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PE20071110A1 - Agentes citotoxicos que comprenden derivados de tomaimicina - Google Patents

Agentes citotoxicos que comprenden derivados de tomaimicina

Info

Publication number
PE20071110A1
PE20071110A1 PE2007000074A PE2007000074A PE20071110A1 PE 20071110 A1 PE20071110 A1 PE 20071110A1 PE 2007000074 A PE2007000074 A PE 2007000074A PE 2007000074 A PE2007000074 A PE 2007000074A PE 20071110 A1 PE20071110 A1 PE 20071110A1
Authority
PE
Peru
Prior art keywords
arilo
optionally substituted
benzodiazepin
ona
ylidene
Prior art date
Application number
PE2007000074A
Other languages
English (en)
Inventor
Laurence Gauzy
Robert Zhao
Yonghong Deng
Wei Li
Herve Bouchard
Ravi V J Chari
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35953949&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20071110(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20071110A1 publication Critical patent/PE20071110A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

REFERIDA A COMPUESTOS DERIVADOS DE TOMAIMICINA DE FORMULA (I), DONDE LAS LINEAS PUNTEADAS REPRESENTAN UN ENLACE SIMPLE O DOBLE, CON LA CONDICION DE QUE CUANDO LAS LINEAS PUNTEADAS REPRESENTAN UN ENLACE SIMPLE, U Y U' SON H Y W Y W' SON OH, OR, OCOR, ENTRE OTROS Y CUANDO LAS LINEAS PUNTEADAS REPRESENTAN UN ENLACE DOBLE, U Y U' ESTAN AUSENTES Y W Y W' SON H; R1, R2, R1' Y R2' SON HALURO O ALQUILO OPCIONALMENTE SUSTITUIDOS, ENTRE OTROS; B Y B' SON ALQUENILO OPCIONALMENTE SUSTITUIDO CON CN, CF3, R, ENTRE OTROS O B Y B' SON UN ATOMO DE OXIGENO; X Y X' SONO, NR, C=O, S(O)q; A Y A' SON ALQUILO O ALQUENILO OPCIONALMENTE SUSTITUIDO CON CF3, CN, ARILO, ENTRE OTROS; Y E Y' SON H U OR; T ES NR, O, S(O)q, ARILO DE 4 A 10 MIEMBROS, ENTRE OTROS; n Y n' ES 0 O 1; q ES 0, 1 O 2; R Y R' SON H, ALQUILO O ARILO OPCIONALMENTE SUSTITUIDOS CON CN, CF3, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 8,8'-[1,3-BENCENODIILBIS(METILENOOXI)]-BIS[(S)-2-ET-(E)-ILIDENO-7-METOXI-1,2,3,11a-TETRAHIDRO-5H-PIRROLO[2,1-c][1,4]BENZODIAZEPIN-5-ONA], 8,8'-[5-METOXI-1,3-BENCENODIILBIS(METILENOOXI)]-BIS[(S)-2-ET-(E)-ILIDENO-7-METOXI-1,2,3,11a-TETRAHIDRO-5H-PIRROLO[2,1-c][1,4]BENZODIAZEPIN-5-ONA], 8,8'-[1,5-PENTANODIILBIS(OXI)]-BIS[(S)-2-ET-(E)-ILIDENO-7-METOXI-1,2,3,11a-TETRAHIDRO-5H-PIRROLO[2,1-c][1,4]BENZODIAZEPIN-5-ONA], ENTRE OTROS. TAMBIEN ESTA REFERIDO A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DEL CRECIMIENTO DE CELULAS CANCEROSAS Y/O PROLIFERATIVAS
PE2007000074A 2006-01-25 2007-01-24 Agentes citotoxicos que comprenden derivados de tomaimicina PE20071110A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06290154A EP1813614B1 (en) 2006-01-25 2006-01-25 Cytotoxic agents comprising new tomaymycin derivatives

Publications (1)

Publication Number Publication Date
PE20071110A1 true PE20071110A1 (es) 2007-12-21

Family

ID=35953949

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000074A PE20071110A1 (es) 2006-01-25 2007-01-24 Agentes citotoxicos que comprenden derivados de tomaimicina

Country Status (39)

Country Link
US (1) US8163736B2 (es)
EP (4) EP1813614B1 (es)
JP (1) JP5116696B2 (es)
KR (1) KR101428112B1 (es)
CN (1) CN101374846B (es)
AR (1) AR059201A1 (es)
AT (1) ATE527262T1 (es)
AU (1) AU2007209072C1 (es)
BR (1) BRPI0707264A2 (es)
CA (1) CA2635482C (es)
CR (1) CR10149A (es)
CY (2) CY1112495T1 (es)
DK (2) DK1813614T3 (es)
DO (1) DOP2007000016A (es)
EA (1) EA017196B1 (es)
EC (1) ECSP088632A (es)
ES (2) ES2374964T3 (es)
GT (1) GT200800147A (es)
HN (1) HN2008001103A (es)
HR (2) HRP20140307T1 (es)
IL (1) IL192472A0 (es)
MA (1) MA30226B1 (es)
ME (1) ME01814B (es)
MX (1) MX2008009582A (es)
MY (1) MY157715A (es)
NI (1) NI200800207A (es)
NO (1) NO341074B1 (es)
NZ (1) NZ569789A (es)
PE (1) PE20071110A1 (es)
PH (1) PH12011502704A1 (es)
PL (2) PL1813614T3 (es)
PT (2) PT1813614E (es)
RS (2) RS52060B (es)
SI (2) SI1813614T1 (es)
TN (1) TNSN08283A1 (es)
TW (1) TWI389909B (es)
UA (1) UA97794C2 (es)
WO (1) WO2007085930A1 (es)
ZA (1) ZA200805649B (es)

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