PE20191528A1 - Nuevos derivados de triazolo[4,5-d]pirimidina - Google Patents
Nuevos derivados de triazolo[4,5-d]pirimidinaInfo
- Publication number
- PE20191528A1 PE20191528A1 PE2019001869A PE2019001869A PE20191528A1 PE 20191528 A1 PE20191528 A1 PE 20191528A1 PE 2019001869 A PE2019001869 A PE 2019001869A PE 2019001869 A PE2019001869 A PE 2019001869A PE 20191528 A1 PE20191528 A1 PE 20191528A1
- Authority
- PE
- Peru
- Prior art keywords
- triazolo
- pyrimidine
- new derivatives
- compound
- preferred
- Prior art date
Links
- GIIGHSIIKVOWKZ-UHFFFAOYSA-N 2h-triazolo[4,5-d]pyrimidine Chemical class N1=CN=CC2=NNN=C21 GIIGHSIIKVOWKZ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 102100036214 Cannabinoid receptor 2 Human genes 0.000 abstract 1
- 101710187022 Cannabinoid receptor 2 Proteins 0.000 abstract 1
- 206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
- UJAVMPUJWMSASE-UHFFFAOYSA-N FC1(F)CCN(C1)c1nc(nc2n(Cc3ccccc3Cl)nnc12)C1CCC1 Chemical compound FC1(F)CCN(C1)c1nc(nc2n(Cc3ccccc3Cl)nnc12)C1CCC1 UJAVMPUJWMSASE-UHFFFAOYSA-N 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Referido a un compuesto de formula (I), en donde R1 es haloalquilo, halofenilo, alcoxifenilo, entre otros; R2 es cicloalquilo, isopropilo, alquenilo, entre otros; R3 y R4 son independientemente H, halogeno, hidroxilo, entre otros; n es 1 o 2. Estos compuestos son derivados de triazolo[4,5-D]pirimidina y son agonistas preferentes del receptor de cannabinoides 2; en donde un compuesto preferido es 3-[(2-clorofenil)metil]-5-ciclobutil-7-(3,3-difluor-pirrolidin-1-il)triazolo[4,5-d]pirimidina. Tambien se refiere a procedimientos para su fabricacion y preparacion de composiciones farmaceuticas en el tratamiento del dolor, ateroesclerosis, retinopatia diabetica, entre otros.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13183385 | 2013-09-06 | ||
| PCT/EP2014/068640 WO2015032769A1 (en) | 2013-09-06 | 2014-09-03 | Novel triazolo[4,5-d]pyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20191528A1 true PE20191528A1 (es) | 2019-10-23 |
Family
ID=49111076
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019001869A PE20191528A1 (es) | 2013-09-06 | 2014-09-03 | Nuevos derivados de triazolo[4,5-d]pirimidina |
| PE2015002700A PE20160691A1 (es) | 2013-09-06 | 2014-09-03 | Nuevos derivados de triazolo[4,5-d]pirimidina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015002700A PE20160691A1 (es) | 2013-09-06 | 2014-09-03 | Nuevos derivados de triazolo[4,5-d]pirimidina |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US9593123B2 (es) |
| EP (3) | EP3943497A1 (es) |
| JP (1) | JP6441356B2 (es) |
| KR (3) | KR20220140651A (es) |
| CN (1) | CN105555788B (es) |
| AR (1) | AR097553A1 (es) |
| AU (1) | AU2014317229B2 (es) |
| CA (1) | CA2915766C (es) |
| CL (1) | CL2016000495A1 (es) |
| CR (1) | CR20160076A (es) |
| DK (2) | DK3041843T3 (es) |
| EA (1) | EA028335B1 (es) |
| ES (2) | ES2714094T3 (es) |
| HR (2) | HRP20190361T1 (es) |
| HU (2) | HUE055201T2 (es) |
| IL (1) | IL243092B (es) |
| LT (2) | LT3041843T (es) |
| MA (1) | MA38826B1 (es) |
| MX (2) | MX367084B (es) |
| MY (1) | MY191628A (es) |
| PE (2) | PE20191528A1 (es) |
| PH (1) | PH12016500250B1 (es) |
| PL (2) | PL3483163T3 (es) |
| PT (2) | PT3483163T (es) |
| RS (2) | RS58390B1 (es) |
| SG (1) | SG11201601714UA (es) |
| SI (2) | SI3483163T1 (es) |
| TR (1) | TR201900662T4 (es) |
| TW (1) | TWI705966B (es) |
| UA (1) | UA116395C2 (es) |
| WO (1) | WO2015032769A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015162630A1 (en) * | 2014-04-25 | 2015-10-29 | Anlon Chemical Research Organization | Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis. |
| JP6669743B2 (ja) | 2014-11-07 | 2020-03-18 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | カンナビノイド受容体２のアゴニストとしてのトリアゾロ［４，５−ｄ］ピリミジン |
| WO2017004133A1 (en) * | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| WO2017076266A1 (zh) * | 2015-11-06 | 2017-05-11 | 江苏恒瑞医药股份有限公司 | 制备坎格雷洛中间体的方法 |
| CN109311895B (zh) | 2016-06-23 | 2021-06-18 | 豪夫迈·罗氏有限公司 | 新型[1,2,3]三唑并[4,5-d]嘧啶衍生物 |
| EP3475280B1 (en) | 2016-06-23 | 2020-04-08 | H. Hoffnabb-La Roche Ag | Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives |
| WO2018015088A1 (en) | 2016-06-23 | 2018-01-25 | F. Hoffmann-La Roche Ag | Novel [1,2,31triazolo[4,5-d]pyrimidine derivatives |
| CN109348716A (zh) * | 2016-06-23 | 2019-02-15 | 豪夫迈·罗氏有限公司 | 对2型大麻素受体具有亲和力的[1,2,3]三唑并[4,5-d]嘧啶衍生物 |
| CN106478639B (zh) * | 2016-09-05 | 2018-09-18 | 郑州大学 | 嘧啶并1,2,4–三氮唑类的lsd1抑制剂、其制备方法及应用 |
| CN106432247B (zh) * | 2016-09-27 | 2018-06-29 | 郑州大学 | 含有腙键的嘧啶并三氮唑类化合物、制备方法及其应用 |
| CN106432248B (zh) * | 2016-09-27 | 2018-11-27 | 郑州大学 | 含嘧啶并三氮唑类lsd1抑制剂、其制备方法及应用 |
| CN106928296A (zh) * | 2017-02-06 | 2017-07-07 | 上海华升生物科技有限公司 | 一种2‑(3,3,3‑三氟丙硫基)腺苷的合成方法 |
| CN106928235A (zh) * | 2017-05-03 | 2017-07-07 | 郑州大学 | 含嘧啶并三氮唑类lsd1抑制剂、其制备方法及应用 |
| CN107033148B (zh) * | 2017-05-03 | 2018-10-26 | 郑州大学 | 含嘧啶并三氮唑—巯基四氮唑类lsd1抑制剂、其制备方法及应用 |
| CN109516990B (zh) * | 2017-09-19 | 2021-06-01 | 天津药物研究院有限公司 | 嘧啶并三氮唑类化合物、其制备方法和用途 |
| CN113582935A (zh) * | 2021-08-27 | 2021-11-02 | 中国医学科学院放射医学研究所 | 一种炎症小体核苷酸结合寡聚化结构域样受体蛋白3抑制剂及其制备方法和应用 |
| CN115246832B (zh) * | 2022-06-15 | 2024-05-24 | 深圳湾实验室 | 一类去泛素化酶usp25和usp28靶向抑制剂及制备和应用 |
| CN119912457B (zh) * | 2025-03-03 | 2025-10-10 | 郑州大学 | 嘧啶并三氮唑类化合物及其制备方法和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999011643A1 (en) | 1997-09-02 | 1999-03-11 | Du Pont Pharmaceuticals Company | Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (crh) antagonists, useful for treating cns and stress-related disorders |
| US6653304B2 (en) | 2000-02-11 | 2003-11-25 | Bristol-Myers Squibb Co. | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
| WO2006009698A2 (en) * | 2004-06-17 | 2006-01-26 | The Regents Of The University Of California | Antagonizing an adenosine a2a receptor to amelioriate one or more components of addictive behavior |
| AR051596A1 (es) | 2004-10-26 | 2007-01-24 | Irm Llc | Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios |
| EP2155747B1 (en) | 2007-05-10 | 2012-10-24 | GE Healthcare Limited | Imidazol (1,2-a)pyridines and related compounds with activity at cannabinoid cb2 receptors |
| CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US9271962B2 (en) | 2008-03-17 | 2016-03-01 | Northeastern University | Inhibitors of fatty acid amide hydrolase and monoacylglycerol lipase for modulation of cannabinoid receptors |
| WO2010120987A1 (en) | 2009-04-17 | 2010-10-21 | Wyeth Llc | Ring fused, ureidoaryl- and carbamoylaryl-bridged morpholino-pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| EP2771326B1 (en) | 2011-10-27 | 2017-12-20 | LEK Pharmaceuticals d.d. | Synthesis of triazolopyrimidine compounds |
| UA111640C2 (uk) * | 2011-11-08 | 2016-05-25 | Ф. Хоффманн-Ля Рош Аг | ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2 |
| US9067943B2 (en) * | 2011-11-25 | 2015-06-30 | Hoffmann-La Roche Inc. | [1,2,3]triazolo[4,5-D]pyrimidine derivatives |
| KR20150027824A (ko) | 2012-07-04 | 2015-03-12 | 에프. 호프만-라 로슈 아게 | 칸나비노이드 수용체 2 작용제로서 신규한 아다만틸 유도체 |
| MX2015007156A (es) | 2012-12-07 | 2015-10-14 | Hoffmann La Roche | Piridina-2-amidas utiles como agonistas receptores de canabinoides 2 (cb2). |
| SG10201800170YA (en) | 2012-12-07 | 2018-02-27 | Hoffmann La Roche | Novel pyridine derivatives |
| RS55951B1 (sr) | 2012-12-07 | 2017-09-29 | Hoffmann La Roche | Derivati pirazina kao agonisti cb2 receptora |
| CA2885987A1 (en) | 2012-12-07 | 2014-06-12 | F. Hoffmann-La Roche Ag | Pyridine-2-amides useful as cb2 agonists |
| JP6514119B2 (ja) | 2013-03-07 | 2019-05-15 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規ピラゾール誘導体 |
| PE20151977A1 (es) | 2013-05-02 | 2016-01-07 | Hoffmann La Roche | Nuevos derivados de purina |
| KR20160002857A (ko) | 2013-05-02 | 2016-01-08 | 에프. 호프만-라 로슈 아게 | CB2 수용체 작용제로서의 피롤로[2,3-d]피리미딘 유도체 |
| KR20160018543A (ko) | 2013-06-11 | 2016-02-17 | 에프. 호프만-라 로슈 아게 | 신규한 테트라졸론 유도체 |
-
2014
- 2014-09-03 KR KR1020227034655A patent/KR20220140651A/ko not_active Ceased
- 2014-09-03 CN CN201480048593.7A patent/CN105555788B/zh active Active
- 2014-09-03 HU HUE18206943A patent/HUE055201T2/hu unknown
- 2014-09-03 UA UAA201603048A patent/UA116395C2/uk unknown
- 2014-09-03 SG SG11201601714UA patent/SG11201601714UA/en unknown
- 2014-09-03 PL PL18206943T patent/PL3483163T3/pl unknown
- 2014-09-03 PL PL14761320T patent/PL3041843T3/pl unknown
- 2014-09-03 JP JP2016539509A patent/JP6441356B2/ja active Active
- 2014-09-03 ES ES14761320T patent/ES2714094T3/es active Active
- 2014-09-03 PT PT182069435T patent/PT3483163T/pt unknown
- 2014-09-03 PE PE2019001869A patent/PE20191528A1/es unknown
- 2014-09-03 DK DK14761320.2T patent/DK3041843T3/en active
- 2014-09-03 EA EA201690478A patent/EA028335B1/ru not_active IP Right Cessation
- 2014-09-03 HU HUE14761320A patent/HUE041760T2/hu unknown
- 2014-09-03 TR TR2019/00662T patent/TR201900662T4/tr unknown
- 2014-09-03 SI SI201431869T patent/SI3483163T1/sl unknown
- 2014-09-03 KR KR1020167008516A patent/KR102349567B1/ko active Active
- 2014-09-03 WO PCT/EP2014/068640 patent/WO2015032769A1/en not_active Ceased
- 2014-09-03 DK DK18206943.5T patent/DK3483163T3/da active
- 2014-09-03 KR KR1020217017887A patent/KR102454344B1/ko active Active
- 2014-09-03 CA CA2915766A patent/CA2915766C/en active Active
- 2014-09-03 AU AU2014317229A patent/AU2014317229B2/en active Active
- 2014-09-03 EP EP21179163.7A patent/EP3943497A1/en active Pending
- 2014-09-03 LT LTEP14761320.2T patent/LT3041843T/lt unknown
- 2014-09-03 PE PE2015002700A patent/PE20160691A1/es unknown
- 2014-09-03 ES ES18206943T patent/ES2883923T3/es active Active
- 2014-09-03 MX MX2016002117A patent/MX367084B/es active IP Right Grant
- 2014-09-03 RS RS20190264A patent/RS58390B1/sr unknown
- 2014-09-03 EP EP14761320.2A patent/EP3041843B1/en active Active
- 2014-09-03 RS RS20211007A patent/RS62234B1/sr unknown
- 2014-09-03 MX MX2019009100A patent/MX391724B/es unknown
- 2014-09-03 SI SI201431099T patent/SI3041843T1/sl unknown
- 2014-09-03 EP EP18206943.5A patent/EP3483163B1/en active Active
- 2014-09-03 PT PT14761320T patent/PT3041843T/pt unknown
- 2014-09-03 HR HRP20190361TT patent/HRP20190361T1/hr unknown
- 2014-09-03 LT LTEP18206943.5T patent/LT3483163T/lt unknown
- 2014-09-03 MY MYPI2016700721A patent/MY191628A/en unknown
- 2014-09-04 AR ARP140103305A patent/AR097553A1/es active IP Right Grant
- 2014-09-04 TW TW103130651A patent/TWI705966B/zh active
-
2015
- 2015-12-14 IL IL243092A patent/IL243092B/en active IP Right Grant
-
2016
- 2016-02-04 PH PH12016500250A patent/PH12016500250B1/en unknown
- 2016-02-04 MA MA38826A patent/MA38826B1/fr unknown
- 2016-02-16 CR CR20160076A patent/CR20160076A/es unknown
- 2016-02-23 US US15/050,753 patent/US9593123B2/en active Active
- 2016-03-04 CL CL2016000495A patent/CL2016000495A1/es unknown
-
2021
- 2021-08-16 HR HRP20211322TT patent/HRP20211322T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20191528A1 (es) | Nuevos derivados de triazolo[4,5-d]pirimidina | |
| PE20061442A1 (es) | Heterociclicos como agonistas del receptor de acido nicotinico para el tratamiento de dislipidemia | |
| PE20170666A1 (es) | 2-(morfolin-4-il)-1,7-naftiridinas | |
| PE20160664A1 (es) | Compuestos heteroaromaticos y su uso como ligandos d1 de dopamina | |
| PE20150399A1 (es) | Nuevos derivados de pirrol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| PE20141578A1 (es) | Derivados de [1,2,3]triazolo[4,5-d]pirimidina como agonistas del receptor de canabinoides 2 | |
| CO2020001244A2 (es) | Derivados de quinolina para tratar infecciones con helmintos | |
| PE20141203A1 (es) | Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas | |
| PE20161405A1 (es) | Analogos de cortistatina y sintesis y usos de los mismos | |
| BR112014014909A2 (pt) | agonistas de tgr5 não sistêmicos | |
| CL2014001174A1 (es) | Compuestos derivados de [1,2,3]triazolo[4,5-d]pirimidina y sus sales, como agonistas del receptor de canabinoides 2; su proceso de obtencion; composicion farmaceutica que los contiene; y su uso para el tratamiento o profilaxis del dolor, aterosclerosis, inflamacion, glaucoma, ataque isquemico transitorio, entre otras enfermedades. | |
| CU20110212A7 (es) | Nuevos derivados de pirimidina y sus usos en el tratamiento del cáncer y otras enfermedades | |
| PE20161066A1 (es) | Derivados de piperidinil-indol como inhibidores del factor de complemento b y usos de los mismos | |
| PE20141110A1 (es) | Derivados heterociclicos novedosos para el tratamiento de trastornos neurologicos | |
| PE20141540A1 (es) | Derivados de 2-amino-4-(piridin-2-il)-5,6-dihidro-4h-1,3-oxazina y su uso como inhibidores de bace-1 y/o bace-2 | |
| PE20142301A1 (es) | Uracilos sustituidos biciclicamente y uso de los mismos | |
| UY33485A (es) | Derivados de acido(2-ariloxiacetilamino)fenilpropionico, procedimientos para su preparacion y uso de los mismos como medicamentos. | |
| CL2015002635A1 (es) | Compuestos y composiciones para el tratamiento de enfermedades parasitarias | |
| PE20141553A1 (es) | Compuestos de triazolopiridina como inhibidores de la ped10a | |
| PE20152032A1 (es) | Compuestos de 3,4-dihidroisoquinolin-2(1h)-il | |
| PE20070854A1 (es) | Compuestos heterociclos como agonistas del receptor de acido nicotinico | |
| EA201200471A1 (ru) | Простые эфирные производные бициклических гетероарилов | |
| PE20142376A1 (es) | Fluormetil-5,6-dihidro-4h-[1,3]oxazinas | |
| PE20170683A1 (es) | Triazolo[4,5-d]pirimidinas como agonistas del receptor canabinoide 2 | |
| PE20141167A1 (es) | Piridopirazinas sustituidas como inhibidores novedosos de ptk |