PE20061448A1 - Compuestos polipeptidos como moduladores del peptido 1 similar al glucagon humano - Google Patents
Compuestos polipeptidos como moduladores del peptido 1 similar al glucagon humanoInfo
- Publication number
- PE20061448A1 PE20061448A1 PE2006000557A PE2006000557A PE20061448A1 PE 20061448 A1 PE20061448 A1 PE 20061448A1 PE 2006000557 A PE2006000557 A PE 2006000557A PE 2006000557 A PE2006000557 A PE 2006000557A PE 20061448 A1 PE20061448 A1 PE 20061448A1
- Authority
- PE
- Peru
- Prior art keywords
- peptide
- bip
- thr
- phe
- amino acid
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 101500028775 Homo sapiens Glucagon Proteins 0.000 title abstract 2
- 101710176384 Peptide 1 Proteins 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 235000001014 amino acid Nutrition 0.000 abstract 3
- 229940024606 amino acid Drugs 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 2
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 2
- 102100040918 Pro-glucagon Human genes 0.000 abstract 2
- AALYNABLSOHPQK-BYPYZUCNSA-N (2s)-2-(1,3-thiazol-4-ylamino)propanoic acid Chemical compound OC(=O)[C@H](C)NC1=CSC=N1 AALYNABLSOHPQK-BYPYZUCNSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 230000002473 insulinotropic effect Effects 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 229960005190 phenylalanine Drugs 0.000 abstract 1
- 235000008729 phenylalanine Nutrition 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A POLIPEPTIDOS AISLADOS SINTETICOS, QUE COMPRENDEN UNA SECUENCIA DE FORMULA (I) (SEQ ID NO:1) EN DONDE Xaa1 ES UN AMINOACIDO DE ORIGEN NATURAL O NO NATURAL SELECCIONADO DE (D) O (L)-HIS, (D) O (L)-N-METIL-HIS, (D) O (L)-4-TIAZOLILALANIN, ENTRE OTROS; Xaa2 ES (D) O (L)-ALA, N-METIL-(L) O (D)-ALA, L-PRO, a-AMINOISOBUTIRICO (Aib); Xaa3 ES L-GLU, L-ASP Y L-GLA; Xaa4 ES GLY; Xaa5 ES L-THR, L-NLE, L-NVA, L-AOC Y L-ALO-THR; Xaa6 ES L-a-ME-PHE, L-a-ET-PHE, L-a-ME-FLUORO-PHE, ENTRE OTROS; Xaa7 ES L-THR Y L-ALO-TREONINA; Xaa8 ES L-SER, L-HIS Y L-ASN; Xaa9 ES L-ASP; Xaa10 ES UN AMINOACIDO DE FORMULA II, III, IV Y V, SIENDO PREFERIDOS: BIP(2'-ME), BIP(3',5'-DI-ME), 4-(3'-PIRIDIL)FENIL ALANINA, ENTRE OTROS; Xaa11 ES UN AMINOACIDO DE FORMULA IIa, IIIa, IVa, O Va, SIENDO PREFERIDOS 4-(2'-PIRIDIL)FENILALANINA-NH2, BIP(2'-ME)-NH2, 4-(2'-METILFENIL)-3-PIRIDILALANINA-NH2, ENTRE OTROS. ESTOS PEPTIDOS SON MODULADORES DEL RECEPTOR DEL PEPTIDO 1 SIMILAR AL GLUCAGON (GLP-1) HUMANO, COMO AGONISTA O AGONISTAS PARCIALES, MOSTRANDO EFICACIA SUPERIOR AL PEPTIDO GLP-1 NATIVO, POR LO QUE SON UTILES PARA EL MEJORAMIENTO DE LAS CONDICIONES DIABETICAS Y RELACIONADOS, YA QUE PRODUCEN RESPUESTAS INSULINOTROPICAS BENEFICAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68480505P | 2005-05-26 | 2005-05-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061448A1 true PE20061448A1 (es) | 2006-12-17 |
Family
ID=37452852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000557A PE20061448A1 (es) | 2005-05-26 | 2006-05-26 | Compuestos polipeptidos como moduladores del peptido 1 similar al glucagon humano |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20070021346A1 (es) |
| EP (1) | EP1883652A2 (es) |
| JP (1) | JP2008542292A (es) |
| KR (1) | KR20080026117A (es) |
| CN (1) | CN101282991A (es) |
| AR (1) | AR053495A1 (es) |
| AU (1) | AU2006249869A1 (es) |
| MX (1) | MX2007014819A (es) |
| PE (1) | PE20061448A1 (es) |
| TW (1) | TW200716679A (es) |
| WO (1) | WO2006127948A2 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7534763B2 (en) | 2004-07-02 | 2009-05-19 | Bristol-Myers Squibb Company | Sustained release GLP-1 receptor modulators |
| US20090227493A1 (en) * | 2005-05-27 | 2009-09-10 | Daiichi Sankyo Company, Limited | Combined drug for treating diabetes |
| JP2009523177A (ja) * | 2006-01-11 | 2009-06-18 | ブリストル−マイヤーズ スクイブ カンパニー | ヒトグルカゴン様ペプチド−１調節因子、並びに糖尿病および関連症状の治療におけるその使用 |
| EP2021014A1 (en) * | 2006-05-26 | 2009-02-11 | Brystol-Myers Squibb Company | Sustained release glp-1 receptor modulators |
| GB0817969D0 (en) | 2008-10-01 | 2008-11-05 | Axcess Ltd | Pharmaceutical composition |
| WO2011048614A2 (en) | 2009-10-22 | 2011-04-28 | Cadila Healthcare Limited | Short chain peptidomimetics based orally active glp-1 agonist and glucagon receptor antagonist |
| JP6006118B2 (ja) * | 2009-12-16 | 2016-10-12 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１アナログ及び誘導体 |
| RU2600440C3 (ru) | 2010-12-16 | 2021-12-10 | Ново Нордиск А/С | Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты |
| CA2832811A1 (en) | 2011-04-12 | 2012-10-18 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| ES2715308T3 (es) | 2012-03-22 | 2019-06-03 | Novo Nordisk As | Composiciones que comprenden un agente de suministro y su preparación |
| US10933120B2 (en) | 2012-03-22 | 2021-03-02 | Novo Nordisk A/S | Compositions of GLP-1 peptides and preparation thereof |
| ES2871328T3 (es) | 2012-06-20 | 2021-10-28 | Novo Nordisk As | Formulación de comprimido que comprende un péptido y un agente de suministro |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| PT2934568T (pt) | 2012-12-21 | 2018-01-04 | Sanofi Sa | Agonistas duplos de glp1/gip ou trigonais de glp1/gip/glucagina |
| SG11201506885UA (en) | 2013-03-21 | 2015-09-29 | Sanofi Aventis Deutschland | Synthesis of cyclic imide containing peptide products |
| HK1219477A1 (zh) | 2013-03-21 | 2017-04-07 | Sanofi-Aventis Deutschland Gmbh | 合成含有乙内酰脲的肽产物 |
| AU2014261336B2 (en) | 2013-05-02 | 2019-02-28 | Novo Nordisk A/S | Oral dosing of GLP-1 compounds |
| PH12017501029B1 (en) * | 2014-12-24 | 2022-04-27 | Lg Chemical Ltd | Biaryl derivative as gpr120 agonist |
| PT3389697T (pt) * | 2015-12-14 | 2021-01-22 | Antaros Medical Ab | Agonistas seletivos do recetor de glucagão compreendendo uma fração quelante para propósitos de imagiologia |
| US11173135B2 (en) | 2016-03-17 | 2021-11-16 | Thiogenesis Therapeutics, Inc. | Compositions for controlled release of cysteamine and systemic treatment of cysteamine sensitive disorders |
| MA49610A (fr) | 2016-12-08 | 2020-05-27 | Univ Case Western Reserve | Procédés et compositions pour améliorer la production de myéline fonctionnelle |
| CA3043151A1 (en) * | 2016-12-09 | 2018-06-14 | Zealand Pharma A/S | Acylated glp-1/glp-2 dual agonists |
| CN118924717A (zh) | 2017-09-20 | 2024-11-12 | 硫创治疗公司 | 用于治疗半胱胺敏感性病症的方法 |
| BR112020014624A2 (pt) | 2018-02-02 | 2020-12-08 | Novo Nordisk A/S | Composições sólidas compreendendo agonista de glp-1, sal de ácido n-(8-(2-hidroxibenzoil) amino)caprílico e lubrificante |
| DK3774838T3 (da) * | 2018-04-10 | 2022-10-31 | Sanofi Aventis Deutschland | Lixisenatidsyntese med capping |
| WO2021070202A1 (en) * | 2019-10-09 | 2021-04-15 | Prasad Alaparthi Lakshmi | A method for preparing glp-1 analogue by solid-phase peptide synthesis |
| WO2022266068A2 (en) * | 2021-06-14 | 2022-12-22 | Resolute Bio, Inc. | Glp-1 receptor agonists having improved pharmacological and drug delivery properties |
