PE20050523A1 - Pirazoles como inhidores de factor de necrosis tumoral - Google Patents
Pirazoles como inhidores de factor de necrosis tumoralInfo
- Publication number
- PE20050523A1 PE20050523A1 PE2004000447A PE2004000447A PE20050523A1 PE 20050523 A1 PE20050523 A1 PE 20050523A1 PE 2004000447 A PE2004000447 A PE 2004000447A PE 2004000447 A PE2004000447 A PE 2004000447A PE 20050523 A1 PE20050523 A1 PE 20050523A1
- Authority
- PE
- Peru
- Prior art keywords
- necrosis factor
- tumor necrosis
- inhidors
- pyrazoles
- compounds
- Prior art date
Links
- 108060008682 Tumor Necrosis Factor Proteins 0.000 title abstract 3
- 102000003390 tumor necrosis factor Human genes 0.000 title abstract 3
- 150000003217 pyrazoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOL DE FORMULA (I), EN DONDE LAS LINEAS PUNTEADAS REPRESENTAN UN PUENTE ETILENO OPCIONAL; R1 ES ALQUILO, CICLOALQUILO, ARILO O PIRIDILO, PUDIENDO ESTOS DOS ULTIMOS, ESTAR SUSTITUIDOS POR ALQUILO, ALCOXI Y AMINO; R2 ES ALQUILO, CICLOALQUILO OPCIONALMENTE SUSTITUIDO, O ES ARILALQUILO SUSTITUIDO CON ALQUILO O ALCOXI; X ES -C(O)-, -C(O)-CH2-, -S(O)2- O -NHC(O)-; A ES ALQUENILO, ALCOXI, ALCOXIALQUILO, ALQUILO, ALQUINILO, ARILO, ARILALQUILO, OPCIONALMENTE SUSTITUIDOS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-(5-TERC-BUTIL-2-p-TOLIL-2H-PIRAZOL-3-IL)-3-{-[1-(1-METILCICLOPROPANOCARBONIL)PIPERIDIN-4-ILMETIL]FENIL}UREA, ESTER 4-METOXIFENILICO DEL ACIDO 4-{4-[3-(5-TERC-BUTIL-2-p-TOLIL-2H-PIRAZOL-3-IL)UREIDO]BENCIL}-1-CARBOXILICO, ESTER BENCILICO DEL ACIDO 4-{4-[3-(5-TERC-BUTIL-2p-TOLIL-2H-PIRAZOL-3-IL)UREIDO]BENCIL}PIPERIDIN-1-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE QUINASA p38 Y/O DEL FACTOR DE NECROSIS TUMORAL (TNF) Y SON UTILES PARA EL TRATAMIENTO DE AFECCIONES INFLAMATORIAS ASOCIADAS A LA PRODUCCION EXCESIVA DE TNF
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46828503P | 2003-05-06 | 2003-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050523A1 true PE20050523A1 (es) | 2005-07-07 |
Family
ID=28792177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2004000447A PE20050523A1 (es) | 2003-05-06 | 2004-05-03 | Pirazoles como inhidores de factor de necrosis tumoral |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7541368B2 (es) |
| EP (1) | EP1622610B1 (es) |
| JP (1) | JP4714150B2 (es) |
| AT (1) | ATE348610T1 (es) |
| AU (2) | AU2004238241A1 (es) |
| BR (1) | BRPI0409991A (es) |
| CA (1) | CA2524043C (es) |
| CL (1) | CL2004000965A1 (es) |
| CY (1) | CY1107433T1 (es) |
| DE (1) | DE602004003806T2 (es) |
| DK (1) | DK1622610T3 (es) |
| ES (1) | ES2277271T3 (es) |
| GB (1) | GB0320244D0 (es) |
| HN (1) | HN2004000150A (es) |
| HR (1) | HRP20070020T3 (es) |
| JO (1) | JO2473B1 (es) |
| MX (1) | MXPA05011400A (es) |
| MY (1) | MY140830A (es) |
| PA (1) | PA8601901A1 (es) |
| PE (1) | PE20050523A1 (es) |
| PL (1) | PL1622610T3 (es) |
| PT (1) | PT1622610E (es) |
| SI (1) | SI1622610T1 (es) |
| TW (1) | TWI335223B (es) |
| UY (1) | UY28310A1 (es) |
| WO (1) | WO2004100946A1 (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| EP1761520B1 (en) * | 2004-06-23 | 2008-07-09 | Eli Lilly And Company | Kinase inhibitors |
| BRPI0514255A (pt) | 2004-08-12 | 2008-06-03 | Pfizer | derivados de triazolopiridinilsulfanil como inibidores da p38 map quinase |
| DE102004039789A1 (de) | 2004-08-16 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU2007210073B2 (en) | 2006-01-31 | 2011-10-06 | Array Biopharma Inc. | Kinase inhibitors and methods of use thereof |
| US20090270350A1 (en) * | 2006-02-10 | 2009-10-29 | Pfizer Inc. | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives |
| WO2007113005A2 (en) * | 2006-04-03 | 2007-10-11 | European Molecular Biology Laboratory (Embl) | 2-substituted 3-aminosulfonyl-thiophene derivatives as aurora kinase inhibitors |
| CA2659155A1 (en) * | 2006-07-20 | 2008-01-24 | Amgen Inc. | Substituted azole aromatic heterocycles as inhibitors of 11.beta.-hsd-1 |
| RU2009110254A (ru) | 2006-08-24 | 2010-09-27 | Новартис АГ (CH) | Производные 2-(пиразин-2-ил)тиазола и 2-(1н-пиразол-3-ил)тиразола и связанные с ним соединения в качестве ингибиторов стеароил-соа десатуразы для лечения метаболических, сердечно-сосудистых и других нарушений |
| EP2066664A1 (en) | 2006-09-22 | 2009-06-10 | Novartis AG | Heterocyclic organic compounds |
| CA2672776A1 (en) | 2006-12-20 | 2008-06-26 | Novartis Ag | 2-substituted 5-membered heterocycles as scd inhibitors |
| DE102007047737A1 (de) * | 2007-10-05 | 2009-04-30 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
| KR20110070887A (ko) * | 2008-10-02 | 2011-06-24 | 레스피버트 리미티드 | Ｐ38 엠에이피 키나제 억제제 |
| GB0818033D0 (en) | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
| WO2010067131A1 (en) * | 2008-12-11 | 2010-06-17 | Respivert Limited | P38 map kinase inhibitors |
| EP2236505A1 (de) | 2009-04-03 | 2010-10-06 | Bayer CropScience AG | Acylierte Aminopyridine und - pyridazine als Insektizide |
| GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
| WO2011021645A1 (ja) * | 2009-08-19 | 2011-02-24 | 大日本住友製薬株式会社 | ２環性ウレア誘導体、またはその薬学的に許容される塩 |
| WO2011066137A1 (en) | 2009-11-24 | 2011-06-03 | Schering Corporation | Substituted biaryl derivatives and methods of use thereof |
| US9024041B2 (en) | 2010-04-08 | 2015-05-05 | Respivert Ltd. | P38 MAP kinase inhibitors |
| KR101332830B1 (ko) | 2012-07-05 | 2013-11-27 | 한국화학연구원 | 페닐우레아 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 항암감작제 |
| TWI648282B (zh) * | 2014-03-27 | 2019-01-21 | 印度商托仁特生技有限公司 | 新熔合咪唑苯并噻唑化合物 |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| WO2017152117A1 (en) | 2016-03-03 | 2017-09-08 | Cornell University | Small molecule ire1-alpha inhibitors |
| CN111601593B (zh) | 2017-10-05 | 2022-04-15 | 弗尔康医疗公司 | P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| EP4219489A3 (en) | 2018-05-30 | 2023-11-15 | Washington University | Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof |
| JP7577655B2 (ja) * | 2018-11-20 | 2024-11-05 | シロナックス・リミテッド | 環状尿素 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE346600T1 (de) * | 1997-12-22 | 2006-12-15 | Bayer Pharmaceuticals Corp | Inhibierung der p38 kinase-aktivität durch die verwendung von aryl- und heteroarylsubstituierten harnstoffen |
| US6316466B1 (en) * | 1998-05-05 | 2001-11-13 | Syntex (U.S.A.) Llc | Pyrazole derivatives P-38 MAP kinase inhibitors |
| UA73492C2 (en) * | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents |
-
2003
- 2003-08-29 GB GBGB0320244.7A patent/GB0320244D0/en not_active Ceased
-
2004
- 2004-04-25 JO JO200448A patent/JO2473B1/en active
- 2004-05-03 PE PE2004000447A patent/PE20050523A1/es not_active Application Discontinuation
- 2004-05-04 HN HN2004000150A patent/HN2004000150A/es unknown
- 2004-05-05 JP JP2006532565A patent/JP4714150B2/ja not_active Expired - Fee Related
- 2004-05-05 WO PCT/US2004/013875 patent/WO2004100946A1/en not_active Ceased
- 2004-05-05 SI SI200430166T patent/SI1622610T1/sl unknown
- 2004-05-05 DK DK04751319T patent/DK1622610T3/da active
- 2004-05-05 MX MXPA05011400A patent/MXPA05011400A/es active IP Right Grant
- 2004-05-05 PT PT04751319T patent/PT1622610E/pt unknown
- 2004-05-05 PL PL04751319T patent/PL1622610T3/pl unknown
- 2004-05-05 AT AT04751319T patent/ATE348610T1/de active
- 2004-05-05 ES ES04751319T patent/ES2277271T3/es not_active Expired - Lifetime
- 2004-05-05 DE DE602004003806T patent/DE602004003806T2/de not_active Expired - Lifetime
- 2004-05-05 EP EP04751319A patent/EP1622610B1/en not_active Expired - Lifetime
- 2004-05-05 CA CA002524043A patent/CA2524043C/en not_active Expired - Fee Related
- 2004-05-05 HR HR20070020T patent/HRP20070020T3/xx unknown
- 2004-05-05 AU AU2004238241A patent/AU2004238241A1/en not_active Abandoned
- 2004-05-05 BR BRPI0409991-5A patent/BRPI0409991A/pt not_active IP Right Cessation
- 2004-05-05 CL CL200400965A patent/CL2004000965A1/es unknown
- 2004-05-06 UY UY28310A patent/UY28310A1/es not_active Application Discontinuation
- 2004-05-06 TW TW093112701A patent/TWI335223B/zh not_active IP Right Cessation
- 2004-05-06 PA PA20048601901A patent/PA8601901A1/es unknown
- 2004-05-06 MY MYPI20041681A patent/MY140830A/en unknown
-
2005
- 2005-11-01 US US11/264,063 patent/US7541368B2/en not_active Expired - Fee Related
-
2007
- 2007-03-15 CY CY20071100359T patent/CY1107433T1/el unknown
-
2010
- 2010-10-26 AU AU2010236021A patent/AU2010236021A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004100946A1 (en) | 2004-11-25 |
| HRP20070020T3 (hr) | 2007-04-30 |
| HN2004000150A (es) | 2008-03-03 |
| CA2524043A1 (en) | 2004-11-25 |
| DE602004003806D1 (de) | 2007-02-01 |
| GB0320244D0 (en) | 2003-10-01 |
| AU2004238241A1 (en) | 2004-11-25 |
| CY1107433T1 (el) | 2012-12-19 |
| ES2277271T3 (es) | 2007-07-01 |
| PT1622610E (pt) | 2007-02-28 |
| ATE348610T1 (de) | 2007-01-15 |
| TWI335223B (en) | 2011-01-01 |
| PL1622610T3 (pl) | 2007-05-31 |
| BRPI0409991A (pt) | 2006-05-09 |
| JP4714150B2 (ja) | 2011-06-29 |
| PA8601901A1 (es) | 2004-11-26 |
| US7541368B2 (en) | 2009-06-02 |
| US20060063796A1 (en) | 2006-03-23 |
| DE602004003806T2 (de) | 2007-11-22 |
| EP1622610B1 (en) | 2006-12-20 |
| MXPA05011400A (es) | 2005-12-12 |
| UY28310A1 (es) | 2004-11-30 |
| CL2004000965A1 (es) | 2005-04-22 |
| MY140830A (en) | 2010-01-29 |
| TW200509912A (en) | 2005-03-16 |
| AU2010236021A1 (en) | 2010-11-18 |
| DK1622610T3 (da) | 2007-04-23 |
| JO2473B1 (en) | 2009-01-20 |
| CA2524043C (en) | 2009-12-29 |
| SI1622610T1 (sl) | 2007-04-30 |
| JP2007502324A (ja) | 2007-02-08 |
| EP1622610A1 (en) | 2006-02-08 |
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