PE20061296A1 - Un metodo para preparar extractos de ginkgo que tiene un contenido bajo de 4'-o-metil piridoxina y/o biflavonas - Google Patents
Un metodo para preparar extractos de ginkgo que tiene un contenido bajo de 4'-o-metil piridoxina y/o biflavonasInfo
- Publication number
- PE20061296A1 PE20061296A1 PE2006000392A PE2006000392A PE20061296A1 PE 20061296 A1 PE20061296 A1 PE 20061296A1 PE 2006000392 A PE2006000392 A PE 2006000392A PE 2006000392 A PE2006000392 A PE 2006000392A PE 20061296 A1 PE20061296 A1 PE 20061296A1
- Authority
- PE
- Peru
- Prior art keywords
- extract
- weight
- concentrate
- content
- solution
- Prior art date
Links
- 239000000284 extract Substances 0.000 title abstract 6
- SVINQHQHARVZFF-UHFFFAOYSA-N Ginkgotoxin Chemical compound COCC1=C(CO)C=NC(C)=C1O SVINQHQHARVZFF-UHFFFAOYSA-N 0.000 title abstract 4
- 235000008100 Ginkgo biloba Nutrition 0.000 title abstract 3
- 235000011201 Ginkgo Nutrition 0.000 title abstract 2
- 241000218628 Ginkgo Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 9
- 239000012141 concentrate Substances 0.000 abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 2
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 2
- 239000001166 ammonium sulphate Substances 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-HQMMCQRPSA-N Ethanol-14C Chemical compound C[14CH2]O LFQSCWFLJHTTHZ-HQMMCQRPSA-N 0.000 abstract 1
- 244000194101 Ginkgo biloba Species 0.000 abstract 1
- 239000004952 Polyamide Substances 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 150000002611 lead compounds Chemical class 0.000 abstract 1
- 239000012074 organic phase Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229920002647 polyamide Polymers 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Alternative & Traditional Medicine (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO PARA OBTENER UN EXTRACTO DE GINKGO BILOBA CON UN CONTENIDO DE MENOS DE 20PPM DE 4'-O-METIL PIRIDOXINA Y/O BIFLAVONAS QUE COMPRENDE: A) OBTENER EL EXTRACTO DE LAS HOJAS DE GINKGO BILOBA UTILIZANDO ACETONA CON AGUA, UN ALCANOL O METANOL ANHIDRO; B) SEPARAR EL SOLVENTE ORGANICO CONCENTRANDO EL SOLVENTE HASTA OBTENER UN CONTENIDO DE 10% EN PESO; C) DILUIR LA SOLUCION ACUOSA REMANENTE CON AGUA HASTA OBTENER UN CONTENIDO DE SOLIDOS DE ENTRE 5% Y 25% EN PESO, ENFRIAR A UNA TEMPERATURA MENOR DE 25ºC Y DEJAR EN REPOSO HASTA LA FORMACION DE UN PRECIPITADO; D) TRATAR LA SOLUCION ACUOSA REMANENTE CON SULFATO DE AMONIO, LUEGO REALIZAR UNA EXTRACCION CON METIL ETIL CETONA O UNA MEZCLA DE METIL ETIL CETONA Y ACETONA; E) CONCENTRAR EL EXTRACTO OBTENIDO Y DILUIR CON UNA MEZCLA DE ETANOL Y AGUA PARA OBTENER UNA SOLUCION QUE CONTIENE 50% EN PESO DE AGUA Y 50% EN PESO DE ETANOL, CON UN CONTENIDO DE SOLIDOS DE 10% EN PESO; F) TRATAR LA SOLUCION CON UN COMPUESTO DE PLOMO O UNA POLIAMIDA INSOLUBLE; G) EXTRAER LA SOLUCION FILTRADA CON UN SOLVENTE ALIFATICO O CICLOALIFATICO; H) CONCENTRAR LA SOLUCION ACUOSA ALCOHOLICA REMANENTE, REALIZAR UN TRATAMIENTO CON SULFATO DE AMONIO Y UNA EXTRACCION CON METIL ETIL CETONA Y ETANOL; I) CONCENTRAR LA FASE ORGANICA J) DISOLVER EL CONCENTRADO; K) FILTRAR SOBRE UNA RESINA DE ADSORCION; Y M) SECAR EL CONCENTRADO A PRESION REDUCIDA. DICHO EXTRACTO ES UTIL PARA EL TRATAMIENTO DE DEMENCIA, TRASTORNOS DE LA CIRCULACION SANGUINEA CEREBRAL
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005020685 | 2005-05-03 | ||
| DE102005061948A DE102005061948A1 (de) | 2005-05-03 | 2005-12-23 | Verbessertes Verfahren zur Herstellung von 4'-O-Methylpyridoxin- und/oder Biflavon-armen Ginkgoextrakten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061296A1 true PE20061296A1 (es) | 2007-01-06 |
Family
ID=36693938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000392A PE20061296A1 (es) | 2005-05-03 | 2006-04-17 | Un metodo para preparar extractos de ginkgo que tiene un contenido bajo de 4'-o-metil piridoxina y/o biflavonas |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20060251746A1 (es) |
| EP (1) | EP1868625B1 (es) |
| JP (2) | JP4304230B2 (es) |
| KR (1) | KR100933721B1 (es) |
| CN (2) | CN101175505A (es) |
| AR (1) | AR054270A1 (es) |
| AT (1) | ATE401903T1 (es) |
| AU (1) | AU2006243378B2 (es) |
| BR (1) | BRPI0611093B1 (es) |
| CA (1) | CA2606843C (es) |
| DE (2) | DE102005061948A1 (es) |
| DK (1) | DK1868625T3 (es) |
| DO (1) | DOP2006000091A (es) |
| ES (1) | ES2310408T3 (es) |
| JO (1) | JO2523B1 (es) |
| MX (1) | MX2007013398A (es) |
| MY (1) | MY143650A (es) |
| NZ (1) | NZ563818A (es) |
| PE (1) | PE20061296A1 (es) |
| PL (1) | PL1868625T3 (es) |
| PT (1) | PT1868625E (es) |
| RU (1) | RU2367459C2 (es) |
| SI (1) | SI1868625T1 (es) |
| TW (1) | TWI376230B (es) |
| UA (1) | UA84519C2 (es) |
| WO (1) | WO2006117169A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2709633T3 (es) * | 2007-12-21 | 2019-04-17 | Dr Willmar Schwabe Gmbh & Co Kg | Uso de un extracto de hojas de Ginkgo biloba |
| EP2494979B1 (de) | 2011-03-04 | 2019-03-27 | Dr. Willmar Schwabe GmbH & Co. KG | Verwendung von Extrakten aus Blättern von Ginkgo biloba zur Prävention und Therapie von Komplikationen nach operativer Arteriosklerose-Behandlung sowie von Folgeerscheinungen der Arteriosklerose |
| MX341428B (es) | 2011-04-27 | 2016-08-18 | Dr Willmar Schwabe Gmbh & Co Kg | Tableta de liberacion controlada de extracto de ginkgo biloba y procedimiento para su obtencion. |
| DE102014202318B4 (de) * | 2014-02-10 | 2016-10-06 | Dr. Willmar Schwabe Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von Ginkgoextrakten |
| CN103919768B (zh) * | 2014-03-30 | 2016-03-16 | 吴静 | 一种含有异银杏双黄酮和白果内酯的药物组合物及其制剂 |
| CN107509997B (zh) * | 2017-09-08 | 2021-02-26 | 南京林业大学 | 一种基于内源糖苷酶酶解结合树脂吸附脱除白果致毒成分的方法及其制备的产品和应用 |
| CN107647407A (zh) * | 2017-11-14 | 2018-02-02 | 宜昌东方昌绿茶业有限公司 | 一种从银杏茶中提取黄酮素的方法 |
| CN113491721B (zh) * | 2020-03-19 | 2022-05-31 | 江苏得乐康生物科技有限公司 | 一种脱除银杏叶提取物中银杏毒素的方法 |
| CN115894424B (zh) * | 2023-01-06 | 2023-05-12 | 中日友好医院(中日友好临床医学研究所) | 新型双黄酮类化合物及其制备方法、药物组合物和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2627387B1 (fr) * | 1988-02-24 | 1992-06-05 | Fabre Sa Pierre | Procede d'obtention d'un extrait de feuilles de ginkgo biloba |
