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CO6260074A2 - Compuestos de 5-(4-(halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones como inhibidores de cinasa - Google Patents

Compuestos de 5-(4-(halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones como inhibidores de cinasa

Info

Publication number
CO6260074A2
CO6260074A2 CO10033947A CO10033947A CO6260074A2 CO 6260074 A2 CO6260074 A2 CO 6260074A2 CO 10033947 A CO10033947 A CO 10033947A CO 10033947 A CO10033947 A CO 10033947A CO 6260074 A2 CO6260074 A2 CO 6260074A2
Authority
CO
Colombia
Prior art keywords
carbon atoms
optionally substituted
halogen
alkyl
halo
Prior art date
Application number
CO10033947A
Other languages
English (en)
Inventor
Valentina Molteni
Xiaolin Li
Xiaodong Liu
Donatella Chianelli
Juliet Nabakka
Jon Loren
Shuli You
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39929716&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6260074(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Irm Llc filed Critical Irm Llc
Publication of CO6260074A2 publication Critical patent/CO6260074A2/es

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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Abstract

1.- Un compuesto de la fórmula (I): o una sal farmacéuticamente aceptable del mismo; R1 es un halo-alquilo que tiene de 1 a 6 átomos de flúor; R2 es alquilo de 1 a 6 átomos de carbono, alquenilo de 2 a 6 átomos de carbono o alquinilo de 2 a 6 átomos de carbono, cada uno de los cuales puede estar opcionalmente sustituido con grupos halógeno, amino o hidroxilo; halógeno, ciano, nitro, (CR2)kOR7, (CR2)kO(CR2)1-4R7, (CR2)kSR7, (CR2)kNR9R10, (CR2)kC(O)Oo-1R7, OC(O)R7, (CR2)kC(S)R7, (CR2)kC(O)NR9R10, (CR2)kC(O)NR(CR2)0-6C(O)Oo-1R7, (CR2)kNRC(O)Oo-1R7, (CR2)kS(O)1-2NR9R10, (CR2)kS(O)1-2R8, (CR2)kNRS(O)1-2R8 o (CR2)kR6; o cualesquiera dos grupos R2 adyacentes pueden formar juntos un anillo de arilo o heteroarilo carbocíclico, heterocíclico, de 5 a 8 miembros, opcionalmente sustituido; R3 es -L-NR4R5, -X-NR-C(O)R8 o -X-NR-C(O)NR4R5 en donde L es -X- C(O), -X-OC(O), -(CR2)j, -SO0-2(CR2)j, -O(CR2)1-4, o ; y X es (CR2)j o [C(R)-(CR2OR)]; R4, R5, R9 y R10 son independientemente H; alquilo de 1 a 6 átomos de carbono, alquenilo de 2 a 6 átomos de carbono o alquinilo de 2 a 6 átomos de carbono, cada uno de los cuales puede estar opcionalmente sustituido con halógeno, amino, hidroxilo, alcoxilo, ciano, carboxilo o R6; (CR2)kCN, (CR2)1-6NR7R7, (CR2)1-6OR7, (CR2)kC(O)O0-1R7, (CR2)kC(O)NR7R7 o (CR2)k-R6; R6 es un cicloalquilo de 3 a 7 átomos de carbono opcionalmente sustituido, arilo de 6 a 10 átomos de carbono, o un anillo de heteroarilo de 5 a 10 miembros o heterocíclico de 5 a 7 miembros; R7 y R8 son independientemente (CR2)k-R6 o alquilo de 1 a 6 átomos de carbono, alquenilo de 2 a 6 átomos de carbono o alquinilo de 2 a 6 átomos de carbono, cada uno de los cuales puede estar opcionalmente sustituido con halógeno, amino, amido, hidroxilo, alcoxilo, ciano, carboxilo o R6; o R7 es H; ...
CO10033947A 2007-08-22 2010-03-23 Compuestos de 5-(4-(halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones como inhibidores de cinasa CO6260074A2 (es)

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