PE20060533A1 - Derivados de dicetopiperazina como antagonistas del receptor de oxitocina - Google Patents
Derivados de dicetopiperazina como antagonistas del receptor de oxitocinaInfo
- Publication number
- PE20060533A1 PE20060533A1 PE2005000713A PE2005000713A PE20060533A1 PE 20060533 A1 PE20060533 A1 PE 20060533A1 PE 2005000713 A PE2005000713 A PE 2005000713A PE 2005000713 A PE2005000713 A PE 2005000713A PE 20060533 A1 PE20060533 A1 PE 20060533A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- dicetopiperazine
- indazol
- methylpropyl
- oxytocin receptor
- Prior art date
Links
- 102000004279 Oxytocin receptors Human genes 0.000 title abstract 2
- 108090000876 Oxytocin receptors Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 2-INDANYL Chemical group 0.000 abstract 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- 208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
- 206010036600 Premature labour Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000026440 premature labor Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE DICETOPIPERAZINA DE FORMULA IA, DONDE R1 ES 2-INDANILO; R2 ES 1-METILPROPILO; R3 ES 1-METIL-INDAZOL-5-ILO; R4 ES METILO; R5 ES H O METILO. SON COMPUESTOS PREFERIDOS: (2R)-2-{(3R,6R)-3-(2,3-DIHIDRO-1H-INDEN-2-IL)-6-[(1S)-1-METILPROPIL]-2,5-DIOXO-1-PIPERAZINIL}-N-METIL-2-(1-METIL-1H-INDAZOL-5-IL)ETANAMIDA, (2R)-2-{(3R,6R)-3-(2,3-DIHIDRO-1H-INDEN-2-IL)-6-[(1S)-1-METILPROPIL]-2,5-DIOXO-1-PIPERAZINIL}-N,N-DIMETIL-2-(1-METIL-1H-INDAZOL-5-IL)ETANAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS SELECTIVOS DEL RECEPTOR DE OXITOCINA Y SON UTILES PARA PREVENIR O CONTROLAR EL PARTO PREMATURO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0414092.7A GB0414092D0 (en) | 2004-06-23 | 2004-06-23 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060533A1 true PE20060533A1 (es) | 2006-09-03 |
Family
ID=32800052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000713A PE20060533A1 (es) | 2004-06-23 | 2005-06-22 | Derivados de dicetopiperazina como antagonistas del receptor de oxitocina |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20070208031A1 (es) |
| EP (1) | EP1758893A1 (es) |
| JP (1) | JP2008503535A (es) |
| CN (1) | CN1989130A (es) |
| AR (1) | AR049651A1 (es) |
| AU (1) | AU2005256471A1 (es) |
| BR (1) | BRPI0512359A (es) |
| CA (1) | CA2571529A1 (es) |
| GB (1) | GB0414092D0 (es) |
| IL (1) | IL179912A0 (es) |
| MA (1) | MA28698B1 (es) |
| MX (1) | MXPA06014544A (es) |
| NO (1) | NO20070157L (es) |
| PE (1) | PE20060533A1 (es) |
| RU (1) | RU2007102272A (es) |
| TW (1) | TW200616635A (es) |
| WO (1) | WO2006000400A1 (es) |
| ZA (1) | ZA200610121B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2641806B1 (fr) * | 1989-01-16 | 1992-05-07 | Diffusion Rech Tech Financ | Procede de stabilisation d'une aire de terrain meuble |
| GB0130677D0 (en) | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Medicaments and novel compounds |
| GB0314738D0 (en) | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Novel compounds |
| GB0414093D0 (en) | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414100D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| CA2695384A1 (en) * | 2007-07-31 | 2009-02-05 | Burnham Institute For Medical Research | Bi-dentate compounds as kinase inhibitors |
| US20100038143A1 (en) * | 2008-08-14 | 2010-02-18 | George Alexander Burnett | Drill cuttings treatment systems |
| JP2013509391A (ja) | 2009-10-30 | 2013-03-14 | グラクソ グループ リミテッド | （３ｒ，６ｒ）−３−（２，３−ジヒドロ−１ｈ−インデン−２−イル）−１−［（１ｒ）−１−（２，６−ジメチル−３−ピリジニル）−２−（４−モルホリニル）−２−オキソエチル］−６−［（１ｓ）−１−メチルプロピル］−２，５−ピペラジンジオンの新規結晶性形態 |
| CN109305969B (zh) * | 2017-07-27 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | 哌嗪-2,5-二酮类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130677D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Medicaments and novel compounds |
| GB0414100D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
-
2004
- 2004-06-23 GB GBGB0414092.7A patent/GB0414092D0/en not_active Ceased
-
2005
- 2005-06-21 AU AU2005256471A patent/AU2005256471A1/en not_active Abandoned
- 2005-06-21 CA CA002571529A patent/CA2571529A1/en not_active Abandoned
- 2005-06-21 RU RU2007102272/04A patent/RU2007102272A/ru not_active Application Discontinuation
- 2005-06-21 CN CNA200580024634XA patent/CN1989130A/zh active Pending
- 2005-06-21 BR BRPI0512359-3A patent/BRPI0512359A/pt not_active IP Right Cessation
- 2005-06-21 WO PCT/EP2005/006761 patent/WO2006000400A1/en not_active Ceased
- 2005-06-21 TW TW094120516A patent/TW200616635A/zh unknown
- 2005-06-21 US US11/630,097 patent/US20070208031A1/en not_active Abandoned
- 2005-06-21 EP EP05755377A patent/EP1758893A1/en not_active Withdrawn
- 2005-06-21 AR ARP050102538A patent/AR049651A1/es unknown
- 2005-06-21 JP JP2007517198A patent/JP2008503535A/ja active Pending
- 2005-06-21 MX MXPA06014544A patent/MXPA06014544A/es not_active Application Discontinuation
- 2005-06-22 PE PE2005000713A patent/PE20060533A1/es not_active Application Discontinuation
-
2006
- 2006-12-04 ZA ZA200610121A patent/ZA200610121B/xx unknown
- 2006-12-07 IL IL179912A patent/IL179912A0/en unknown
- 2006-12-29 MA MA29584A patent/MA28698B1/fr unknown
-
2007
- 2007-01-09 NO NO20070157A patent/NO20070157L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2571529A1 (en) | 2006-01-05 |
| US20070208031A1 (en) | 2007-09-06 |
| TW200616635A (en) | 2006-06-01 |
| AU2005256471A1 (en) | 2006-01-05 |
| JP2008503535A (ja) | 2008-02-07 |
| EP1758893A1 (en) | 2007-03-07 |
| MA28698B1 (fr) | 2007-06-01 |
| RU2007102272A (ru) | 2008-07-27 |
| ZA200610121B (en) | 2008-08-27 |
| MXPA06014544A (es) | 2007-03-12 |
| CN1989130A (zh) | 2007-06-27 |
| IL179912A0 (en) | 2007-05-15 |
| AR049651A1 (es) | 2006-08-23 |
| WO2006000400A1 (en) | 2006-01-05 |
| BRPI0512359A (pt) | 2008-03-04 |
| NO20070157L (no) | 2007-01-23 |
| GB0414092D0 (en) | 2004-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |