2009000368A PE 2009000368 A PE2009000368 A PE 2009000368A PE 20091673 A1 PE20091673 A1 PE 20091673A1
Authority
PE
Peru
Prior art keywords
benzamide
compositions containing
carbazol
benzimidazol
hydroxy
Prior art date
Application number
PE2009000368A
Other languages
English (en)
Inventor
Marcel Alasia
Luc Bertin
Victor Certal
Franck Halley
Patrick Mailliet
Herve Minoux
Jean-Marie Ruxer
Perez Maria Mendez
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39930567&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091673(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20091673A1 publication Critical patent/PE20091673A1/es

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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Organic Chemistry (AREA)
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE HET ES DE PREFERENCIA BENZIMIDAZOL-2-IL, BENZOPIRIDIN-3-IL, TIAZOL-2-IL, ENTRE OTROS; R ES 2-(4-HIDROXI-CICLOHEXILAMINO)BENZAMIDA, 2-AMINO-BENZAMIDA, 1-ETANOL-3-AMINO-BENZOISOXAZOL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-[4-(6-FLUORO-1H-BENZIMIDAZOL-2-IL)-9H-CARBAZOL-9-IL]-2-(4-TRANS-HIDROXI-CICLOHEXILAMINO)-BENZAMIDA; 2-(DIETILAMINO-ETILAMINO)-4-[4-(6-FLUORO-1H-BENZIMIDAZOL-2-IL)-9H-CARBAZOL-9-IL]-BENZAMIDA; 3-(TRANS-4-HIDROXI-CILOHEXILAMINO)-5-[(4-QUINOLEIN-3-IL)-9H-CARBAZOL-9-IL]-PIRIDIN-2-CARBOXAMIDA; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA CHAPERONA HSP90 (PROTEINA DE CHOQUE TERMICO) UTILES EN EL TRATAMIENTO DE TUMORES MALIGNOS
PE2009000368A 2008-03-14 2009-03-12 Nuevos derivados de carbazol, inhibidores de hsp90, composiciones que los contienen y utilizacion PE20091673A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0801394A FR2928645A1 (fr) 2008-03-14 2008-03-14 Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation

Publications (1)

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PE20091673A1 true PE20091673A1 (es) 2009-11-14

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PE2009000368A PE20091673A1 (es) 2008-03-14 2009-03-12 Nuevos derivados de carbazol, inhibidores de hsp90, composiciones que los contienen y utilizacion

Country Status (24)

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US (1) US8309721B2 (es)
EP (1) EP2265598A2 (es)
JP (1) JP5674483B2 (es)
KR (1) KR20100130603A (es)
CN (1) CN102026992A (es)
AR (1) AR070836A1 (es)
AU (1) AU2009232121A1 (es)
BR (1) BRPI0909731A2 (es)
CA (1) CA2718488A1 (es)
CL (1) CL2009000619A1 (es)
CO (1) CO6251295A2 (es)
CR (1) CR11653A (es)
DO (1) DOP2010000272A (es)
EA (1) EA201071078A1 (es)
EC (1) ECSP10010473A (es)
FR (1) FR2928645A1 (es)
IL (1) IL208059A0 (es)
MA (1) MA32206B1 (es)
MX (1) MX2010010018A (es)
NI (1) NI201000150A (es)
PE (1) PE20091673A1 (es)
TW (1) TW200938541A (es)
UY (1) UY31711A (es)
WO (1) WO2009122034A2 (es)

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PL3201177T3 (pl) * 2014-10-01 2019-05-31 Janssen Pharmaceuticals Inc Mono- lub di-podstawione indole jako inhibitory replikacji wirusa dengi
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KR20180004193A (ko) * 2015-04-29 2018-01-10 아레나 파마슈티칼스, 인크. Gpr52와 관련된 장애의 치료 또는 예방을 위한 gpr52 조절제로서 1-헤테로아릴-인돌린-4-카르복스아미드
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) * 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) * 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
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DE102017008073A1 (de) * 2017-08-28 2019-02-28 Henkel Ag & Co. Kgaa Neue anionische Tenside und Wasch- und Reinigungsmittel, welche diese enthalten
CN111217741B (zh) * 2019-03-01 2022-03-15 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 氟取代单咔唑类衍生物、其制备方法及应用
TWI893378B (zh) * 2022-04-28 2025-08-11 大陸商北京丹擎醫藥科技有限公司 三環雜環衍生物，其組合物和應用
CN120603829A (zh) * 2023-03-31 2025-09-05 上海翊维康医药有限责任公司 杂芳环化合物及其制备方法和用途
CN117229196A (zh) * 2023-08-23 2023-12-15 贵州省茶叶研究所 一类水杨醛咔唑化合物及其应用
CN117159570B (zh) * 2023-11-01 2024-01-23 云南中医药大学 6-酰氧基甘露糖叠氮乙苷衍生物与氟康唑联合在制备抗耐药白念珠菌药物中的应用
CN117486782A (zh) * 2023-12-29 2024-02-02 中国医学科学院药用植物研究所 一种n-取代咔唑衍生物及其制备方法和应用

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BRPI0909731A2 (pt) 2019-03-06
MA32206B1 (fr) 2011-04-01
KR20100130603A (ko) 2010-12-13
FR2928645A1 (fr) 2009-09-18
JP2011513473A (ja) 2011-04-28
CO6251295A2 (es) 2011-02-21
WO2009122034A3 (fr) 2009-12-03
IL208059A0 (en) 2010-12-30
EP2265598A2 (fr) 2010-12-29
AR070836A1 (es) 2010-05-05
US8309721B2 (en) 2012-11-13
WO2009122034A2 (fr) 2009-10-08
NI201000150A (es) 2011-03-29
UY31711A (es) 2009-11-10
JP5674483B2 (ja) 2015-02-25
ECSP10010473A (es) 2010-10-30
CN102026992A (zh) 2011-04-20
CL2009000619A1 (es) 2011-02-18
TW200938541A (en) 2009-09-16
CA2718488A1 (fr) 2009-10-08
CR11653A (es) 2010-11-22
AU2009232121A1 (en) 2009-10-08
MX2010010018A (es) 2010-12-15
EA201071078A1 (ru) 2011-04-29
US20110166169A1 (en) 2011-07-07
DOP2010000272A (es) 2010-10-15
WO2009122034A8 (fr) 2010-08-19

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