| CN114456228B (zh) * | 2022-02-21 | 2023-09-12 | 山东大学 | 一种取代甘氨酸-3,5-二氟苯丙氨酸类肽衍生物及其制备方法与应用 |
| CN118955628B (zh) * | 2024-10-18 | 2024-12-20 | 山东华涛食品有限公司 | 一种竞争型抑制α-葡萄糖苷酶活性的甘薯肽 |
| CN120383542B (zh) * | 2025-06-27 | 2025-09-12 | 吉尔多肽生物制药(大连市)有限公司 | 一种Fmoc-（S）-2-氨基-3-（2'-乙基-4'-甲氧基联苯-4-基）丙酸的合成方法 |
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| US5491134A (en) * | 1994-09-16 | 1996-02-13 | Bristol-Myers Squibb Company | Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives |
| US5541204A (en) * | 1994-12-02 | 1996-07-30 | Bristol-Myers Squibb Company | Aryloxypropanolamine β 3 adrenergic agonists |
| US5770615A (en) * | 1996-04-04 | 1998-06-23 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
| US5962440A (en) * | 1996-05-09 | 1999-10-05 | Bristol-Myers Squibb Company | Cyclic phosphonate ester inhibitors of microsomal triglyceride transfer protein and method |
| US5827875A (en) * | 1996-05-10 | 1998-10-27 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| US5885983A (en) * | 1996-05-10 | 1999-03-23 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| US5760246A (en) * | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| TW536540B (en) * | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| WO1999003880A1 (en) * | 1997-07-15 | 1999-01-28 | Novo Nordisk A/S | Nociceptin analogues |
| EP1241158A4 (en) * | 1999-12-13 | 2004-02-11 | Chugai Pharmaceutical Co Ltd | HYDROXYCARBONYL-HALOGENOALKYLE SIDE CHAIN COMPOUND |
| CA2372352A1 (en) * | 2000-04-07 | 2001-10-18 | Hyun-Gyu Park | Sulfonamide derivative as a matrix metalloproteinase inhibitor |
| US6579889B2 (en) * | 2000-06-22 | 2003-06-17 | Merck & Co., Inc. | Substituted isonipecotyl derivatives as inhibitors of cell adhesion |
| US7238671B2 (en) * | 2001-10-18 | 2007-07-03 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
| US7238670B2 (en) * | 2001-10-18 | 2007-07-03 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
| TW200611704A (en) * | 2004-07-02 | 2006-04-16 | Bristol Myers Squibb Co | Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions |
| US7145040B2 (en) * | 2004-07-02 | 2006-12-05 | Bristol-Myers Squibb Co. | Process for the preparation of amino acids useful in the preparation of peptide receptor modulators |
-
2006
- 2006-05-26 AR ARP060102210A patent/AR053495A1/es unknown
- 2006-05-26 CN CNA2006800269581A patent/CN101282991A/zh active Pending
- 2006-05-26 AU AU2006249869A patent/AU2006249869A1/en not_active Abandoned
- 2006-05-26 KR KR1020077030167A patent/KR20080026117A/ko not_active Withdrawn
- 2006-05-26 EP EP06760391A patent/EP1883652A2/en not_active Withdrawn
- 2006-05-26 JP JP2008513732A patent/JP2008542292A/ja active Pending
- 2006-05-26 TW TW095118802A patent/TW200716679A/zh unknown
- 2006-05-26 WO PCT/US2006/020332 patent/WO2006127948A2/en not_active Ceased
- 2006-05-26 MX MX2007014819A patent/MX2007014819A/es not_active Application Discontinuation
- 2006-05-26 US US11/442,017 patent/US20070021346A1/en not_active Abandoned
- 2006-05-26 PE PE2006000557A patent/PE20061448A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20070021346A1 (en) | 2007-01-25 |
| JP2008542292A (ja) | 2008-11-27 |
| WO2006127948A2 (en) | 2006-11-30 |
| TW200716679A (en) | 2007-05-01 |
| EP1883652A2 (en) | 2008-02-06 |
| CN101282991A (zh) | 2008-10-08 |
| KR20080026117A (ko) | 2008-03-24 |
| WO2006127948A3 (en) | 2007-04-19 |
| AU2006249869A1 (en) | 2006-11-30 |
| MX2007014819A (es) | 2008-02-14 |
| AR053495A1 (es) | 2007-05-09 |
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