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PE20070708A1 - Formulacion en aerosol para inhalacion de beta-agonistas - Google Patents

Formulacion en aerosol para inhalacion de beta-agonistas

Info

Publication number
PE20070708A1
PE20070708A1 PE2006001218A PE2006001218A PE20070708A1 PE 20070708 A1 PE20070708 A1 PE 20070708A1 PE 2006001218 A PE2006001218 A PE 2006001218A PE 2006001218 A PE2006001218 A PE 2006001218A PE 20070708 A1 PE20070708 A1 PE 20070708A1
Authority
PE
Peru
Prior art keywords
hydroxy
alkyl
ethyl
halogen
salts
Prior art date
Application number
PE2006001218A
Other languages
English (en)
Inventor
Barbara Niklaus-Humke
Michael Nowak
Kirsten Radau
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35241312&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070708(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20070708A1 publication Critical patent/PE20070708A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE REFIERE A UNA FORMULACION EN AEROSOL SIN GAS PROPELENTE QUE COMPRENDE:A) UN COMPUESTO DE FORMULA I, DONDE R1 ES H, ALQUILO C1-C4, O-(ALQUILO C1-C4), HALOGENO; R2 ES H, ALQUILO C1-C4, HALOGENO, O-(ALQUILO C1-C4); R3 ES H, HALOGENO, OH, -O-ALQUILEN C1-C4-COOH, ENTRE OTROS; X ES ANION DE CARGA NEGATIVA SIMPLE SELECCIONADO ENTRE CLORURO, BROMURO, YODURO, METANSULFONATO, NITRATO, MALEATO; ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-HIDROXI-8-{1-HIDROXI-2-[2-(ESTER ETILICO DEL ACIDO 4-FENOXI-ACETICO)-1,1-DIMETIL-ETILAMINO]ETIL}-4H-BENZO[1,4]OXAZIN-3-ONA; 8-{2-[2-(4-ETILO-FENIL)-1,1-DIMETIL-ETILAMINO]-1-HIDROXI-ETIL}-6-HIDROXI-4H-BENZO[1,4]OXAZIN-3-ONA; ENTRE OTROS. B) OTRO PRINCIPIO ACTIVO SELECCIONADO ENTRE SALES DE OXITROPIO, SALES DE TIOTROPIO, SALES DE GLUCOPIRRONIO, ENTRE OTROS. DICHA FORMULACION ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES DE LAS VIAS RESPIRATORIAS
PE2006001218A 2005-10-10 2006-10-06 Formulacion en aerosol para inhalacion de beta-agonistas PE20070708A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05109376 2005-10-10

Publications (1)

Publication Number Publication Date
PE20070708A1 true PE20070708A1 (es) 2007-08-06

Family

ID=35241312

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001218A PE20070708A1 (es) 2005-10-10 2006-10-06 Formulacion en aerosol para inhalacion de beta-agonistas

Country Status (31)

Country Link
US (3) US20070088030A1 (es)
EP (1) EP1940349B1 (es)
JP (1) JP2009511542A (es)
KR (1) KR20080059290A (es)
CN (1) CN101282712A (es)
AR (1) AR058082A1 (es)
AU (1) AU2006301330B9 (es)
BR (1) BRPI0617278A2 (es)
CA (1) CA2624786C (es)
CY (1) CY1120199T1 (es)
DK (1) DK1940349T3 (es)
EA (1) EA200800927A1 (es)
EC (1) ECSP088294A (es)
ES (1) ES2668364T3 (es)
HR (1) HRP20180713T1 (es)
HU (1) HUE039186T2 (es)
IL (1) IL190682A (es)
LT (1) LT1940349T (es)
MY (1) MY163503A (es)
NO (1) NO343363B1 (es)
NZ (1) NZ567545A (es)
PE (1) PE20070708A1 (es)
PL (1) PL1940349T3 (es)
PT (1) PT1940349T (es)
RS (1) RS57085B1 (es)
SI (1) SI1940349T1 (es)
TW (1) TWI389692B (es)
UA (1) UA99250C2 (es)
UY (1) UY29844A1 (es)
WO (1) WO2007042468A2 (es)
ZA (1) ZA200801390B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US20050272726A1 (en) * 2004-04-22 2005-12-08 Boehringer Ingelheim International Gmbh Novel medicaments for the treatment of respiratory diseases
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
US20050255050A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Powder formulations for inhalation, comprising enantiomerically pure beta agonists
US20050256115A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Aerosol formulation for the inhalation of beta-agonists
CN101208316B (zh) * 2005-08-15 2012-05-09 贝林格尔·英格海姆国际有限公司 制备β-模拟物的方法
US20110281858A1 (en) * 2008-11-21 2011-11-17 Boehringer Ingelheim International Gmbh Aerosol formulation for the inhalation of beta agonists
US20110319402A1 (en) * 2008-11-21 2011-12-29 Boehringer Ingelheim International Gmbh Aerosol formulation for the inhalation of beta agonists
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
WO2014016548A2 (en) 2012-07-27 2014-01-30 Cipla Limited Pharmaceutical composition
WO2014056840A1 (en) * 2012-10-09 2014-04-17 Boehringer Ingelheim International Gmbh Beta-2-adrenoceptor agonist for the treatment of cough
US20140235627A1 (en) * 2012-12-21 2014-08-21 Boehringer Ingelheim International Gmbh ß2-ADRENOCEPTOR AGONIST FOR IMPROVEMENT OF EXERCISE TOLERANCE
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
SG10201912198WA (en) * 2015-05-18 2020-02-27 Glenmark Specialty Sa Tiotropium inhalation solution for nebulization
JP2019536812A (ja) 2016-12-12 2019-12-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング オロダテロールとの同時投与による間質性肺疾患の処置方法に使用するためのニンテダニブ
US20210322311A1 (en) * 2020-04-16 2021-10-21 Cai Gu Huang Inhalable Formulation of a Solution Containing Tiotropium Bromide and Olodaterol
CN115703121A (zh) * 2021-08-07 2023-02-17 广州谷森制药有限公司 一种含噻托溴铵、奥达特罗药品制剂和除醛包材容器的组合
CN114259481A (zh) * 2021-11-26 2022-04-01 南京华盖制药有限公司 一种奥达特罗复方吸入溶液

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3134590A1 (de) * 1981-09-01 1983-03-10 Boehringer Ingelheim KG, 6507 Ingelheim Neue benzo-heterocyclen
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
WO1994013263A1 (en) * 1992-12-09 1994-06-23 Jager Paul D Stabilized medicinal aerosol solution formulations
NZ522677A (en) * 2000-04-27 2004-10-29 Boehringer Ingelheim Pharma Novel, slow-acting betamimetics, a method for their production and their use as medicaments
DE10216036A1 (de) 2002-04-11 2003-10-23 Boehringer Ingelheim Pharma Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz
DE10253282A1 (de) * 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung
US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US7244728B2 (en) * 2004-03-17 2007-07-17 Boehringer Ingelheim International Gmbh Long acting betamimetics for the treatment of respiratory diseases
US20050272726A1 (en) * 2004-04-22 2005-12-08 Boehringer Ingelheim International Gmbh Novel medicaments for the treatment of respiratory diseases
US20050239778A1 (en) * 2004-04-22 2005-10-27 Boehringer Ingelheim International Gmbh Novel medicament combinations for the treatment of respiratory diseases
EA013157B1 (ru) * 2004-04-22 2010-02-26 Бёрингер Ингельхайм Интернациональ Гмбх Содержащие бензоксазины лекарственные комбинации для лечения заболеваний дыхательных путей
US20050256115A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Aerosol formulation for the inhalation of beta-agonists
US20050255050A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Powder formulations for inhalation, comprising enantiomerically pure beta agonists
US7220742B2 (en) * 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments

Also Published As

Publication number Publication date
UY29844A1 (es) 2007-05-31
CA2624786A1 (en) 2007-04-19
BRPI0617278A2 (pt) 2011-07-19
EP1940349B1 (de) 2018-02-14
HUE039186T2 (hu) 2018-12-28
PL1940349T3 (pl) 2018-07-31
NO20080801L (no) 2008-04-29
AU2006301330B2 (en) 2012-11-22
TWI389692B (zh) 2013-03-21
JP2009511542A (ja) 2009-03-19
IL190682A (en) 2015-06-30
US20100009984A1 (en) 2010-01-14
WO2007042468A2 (de) 2007-04-19
RS57085B1 (sr) 2018-06-29
CN101282712A (zh) 2008-10-08
AU2006301330B9 (en) 2013-01-17
CA2624786C (en) 2015-06-16
ZA200801390B (en) 2009-01-28
ECSP088294A (es) 2008-04-28
NZ567545A (en) 2011-07-29
AR058082A1 (es) 2008-01-23
CY1120199T1 (el) 2018-12-12
MY163503A (en) 2017-09-15
WO2007042468A3 (de) 2007-08-02
US20070088030A1 (en) 2007-04-19
EP1940349A2 (de) 2008-07-09
UA99250C2 (ru) 2012-08-10
AU2006301330A1 (en) 2007-04-19
LT1940349T (lt) 2018-05-10
EA200800927A1 (ru) 2008-10-30
IL190682A0 (en) 2008-11-03
TW200730178A (en) 2007-08-16
ES2668364T3 (es) 2018-05-17
NO343363B1 (no) 2019-02-11
KR20080059290A (ko) 2008-06-26
SI1940349T1 (en) 2018-05-31
US20110190284A1 (en) 2011-08-04
HRP20180713T1 (hr) 2018-06-15
PT1940349T (pt) 2018-04-30
DK1940349T3 (en) 2018-05-28

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