PE20051159A1 - Derivados de heteroarilaminopirazol como estimulantes de la produccion de insulina - Google Patents
Derivados de heteroarilaminopirazol como estimulantes de la produccion de insulinaInfo
- Publication number
- PE20051159A1 PE20051159A1 PE2005000226A PE2005000226A PE20051159A1 PE 20051159 A1 PE20051159 A1 PE 20051159A1 PE 2005000226 A PE2005000226 A PE 2005000226A PE 2005000226 A PE2005000226 A PE 2005000226A PE 20051159 A1 PE20051159 A1 PE 20051159A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- phenyl
- substituted
- ter
- butyl
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 239000000021 stimulant Substances 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 2-METHYLPHENYL Chemical class 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000003914 insulin secretion Effects 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE ES HET ES UN RADICAL ANULAR HETEROCICLICO AROMATICO SUSTITUIDO; R ES H, ALQUILO C1-C6; R1 ES H, ALQUILO C1-C6 SUSTITUIDO O NO CON FENILO, ALQUENILO C3-C6, ENTRE OTROS; R2 ES H, HALO, ALQUILO C1-C6, PIRIDILO, ENTRE OTROS; R3 ES ALQUILO C1-C6, CICLOALQUILO C3-C6, HALOALQUILO C2-C3, FENILO, ENTRE OTROS; R4 ES ALQUILO C1-C6 SUSTITUIDO O NO, ALQUILTIO C1-C6, ENTRE OTROS; n ES 0-3; X ES CO2R7, CONR5R6, SO2NH2; R5 ES H, ALQUILO C1-C6, FENILO SUSTITUIDO O NO; R6 ES H, ALQUILO C1-C6 O R5 Y R6 TOMADOS JUNTO CON EL ATOMO DE N AL CUAL ESTAN UNIDOS, PUEDEN FORMAR PIPERIDINA, MORFOLINA, TIOMORFOLINA, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO 2-{[3-TER-BUTIL-1-(2-METILFENIL)-1H-PIRAZOL-5-IL]AMINO}-6-METILNICOTINICO; ACIDO 3-{[3-TER-BUTIL-1-(2,6-DIMETILFENIL)-1H-PIRAZOL-5-IL]AMINO}PIRIDIN-2-CARBOXILICO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FERMACEUTICA. DICHOS COMPUESTOS ESTIMULAN LA SECRECION DE INSULINA EN PRESENCIA DE GLUCOSA SIENDO UTILES EN EL TRATAMIENTO DE LA DIABETES
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54833104P | 2004-02-27 | 2004-02-27 | |
| US57290604P | 2004-05-20 | 2004-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20051159A1 true PE20051159A1 (es) | 2006-02-22 |
Family
ID=34976070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000226A PE20051159A1 (es) | 2004-02-27 | 2005-02-25 | Derivados de heteroarilaminopirazol como estimulantes de la produccion de insulina |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7517878B2 (es) |
| EP (1) | EP1720863A4 (es) |
| JP (1) | JP2007525513A (es) |
| KR (1) | KR20060124727A (es) |
| AR (1) | AR049418A1 (es) |
| AU (1) | AU2005220723A1 (es) |
| BR (1) | BRPI0508051A (es) |
| CA (1) | CA2557527A1 (es) |
| EC (1) | ECSP066883A (es) |
| IL (1) | IL177232A0 (es) |
| MA (1) | MA28479B1 (es) |
| NO (1) | NO20064325L (es) |
| PE (1) | PE20051159A1 (es) |
| RU (1) | RU2006134004A (es) |
| TW (1) | TW200538130A (es) |
| UY (1) | UY28774A1 (es) |
| WO (1) | WO2005086656A2 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007005857A (es) | 2004-11-17 | 2007-10-10 | Mikana Therapeutics Inc | Inhibidores de cinasa. |
| WO2006065590A2 (en) * | 2004-12-16 | 2006-06-22 | Xtl Biopharmaceuticals Inc. | Pyridine and pyrimidine antiviral compositions |
| WO2006105127A2 (en) | 2005-03-31 | 2006-10-05 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
| KR20140025610A (ko) * | 2005-09-30 | 2014-03-04 | 미카나 테라퓨틱스, 인크. | 치환된 피라졸 화합물 |
| PT2013204E (pt) * | 2006-03-24 | 2015-06-09 | Array Biopharma Inc | Análogos de 2-aminopiridina como activadores da glucoquinase |
| SA08280783B1 (ar) * | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | مشتقات بيريدوبيريميدين كمثبطات pde4 |
| US8362037B2 (en) * | 2007-03-23 | 2013-01-29 | Array Biopharma, Inc. | 2-aminopyridine analogs as glucokinase activators |
| EP2166849A4 (en) * | 2007-06-11 | 2010-09-15 | Miikana Therapeutics Inc | SUBSTITUTED PYRAZOL COMPOUNDS |
| SI2209778T1 (sl) | 2007-09-21 | 2012-12-31 | Array Biopharma, Inc. | Piridin-2-il-amino-I, 2,4-tiadiazol derivati kot aktivatorji glukokinaze za zdravljenje sladkorne bolezni |
| US9315449B2 (en) | 2008-05-15 | 2016-04-19 | Duke University | Substituted pyrazoles as heat shock transcription factor activators |
