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EA200900605A1 - Новые производные фенилсульфамоил бензамидов в качестве антагонистов брадикининовых рецепторов - Google Patents

Новые производные фенилсульфамоил бензамидов в качестве антагонистов брадикининовых рецепторов

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Publication number
EA200900605A1
EA200900605A1 EA200900605A EA200900605A EA200900605A1 EA 200900605 A1 EA200900605 A1 EA 200900605A1 EA 200900605 A EA200900605 A EA 200900605A EA 200900605 A EA200900605 A EA 200900605A EA 200900605 A1 EA200900605 A1 EA 200900605A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antagonists
new derivatives
phenylsulfamoil
bradikinine
benzamides
Prior art date
Application number
EA200900605A
Other languages
English (en)
Other versions
EA018032B1 (ru
Inventor
Дьюла Беке
Эва Бозо
Шандор Фаркаш
Каталин Хорнок
Дьёрдь Кешеру
Эва Шмидт
Эва Сентирмай
Иштван Ваго
Моника Ваштаг
Original Assignee
Рихтер Гедеон Нирт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рихтер Гедеон Нирт. filed Critical Рихтер Гедеон Нирт.
Publication of EA200900605A1 publication Critical patent/EA200900605A1/ru
Publication of EA018032B1 publication Critical patent/EA018032B1/ru

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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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Abstract

Настоящее изобретение относится к новым производным фенилсульфамоил бензамида формулы (I), где R-Rи Z соответствуют тому, как указано в формуле изобретения, и их оптическим антиподам, или рацематам, и/или солям, и/или гидратам, и/или сольватам, которые являются селективными антагонистами брадикинина В1, к способу получения таких соединений, к фармакологическим композициям, их содержащим, и к их применению в лечении и профилактике болевых и воспалительных состояний.
EA200900605A 2006-10-27 2007-10-27 Производные фенилсульфамоилбензамидов в качестве антагонистов брадикининовых рецепторов, способ их получения и фармацевтическая композиция, их содержащая EA018032B1 (ru)

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HU0600809A HUP0600809A3 (en) 2006-10-27 2006-10-27 New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
PCT/HU2007/000103 WO2008050167A1 (en) 2006-10-27 2007-10-27 New phenylsulfamoyl benzamide derivatives as bradykinin antagonists

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HUP0600808A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them
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US8937073B2 (en) 2010-08-20 2015-01-20 Boehringer Ingelheim International Gmbh Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists
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CN106601606B (zh) * 2015-10-19 2019-09-20 中芯国际集成电路制造(上海)有限公司 Nmos器件、半导体装置及其制造方法
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KR20210150011A (ko) * 2020-06-03 2021-12-10 주식회사 삼오파마켐 프로베네시드 및 아르기닌의 아미드 유도체, 이를 포함하는 약제학적 조성물 및 이의 제조 방법
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HUP0600808A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them
KR20100081349A (ko) * 2007-10-27 2010-07-14 리히터 게데온 닐트. 브라디키닌 ｂ１ 길항제인 신규 비펩티드 유도체
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US20110190347A1 (en) * 2008-08-21 2011-08-04 Richter Gedeon Nyrt. Methods for treating neuropathic pain

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HU0600809D0 (en) 2006-12-28
EP2057116B1 (en) 2013-02-13
MY155039A (en) 2015-08-28
NZ575765A (en) 2011-12-22
MA30912B1 (fr) 2009-11-02
US20100105686A1 (en) 2010-04-29
TN2009000108A1 (en) 2010-08-19
AU2007310587A1 (en) 2008-05-02
JP2010507643A (ja) 2010-03-11
WO2008050167A1 (en) 2008-05-02
CN101528680A (zh) 2009-09-09
HUP0600809A3 (en) 2008-09-29
CA2667481A1 (en) 2008-05-02
NO20092049L (no) 2009-07-17
IL197586A0 (en) 2009-12-24
US20120295910A1 (en) 2012-11-22
EP2057116A1 (en) 2009-05-13
GEP20125393B (en) 2012-02-10
KR20090076926A (ko) 2009-07-13
HUP0600809A2 (en) 2008-08-28
EA018032B1 (ru) 2013-05-30
MX2009004528A (es) 2009-07-02

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