PE20061363A1 - Derivados de 4-fenil-5-oxo-1,4,5,6,7,8-hexahidroquinolina como agonistas del receptor fsh - Google Patents
Derivados de 4-fenil-5-oxo-1,4,5,6,7,8-hexahidroquinolina como agonistas del receptor fshInfo
- Publication number
- PE20061363A1 PE20061363A1 PE2006000464A PE2006000464A PE20061363A1 PE 20061363 A1 PE20061363 A1 PE 20061363A1 PE 2006000464 A PE2006000464 A PE 2006000464A PE 2006000464 A PE2006000464 A PE 2006000464A PE 20061363 A1 PE20061363 A1 PE 20061363A1
- Authority
- PE
- Peru
- Prior art keywords
- oxo
- phenyl
- alkyl
- bromo
- propyl
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title abstract 2
- GTFDKLAZHJQLIA-UHFFFAOYSA-N 4-phenyl-4,6,7,8-tetrahydro-1h-quinolin-5-one Chemical class O=C1CCCC(NC=C2)=C1C2C1=CC=CC=C1 GTFDKLAZHJQLIA-UHFFFAOYSA-N 0.000 title 1
- -1 AMINO, HYDROXY Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 208000021267 infertility disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS; R2 Y R3 SON CADA UNO HALOGENO, ALQUILO C1-C4, ALQUENILO C2-C4, ALQUINILOXI C3-C4, ENTRE OTROS; R4 ES FENILO O HETEROARILO C2-C5, AMBOS SUSTITUIDOS CON R7 Y SUSTITUIDO O NO EN EL ANILLO HETEROAROMATICO CON 1 O MAS AMINO, HIDROXI, HALOGENO, NITRO, ENTRE OTROS; R7 ES H, ALQUILTIO C1-C4, ALQUILSULFONILO C1-C4, TRIFLUOROMETILSULFONILO, AMINOIMINOMETILO, ENTRE OTROS; X ES O, NH, AMINOALQUIL C1-C4, ENTRE OTROS; Y ES CH2, CO, SO2; Z ES CN, NO2. SON COMPUESTOS PREFERIDOS: N-{3-[2-BROMO-4-(3-CIANO-2-METIL-5-OXO-7-PROPIL-1,4,5,6,7,8-HEXAHIDROQUINOLIN-4-IL)-6-ETOXIFENOXIMETIL]-FENIL}-3,4,5-TRIMETOXIBENZAMIDA; 4-{3-BROMO-4-[3-(3,6-DIHIDRO-2H-PIRIDINA-1-CARBONIL)-BENCILOXI]-5-ETOXIFENIL}-2METIL-5-OXO-7-PROPIL-1,4,5,6,7,8-HEXAHIDRO-QUINOLINA-3-CARBONITRILO; N-{2-[2-BROMO-4-(3-CIANO-2-METIL-5-OXO-7-PROPIL-1,4,5,6,7,8-HEXAHIDROQUINOLIN-4-IL)-6-ETOXIMETOXIFENIL]-FENIL}-AMIDA DEL ACIDO FURANO-2-CARBOXILICO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR DE FSH, UTILES EN EL TRATAMIENTO DE TRASTORNOS DE LA FERTILIDAD
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05103735 | 2005-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061363A1 true PE20061363A1 (es) | 2007-01-15 |
Family
ID=34939693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000464A PE20061363A1 (es) | 2005-05-04 | 2006-05-03 | Derivados de 4-fenil-5-oxo-1,4,5,6,7,8-hexahidroquinolina como agonistas del receptor fsh |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8022218B2 (es) |
| EP (1) | EP1881830B1 (es) |
| JP (1) | JP5129737B2 (es) |
| KR (1) | KR20080010426A (es) |
| CN (1) | CN101212973B (es) |
| AR (1) | AR057005A1 (es) |
| AT (1) | ATE410166T1 (es) |
| AU (1) | AU2006243868B2 (es) |
| BR (1) | BRPI0611120A2 (es) |
| CA (1) | CA2606683C (es) |
| CY (1) | CY1108632T1 (es) |
| DE (1) | DE602006003094D1 (es) |
| DK (1) | DK1881830T3 (es) |
| ES (1) | ES2314908T3 (es) |
| HR (1) | HRP20080667T3 (es) |
| IL (1) | IL186748A (es) |
| MX (1) | MX2007013751A (es) |
| NO (1) | NO20075617L (es) |
| NZ (1) | NZ562686A (es) |
| PE (1) | PE20061363A1 (es) |
| PL (1) | PL1881830T3 (es) |
| PT (1) | PT1881830E (es) |
| RS (1) | RS50707B (es) |
| RU (1) | RU2412170C2 (es) |
| SI (1) | SI1881830T1 (es) |
| TW (1) | TW200719894A (es) |
| UA (1) | UA92007C2 (es) |
| WO (1) | WO2006117368A1 (es) |
| ZA (1) | ZA200709090B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA92009C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия |
| JP4869336B2 (ja) * | 2005-05-04 | 2012-02-08 | ナームローゼ・フエンノートチヤツプ・オルガノン | ジヒドロピリジン誘導体 |
| UA92008C2 (en) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
| TW200944523A (en) | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
| US8071587B2 (en) | 2009-05-27 | 2011-12-06 | N. V. Organon | (Dihydro)imidazoiso[5,1-A]quinolines |
| TW201116531A (en) | 2009-07-29 | 2011-05-16 | Organon Nv | Ring-annulated dihydropyrrolo[2,1-a]isoquinolines |
| US8431564B2 (en) | 2009-07-29 | 2013-04-30 | Merck Sharp & Dohme B.V. | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines |
| TW201116515A (en) | 2009-07-31 | 2011-05-16 | Organon Nv | Dihydrobenzoindazoles |
| EP2694472B1 (en) | 2011-04-05 | 2020-03-11 | Takeda Pharmaceutical Company Limited | Sulfonamide derivative and use thereof |
| US20150296779A1 (en) * | 2012-11-28 | 2015-10-22 | Stichting Dienst Landbouwkundig Onderzoek | Substituted dihydropyridines for somatic embryogenesis in plants |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1070162B (de) | 1959-12-03 | Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M | Verfahren zur Herstellung von 5 - Brom - 3 - nitro - 4 - hydroxybenzaldehyd bzw. 5 - Chlor - 3 - nitro - 4 - hydroxybenzaldehyd | |
| GB9318935D0 (en) * | 1992-10-20 | 1993-10-27 | Zeneca Ltd | Heterocyclic derivatives |
| US5455253A (en) * | 1992-10-20 | 1995-10-03 | Zeneca Limited | Heterocyclic derivatives |
| DE4430639A1 (de) | 1994-08-29 | 1996-03-07 | Bayer Ag | Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten |
| GB9515445D0 (en) | 1995-07-27 | 1995-09-27 | Pharmacia Spa | Dihydropyridine and pyridine derivatives and process for their preparation |
| WO1997014682A1 (en) * | 1995-10-19 | 1997-04-24 | Takeda Chemical Industries, Ltd. | Quinoline derivatives as gnrh antagonists |
| US6593335B1 (en) * | 1997-12-18 | 2003-07-15 | Abbott Laboratories | Potassium channel openers |
| US6235755B1 (en) | 1998-08-07 | 2001-05-22 | Applied Research Systems Ars Holding N.A. | FSH mimetics for the treatment of infertility |
| EP1307193A1 (en) | 2000-07-27 | 2003-05-07 | Affymax Research Institute | Agonists of follicle stimulating hormone activity |
| IL159288A0 (en) | 2001-07-02 | 2004-06-01 | Akzo Nobel Nv | Tetrahydroquinoline derivatives |
| JP2003026630A (ja) | 2001-07-13 | 2003-01-29 | Taoka Chem Co Ltd | カラーカプラー中間体用カルボン酸クロリド類の製造法 |
| TWI322012B (en) | 2002-12-20 | 2010-03-21 | Organon Nv | Tetrahydroquinoline derivatives |
| UA92009C2 (ru) | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия |
| JP4869336B2 (ja) | 2005-05-04 | 2012-02-08 | ナームローゼ・フエンノートチヤツプ・オルガノン | ジヒドロピリジン誘導体 |
| UA92008C2 (en) | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
-
2006
- 2006-02-05 UA UAA200711802A patent/UA92007C2/ru unknown
- 2006-05-02 DK DK06743394T patent/DK1881830T3/da active
- 2006-05-02 PT PT06743394T patent/PT1881830E/pt unknown
- 2006-05-02 KR KR1020077026919A patent/KR20080010426A/ko not_active Ceased
- 2006-05-02 SI SI200630157T patent/SI1881830T1/sl unknown
- 2006-05-02 US US11/912,736 patent/US8022218B2/en active Active
- 2006-05-02 CN CN2006800237595A patent/CN101212973B/zh not_active Expired - Fee Related
- 2006-05-02 MX MX2007013751A patent/MX2007013751A/es active IP Right Grant
- 2006-05-02 RS RSP-2008/0582A patent/RS50707B/sr unknown
- 2006-05-02 EP EP06743394A patent/EP1881830B1/en active Active
- 2006-05-02 BR BRPI0611120-3A patent/BRPI0611120A2/pt not_active IP Right Cessation
- 2006-05-02 HR HR20080667T patent/HRP20080667T3/xx unknown
- 2006-05-02 AT AT06743394T patent/ATE410166T1/de active
- 2006-05-02 AU AU2006243868A patent/AU2006243868B2/en not_active Ceased
- 2006-05-02 CA CA2606683A patent/CA2606683C/en not_active Expired - Fee Related
- 2006-05-02 RU RU2007144989/04A patent/RU2412170C2/ru not_active IP Right Cessation
- 2006-05-02 WO PCT/EP2006/061972 patent/WO2006117368A1/en not_active Ceased
- 2006-05-02 NZ NZ562686A patent/NZ562686A/en not_active IP Right Cessation
- 2006-05-02 PL PL06743394T patent/PL1881830T3/pl unknown
- 2006-05-02 DE DE602006003094T patent/DE602006003094D1/de active Active
- 2006-05-02 JP JP2008509434A patent/JP5129737B2/ja not_active Expired - Fee Related
- 2006-05-02 ES ES06743394T patent/ES2314908T3/es active Active
- 2006-05-03 PE PE2006000464A patent/PE20061363A1/es not_active Application Discontinuation
- 2006-05-03 TW TW095115774A patent/TW200719894A/zh unknown
- 2006-05-03 AR ARP060101779A patent/AR057005A1/es unknown
-
2007
- 2007-10-18 IL IL186748A patent/IL186748A/en not_active IP Right Cessation
- 2007-10-22 ZA ZA200709090A patent/ZA200709090B/xx unknown
- 2007-11-06 NO NO20075617A patent/NO20075617L/no not_active Application Discontinuation
-
2008
- 2008-12-22 CY CY20081101479T patent/CY1108632T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |