PE20090476A1 - Soluciones farmaceuticas - Google Patents
Soluciones farmaceuticasInfo
- Publication number
- PE20090476A1 PE20090476A1 PE2008001158A PE2008001158A PE20090476A1 PE 20090476 A1 PE20090476 A1 PE 20090476A1 PE 2008001158 A PE2008001158 A PE 2008001158A PE 2008001158 A PE2008001158 A PE 2008001158A PE 20090476 A1 PE20090476 A1 PE 20090476A1
- Authority
- PE
- Peru
- Prior art keywords
- telbivudine
- agent
- pharmaceutical solutions
- parabene
- desoxy
- Prior art date
Links
- 239000003186 pharmaceutical solution Substances 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 abstract 3
- IQFYYKKMVGJFEH-CSMHCCOUSA-N telbivudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1O[C@@H](CO)[C@H](O)C1 IQFYYKKMVGJFEH-CSMHCCOUSA-N 0.000 abstract 3
- 229960005311 telbivudine Drugs 0.000 abstract 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N E-Sorbic acid Chemical compound C\C=C\C=C\C(O)=O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 abstract 1
- 241000700721 Hepatitis B virus Species 0.000 abstract 1
- -1 PARABENE Substances 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 235000019636 bitter flavor Nutrition 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000000873 masking effect Effects 0.000 abstract 1
- 229940100688 oral solution Drugs 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 235000010199 sorbic acid Nutrition 0.000 abstract 1
- 239000004334 sorbic acid Substances 0.000 abstract 1
- 229940075582 sorbic acid Drugs 0.000 abstract 1
- 229940104230 thymidine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A UNA SOLUCION ORAL QUE CONTIENE: A) 2'-DESOXI-L-TIMIDINA (TELBIVUDINA) EN UNA CANTIDAD DE HASTA 50MG/ML DE TELBIVUDINA; B) UN SISTEMA DE SOLVENTE QUE COMPRENDE i) UN AGENTE ENMASCARADOR DEL SABOR AMARGO DE LA TELBIVUDINA, ii) UN AGENTE CONSERVADOR TAL COMO PARABENO, ACIDO SORBICO O ACIDO BENZOICO EN UNA CONCENTRACION DE 0.1 A 2.5MG/ML, Y iii) UN AGENTE REGULADOR DE PH PARA PERMITIR LA ESTABILIDAD DEL FARMACO TAL COMO HIDROXIDO DE SODIO 1N QUE REGULA EL PH DE 3 A 5. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE LA INFECCION PRODUCIDA POR EL VIRUS DE LA HEPATITIS B (HBV)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07112381 | 2007-07-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090476A1 true PE20090476A1 (es) | 2009-05-12 |
Family
ID=38724394
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012002012A PE20130180A1 (es) | 2007-07-12 | 2008-07-10 | Soluciones farmaceuticas orales que comprenden telbivudina |
| PE2008001158A PE20090476A1 (es) | 2007-07-12 | 2008-07-10 | Soluciones farmaceuticas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012002012A PE20130180A1 (es) | 2007-07-12 | 2008-07-10 | Soluciones farmaceuticas orales que comprenden telbivudina |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8445457B2 (es) |
| EP (1) | EP2178503A1 (es) |
| JP (1) | JP5314014B2 (es) |
| KR (3) | KR20140019040A (es) |
| CN (1) | CN101686938B (es) |
| AR (1) | AR067630A1 (es) |
| AU (1) | AU2008274170B2 (es) |
| BR (1) | BRPI0815562A2 (es) |
| CA (1) | CA2693609A1 (es) |
| CL (1) | CL2008002025A1 (es) |
| CO (1) | CO6270204A2 (es) |
| EC (1) | ECSP109871A (es) |
| IL (1) | IL202961A (es) |
| MA (1) | MA31507B1 (es) |
| MY (1) | MY147366A (es) |
| NZ (1) | NZ582443A (es) |
| PE (2) | PE20130180A1 (es) |
| RU (1) | RU2493826C2 (es) |
| TN (1) | TN2010000008A1 (es) |
| TW (1) | TW200911302A (es) |
| WO (1) | WO2009007426A1 (es) |
| ZA (1) | ZA200908993B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108329246B (zh) | 2011-05-13 | 2021-02-26 | 阵列生物制药公司 | 作为trka激酶抑制剂的吡咯烷基脲和吡咯烷基硫脲化合物 |
| WO2014059363A1 (en) * | 2012-10-11 | 2014-04-17 | Antrim Pharmaceuticals Llc | Oral solution formulations of aripiprazole |
| US10835533B2 (en) | 2014-05-15 | 2020-11-17 | Array Biopharma Inc. | 1 -((3S,4R)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1H-pyrazol-5-yl)urea as a TrkA kinase inhibitor |
| JP6526904B2 (ja) * | 2015-04-26 | 2019-06-05 | マッカイ メモリアル ホスピタルＭａｃｋａｙ Ｍｅｍｏｒｉａｌ Ｈｏｓｐｉｔａｌ | 腎疾患を有する患者の腎臓及び／又は心臓機能の改善方法 |
| CN107550866A (zh) * | 2016-06-30 | 2018-01-09 | 康普药业股份有限公司 | 一种替比夫定制剂 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5856364A (en) | 1991-03-01 | 1999-01-05 | Warner Lambert Company | Therapeutic antiviral-wound healing compositions and methods for preparing and using same |
| WO1999016447A1 (fr) * | 1997-09-26 | 1999-04-08 | Wakamoto Pharmaceutical Co., Ltd. | Preparation aqueuse contenant un agent antiviral a ossature purine ou pyrimidine |
| DE19817264A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
| DE19817265A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Verwendung von Dihydropyrimidinen als Arzneimittel und neue Stoffe |
| PE20030545A1 (es) | 2001-10-31 | 2003-06-19 | Schering Corp | Formulaciones de jarabe de ribavirina |
| TWI244393B (en) * | 2002-08-06 | 2005-12-01 | Idenix Pharmaceuticals Inc | Crystalline and amorphous forms of beta-L-2'-deoxythymidine |
| US20090156545A1 (en) | 2005-04-01 | 2009-06-18 | Hostetler Karl Y | Substituted Phosphate Esters of Nucleoside Phosphonates |
-
2008
- 2008-07-10 BR BRPI0815562-3A2A patent/BRPI0815562A2/pt not_active IP Right Cessation
- 2008-07-10 JP JP2010515512A patent/JP5314014B2/ja not_active Expired - Fee Related
- 2008-07-10 NZ NZ582443A patent/NZ582443A/en not_active IP Right Cessation
- 2008-07-10 CA CA2693609A patent/CA2693609A1/en not_active Abandoned
- 2008-07-10 US US12/667,975 patent/US8445457B2/en not_active Expired - Fee Related
- 2008-07-10 EP EP08774979A patent/EP2178503A1/en not_active Withdrawn
- 2008-07-10 WO PCT/EP2008/059016 patent/WO2009007426A1/en not_active Ceased
- 2008-07-10 KR KR1020147002720A patent/KR20140019040A/ko not_active Ceased
- 2008-07-10 PE PE2012002012A patent/PE20130180A1/es not_active Application Discontinuation
- 2008-07-10 AR ARP080102959A patent/AR067630A1/es unknown
- 2008-07-10 CN CN2008800241250A patent/CN101686938B/zh active Active
- 2008-07-10 KR KR1020107000530A patent/KR20100029829A/ko not_active Ceased
- 2008-07-10 PE PE2008001158A patent/PE20090476A1/es not_active Application Discontinuation
- 2008-07-10 RU RU2010104395/15A patent/RU2493826C2/ru not_active IP Right Cessation
- 2008-07-10 MY MYPI20095510A patent/MY147366A/en unknown
- 2008-07-10 AU AU2008274170A patent/AU2008274170B2/en not_active Ceased
- 2008-07-10 KR KR1020127016214A patent/KR20120078754A/ko not_active Withdrawn
- 2008-07-11 CL CL2008002025A patent/CL2008002025A1/es unknown
- 2008-07-11 TW TW097126552A patent/TW200911302A/zh unknown
-
2009
- 2009-12-17 ZA ZA200908993A patent/ZA200908993B/xx unknown
- 2009-12-24 IL IL202961A patent/IL202961A/en not_active IP Right Cessation
-
2010
- 2010-01-07 MA MA32485A patent/MA31507B1/fr unknown
- 2010-01-07 TN TNP2010000008A patent/TN2010000008A1/fr unknown
- 2010-01-12 EC EC2010009871A patent/ECSP109871A/es unknown
- 2010-01-12 CO CO10002343A patent/CO6270204A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP5314014B2 (ja) | 2013-10-16 |
| AU2008274170A1 (en) | 2009-01-15 |
| CN101686938B (zh) | 2012-09-05 |
| RU2493826C2 (ru) | 2013-09-27 |
| KR20100029829A (ko) | 2010-03-17 |
| BRPI0815562A2 (pt) | 2015-02-18 |
| ECSP109871A (es) | 2010-02-26 |
| NZ582443A (en) | 2011-04-29 |
| TW200911302A (en) | 2009-03-16 |
| RU2010104395A (ru) | 2011-08-20 |
| EP2178503A1 (en) | 2010-04-28 |
| MY147366A (en) | 2012-11-30 |
| MA31507B1 (fr) | 2010-07-01 |
| CN101686938A (zh) | 2010-03-31 |
| CA2693609A1 (en) | 2009-01-15 |
| US20100197629A1 (en) | 2010-08-05 |
| US8445457B2 (en) | 2013-05-21 |
| IL202961A (en) | 2013-10-31 |
| WO2009007426A1 (en) | 2009-01-15 |
| CL2008002025A1 (es) | 2009-05-08 |
| KR20120078754A (ko) | 2012-07-10 |
| KR20140019040A (ko) | 2014-02-13 |
| AU2008274170B2 (en) | 2011-06-09 |
| TN2010000008A1 (en) | 2011-09-26 |
| ZA200908993B (en) | 2010-09-29 |
| PE20130180A1 (es) | 2013-03-06 |
| CO6270204A2 (es) | 2011-04-20 |
| JP2010533146A (ja) | 2010-10-21 |
| AR067630A1 (es) | 2009-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |