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BR0311333A - ésteres na posição 20 de camptotecinas - Google Patents

ésteres na posição 20 de camptotecinas

Info

Publication number
BR0311333A
BR0311333A BR0311333-7A BR0311333A BR0311333A BR 0311333 A BR0311333 A BR 0311333A BR 0311333 A BR0311333 A BR 0311333A BR 0311333 A BR0311333 A BR 0311333A
Authority
BR
Brazil
Prior art keywords
esters
camptothecins
compounds
mixtures
individual
Prior art date
Application number
BR0311333-7A
Other languages
English (en)
Inventor
Mauro Marzi
Domenico Alloatti
Claudio Pisano
Maria Ornella Tinti
Loredana Vesci
Franco Zunino
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Publication of BR0311333A publication Critical patent/BR0311333A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)

Abstract

"éSTERES NA POSIçãO 20 DE CAMPTOTECINAS". Compostos de fórmula (I) são descritos: (I) onde os grupos são como definidos na descrição aqui abaixo, as misturas racêmicas, seus enantiómeros individuais, seus diastereoisómeros individuais, suas misturas, e seus sais farmaceuticamente aceitáveis. Os referidos compostos são inibidores de topoisomerase I.
BR0311333-7A 2002-05-31 2003-05-28 ésteres na posição 20 de camptotecinas BR0311333A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002RM000305A ITRM20020305A1 (it) 2002-05-31 2002-05-31 Camptotecine con anello lattonico modificato.
PCT/IT2003/000328 WO2003101995A2 (en) 2002-05-31 2003-05-28 Camptothecins with a modified lactone ring

Publications (1)

Publication Number Publication Date
BR0311333A true BR0311333A (pt) 2005-03-15

Family

ID=11456338

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0311333-7A BR0311333A (pt) 2002-05-31 2003-05-28 ésteres na posição 20 de camptotecinas
BR0311329-9A BR0311329A (pt) 2002-05-31 2003-05-28 Camptotecinas com um anel de lactona modificado

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR0311329-9A BR0311329A (pt) 2002-05-31 2003-05-28 Camptotecinas com um anel de lactona modificado

Country Status (22)

Country Link
US (1) US7273873B2 (pt)
EP (2) EP1719775B1 (pt)
JP (1) JP4693410B2 (pt)
KR (1) KR101042042B1 (pt)
CN (1) CN1656100A (pt)
AR (1) AR040139A1 (pt)
AT (2) ATE339422T1 (pt)
AU (2) AU2003241160B2 (pt)
BR (2) BR0311333A (pt)
CA (2) CA2706635A1 (pt)
CY (2) CY1107311T1 (pt)
DE (2) DE60308368T3 (pt)
DK (2) DK1719775T3 (pt)
ES (2) ES2312090T3 (pt)
IT (1) ITRM20020305A1 (pt)
MX (1) MXPA04011682A (pt)
PE (1) PE20050120A1 (pt)
PL (1) PL374346A1 (pt)
PT (2) PT1511752E (pt)
SI (2) SI1511752T1 (pt)
TW (1) TWI325866B (pt)
WO (1) WO2003101995A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
ITRM20030344A1 (it) 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
ES2400607T3 (es) 2007-08-01 2013-04-11 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Forma cristalina ll de 7-(dimetoxi-metil)camptotecina, su uso como compuesto intermedio y productos obtenidos a partir de la misma
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN104530066A (zh) * 2015-01-06 2015-04-22 华东师范大学 一类新型高喜树碱衍生物、制备方法和用途
CN112566666A (zh) 2018-05-14 2021-03-26 努瓦申生物公司 靶向抗癌核激素受体的化合物
AU2020274113A1 (en) 2019-05-14 2021-11-11 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
WO2021097046A1 (en) 2019-11-13 2021-05-20 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
JP2024510792A (ja) 2021-03-23 2024-03-11 ニューベイション・バイオ・インコーポレイテッド 抗がん核内ホルモン受容体標的化化合物
JP2024516024A (ja) 2021-05-03 2024-04-11 ニューベイション・バイオ・インコーポレイテッド 抗がん核内ホルモン受容体標的化化合物
IL319588A (en) * 2022-09-28 2025-05-01 Nuvation Bio Inc Nuclear hormone receptor-targeted compounds against cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS57116076A (en) * 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Novel camptothecin derivative and its preparation
FR2532591A1 (fr) 1982-09-02 1984-03-09 Hutchinson Nouveau dispositif de securite pour pneumatiques de vehicules ou autres engins
JP3576171B2 (ja) * 1995-06-21 2004-10-13 ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・（エス．セー．エール．アー．エス） カンプトテシンの新規な同族体、その製造方法、その医薬としての用途及びこれを含有する医薬組成物
ATE216998T1 (de) * 1999-03-09 2002-05-15 Sigma Tau Ind Farmaceuti Camptothecin-derivate mit antitumor-wirkung

Also Published As

Publication number Publication date
PL374346A1 (en) 2005-10-17
AR040139A1 (es) 2005-03-16
AU2003241160B2 (en) 2009-08-20
WO2003101995A8 (en) 2004-12-23
AU2009236044B8 (en) 2011-07-21
EP1719775A1 (en) 2006-11-08
DK1511752T3 (da) 2007-01-29
PT1511752E (pt) 2007-01-31
KR20050036909A (ko) 2005-04-20
TWI325866B (en) 2010-06-11
CY1107311T1 (el) 2012-11-21
TW200404806A (en) 2004-04-01
BR0311329A (pt) 2005-02-22
DE60308368T3 (de) 2010-09-16
ES2273002T3 (es) 2007-05-01
AU2009236044B2 (en) 2011-03-24
EP1511752B3 (en) 2010-03-10
ES2273002T7 (es) 2011-08-01
US7273873B2 (en) 2007-09-25
SI1719775T1 (sl) 2009-04-30
ITRM20020305A0 (it) 2002-05-31
EP1511752B1 (en) 2006-09-13
EP1511752B8 (en) 2007-04-18
PT1719775E (pt) 2008-09-30
ATE339422T1 (de) 2006-10-15
AU2009236044A1 (en) 2009-12-03
EP1511752A2 (en) 2005-03-09
JP2005531602A (ja) 2005-10-20
DE60322754D1 (de) 2008-09-18
ITRM20020305A1 (it) 2003-12-01
MXPA04011682A (es) 2005-03-31
CA2706635A1 (en) 2003-12-11
JP4693410B2 (ja) 2011-06-01
AU2009236044A8 (en) 2011-07-21
CA2485201A1 (en) 2003-12-11
EP1719775B1 (en) 2008-08-06
CA2485201C (en) 2010-11-02
US20050154003A1 (en) 2005-07-14
ES2312090T3 (es) 2009-02-16
KR101042042B1 (ko) 2011-06-16
WO2003101995A3 (en) 2004-02-19
CN1656100A (zh) 2005-08-17
WO2003101995A2 (en) 2003-12-11
DE60308368T2 (de) 2007-09-06
DK1719775T3 (da) 2008-11-17
DE60308368D1 (de) 2006-10-26
CY1108793T1 (el) 2014-04-09
PE20050120A1 (es) 2005-03-04
SI1511752T1 (sl) 2007-02-28
DK1511752T5 (da) 2010-06-14
AU2003241160A1 (en) 2003-12-19
ATE403659T1 (de) 2008-08-15

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2465 DE 03-04-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.