| GB8822004D0 (en) * | 1988-09-20 | 1988-10-19 | Indena Spa | New extracts of ginkgo biloba & their methods of preparation |
| DE3940091A1 (de) * | 1989-12-04 | 1991-06-06 | Schwabe Willmar Gmbh & Co | Extrakt aus blaettern von ginkgo biloba, verfahren zu seiner herstellung und den extrakt enthaltende arzneimittel |
| JP3518882B2 (ja) | 1993-11-12 | 2004-04-12 | ダイセル化学工業株式会社 | イチョウエキス及びその製造法 |
| DE19756848C2 (de) * | 1997-12-19 | 2003-01-16 | Schwabe Willmar Gmbh & Co | Extrakte aus Blättern von Ginkgo biloba mit vermindertem Gehalt an 4'-O-Methylpyridoxin und Biflavonen |
| US20040076691A1 (en) * | 2002-01-16 | 2004-04-22 | David Haines | Anti-inflammatory formulations |
| CN1251675C (zh) * | 2004-02-10 | 2006-04-19 | 张正生 | 一种注射用银杏达莫粉针剂及其制备方法 |
| CN100451013C (zh) * | 2004-04-21 | 2009-01-14 | 徐州技源天然保健品有限公司 | 一种从卷柏中提取穗花杉双黄酮提取物的生产工艺 |
-
2005
- 2005-12-23 DE DE102005061948A patent/DE102005061948A1/de not_active Withdrawn
-
2006
- 2006-04-02 JO JO200689A patent/JO2523B1/en active
- 2006-04-03 TW TW095111812A patent/TWI376230B/zh not_active IP Right Cessation
- 2006-04-14 MY MYPI20061717A patent/MY143650A/en unknown
- 2006-04-17 PE PE2006000392A patent/PE20061296A1/es active IP Right Grant
- 2006-04-20 DO DO2006000091A patent/DOP2006000091A/es unknown
- 2006-04-28 PL PL06742753T patent/PL1868625T3/pl unknown
- 2006-04-28 CN CNA2006800134122A patent/CN101175505A/zh active Pending
- 2006-04-28 DK DK06742753T patent/DK1868625T3/da active
- 2006-04-28 AT AT06742753T patent/ATE401903T1/de active
- 2006-04-28 BR BRPI0611093-2A patent/BRPI0611093B1/pt not_active IP Right Cessation
- 2006-04-28 WO PCT/EP2006/004029 patent/WO2006117169A1/en not_active Ceased
- 2006-04-28 CN CN201410231982.5A patent/CN104189025A/zh active Pending
- 2006-04-28 JP JP2008509353A patent/JP4304230B2/ja not_active Expired - Fee Related
- 2006-04-28 KR KR1020077023531A patent/KR100933721B1/ko not_active Expired - Fee Related
- 2006-04-28 SI SI200630089T patent/SI1868625T1/sl unknown
- 2006-04-28 PT PT06742753T patent/PT1868625E/pt unknown
- 2006-04-28 RU RU2007143632/15A patent/RU2367459C2/ru active
- 2006-04-28 CA CA2606843A patent/CA2606843C/en not_active Expired - Fee Related
- 2006-04-28 UA UAA200711514A patent/UA84519C2/ru unknown
- 2006-04-28 NZ NZ563818A patent/NZ563818A/en not_active IP Right Cessation
- 2006-04-28 EP EP06742753A patent/EP1868625B1/en active Active
- 2006-04-28 MX MX2007013398A patent/MX2007013398A/es active IP Right Grant
- 2006-04-28 AU AU2006243378A patent/AU2006243378B2/en not_active Ceased
- 2006-04-28 DE DE602006001949T patent/DE602006001949D1/de active Active
- 2006-04-28 ES ES06742753T patent/ES2310408T3/es active Active
- 2006-05-02 US US11/416,924 patent/US20060251746A1/en not_active Abandoned
- 2006-05-03 AR AR20060101796A patent/AR054270A1/es unknown
-
2008
- 2008-07-09 US US12/217,803 patent/US8642099B2/en active Active
-
2009
- 2009-03-16 JP JP2009063133A patent/JP2009173663A/ja active Pending
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