PE20050120A1 - Camptotecinas con un anillo de lactona modificada - Google Patents
Camptotecinas con un anillo de lactona modificadaInfo
- Publication number
- PE20050120A1 PE20050120A1 PE2003000529A PE2003000529A PE20050120A1 PE 20050120 A1 PE20050120 A1 PE 20050120A1 PE 2003000529 A PE2003000529 A PE 2003000529A PE 2003000529 A PE2003000529 A PE 2003000529A PE 20050120 A1 PE20050120 A1 PE 20050120A1
- Authority
- PE
- Peru
- Prior art keywords
- kitchens
- lactone ring
- modified lactone
- homocamptotecina
- cycloalkyl
- Prior art date
Links
- 150000002596 lactones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000003915 DNA Topoisomerases Human genes 0.000 abstract 1
- 108090000323 DNA Topoisomerases Proteins 0.000 abstract 1
- 208000030852 Parasitic disease Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003071 parasitic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epoxy Compounds (AREA)
Abstract
REFERIDA A UN COMPUESTO DE FORMULA (I) O (II), DONDE R1 ES H O GRUPO -C(R5)-N-OR4; R4 ES H, ALQUENILO C1-C5, CICLOALQUILO C3-C10, ENTRE OTROS; R5 ES H, ALQUILO C1-C5, CICLOALQUILO C3-C10, ENTRE OTROS; R2 Y R3 SON CADA UNO H, HIDROXI, ALCOXI C1-C5 RECTO O RAMIFICADO; n= 1,2; Z ES H, ALQUILO C1-C4 RECTO O RAMIFICADO. TAMBIEN REFERIDA A UN PROCEDIMIENTO DE PREPARACION DE ESTOS COMPUESTOS, SIENDO PREFERIDOS: -R,S-7-METOXIIMINOMETIL-HOMOCAMPTOTECINA; -R,S-7-ISOPROPOXIIMINOMETIL-HOMOCAMPTOTECINA; -R,S-7-ALILOXIIMINOMETIL-HOMOCAMPTOTECINA; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES COMO INHIBIDORES DE LA TOPOISOMERASA I, EN EL TRATAMIENTO DE INFECCIONES PARASITARIAS O VIRALES, ENTRE OTRAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002RM000305A ITRM20020305A1 (it) | 2002-05-31 | 2002-05-31 | Camptotecine con anello lattonico modificato. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050120A1 true PE20050120A1 (es) | 2005-03-04 |
Family
ID=11456338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000529A PE20050120A1 (es) | 2002-05-31 | 2003-05-30 | Camptotecinas con un anillo de lactona modificada |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7273873B2 (es) |
| EP (2) | EP1719775B1 (es) |
| JP (1) | JP4693410B2 (es) |
| KR (1) | KR101042042B1 (es) |
| CN (1) | CN1656100A (es) |
| AR (1) | AR040139A1 (es) |
| AT (2) | ATE339422T1 (es) |
| AU (2) | AU2003241160B2 (es) |
| BR (2) | BR0311329A (es) |
| CA (2) | CA2485201C (es) |
| CY (2) | CY1107311T1 (es) |
| DE (2) | DE60308368T3 (es) |
| DK (2) | DK1511752T5 (es) |
| ES (2) | ES2312090T3 (es) |
| IT (1) | ITRM20020305A1 (es) |
| MX (1) | MXPA04011682A (es) |
| PE (1) | PE20050120A1 (es) |
| PL (1) | PL374346A1 (es) |
| PT (2) | PT1719775E (es) |
| SI (2) | SI1511752T1 (es) |
| TW (1) | TWI325866B (es) |
| WO (1) | WO2003101995A2 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
| ITRM20030344A1 (it) | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
| US8269007B2 (en) | 2007-08-01 | 2012-09-18 | Sigma-Tau Industrie Farmaceutiche Riunite Spa | Crystalline form II of 7-(dimethoxy-methyl) camptothecin, its use as intermediate and products obtained therefrom |
| CN102746314B (zh) * | 2011-04-18 | 2016-07-06 | 华东师范大学 | 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途 |
| CN104530066A (zh) * | 2015-01-06 | 2015-04-22 | 华东师范大学 | 一类新型高喜树碱衍生物、制备方法和用途 |
| US20190375732A1 (en) | 2018-05-14 | 2019-12-12 | David Hung | Anti-cancer nuclear hormone receptor-targeting compounds |
| KR20220008869A (ko) | 2019-05-14 | 2022-01-21 | 누베이션 바이오 인크. | 항암 핵 호르몬 수용체-표적화 화합물 |
| TW202131930A (zh) | 2019-11-13 | 2021-09-01 | 美商諾維雪碧歐公司 | 抗癌核荷爾蒙受體標靶化合物 |
| BR112023019420A2 (pt) | 2021-03-23 | 2023-10-24 | Nuvation Bio Inc | Compostos de direcionamento ao receptor de hormônio nuclear anticâncer |
| EP4334314A1 (en) | 2021-05-03 | 2024-03-13 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| CN120265635A (zh) * | 2022-09-28 | 2025-07-04 | 诺维逊生物股份有限公司 | 抗癌核激素受体靶向化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57116076A (en) * | 1981-01-09 | 1982-07-19 | Yakult Honsha Co Ltd | Novel camptothecin derivative and its preparation |
| US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
| FR2532591A1 (fr) | 1982-09-02 | 1984-03-09 | Hutchinson | Nouveau dispositif de securite pour pneumatiques de vehicules ou autres engins |
| AU716377B2 (en) * | 1995-06-21 | 2000-02-24 | Ipsen Pharma S.A.S. | New analogues of camptothecin, preparation processes, their use as medicaments and the pharmaceutical compositions containing them |
| EP1044977B1 (en) * | 1999-03-09 | 2002-05-02 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Camptothecin derivatives having antitumor activity |
-
2002
- 2002-05-31 IT IT2002RM000305A patent/ITRM20020305A1/it unknown
-
2003
- 2003-05-26 TW TW092114164A patent/TWI325866B/zh not_active IP Right Cessation
- 2003-05-28 AT AT03730480T patent/ATE339422T1/de active
- 2003-05-28 CA CA2485201A patent/CA2485201C/en not_active Expired - Fee Related
- 2003-05-28 DE DE60308368T patent/DE60308368T3/de not_active Expired - Lifetime
- 2003-05-28 KR KR1020047016880A patent/KR101042042B1/ko not_active Expired - Fee Related
- 2003-05-28 ES ES06116366T patent/ES2312090T3/es not_active Expired - Lifetime
- 2003-05-28 PT PT06116366T patent/PT1719775E/pt unknown
- 2003-05-28 CN CNA038125439A patent/CN1656100A/zh active Pending
- 2003-05-28 PT PT03730480T patent/PT1511752E/pt unknown
- 2003-05-28 SI SI200330509T patent/SI1511752T1/sl unknown
- 2003-05-28 AT AT06116366T patent/ATE403659T1/de active
- 2003-05-28 DK DK03730480.5T patent/DK1511752T5/da active
- 2003-05-28 BR BR0311329-9A patent/BR0311329A/pt not_active IP Right Cessation
- 2003-05-28 MX MXPA04011682A patent/MXPA04011682A/es active IP Right Grant
- 2003-05-28 SI SI200331380T patent/SI1719775T1/sl unknown
- 2003-05-28 DE DE60322754T patent/DE60322754D1/de not_active Expired - Lifetime
- 2003-05-28 ES ES03730480T patent/ES2273002T7/es active Active
- 2003-05-28 BR BR0311333-7A patent/BR0311333A/pt not_active IP Right Cessation
- 2003-05-28 PL PL03374346A patent/PL374346A1/xx unknown
- 2003-05-28 DK DK06116366T patent/DK1719775T3/da active
- 2003-05-28 WO PCT/IT2003/000328 patent/WO2003101995A2/en not_active Ceased
- 2003-05-28 CA CA2706635A patent/CA2706635A1/en not_active Abandoned
- 2003-05-28 EP EP06116366A patent/EP1719775B1/en not_active Expired - Lifetime
- 2003-05-28 US US10/511,724 patent/US7273873B2/en not_active Expired - Fee Related
- 2003-05-28 JP JP2004509686A patent/JP4693410B2/ja not_active Expired - Fee Related
- 2003-05-28 AU AU2003241160A patent/AU2003241160B2/en not_active Ceased
- 2003-05-28 EP EP03730480A patent/EP1511752B3/en not_active Expired - Lifetime
- 2003-05-30 PE PE2003000529A patent/PE20050120A1/es not_active Application Discontinuation
- 2003-05-30 AR ARP030101915A patent/AR040139A1/es unknown
-
2006
- 2006-11-14 CY CY20061101648T patent/CY1107311T1/el unknown
-
2008
- 2008-10-31 CY CY20081101240T patent/CY1108793T1/el unknown
-
2009
- 2009-11-12 AU AU2009236044A patent/AU2009236044B8/en not_active Ceased
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20130012A1 (es) | Derivados de pirazol como inhibidores de jak | |
| PE20050289A1 (es) | Inhbidores de la arn polimerasa dependientes de arn del virus de la hepatitis c y composiciones y tratamiento que los usan | |
| PE20020228A1 (es) | Compuestos organicos como inhibidores de 3',5' guanosin monofosfato ciclico fosfodiesterasa | |
| PE20121479A1 (es) | Inhibidores del virus de la hepatitis c | |
| CO5580779A2 (es) | Pirimidinonas como receptor 1 de la hormona concentradora de la melanina | |
| PE20090630A1 (es) | Derivados de indol 2-carboxi sustituidos y metodos para su utilizacion | |
| PE20050482A1 (es) | Derivados de dihidrobenzofuranilo alcanamida | |
| PE20060238A1 (es) | Inhibidores de integrasa del virus de inmunodeficiencia humana: compuestos de pirimidinona ciclica | |
| AR054560A1 (es) | Espiropiperidina como inhibidores de beta-secretasa para el tratamiento de la enfermedad de alzheimer | |
| PE20080839A1 (es) | Determinadas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas | |
| CO5580788A2 (es) | Compuestos de bencimidazol sustituidos utiles como inhibidores de proteina cinasas | |
| UY28150A1 (es) | Agentes terapeuticos | |
| CO5130004A1 (es) | 1-aril-3-arilmetil-1,8-naftiridin-4(1h)-onas | |
| AR037907A1 (es) | Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6 | |
| CY1107747T1 (el) | Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης | |
| PE20050120A1 (es) | Camptotecinas con un anillo de lactona modificada | |
| AR009413A1 (es) | Un compuesto, el cual es un derivado de distamicina benzoheterociclico, su utilizacion, un procedimiento para producirlo y una composicionfarmaceutica que lo comprende | |
| AR026352A1 (es) | Derivados de imidazopiridina como inhibidores de la fosfodiesterasa vii. | |
| AR043487A1 (es) | Heterociclos fusionados de pirimidina y usos de los mismos | |
| PE20050231A1 (es) | Derivados de piperidinium y pirrolidinium como antagonistas del receptor muscarinico m3 | |
| PE20020144A1 (es) | Derivados de pleuromutilinas como agentes antibacterianos | |
| ATE505462T1 (de) | Neue biologischaktive molekü le | |
| PE20040533A1 (es) | Esteres en posicion 20 de las camptotecinas | |
| AR039119A1 (es) | Derivados de fenil amidas siliconadas utiles como microbiocidas | |
| PE20090771A1 (es) | Derivados de cinolina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |