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PE20060610A1 - Derivados tetraciclicos como moduladores de los receptores de estrogeno - Google Patents

Derivados tetraciclicos como moduladores de los receptores de estrogeno

Info

Publication number
PE20060610A1
PE20060610A1 PE2005001265A PE2005001265A PE20060610A1 PE 20060610 A1 PE20060610 A1 PE 20060610A1 PE 2005001265 A PE2005001265 A PE 2005001265A PE 2005001265 A PE2005001265 A PE 2005001265A PE 20060610 A1 PE20060610 A1 PE 20060610A1
Authority
PE
Peru
Prior art keywords
fluorine
modulators
tetraen
ona
alkyl
Prior art date
Application number
PE2005001265A
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English (en)
Inventor
Robert R Wilkening
Amy Fried
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35759216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20060610(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PE20060610A1 publication Critical patent/PE20060610A1/es

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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE X ES O, N-ORa, N-N(Ra)2, ENTRE OTROS; DONDE Ra ES H, ALQUILO(C1-C4), FENILO; R1 ES FLUORO, ALQUILO(C1-C4), CIANO, ENTRE OTROS; R2 ES H, Ra, (C=O)Ra; R3 ES H, FLUORO, CLORO, ENTRE OTROS; R4 ES H, FLUORO, HIDROXILO, ENTRE OTROS; R5 ES H, FLUORO, CLORO, ENTRE OTROS; R6 ES H, FLUORO, ALQUILO(C1-C5) OPCIONALMENTE SUSTITUIDO. SON COMPUESTOS PREFERIDOS: 1,5-DICLORO-2-HIDROXIGIBBA-1,3,4a(10a),4b-TETRAEN-6-ONA, 2-HIDROXI-5-METILGIBBA-1,3,4a(10a),4b-TETRAEN-6-ONA, 2-HIDROXI-5-(TRIFLUOROMETIL)GIBBA-1,3,4a(10a),4b-TETRAEN-6-ONA, ENTRE OTROS. DICHOS COMPUESTOS SON MODULADORES SELECTIVOS DE LOS RECEPTORES DE ESTROGENO SIENDO UTILES EN EL TRATAMIENTO Y PREVENCION DE TRANSTORNOS RELACIONADOS CON EL ESTROGENO TALES COMO PERDIDA OSEA, FRACTURAS, OSTEOPOROSIS
PE2005001265A 2004-11-01 2005-10-28 Derivados tetraciclicos como moduladores de los receptores de estrogeno PE20060610A1 (es)

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US62391004P 2004-11-01 2004-11-01

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PE20060610A1 true PE20060610A1 (es) 2006-08-11

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PE2005001265A PE20060610A1 (es) 2004-11-01 2005-10-28 Derivados tetraciclicos como moduladores de los receptores de estrogeno

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US (1) US7151196B2 (es)
EP (1) EP1809594A1 (es)
JP (1) JP2008518960A (es)
KR (1) KR20070083896A (es)
CN (1) CN101068764B (es)
AR (1) AR051597A1 (es)
AU (1) AU2005302143A1 (es)
BR (1) BRPI0517224A (es)
CA (1) CA2585658A1 (es)
IL (1) IL182829A0 (es)
MX (1) MX2007005267A (es)
NO (1) NO20072771L (es)
PE (1) PE20060610A1 (es)
RU (1) RU2007120392A (es)
TW (1) TW200631933A (es)
WO (1) WO2006050402A1 (es)

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