CY1118723T1 - Ενωσεις βενζοθειαζολιου και αζαβενζοθειαζολιου χρησιμες ως αναστολεiς κινασης - Google Patents
Ενωσεις βενζοθειαζολιου και αζαβενζοθειαζολιου χρησιμες ως αναστολεiς κινασηςInfo
- Publication number
- CY1118723T1 CY1118723T1 CY20161100641T CY161100641T CY1118723T1 CY 1118723 T1 CY1118723 T1 CY 1118723T1 CY 20161100641 T CY20161100641 T CY 20161100641T CY 161100641 T CY161100641 T CY 161100641T CY 1118723 T1 CY1118723 T1 CY 1118723T1
- Authority
- CY
- Cyprus
- Prior art keywords
- kinase
- benzothiazole
- suspensions
- formula
- compounds useful
- Prior art date
Links
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 2
- FNQJDLTXOVEEFB-UHFFFAOYSA-N 1,2,3-benzothiadiazole Chemical class C1=CC=C2SN=NC2=C1 FNQJDLTXOVEEFB-UHFFFAOYSA-N 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 239000000725 suspension Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Ένωση του Τύπου (I), ή εναντιομερές, διαστερεομερές ή φαρμακευτικώς αποδεκτό άλας αυτής, όπου το Α επιλέγεται ανεξαρτήτως από: (α), (β), (γ), ή (δ), περαιτέρω όπου τα R1, R2, R3, R4, R5, R6, R7, και W είναι όπως περιγράφονται στο παρόν. Επίσης αποκαλύπτεται ένωση του τύπου (II), ή εναντιομερές, διαστερεομερές, ή φαρμακευτικώς αποδεκτό άλας αυτής, όπου καθένα από τα G, Χ και Υ είναι ανεξαρτήτως CH ή N, όπου σε κάθε εμφάνιση τουλάχιστον ένα από τα G, Χ ή Υ είναι Ν και τα άλλα δυο από τα G, Χ ή Υ είναι CH, και το Β επιλέγεται ανεξαρτήτως από: (α), (β), (γ), (δ), ή (ε), περαιτέρω όπου τα R1, R2, R3, R4, R5, R8, R9 και Ζ είναι όπως περιγράφονται στο παρόν. Επίσης αποκαλύπτονται φαρμακευτικές συνθέσεις που περιέχουν ενώσεις του Τύπου (I) και του Τύπου (II), και μεθόδους θεραπευτικής αγωγής καταστάσεων που συνδέονται με τη δραστικότητα κινάσης p38.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70435105P | 2005-08-01 | 2005-08-01 | |
| US11/494,234 US7473784B2 (en) | 2005-08-01 | 2006-07-27 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
| PCT/US2006/029520 WO2007016392A2 (en) | 2005-08-01 | 2006-07-28 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118723T1 true CY1118723T1 (el) | 2017-07-12 |
Family
ID=37569657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100641T CY1118723T1 (el) | 2005-08-01 | 2016-07-07 | Ενωσεις βενζοθειαζολιου και αζαβενζοθειαζολιου χρησιμες ως αναστολεiς κινασης |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7473784B2 (el) |
| EP (2) | EP2266981B1 (el) |
| CY (1) | CY1118723T1 (el) |
| DK (1) | DK1910348T3 (el) |
| ES (1) | ES2578278T3 (el) |
| HU (1) | HUE029733T2 (el) |
| PL (1) | PL1910348T3 (el) |
| PT (1) | PT1910348T (el) |
| SI (1) | SI1910348T1 (el) |
| WO (1) | WO2007016392A2 (el) |
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| ME01498B (me) | 2004-11-18 | 2014-04-20 | Synta Pharmaceuticals Corp | Jedinjenja triazola koja modulišu aktivnost hsp90 |
| AU2006279794B2 (en) * | 2005-08-12 | 2011-04-07 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate HSP90 activity |
| TWI446910B (zh) | 2005-08-18 | 2014-08-01 | Synta Pharmaceuticals Corp | 調節ｈｓｐ９０活性的三唑化合物 |
| US20080027047A1 (en) * | 2006-05-25 | 2008-01-31 | Weiwen Ying | Compounds that modulate HSP90 activity and methods for identifying same |
| EP2617398B1 (en) | 2007-03-13 | 2017-11-15 | Optimedica Corporation | Intraocular lens for improved placement |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| JP5561702B2 (ja) * | 2007-08-02 | 2014-07-30 | アムジエン・インコーポレーテツド | Ｐｉ３キナーゼ調節剤および使用方法 |
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| WO2009126635A1 (en) * | 2008-04-09 | 2009-10-15 | Abbott Laboratories | 2-amino-benzothiazole derivates useful as inhibitors of rock kinases |
| JP5762971B2 (ja) | 2008-12-03 | 2015-08-12 | プレシディオ ファーマシューティカルズ インコーポレイテッド | Ｈｃｖｎｓ５ａの阻害剤 |
| WO2010100144A1 (en) * | 2009-03-04 | 2010-09-10 | Merck Serono S.A. | Fused bicyclic compounds as inhibitors for pi3 kinase |
| US20190127365A1 (en) | 2017-11-01 | 2019-05-02 | Merck Sharp & Dohme Corp. | Inhibitors of hepatitis c virus replication |
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| CA2763140A1 (en) | 2009-05-29 | 2010-12-02 | Schering Corporation | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
