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PE20071164A1 - Compuestos heterociclico fusionado como antagonista del receptor mineralocorticoide - Google Patents

Compuestos heterociclico fusionado como antagonista del receptor mineralocorticoide

Info

Publication number
PE20071164A1
PE20071164A1 PE2006001708A PE2006001708A PE20071164A1 PE 20071164 A1 PE20071164 A1 PE 20071164A1 PE 2006001708 A PE2006001708 A PE 2006001708A PE 2006001708 A PE2006001708 A PE 2006001708A PE 20071164 A1 PE20071164 A1 PE 20071164A1
Authority
PE
Peru
Prior art keywords
fused heterocyclic
mineralocorticoid receptor
heterocyclic compounds
benzoxazin
independently
Prior art date
Application number
PE2006001708A
Other languages
English (en)
Inventor
Shoji Fukumoto
Nobuyuki Matsunaga
Taiichi Ohra
Norio Ohyabu
Tomoaki Hasui
Takashi Motoyaji
Christopher Stephen Seidem
Tony Pisal Tang
Lisa A Demeese
Cassandra Gauthier
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20071164A1 publication Critical patent/PE20071164A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

COMPUESTOS HETEROCICLICO FUSIONADO DE FORMULA (Ia), EN DONDE A ES DE FORMULA a), EN DONDE X1 Y X2 IGUALES O DIFERENTES ES UN ENLACE QUIMICO, CH2, O, NH, ENTRE OTROS; X3 ES CH2, O, ENTRE OTROS; ---- ES UN ENLACE SIMPLE O DOBLE; R Y R' SON INDEPENDIENTEMENTE UN HIDROCARBURO ALIFATICO, HIDROXILO, AMINO, ENTRE OTROS; k ES DE 0 A 4; l ES DE 0 A 3; Xa, Xb Y Xc SON INDEPENDIENTEMENTE CH O N; HET ES UN HETEROCICLICO DE FORMULA i), iv), vi), ENTRE OTROS, EN DONDE X4 ES CH O N; X5, X6, X5' Y X6' SON INDEPENDIENTEMENTE CH2, CH, N, O, S, ENTRE OTROS. SON SELECCIONADOS: 6-(7-FENIL-7H-[1,2,4]TRIAZOLO[3,4-b][1,3,4]TIADIAZIN-6-IL)-2H-1,4-BENZOXAZIN-3(4H)-ONA, 6-[2-(4-FLUOROFENIL)-2H-TIOCROMEN-3-IL]-2H-1,4-BENZOXAZIN-3(4H)-ONA, 3-(3-OXO-3,4-DIHIDRO-2H-1,4-BENZOXAZIN-6-IL)-2-FENIL-2H-TIOCROMEN-7-CARBONITRILO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS TIENEN ACTIVIDAD ANTAGONICA AL RECEPTOR MINERALOCORTICOIDE, POR LO QUE SON UTILES EN EL TRATAMIENTO DE HIPERTENSION, FALLA CARDIACA Y LO SIMILAR
PE2006001708A 2005-12-28 2006-12-27 Compuestos heterociclico fusionado como antagonista del receptor mineralocorticoide PE20071164A1 (es)

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