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PE20080931A1 - Imidazopirazinas como inhibidores de proteina quinasa - Google Patents

Imidazopirazinas como inhibidores de proteina quinasa

Info

Publication number
PE20080931A1
PE20080931A1 PE2007001524A PE2007001524A PE20080931A1 PE 20080931 A1 PE20080931 A1 PE 20080931A1 PE 2007001524 A PE2007001524 A PE 2007001524A PE 2007001524 A PE2007001524 A PE 2007001524A PE 20080931 A1 PE20080931 A1 PE 20080931A1
Authority
PE
Peru
Prior art keywords
alkyl
compounds
imidazopyrazines
protein kinase
kinase inhibitors
Prior art date
Application number
PE2007001524A
Other languages
English (en)
Inventor
David B Belanger
M Arshad Siddiqui
Timothy J Guzi
Patrick J Curran
Praveen K Tadikonda
Blake Hamann
Panduranga Adulla P Reddy
Lianyun Zhao
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39276164&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080931(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20080931A1 publication Critical patent/PE20080931A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE IMIDAZO[1,2-a]PIRAZINA DE FORMULA (I) DONDE L ES S, S(O) O S(O2); G ES ALQUILO(C1-C20), ALQUENILO(C2-C15), CICLOALQUILO(C3-C10), ENTRE OTROS; R1 ES H, HALO, ALQUILO(C1-C20), ARILO(C6-C14), ENTRE OTROS; R2 ES H, ALQUILO(C1-C20), ARILO(C6-C14), ALQUENILO(C2-C15), ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON CF3, CN, OCF3, ENTRE OTROS SUSTITUYENTES; R3 ES H, ALQUILO(C1-C20), CICLOALQUILO(C3-C10), HETEROARILO DE 5 A 14 MIEMBROS, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON HALO, CF3, CN, OCF3, ENTRE OTROS SUSTITUYENTES. SON COMPUESTOS PREFERIDOS LOS COMPUESTOS DE FORMULA (i), (ii), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE AURORA QUINASA SIENDO UTILES EN EL TRATAMIENTO DE CANCER, ARTRITIS, ENFERMEDAD DE ALZHEIMER
PE2007001524A 2006-11-08 2007-11-06 Imidazopirazinas como inhibidores de proteina quinasa PE20080931A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85824406P 2006-11-08 2006-11-08

Publications (1)

Publication Number Publication Date
PE20080931A1 true PE20080931A1 (es) 2008-07-19

Family

ID=39276164

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001524A PE20080931A1 (es) 2006-11-08 2007-11-06 Imidazopirazinas como inhibidores de proteina quinasa

Country Status (11)

Country Link
US (1) US7511040B2 (es)
EP (1) EP2079746A2 (es)
JP (1) JP2010509328A (es)
CN (1) CN101589045A (es)
AR (1) AR063581A1 (es)
CA (1) CA2669465A1 (es)
CL (1) CL2007003212A1 (es)
MX (1) MX2009005011A (es)
PE (1) PE20080931A1 (es)
TW (1) TW200829588A (es)
WO (1) WO2008057512A2 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0716292D0 (en) 2007-08-21 2007-09-26 Biofocus Dpi Ltd Imidazopyrazine compounds
JP5518062B2 (ja) * 2008-07-24 2014-06-11 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ オーロラキナーゼ阻害剤および抗悪性腫瘍剤を含む治療用組み合わせ
JP5683462B2 (ja) * 2008-07-24 2015-03-11 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ オーロラキナーゼ阻害剤および抗増殖剤を含む治療用組み合わせ
ES2536730T3 (es) * 2008-09-19 2015-05-28 Nerviano Medical Sciences S.R.L. Derivados de 3,4-dihidro-2H-pirrolo[1,2-a]pirazin-1-ona
TW201107329A (en) * 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
WO2011028638A1 (en) 2009-09-04 2011-03-10 Schering Corporation Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors
EP2493889B1 (en) 2009-10-30 2017-09-06 Janssen Pharmaceutica, N.V. IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
CA2793279A1 (en) 2010-03-18 2011-09-22 Ulrich Klar Imidazopyrazines
JP5824040B2 (ja) 2010-06-01 2015-11-25 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 置換イミダゾピラジン
EP2575815A4 (en) 2010-06-04 2013-12-25 Albany Molecular Res Inc GLYCIN TRANSPORTER 1 INHIBITORS, METHODS OF MAKING THE SAME, AND USES THEREOF
WO2012080230A1 (en) 2010-12-17 2012-06-21 Bayer Pharma Aktiengesellschaft 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
US9212184B2 (en) 2010-12-17 2015-12-15 Bayer Intellectual Property Gmbh 6-thio-substituted imidazo[1,2-a]pyrazines as Mps-1 inhibitors
WO2012080236A1 (en) 2010-12-17 2012-06-21 Bayer Pharma Aktiengesellschaft 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
US8673905B2 (en) * 2011-03-17 2014-03-18 Hoffmann-La Roche Inc. Imidazo pyrazines
MX344600B (es) 2011-06-27 2016-12-20 Janssen Pharmaceutica Nv Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxalina.
HK1206250A1 (en) 2012-06-26 2016-01-08 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl-[1,2,4] triazolo [4,3-a] quinoxaline compounds and ped 10 inhibitors for use in the treatment of neurological or metabolic disorders
CN104411314B (zh) 2012-07-09 2017-10-20 詹森药业有限公司 磷酸二酯酶10的抑制剂
MX2017000610A (es) 2014-07-14 2017-04-27 Gilead Sciences Inc Metodos combinados para tratar canceres.
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
JP6541871B2 (ja) * 2015-08-13 2019-07-10 北京韓美薬品有限公司 Ｉｒａｋ４阻害剤、及びその応用
CN107056789B (zh) * 2017-04-21 2019-03-29 陈剑 具有取代吡嗪并咪唑类衍生物,其制备及其在医药上的应用
WO2022061155A1 (en) * 2020-09-17 2022-03-24 The Translational Genomics Research Institute Imidazopyridazine and imidazopyrazine compounds as inhibitors of cdk7
CN117050085A (zh) * 2023-06-26 2023-11-14 广西大学 芳基取代的8-氨基咪唑并吡嗪类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE377600T1 (de) * 2002-09-23 2007-11-15 Schering Corp Imidazopyrazine als cdk-inhibitoren
US7186832B2 (en) * 2003-02-20 2007-03-06 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
WO2005085252A1 (en) * 2004-03-04 2005-09-15 Biofocus Discovery Limited Imidazo ‘1,2-a’ pyrazine compounds which interact with protein kinases
EP1812439B2 (en) * 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinase inhibitors
TW200803863A (en) * 2005-11-10 2008-01-16 Schering Corp Method for inhibiting protein kinases
AR056785A1 (es) * 2005-11-10 2007-10-24 Schering Corp COMPUESTOS DE IMIDAZO[1,2-A]PIRAZINAS, uTILES COMO INHIBIDORES, REGULADORES O MODULADORES DE PROTEINQUINASAS

Also Published As

Publication number Publication date
WO2008057512A3 (en) 2008-06-26
TW200829588A (en) 2008-07-16
US20080139571A1 (en) 2008-06-12
CN101589045A (zh) 2009-11-25
JP2010509328A (ja) 2010-03-25
WO2008057512A2 (en) 2008-05-15
CL2007003212A1 (es) 2008-06-27
EP2079746A2 (en) 2009-07-22
MX2009005011A (es) 2009-05-20
CA2669465A1 (en) 2008-05-15
US7511040B2 (en) 2009-03-31
AR063581A1 (es) 2009-02-04

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