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| EP2575866A4 (en) * | 2010-05-24 | 2013-10-16 | Presidio Pharmaceuticals Inc | HCV NS5A INHIBITORS |
| EP2588450B1 (en) | 2010-07-02 | 2017-05-24 | Gilead Sciences, Inc. | Napht-2-ylacetic acid derivatives to treat aids |
| SG186821A1 (en) | 2010-07-02 | 2013-02-28 | Gilead Sciences Inc | 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds |
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| CA2812779A1 (en) | 2010-09-29 | 2012-04-19 | Merck Sharp & Dohme Corp. | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
| CN103298792A (zh) | 2010-11-19 | 2013-09-11 | 利亘制药公司 | 杂环胺及其用途 |
| TWI410425B (zh) * | 2010-12-03 | 2013-10-01 | Lilly Co Eli | 唑并［５，４－ｂ］吡啶－５－基化合物 |
| WO2012122716A1 (en) | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Tetracyclic xanthene derivatives and methods of use thereof for treatment of viral diseases |
| SG194512A1 (en) * | 2011-04-21 | 2013-12-30 | Gilead Sciences Inc | Benzothiazole compounds and their pharmaceutical use |
| AR086992A1 (es) | 2011-06-20 | 2014-02-05 | Bayer Ip Gmbh | Tienilpiri(mi)dinilpirazoles |
| BR112014008223A2 (pt) | 2011-10-06 | 2017-04-25 | Bayer Ip Gmbh | heterociclilpiri (mi) dinilpirazol |
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| CA2850881C (en) | 2012-04-20 | 2021-02-16 | Gilead Sciences, Inc. | Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection |
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| EP3265454B1 (en) * | 2015-03-02 | 2020-02-26 | Rigel Pharmaceuticals, Inc. | Tgf-beta inhibitors |
| US10807983B2 (en) | 2015-03-16 | 2020-10-20 | Ligand Pharmaceuticals, Inc. | Imidazo-fused heterocycles and uses thereof |
| JP7376471B2 (ja) | 2017-06-05 | 2023-11-08 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| EP3654975A4 (en) * | 2017-07-21 | 2021-06-23 | Icahn School of Medicine at Mount Sinai | BENZOTHIAZOLE AND PYRIDOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| PT3691620T (pt) | 2017-10-05 | 2022-10-06 | Fulcrum Therapeutics Inc | Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd |
| JP7399870B2 (ja) | 2018-03-27 | 2023-12-18 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| LT3814357T (lt) | 2018-06-27 | 2024-06-25 | Ptc Therapeutics, Inc. | Heterocikliniai ir heteroarilų junginiai, skirti hantingtono ligos gydymui |
| EA202092899A1 (ru) * | 2018-06-27 | 2021-05-14 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Гетероарильные соединения для лечения болезни гентингтона |
| CN114437113B (zh) * | 2022-03-18 | 2023-05-02 | 西安交通大学 | 一种噻唑并吡啶环联三氮唑类化合物及其制备方法和应用 |
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| US7320995B2 (en) | 2002-08-09 | 2008-01-22 | Eli Lilly And Company | Benzimidazoles and benzothiazoles as inhibitors of map kinase |
-
2006
- 2006-07-27 US US11/494,234 patent/US7473784B2/en active Active
- 2006-07-28 PL PL06788851.1T patent/PL1910348T3/pl unknown
- 2006-07-28 DK DK06788851.1T patent/DK1910348T3/en active
- 2006-07-28 SI SI200632054A patent/SI1910348T1/sl unknown
- 2006-07-28 EP EP10184708.5A patent/EP2266981B1/en not_active Not-in-force
- 2006-07-28 ES ES06788851.1T patent/ES2578278T3/es active Active
- 2006-07-28 EP EP06788851.1A patent/EP1910348B1/en not_active Not-in-force
- 2006-07-28 PT PT67888511T patent/PT1910348T/pt unknown
- 2006-07-28 HU HUE06788851A patent/HUE029733T2/en unknown
- 2006-07-28 WO PCT/US2006/029520 patent/WO2007016392A2/en not_active Ceased
-
2008
- 2008-12-12 US US12/333,425 patent/US7994337B2/en active Active
-
2016
- 2016-07-07 CY CY20161100641T patent/CY1118723T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7994337B2 (en) | 2011-08-09 |
| SI1910348T1 (sl) | 2016-06-30 |
| ES2578278T3 (es) | 2016-07-22 |
| EP2266981A2 (en) | 2010-12-29 |
| US20070185175A1 (en) | 2007-08-09 |
| EP1910348B1 (en) | 2016-04-13 |
| US7473784B2 (en) | 2009-01-06 |
| WO2007016392A3 (en) | 2007-05-24 |
| HUE029733T2 (en) | 2017-03-28 |
| EP2266981B1 (en) | 2016-07-06 |
| US20090118272A1 (en) | 2009-05-07 |
| PL1910348T3 (pl) | 2016-09-30 |
| EP1910348A2 (en) | 2008-04-16 |
| WO2007016392A2 (en) | 2007-02-08 |
| EP2266981A3 (en) | 2011-05-04 |
| DK1910348T3 (en) | 2016-08-01 |
| PT1910348T (pt) | 2016-07-11 |
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