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PE20091959A1 - Derivados de urea heterociclicos como antibacterianos - Google Patents

Derivados de urea heterociclicos como antibacterianos

Info

Publication number
PE20091959A1
PE20091959A1 PE2009000777A PE2009000777A PE20091959A1 PE 20091959 A1 PE20091959 A1 PE 20091959A1 PE 2009000777 A PE2009000777 A PE 2009000777A PE 2009000777 A PE2009000777 A PE 2009000777A PE 20091959 A1 PE20091959 A1 PE 20091959A1
Authority
PE
Peru
Prior art keywords
alkyl
urea
bipyridin
oxadiazol
dihydro
Prior art date
Application number
PE2009000777A
Other languages
English (en)
Inventor
Brian Sherer
Fei Zhou
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40848376&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091959(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20091959A1 publication Critical patent/PE20091959A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE UREA DE FORMULA (I), DONDE X ES N, CH O CR4; L ES ALQUILENO C1-C6, -CH=CH-ALQUILENO C1-C4, -C=C-ALQUILENO C1-C4; R1 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS; R2 ES H O ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON HALO, NITRO, CN, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, [ALQUIL C1-C6]3SILILO, ENTRE OTROS; R4 ES HALO, NITRO, CN, HIDROXI, ENTRE OTROS; R5 ES H O UN HETEROCICLILO OPCIONALMENTE SUSTITUIDO CON =O, =S, ENTRE OTROS; R6 ES HALO, NITRO, CN, ENTRE OTROS; m ES 0 O 1; p ES 0, 1, 2 O 3; EL ANILLO B ES CARBOCICLILO C13-C14 O HETEROCICLILO. SON COMPUESTOS PREFERIDOS: 1-ETIL-3-(5'-(5-OXO-4,5-DIHIDRO-1,3,4-OXADIAZOL-2-IL)-4-(PIRIDIN-2-ILETINIL)-3,3'-BIPIRIDIN-6-IL)UREA, 1-ETIL-3-(4-ETINIL-5'-(5-OXO-4,5-DIHIDRO-1,3,4-OXADIAZOL-2-IL)-3,3'-BIPIRIDIN-6-IL)UREA, 1-ETIL-3-(5'-(5-OXO-4,5-DIHIDRO-1,3,4-OXADIAZOL-2-IL)-4-((TRIMETILSILIL)ETINIL)-3,3'-BIPIRIDIN-6-IL)UREA. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA ADN GIRASA BACTERIANA Y/O LA TOPOISOMERASA IV Y SON UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS TALES COMO NEUMONIA, INFECCIONES DE LA PIEL Y DE ESTRUCTURAS DE LA PIEL, SINUSITIS AGUDA, OTITIS MEDIA AGUDA, ENTRE OTRAS
PE2009000777A 2008-06-04 2009-06-04 Derivados de urea heterociclicos como antibacterianos PE20091959A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5872808P 2008-06-04 2008-06-04
US15409309P 2009-02-20 2009-02-20

Publications (1)

Publication Number Publication Date
PE20091959A1 true PE20091959A1 (es) 2010-02-13

Family

ID=40848376

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000777A PE20091959A1 (es) 2008-06-04 2009-06-04 Derivados de urea heterociclicos como antibacterianos

Country Status (22)

Country Link
US (1) US20090325902A1 (es)
EP (1) EP2313402A1 (es)
JP (1) JP2011522030A (es)
KR (1) KR20110019737A (es)
CN (1) CN102105468A (es)
AR (1) AR072046A1 (es)
AU (1) AU2009254937A1 (es)
BR (1) BRPI0913583A2 (es)
CA (1) CA2725572A1 (es)
CL (1) CL2009001345A1 (es)
CO (1) CO6351722A2 (es)
CR (1) CR11824A (es)
DO (1) DOP2010000374A (es)
EA (1) EA201001859A1 (es)
EC (1) ECSP10010659A (es)
IL (1) IL209500A0 (es)
MX (1) MX2010013251A (es)
PE (1) PE20091959A1 (es)
TW (1) TW201002728A (es)
UY (1) UY31865A (es)
WO (1) WO2009147440A1 (es)
ZA (1) ZA201008609B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012010666A (es) 2010-03-31 2012-10-05 Actelion Pharmaceuticals Ltd Derivados de isoquinolin-3-ilurea antibacterianos.
WO2011133920A1 (en) 2010-04-23 2011-10-27 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
EP2593434A1 (en) 2010-07-16 2013-05-22 Purdue Pharma LP Pyridine compounds as sodium channel blockers
AR088729A1 (es) 2011-03-29 2014-07-02 Actelion Pharmaceuticals Ltd Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica
AU2013203824A1 (en) 2012-03-16 2013-10-03 Purdue Pharma L.P. Substituted pyridines and pryimidines as sodium channel blockers
US9714252B2 (en) 2012-12-20 2017-07-25 Purdue Pharma L.P. Cyclic sulfonamides as sodium channel blockers
CN106866571B (zh) * 2017-01-20 2018-06-29 中国药科大学 杂环脲类化合物及其药物组合物和应用
EP3604281A4 (en) 2017-03-24 2020-08-19 Taisho Pharmaceutical Co., Ltd. 2(1h)-quinolinone derivative

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135953A (en) * 1984-12-28 1992-08-04 Ciba-Geigy Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals
DE60139964D1 (de) * 2000-12-15 2009-10-29 Vertex Pharma Bakterielle Gyrase-Hemmer sowie deren Verwendung
JP2008531671A (ja) * 2005-03-04 2008-08-14 アストラゼネカ アクチボラグ 化合物
DE602007014256D1 (de) * 2006-12-04 2011-06-09 Astrazeneca Ab Antibakterielle polycyclische harnstoffverbindungen

Also Published As

Publication number Publication date
EA201001859A1 (ru) 2011-08-30
DOP2010000374A (es) 2011-01-15
UY31865A (es) 2010-01-29
AR072046A1 (es) 2010-08-04
ECSP10010659A (es) 2011-01-31
CL2009001345A1 (es) 2010-06-11
MX2010013251A (es) 2010-12-21
CA2725572A1 (en) 2009-12-10
JP2011522030A (ja) 2011-07-28
AU2009254937A1 (en) 2009-12-10
BRPI0913583A2 (pt) 2015-10-27
TW201002728A (en) 2010-01-16
CO6351722A2 (es) 2011-12-20
CR11824A (es) 2011-01-12
KR20110019737A (ko) 2011-02-28
EP2313402A1 (en) 2011-04-27
CN102105468A (zh) 2011-06-22
IL209500A0 (en) 2011-01-31
ZA201008609B (en) 2011-08-31
US20090325902A1 (en) 2009-12-31
WO2009147440A1 (en) 2009-12-10

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