PE20040765A1 - 4-amino piperidinas n,n-disustituidas como inhibidores de la captacion de monoamina - Google Patents
4-amino piperidinas n,n-disustituidas como inhibidores de la captacion de monoaminaInfo
- Publication number
- PE20040765A1 PE20040765A1 PE2003001225A PE2003001225A PE20040765A1 PE 20040765 A1 PE20040765 A1 PE 20040765A1 PE 2003001225 A PE2003001225 A PE 2003001225A PE 2003001225 A PE2003001225 A PE 2003001225A PE 20040765 A1 PE20040765 A1 PE 20040765A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halogen
- inhibitors
- cyane
- methylpropyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000003053 piperidines Chemical class 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 150000002367 halogens Chemical class 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 3
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
- KTOQRRDVVIDEAA-UHFFFAOYSA-N 2-methylpropane Chemical class [CH2]C(C)C KTOQRRDVVIDEAA-UHFFFAOYSA-N 0.000 abstract 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical group C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- -1 N- (1-METHYLPROPYL) -N - {[2- (TRIFLUOROMETHYL) PHENYL] METHYL} PIPERIDIN-4-AMINE Chemical compound 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- NXLRWHDKDFVMNY-UHFFFAOYSA-N n-[(4-methoxyphenyl)methyl]-n-(2-methylpropyl)piperidin-4-amine Chemical compound C1=CC(OC)=CC=C1CN(CC(C)C)C1CCNCC1 NXLRWHDKDFVMNY-UHFFFAOYSA-N 0.000 abstract 1
- 229960002748 norepinephrine Drugs 0.000 abstract 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA I, DONDE n ES 1, 2 O 3; R1 ES ALQUILO(C2-C10), ALQUENILO(C2-C10), CICLOALQUILO(C3-C8) O CICLOALQUIL(C4-C10)-ALQUILO, DONDE UN ENLACE C-C DEL CICLOALQUIL ESTA SUSTITUIDO POR UN ENLACE C-O, S-C o C=C, Y OPCIONALMENTE SUSTITUIDO POR 1 A 7 SUSTITUYENTES DE HALOGENO Y/O CON 1 A 3 HIDROXI, CIANO, ALQUILO(C1-C4), ENTRE OTROS; R2, R3 Y R4 SON H, ALQUILO(C1-C4), ALQUILO(C1-C4)-S(O)x DONDE x ES 0, 1 O 2, ALCOXI(C1-C4) (OPCIONALMENTE SUSTITUIDO CON 1 A 7 HALOGENOS), CIANO, HALOGENO, ENTRE OTROS; O R2 Y R3 O R3 Y R4, JUNTOS FORMAN UN ANILLO DE BENCENO ADICIONAL (OPCIONALMENTE SUSTITUIDO POR 1 A 3 HALOGENOS, ALQUILO(C1-C4) O ALCOXI(C1-C4); R5 Y R6 SON H, HALOGENO, ALQUILO(C1-C4), ALCOXI(C1-C4) (OPCIONALMENTE SUSTITUIDOS CON 1 A 7 HALOGENOS); R7 Y R8 SON H O ALQUILO(C1-C4); R9 Y R10 SON H, HALOGENO, HIDROXI, CIANO, ALQUILO C1-C4 O ALCOXI(C1-C4). SON COMPUESTOS PREFERIDOS: N-(1-METILETIL)-N-{[2-(TRIFLUOROMETIL)FENIL]METIL}PIPERIDIN-4-AMINA, N-(2-METILPROPIL)-N-{[4-(METOXI)FENIL]METIL}PIPERIDIN-4-AMINA, N-(2-METILPROPIL)-N-{[4-(CLORO)FENIL]METIL}PIPERIDIN-4-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA SU PRODUCCION Y UNA FORMA FARMACEUTICA QUE LO CONTIENE. ESTOS COMPUESTOS SON INHIBIDORES DE LA CAPTACION DE SEROTONINA Y/O NOREPINEFRINA Y/O DOPAMINA Y SON UTILES PARA EL TRATAMIENTO DE TRANSTORNOS DEL SISTEMA NERVIOSO CENTRAL O PERIFERICO
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0228482A GB0228482D0 (en) | 2002-12-06 | 2002-12-06 | Inhibitors of monoamine uptake |
| US43472002P | 2002-12-18 | 2002-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040765A1 true PE20040765A1 (es) | 2004-12-02 |
Family
ID=32510397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003001225A PE20040765A1 (es) | 2002-12-06 | 2003-12-02 | 4-amino piperidinas n,n-disustituidas como inhibidores de la captacion de monoamina |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060079554A1 (es) |
| EP (1) | EP1569905A2 (es) |
| AR (1) | AR042284A1 (es) |
| AU (1) | AU2003290735A1 (es) |
| PE (1) | PE20040765A1 (es) |
| WO (1) | WO2004052858A2 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005000811A1 (en) * | 2003-06-11 | 2005-01-06 | Eli Lilly And Company | 3-aminopyrrolidines as inhibitors of monoamine uptake |
| WO2005053663A2 (en) * | 2003-11-24 | 2005-06-16 | Eli Lilly And Company | Norepinephrine reuptake inhibitors useful for treatment of cognitive failure |
| WO2005060949A2 (en) * | 2003-12-12 | 2005-07-07 | Eli Lilly And Company | Selective norepinephrine reuptake inhibitors for the treatment of hot flashes, impulse control disorders and personality change due to a general medical condition |
| ATE471320T1 (de) | 2004-02-27 | 2010-07-15 | Lilly Co Eli | 4-aminopiperidinderivate als inhibitoren der monoamin-aufnahme |
| WO2005118531A1 (en) * | 2004-06-01 | 2005-12-15 | Eli Lilly And Company | Aminomethyl-azacycle derivatives as inhibitors of monoamine uptake |
| CA2613235A1 (en) * | 2005-06-30 | 2007-01-11 | Prosidion Limited | Gpcr agonists |
| US20100167986A1 (en) * | 2005-09-30 | 2010-07-01 | Amjad Ali | Cholesteryl Ester Transfer Protein Inhibitors |
| PE20080371A1 (es) | 2006-05-19 | 2008-04-09 | Wyeth Corp | N-benzoil-y-n-bencilpirrolidin-3-ilaminas como antagonistas de histamina-3 |
| UA112897C2 (uk) | 2012-05-09 | 2016-11-10 | Байєр Фарма Акцієнгезелльшафт | Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань |
| JP2016536362A (ja) | 2013-11-08 | 2016-11-24 | バイエル ファーマ アクチエンゲゼルシャフト | 置換されているウラシル類及びそれらの使用 |
| CA2980071A1 (en) | 2015-03-18 | 2016-09-22 | Bayer Pharma Aktiengesellschaft | Method for preparation of (4s)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro pyrimidine-5-carbonitrile |
| WO2018045376A2 (en) * | 2016-09-02 | 2018-03-08 | Ikaria Inc. | Functionally modified polypeptides and radiobiosynthesis |
| CN110256285B (zh) * | 2019-07-09 | 2022-03-18 | 上海出入境检验检疫局动植物与食品检验检疫技术中心 | 一种稳定同位素标记拟除虫菊酯的合成方法 |
| WO2024105007A1 (en) * | 2022-11-15 | 2024-05-23 | Samsara Therapeutics Inc. | Autophagy inducing compounds and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0026469B1 (en) * | 1979-10-01 | 1984-11-28 | Sandoz Ag | Dibenzazepine derivatives, their production and pharmaceutical compositions containing them |
| DK397387A (da) * | 1986-07-31 | 1988-02-01 | Otsuka Pharma Co Ltd | Carbostyrilderivater og salte deraf samt fremgangsmaade til fremstilling af saadanne forbindelser |
| US5567718A (en) * | 1994-08-11 | 1996-10-22 | Hoechst Marion Roussel Inc. | 2,3-dihydro-1h-isoindole derivatives and their use as serotonin reuptake inhibitors |
| DE60307308T2 (de) * | 2002-10-04 | 2006-12-28 | Ucb S.A. | 4-aminopiperidin-derivate, verfahren zur herstellung und ihre verwendung als arzneimittel |
-
2003
- 2003-11-25 WO PCT/US2003/035972 patent/WO2004052858A2/en not_active Ceased
- 2003-11-25 EP EP03783319A patent/EP1569905A2/en not_active Withdrawn
- 2003-11-25 AU AU2003290735A patent/AU2003290735A1/en not_active Abandoned
- 2003-11-25 US US10/536,295 patent/US20060079554A1/en not_active Abandoned
- 2003-12-02 PE PE2003001225A patent/PE20040765A1/es not_active Application Discontinuation
- 2003-12-03 AR ARP030104457A patent/AR042284A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003290735A8 (en) | 2004-06-30 |
| WO2004052858A3 (en) | 2004-08-12 |
| AU2003290735A1 (en) | 2004-06-30 |
| EP1569905A2 (en) | 2005-09-07 |
| AR042284A1 (es) | 2005-06-15 |
| US20060079554A1 (en) | 2006-04-13 |
| WO2004052858A2 (en) | 2004-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |