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PE20040946A1 - Compuestos de pirazolotriazina como ligandos del receptor cannabinoide - Google Patents

Compuestos de pirazolotriazina como ligandos del receptor cannabinoide

Info

Publication number
PE20040946A1
PE20040946A1 PE2004000124A PE2004000124A PE20040946A1 PE 20040946 A1 PE20040946 A1 PE 20040946A1 PE 2004000124 A PE2004000124 A PE 2004000124A PE 2004000124 A PE2004000124 A PE 2004000124A PE 20040946 A1 PE20040946 A1 PE 20040946A1
Authority
PE
Peru
Prior art keywords
link
cannabinoid receptor
bridge
methylpyrazole
triazin
Prior art date
Application number
PE2004000124A
Other languages
English (en)
Inventor
David Andrew Griffith
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20040946A1 publication Critical patent/PE20040946A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/34—Tobacco-abuse
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A DERIVADOS DE PIRAZOLOTRIAZINA DE FORMULA I, INCLUYENDO SUS SALES, SOLVATOS E HIDRATOS FARMACEUTICAMENTE ACEPTABLES, DONDE R1 Y R2 SON ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS; R3 ES H, ALCOXI C1-C4, ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON HALO; R4 ES UN GRUPO DE FORMULA IA, IB, ENTRE OTROS; EN DONDE R4a ES H o ALQUILO C1-C3; R4b Y R4b` SON H, CN, HIDROXI, AMINO, ENTRE OTROS; o R4b Y R4b` JUNTO CON R4f O R4f` FORMAN UN ENLACE, PUENTE METILENO O PUENTE ETILENO; X ES UN ENLACE CH2-CH2 o C(R4c)(R4c`); R4c Y R4c` SON H, CN, HIDROXI, AMINO, ENTRE OTROS; o R4c Y R4c` JUNTO CON R4f O R4f` FORMAN UN ENLACE, PUENTE METILENO O PUENTE ETILENO; Y ES O, S, ENTRE OTROS; Z ES UN ENLACE, CH2-CH2, ENTRE OTROS; CON LA CONDICION DE QUE R4 NO ES n-BUTILAMINA O DIETILAMINA CUANDO R1 SEA FENILO. SON CUMPUESTOS PREFERIDOS: AMIDA DEL ACIDO 1-[7-(2-CLOROFENIL)-8-(2,4-DICLOROFENIL)-2-METILPIRAZOLO[1,5-a][1,3,5]TRIAZIN-4-IL]-3-ETILAMINOAZETIDIN-3-CARBOXILICO; AMIDA DEL ACIDO 1-[7,8-BIS-(2-CLOROFENIL)-2-METILPIRAZOLO[1,5-a][1,3,5]TRIAZIN-4-IL]-3-ETILAMINOAZETIDIN-3-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS ACTUAN COMO LIGANDOS DEL RECEPTOR DE CANNABINOIDES, EN PARTICULAR ANTAGONISTAS DEL RECEPTOR CB1
PE2004000124A 2003-02-06 2004-02-03 Compuestos de pirazolotriazina como ligandos del receptor cannabinoide PE20040946A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44572803P 2003-02-06 2003-02-06

Publications (1)

Publication Number Publication Date
PE20040946A1 true PE20040946A1 (es) 2005-01-01

Family

ID=32851000

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000124A PE20040946A1 (es) 2003-02-06 2004-02-03 Compuestos de pirazolotriazina como ligandos del receptor cannabinoide

Country Status (29)

Country Link
US (1) US7329658B2 (es)
EP (1) EP1592691A1 (es)
JP (1) JP4018736B2 (es)
KR (1) KR20050099531A (es)
CN (1) CN1768061A (es)
AP (1) AP2005003368A0 (es)
AR (1) AR043038A1 (es)
AU (1) AU2004209447A1 (es)
BR (1) BRPI0406957A (es)
CA (1) CA2513409A1 (es)
CL (1) CL2004000182A1 (es)
CR (1) CR7932A (es)
EA (1) EA200501253A1 (es)
EC (1) ECSP055945A (es)
GT (1) GT200400013A (es)
HR (1) HRP20050659A2 (es)
IS (1) IS7936A (es)
MA (1) MA27652A1 (es)
MX (1) MXPA05007562A (es)
NL (1) NL1025404C2 (es)
NO (1) NO20054082L (es)
OA (1) OA12980A (es)
PE (1) PE20040946A1 (es)
PL (1) PL379009A1 (es)
TN (1) TNSN05190A1 (es)
TW (1) TWI260223B (es)
UY (1) UY28178A1 (es)
WO (1) WO2004069837A1 (es)
ZA (1) ZA200506255B (es)

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