| EP2135865A1 (de) | 2008-06-17 | 2009-12-23 | Bayer CropScience AG | Substituierte 1-(Diazinyl) pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| DE102008039083A1 (de) * | 2008-08-21 | 2010-02-25 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Aminopyrazole und ihre Verwendung |
| DE102008039082A1 (de) | 2008-08-21 | 2010-02-25 | Bayer Schering Pharma Aktiengesellschaft | Azabicyclisch-substituierte 5-Aminopyrazole und ihre Verwendung |
| EP2194052A1 (de) | 2008-12-06 | 2010-06-09 | Bayer CropScience AG | Substituierte 1-(Thiazolyl)- und 1-(Isothiazolyl)pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| HRP20160967T1 (hr) * | 2009-10-06 | 2016-10-07 | Millennium Pharmaceuticals, Inc. | Heterociklički spojevi korisni kao pdk1 inhibitori |
| WO2011073098A1 (de) | 2009-12-15 | 2011-06-23 | Bayer Cropscience Ag | 1-(heteroaryl)-pyrazol-4-yl-essigsäuren, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren |
| WO2016044666A1 (en) * | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Heterocycle substituted amino-pyridine compounds and methods of use thereof |
| WO2016092559A1 (en) * | 2014-12-12 | 2016-06-16 | Oat & Iil India Laboratories Private Limited | Substituted pyrazole derivatives having activity as fungicides |
| WO2017087905A1 (en) | 2015-11-20 | 2017-05-26 | Denali Therapeutics Inc. | Compound, compositions, and methods |
| US11028080B2 (en) | 2016-03-11 | 2021-06-08 | Denali Therapeutics Inc. | Substituted pyrimidines as LRKK2 inhibitors |
| KR101725292B1 (ko) | 2016-03-30 | 2017-04-10 | 한국과학기술연구원 | 항암 활성을 갖는 신규 피리미딘-4-카르복시산 유도체 |
| LT3472153T (lt) | 2016-06-16 | 2021-12-27 | Denali Therapeutics Inc. | Pirimidin-2-ilamino-1h-pirazolai kaip lrrk2 inhibitoriai, skirti naudoti neurodegeneracinių sutrikimų gydyme |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4405207A1 (de) * | 1994-02-18 | 1995-08-24 | Bayer Ag | N-Pyrazolylaniline und N-Pyrazolylaminopyridine |
| US20020103185A1 (en) * | 2000-08-31 | 2002-08-01 | Sanner Mark A. | Pyrazole derivatives |
| US6660731B2 (en) * | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US7319102B1 (en) * | 2003-12-09 | 2008-01-15 | The Procter & Gamble Company | Pyrrolo[2,3-d]pyrimidine cytokine inhibitors |
-
2005
- 2005-02-21 AR ARP050100628A patent/AR049418A1/es unknown
- 2005-02-24 EP EP05723606A patent/EP1720863A4/en not_active Withdrawn
- 2005-02-24 RU RU2006134004/04A patent/RU2006134004A/ru not_active Application Discontinuation
- 2005-02-24 KR KR1020067017159A patent/KR20060124727A/ko not_active Withdrawn
- 2005-02-24 AU AU2005220723A patent/AU2005220723A1/en not_active Abandoned
- 2005-02-24 BR BRPI0508051-7A patent/BRPI0508051A/pt not_active IP Right Cessation
- 2005-02-24 CA CA002557527A patent/CA2557527A1/en not_active Abandoned
- 2005-02-24 JP JP2007500954A patent/JP2007525513A/ja active Pending
- 2005-02-24 US US11/064,700 patent/US7517878B2/en not_active Expired - Fee Related
- 2005-02-24 WO PCT/US2005/005794 patent/WO2005086656A2/en not_active Ceased
- 2005-02-25 UY UY28774A patent/UY28774A1/es not_active Application Discontinuation
- 2005-02-25 TW TW094105697A patent/TW200538130A/zh unknown
- 2005-02-25 PE PE2005000226A patent/PE20051159A1/es not_active Application Discontinuation
-
2006
- 2006-08-02 IL IL177232A patent/IL177232A0/en unknown
- 2006-09-22 MA MA29334A patent/MA28479B1/fr unknown
- 2006-09-25 NO NO20064325A patent/NO20064325L/no not_active Application Discontinuation
- 2006-09-26 EC EC2006006883A patent/ECSP066883A/es unknown
-
2009
- 2009-04-13 US US12/422,804 patent/US20090209451A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060124727A (ko) | 2006-12-05 |
| TW200538130A (en) | 2005-12-01 |
| JP2007525513A (ja) | 2007-09-06 |
| US7517878B2 (en) | 2009-04-14 |
| CA2557527A1 (en) | 2005-09-22 |
| AU2005220723A1 (en) | 2005-09-22 |
| MA28479B1 (fr) | 2007-03-01 |
| WO2005086656A2 (en) | 2005-09-22 |
| RU2006134004A (ru) | 2008-04-10 |
| EP1720863A2 (en) | 2006-11-15 |
| NO20064325L (no) | 2006-11-22 |
| WO2005086656A3 (en) | 2005-12-29 |
| UY28774A1 (es) | 2005-08-31 |
| EP1720863A4 (en) | 2009-04-22 |
| US20090209451A1 (en) | 2009-08-20 |
| ECSP066883A (es) | 2006-11-24 |
| US20050192294A1 (en) | 2005-09-01 |
| AR049418A1 (es) | 2006-08-02 |
| IL177232A0 (en) | 2006-12-10 |
| BRPI0508051A (pt) | 2007-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |