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PE20081795A1 - Moduladores de htra1-pdz y htra3-pdz - Google Patents

Moduladores de htra1-pdz y htra3-pdz

Info

Publication number
PE20081795A1
PE20081795A1 PE2008000341A PE2008000341A PE20081795A1 PE 20081795 A1 PE20081795 A1 PE 20081795A1 PE 2008000341 A PE2008000341 A PE 2008000341A PE 2008000341 A PE2008000341 A PE 2008000341A PE 20081795 A1 PE20081795 A1 PE 20081795A1
Authority
PE
Peru
Prior art keywords
pdz
htra3
htra1
sequence
polypeptide
Prior art date
Application number
PE2008000341A
Other languages
English (en)
Inventor
Brent A Appleton
Steven T Runyon
Sachdev S Sidhu
Nicholas J Skelton
Christian Wiesmann
Yingnan Zhang
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20081795A1 publication Critical patent/PE20081795A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Gyroscopes (AREA)
  • Compression, Expansion, Code Conversion, And Decoders (AREA)
  • Digital Transmission Methods That Use Modulated Carrier Waves (AREA)

Abstract

SE REFIERE A UN POLIPEPTIDO QUE SE UNE A UN DOMINIO PDZ DE HtrA1 QUE COMPRENDE LA SECUENCIA DIETWLL (IDENTIFICADOR DE SECUENCIA Nº 3), GWKTWIL (IDENTIFICADOR DE SECUENCIA Nº 4), DSRIWWV (IDENTIFICADOR DE SECUENCIA Nº 5) O WDKIWHV (IDENTIFICADOR DE SECUENCIA Nº 6). DONDE DICHO POLIPEPTIDO COMPRENDE UNA SECUENCIA CON UNA LEUCINA O VALINA EN LA POSICION 0; UN TRIPTOFANO, ISOLEUCINA O FENILALANINA EN LA POSICION 1; UNA TREONINA O ISOLEUCINA EN LA POSICION 3; Y ACIDO GLUTAMICO, LISINA, ARGININA O ACIDO ASPARTICO EN LA POSICION 4. SE REFIERE TAMBIEN A UN POLIPEPTIDO QUE SE UNE A UN DOMINIO PDZ DE HtrA3 Y A UN METODO PARA IDENTIFICAR UN COMPUESTO CON CAPACIDAD PARA MODULAR LA INTERACCION ENTRE UN LIGANDO Y UN DOMINIO PDZ DE HtrA1 O UN DOMINIO PDZ DE HtrA3
PE2008000341A 2007-02-16 2008-02-15 Moduladores de htra1-pdz y htra3-pdz PE20081795A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89042807P 2007-02-16 2007-02-16

Publications (1)

Publication Number Publication Date
PE20081795A1 true PE20081795A1 (es) 2009-01-08

Family

ID=39590928

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000341A PE20081795A1 (es) 2007-02-16 2008-02-15 Moduladores de htra1-pdz y htra3-pdz

Country Status (6)

Country Link
EP (1) EP2111413A2 (es)
AR (1) AR065370A1 (es)
CL (1) CL2008000493A1 (es)
PE (1) PE20081795A1 (es)
TW (1) TW200846358A (es)
WO (1) WO2008101160A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
ES2397441T5 (es) 2006-02-13 2022-09-14 Daiichi Sankyo Co Ltd Secuencias polinucleotídicas y polipeptídicas implicadas en el proceso de remodelación ósea
CA2850032C (en) 2011-10-14 2022-06-07 Genentech, Inc. Anti-htra1 antibodies and methods of use
JP6268173B2 (ja) 2012-07-19 2018-01-24 第一三共株式会社 抗Ｓｉｇｌｅｃ−１５抗体
JP6750010B2 (ja) * 2015-10-30 2020-09-02 ジェネンテック， インコーポレイテッド 抗ＨｔｒＡ１抗体及びその使用方法
CN108699106B (zh) 2016-03-04 2021-11-30 豪夫迈·罗氏有限公司 作为htra1抑制剂的新型三氟甲基丙酰胺衍生物
WO2017148967A1 (en) * 2016-03-04 2017-09-08 F. Hoffmann-La Roche Ag New difluoroketamide derivatives as htra1 inhibitors
CN109415330A (zh) 2016-07-18 2019-03-01 豪夫迈·罗氏有限公司 作为htra1抑制剂的新型二氟酮酰胺衍生物
JP2019526564A (ja) 2016-08-23 2019-09-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｈｔｒａ１阻害剤としての新規なトリフルオロメチルプロパンアミド誘導体
EP3504193A1 (en) 2016-08-23 2019-07-03 H. Hoffnabb-La Roche Ag New difluoroketamide derivatives as htra1 inhibitors
US11149067B2 (en) 2017-05-12 2021-10-19 Universität Duisburg-Essen Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors
WO2020083916A1 (en) * 2018-10-22 2020-04-30 University Of Copenhagen Virally expressed inhibitors of pdz domains, such as pick1 and uses thereof
AU2021232645A1 (en) * 2020-03-06 2022-09-15 University Of Copenhagen Lipid conjugated peptide inhibitors of PICK1

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090087878A9 (en) * 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants

Also Published As

Publication number Publication date
CL2008000493A1 (es) 2008-06-27
WO2008101160A2 (en) 2008-08-21
AR065370A1 (es) 2009-06-03
WO2008101160A3 (en) 2009-02-19
TW200846358A (en) 2008-12-01
EP2111413A2 (en) 2009-10-28

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal