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PE20061356A1 - Compuestos oxindol oxazolidinona como agente antibacteriano - Google Patents

Compuestos oxindol oxazolidinona como agente antibacteriano

Info

Publication number
PE20061356A1
PE20061356A1 PE2006000364A PE2006000364A PE20061356A1 PE 20061356 A1 PE20061356 A1 PE 20061356A1 PE 2006000364 A PE2006000364 A PE 2006000364A PE 2006000364 A PE2006000364 A PE 2006000364A PE 20061356 A1 PE20061356 A1 PE 20061356A1
Authority
PE
Peru
Prior art keywords
oxo
oxindol
oxazolidinone compounds
antibacterial agent
compounds
Prior art date
Application number
PE2006000364A
Other languages
English (en)
Inventor
Mikhail F Gordeev
Gary W Luehr
Vara Prasad Venkata Nagendra Yosyula
Original Assignee
Pharmacia And Upjohn Company Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia And Upjohn Company Llc filed Critical Pharmacia And Upjohn Company Llc
Publication of PE20061356A1 publication Critical patent/PE20061356A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS OXINDOL OXAZOLIDINONA DE FORMULA (I), EN DONDE R1 ES ALQUILO(C1-C4) OPCIONALMENTE SUSTITUIDO CON FLUOR O R1 ES CICLOPROPILO O CICLOPROPILMETILO Y R2 ES METILO O ETILO. SON PREFERIDOS ESTER METILICO DEL ACIDO (5S)-[3-(1-ETIL-2-OXO-2,3-DIHIDRO-1H-INDOL-5-IL)-2-OXO-OXAZOLIDIN-5-ILMETIL]-CARBAMICO, (5S)-[3-(1-CICLOPROPIL-2-OXO-2,3-DIHIDRO-1H-INDOL-5-IL)-2-OXO-OXAZOLIDIN-5-ILMETIL]-CARBAMICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA, DE ADMINISTRACION VIA BUCAL, PARENTERAL, TOPICA, RECTAL O INTRANASAL. ESTOS COMPUESTOS SON INHIBIDORES DE LA SINTESIS DE PROTEINAS BACTERIANAS POR LO QUE ES UTIL EN EL TRATAMIENTO DE INFECCIONES IMPORTANTES CAUSADAS POR BACTERIAS GRAMPOSITIVAS O NEGATIVAS, ANAEROBIOS O ACIDORRESISTENTES
PE2006000364A 2005-04-06 2006-04-04 Compuestos oxindol oxazolidinona como agente antibacteriano PE20061356A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66871605P 2005-04-06 2005-04-06
US68400005P 2005-05-24 2005-05-24

Publications (1)

Publication Number Publication Date
PE20061356A1 true PE20061356A1 (es) 2007-01-13

Family

ID=36648715

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000364A PE20061356A1 (es) 2005-04-06 2006-04-04 Compuestos oxindol oxazolidinona como agente antibacteriano

Country Status (21)

Country Link
US (1) US20060229348A1 (es)
EP (1) EP1869029A1 (es)
KR (1) KR20070116989A (es)
AP (1) AP2007004173A0 (es)
AR (1) AR053350A1 (es)
AU (1) AU2006231918A1 (es)
BR (1) BRPI0607873A2 (es)
CA (1) CA2603943A1 (es)
CR (1) CR9418A (es)
DO (1) DOP2006000079A (es)
EA (1) EA200701895A1 (es)
GT (1) GT200600132A (es)
IL (1) IL186051A0 (es)
MX (1) MX2007011873A (es)
NL (1) NL1031524C2 (es)
NO (1) NO20075547L (es)
PE (1) PE20061356A1 (es)
TN (1) TNSN07374A1 (es)
TW (1) TW200637855A (es)
UY (1) UY29453A1 (es)
WO (1) WO2006106426A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102214988B1 (ko) * 2019-06-20 2021-02-10 영남대학교 산학협력단 신규한 옥시인돌 유도체 및 이를 유효성분으로 함유하는 항균용 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU617871B2 (en) * 1988-09-15 1991-12-05 Pharmacia & Upjohn Company In position 3 substituted-5-beta-amidomethyl-oxazolidin-2- ones
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
DE19649095A1 (de) * 1996-02-06 1997-08-07 Bayer Ag Neue Heteroaryl-Oxazolidinone
EP1071654B1 (en) * 1998-04-14 2003-10-22 Samsung Fine Chemicals Co., Ltd. A process for preparing chiral (s)-2,3-disubstituted-1-propylamine derivatives
EP1181288B1 (en) * 1999-05-27 2003-07-30 PHARMACIA & UPJOHN COMPANY Bicyclic oxazolidinones as antibacterial agent
PE20011124A1 (es) * 2000-03-31 2001-10-28 Upjohn Co Nuevos agentes antibacterianos de benzosultam oxazolidinona
US7012088B2 (en) * 2003-02-24 2006-03-14 Pharmacia & Upjohn Company Indolone oxazolidinones and derivatives thereof
EA200700322A1 (ru) * 2004-08-06 2007-08-31 Фармация Энд Апджон Компани Ллс Оксазолидиноны, содержащие оксиндолы, в качестве антибактериальных агентов

Also Published As

Publication number Publication date
US20060229348A1 (en) 2006-10-12
UY29453A1 (es) 2006-11-30
AR053350A1 (es) 2007-05-02
TNSN07374A1 (fr) 2009-03-17
AP2007004173A0 (en) 2007-10-31
WO2006106426A1 (en) 2006-10-12
IL186051A0 (en) 2008-02-09
MX2007011873A (es) 2007-11-07
GT200600132A (es) 2006-11-22
BRPI0607873A2 (pt) 2009-10-20
CR9418A (es) 2007-10-21
AU2006231918A1 (en) 2006-10-12
NL1031524C2 (nl) 2007-01-30
EA200701895A1 (ru) 2008-04-28
EP1869029A1 (en) 2007-12-26
CA2603943A1 (en) 2006-10-12
NO20075547L (no) 2007-11-01
DOP2006000079A (es) 2006-11-15
TW200637855A (en) 2006-11-01
KR20070116989A (ko) 2007-12-11
NL1031524A1 (nl) 2006-10-09

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