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PE20060585A1 - Derivados de 2-amido-4-feniltiazol como antagonistas de quimiocinas y su preparacion - Google Patents

Derivados de 2-amido-4-feniltiazol como antagonistas de quimiocinas y su preparacion

Info

Publication number
PE20060585A1
PE20060585A1 PE2005001227A PE2005001227A PE20060585A1 PE 20060585 A1 PE20060585 A1 PE 20060585A1 PE 2005001227 A PE2005001227 A PE 2005001227A PE 2005001227 A PE2005001227 A PE 2005001227A PE 20060585 A1 PE20060585 A1 PE 20060585A1
Authority
PE
Peru
Prior art keywords
phenyl
metoxy
piperidine
carbonyl
amide
Prior art date
Application number
PE2005001227A
Other languages
English (en)
Inventor
Pierre Casellas
Daniel Floutard
Samir Jegham
Pierre Lionel Fraisse
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20060585A1 publication Critical patent/PE20060585A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE R1 ES H, HALOGENO, ALQUILO (C1-C4), ENTRE OTROS; R2 ES H, HALOGENO, OH, ENTRE OTROS; Y ES H, HALOGENO; R3 ES FENILO SUSTITUIDO; HETEROCICLICO OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; M ES 2 A 4; N ES 0 A 2; P ES 0 A 3. SON COMPUESTOS PREFERIDOS: ACIDO 1-(1,5-DIMETIL-1H-PIRAZOL-3-CARBONIL)-PIPERIDINA-3-CARBOXILICO-[4-(5-CICLOHEXIL-2-METOXI-FENIL)-TIAZOL-2-IL]-AMIDA, ACIDO 1-(1-METIL-1H-IMIDAZOL-2-CARBONIL)-PIPERIDINA-3-CARBOXILICO-[4-(5-CICLOHEXIL-2-METOXI-FENIL)-TIAZOL-2-IL]-AMIDA, ACIDO 1-(PIRIMIDINA-4-CARBONIL)-PIPERIDINA-3-CARBOXILICO-[4-(5-CICLOHEXIL-2-METOXI-FENIL)-TIAZOL-2-IL]-AMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS DE LAS QUIMIOCINAS, EN PARTICULAR DE LA PROTEINA QUIMIOTACTICA MONOCITARIA HUMANA (HMCP-1) SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES Y SINDROMES INMUNOINFLAMATORIOS AGUDOS Y CRONICOS TALES COMO ATEROESCLEROSIS, FIBROSIS PULMONARES, COLITIS
PE2005001227A 2004-10-19 2005-10-19 Derivados de 2-amido-4-feniltiazol como antagonistas de quimiocinas y su preparacion PE20060585A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0411083A FR2876692B1 (fr) 2004-10-19 2004-10-19 Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
PE20060585A1 true PE20060585A1 (es) 2006-08-18

Family

ID=34950743

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001227A PE20060585A1 (es) 2004-10-19 2005-10-19 Derivados de 2-amido-4-feniltiazol como antagonistas de quimiocinas y su preparacion

Country Status (27)

Country Link
US (1) US7598392B2 (es)
EP (1) EP1807421B1 (es)
JP (1) JP2008517042A (es)
KR (1) KR20070085395A (es)
CN (1) CN101065376A (es)
AR (1) AR051334A1 (es)
AT (1) ATE502035T1 (es)
AU (1) AU2005296958A1 (es)
BR (1) BRPI0518231A2 (es)
CA (1) CA2584774A1 (es)
DE (1) DE602005026964D1 (es)
EA (1) EA200700901A1 (es)
EC (1) ECSP077402A (es)
FR (1) FR2876692B1 (es)
GT (1) GT200500292A (es)
IL (1) IL182624A0 (es)
MA (1) MA29017B1 (es)
MX (1) MX2007004740A (es)
NO (1) NO20072515L (es)
PA (1) PA8649901A1 (es)
PE (1) PE20060585A1 (es)
SV (1) SV2006002274A (es)
TN (1) TNSN07145A1 (es)
TW (1) TW200630364A (es)
UY (1) UY29169A1 (es)
WO (1) WO2006042954A1 (es)
ZA (1) ZA200703876B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854158B1 (fr) 2003-04-25 2006-11-17 Sanofi Synthelabo Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
FR2872813B1 (fr) 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
US7595398B2 (en) * 2005-12-12 2009-09-29 Smithkline Beecham Corporation N-(5-membered aromatic ring)-amido anti-viral compounds
FR2895989B1 (fr) 2006-01-06 2010-04-30 Sanofi Aventis Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
WO2009076404A1 (en) * 2007-12-10 2009-06-18 Epix Delaware, Inc. Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
CA2708364A1 (en) 2007-12-11 2009-06-18 Efrat Ben-Zeev Carboxamide compounds and their use as chemokine receptor agonists
EP2349484A2 (en) * 2008-07-15 2011-08-03 Novartis AG Heteroaryl derivatives as dgat1 inhibitors
DK2381778T3 (en) * 2008-12-22 2016-09-12 Chemocentryx Inc C5aR antagonists
EA023259B1 (ru) 2011-01-04 2016-05-31 Новартис Аг Индольные соединения или их аналоги, полезные для лечения возрастной макулярной дегенерации (amd)
JP6154897B2 (ja) 2012-06-28 2017-06-28 ノバルティス アーゲー ピロリジン誘導体、および補体経路調節因子としてのその使用
EP2867227B1 (en) 2012-06-28 2018-11-21 Novartis AG Complement pathway modulators and uses thereof
WO2014002051A2 (en) 2012-06-28 2014-01-03 Novartis Ag Complement pathway modulators and uses thereof
WO2014002054A1 (en) 2012-06-28 2014-01-03 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
US9388199B2 (en) 2012-06-28 2016-07-12 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
EA201590200A1 (ru) 2012-07-12 2015-08-31 Новартис Аг Модуляторы пути активации комплемента и их применение
EP4114529A1 (en) 2020-03-03 2023-01-11 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
US12234231B2 (en) 2021-08-25 2025-02-25 PIC Therapeutics, Inc. EIF4E inhibitors and uses thereof
WO2023028238A1 (en) 2021-08-25 2023-03-02 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
KR20240140019A (ko) * 2023-03-15 2024-09-24 현대약품 주식회사 신규한 화합물, 및 이를 포함하는 약학적 조성물

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2146898A (en) * 1937-12-06 1939-02-14 Int Harvester Co Potato digger
FR2406634A1 (fr) * 1977-10-19 1979-05-18 Fabre Sa Pierre Immunostimulants derives d'amino thiazoles
FR2677356B1 (fr) 1991-06-05 1995-03-17 Sanofi Sa Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant.
AU2000092A (en) 1991-06-21 1993-01-25 Boehringer Mannheim Italia S.P.A. 2-amino-4-aryl-thiazoles with antiasthmatic and anti-inflammatory activities on the respiratory tract
US6506751B1 (en) * 1999-11-12 2003-01-14 Millennium Pharmaceuticals, Inc. Thiazolidinone compounds useful as chemokine inhibitors
US6797820B2 (en) * 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
US6852752B2 (en) * 1999-12-17 2005-02-08 Vicuron Pharmaceuticals Inc. Urea compounds, compositions and methods of use and preparation
KR20030064852A (ko) 2000-12-22 2003-08-02 이시하라 산교 가부시끼가이샤 아닐린 유도체 또는 그의 염 및 이들을 함유하는사이토카인 생산 억제제
US7265134B2 (en) 2001-08-17 2007-09-04 Merck & Co., Inc. Tyrosine kinase inhibitors
TW200403058A (en) * 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
FR2854158B1 (fr) * 2003-04-25 2006-11-17 Sanofi Synthelabo Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
TW200423931A (en) 2003-04-30 2004-11-16 Hoffmann La Roche Novel aniline derivatives, their manufacture and use as pharmaceutical agents
FR2872813B1 (fr) * 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
RU2423349C2 (ru) 2004-12-24 2011-07-10 Астразенека Аб Гетероциклические соединения в качестве антагонистов ccr2b
FR2895989B1 (fr) 2006-01-06 2010-04-30 Sanofi Aventis Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
AR051334A1 (es) 2007-01-03
UY29169A1 (es) 2006-05-31
EP1807421B1 (fr) 2011-03-16
BRPI0518231A2 (pt) 2008-11-11
EA200700901A1 (ru) 2007-10-26
TNSN07145A1 (fr) 2008-11-21
FR2876692A1 (fr) 2006-04-21
JP2008517042A (ja) 2008-05-22
IL182624A0 (en) 2007-07-24
CA2584774A1 (fr) 2006-04-27
PA8649901A1 (es) 2006-06-02
MA29017B1 (fr) 2007-11-01
SV2006002274A (es) 2006-06-28
FR2876692B1 (fr) 2007-02-23
ECSP077402A (es) 2007-05-30
DE602005026964D1 (de) 2011-04-28
WO2006042954A1 (fr) 2006-04-27
AU2005296958A1 (en) 2006-04-27
EP1807421A1 (fr) 2007-07-18
KR20070085395A (ko) 2007-08-27
CN101065376A (zh) 2007-10-31
GT200500292A (es) 2006-05-11
MX2007004740A (es) 2007-06-18
US20070259847A1 (en) 2007-11-08
US7598392B2 (en) 2009-10-06
TW200630364A (en) 2006-09-01
NO20072515L (no) 2007-06-28
WO2006042954A8 (fr) 2008-03-13
ZA200703876B (en) 2008-12-31
ATE502035T1 (de) 2011-04-15

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FD Application declared void or lapsed