PE20030357A1 - Cristales de hidrato de piridinil-metiltio-benzimidazol y procedimiento para su preparacion - Google Patents
Cristales de hidrato de piridinil-metiltio-benzimidazol y procedimiento para su preparacionInfo
- Publication number
- PE20030357A1 PE20030357A1 PE2002000736A PE2002000736A PE20030357A1 PE 20030357 A1 PE20030357 A1 PE 20030357A1 PE 2002000736 A PE2002000736 A PE 2002000736A PE 2002000736 A PE2002000736 A PE 2002000736A PE 20030357 A1 PE20030357 A1 PE 20030357A1
- Authority
- PE
- Peru
- Prior art keywords
- cycloalkyl
- alkyl
- methylthi
- pyridinyl
- procedure
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000012429 reaction media Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- -1 2-PYRIDINYL Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A CRISTALES DE HIDRATO DE 2-(2-PIRIDINIL)METILTIO-1H-BENZIMIDAZOL DE FORMULA I DONDE R1, R2, R3 SON H, ALQUILO C1-C8, CICLOALQUILO C3-C8, FLUOROALQUILO C2-C8, ALCOXI C1-C8; R4 Y R5 SON H, ALQUILO C1-C8, CICLOALQUILO C3-C8, CH2-C3-C8-CICLOALQUILO, C2-C8-FLUOROALQUILO, C1-C8 ALCOXI; R4 Y R5 SON H, ALQUILO C1-C8, CICLOALQUILO C3-C8, FLUOROALQUILO C2-C8, ENTRE OTROS; R6 ES H, ALQUILO C1-C2; X ES 0,5-2. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA AISLAR UN COMPUESTO A PARTIR DE UN MEDIO DE REACCION EN EL QUE SE ENCUENTRA EN FORMA DE BASE LIBRE CARACTERIZADO PORQUE UN SOLVENTE ORGANICO MISCIBLE CON AGUA EN EL MEDIO SE ELIMINA PARCIALMENTE, AL MEDIO DE REACCION SE AGREGA A UN TEMPERATURA INFERIOR A 40 ºC AL MENOS 55% DE AGUA CON RELACION AL MEDIO DE REACCION Y LOS HIDRATOS RESULTANTES EN FORMA DE CRISTALES SE SEPARAN Y SE PURIFICAN
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10140492A DE10140492A1 (de) | 2001-08-17 | 2001-08-17 | Hydrate von gegebenenfalls substituierten 2-(2-Pyridinyl)methylthio-1H-benzimidazolen und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030357A1 true PE20030357A1 (es) | 2003-04-26 |
Family
ID=7695825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000736A PE20030357A1 (es) | 2001-08-17 | 2002-08-15 | Cristales de hidrato de piridinil-metiltio-benzimidazol y procedimiento para su preparacion |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7435825B2 (es) |
| EP (1) | EP1421076B1 (es) |
| AR (1) | AR036263A1 (es) |
| AT (1) | ATE375337T1 (es) |
| CA (1) | CA2457576C (es) |
| DE (2) | DE10140492A1 (es) |
| ES (1) | ES2295389T3 (es) |
| IL (2) | IL160252A0 (es) |
| PE (1) | PE20030357A1 (es) |
| PT (1) | PT1421076E (es) |
| WO (1) | WO2003016301A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003303240A1 (en) | 2002-12-19 | 2004-07-14 | Eva Pharmaceutical Industries Ltd. | Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates |
| EP1615913A2 (en) * | 2003-06-10 | 2006-01-18 | Teva Pharmaceutical Industries Limited | Process for preparing 2-(pyridinyl)methyl sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole |
| WO2018050028A1 (zh) | 2016-09-14 | 2018-03-22 | 北京韩美药品有限公司 | 一种能够特异性地结合il-17a的抗体及其功能片段 |
| CN116253716A (zh) * | 2023-02-08 | 2023-06-13 | 苏州东瑞制药有限公司 | 一种乌非拉唑的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| ZA825106B (en) | 1981-08-13 | 1983-04-27 | Haessle Ab | Novel pharmaceutical compositions |
| IE53249B1 (en) * | 1981-09-04 | 1988-09-14 | Anderson Cook Inc | Method for making a composite metal-plastic gear |
| JPH0643426B2 (ja) | 1986-07-25 | 1994-06-08 | 東京田辺製薬株式会社 | イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤 |
| WO1997029103A2 (en) | 1996-02-06 | 1997-08-14 | Pdi-Research Laboratories, Inc. | Synthesis of omeprazole-type pyridine derivatives and intermediates thereof |
| TW385306B (en) | 1996-11-14 | 2000-03-21 | Takeda Chemical Industries Ltd | Method for producing crystals of benzimidazole derivatives |
| CA2204580A1 (en) | 1997-05-06 | 1998-11-06 | Michel Zoghbi | Synthesis of pharmaceutically useful pyridine derivatives |
| GB9717107D0 (en) * | 1997-08-12 | 1997-10-15 | Univ Oxford | Organic compound synthesis |
| US6166213A (en) | 1998-08-11 | 2000-12-26 | Merck & Co., Inc. | Omeprazole process and compositions thereof |
| PL333847A1 (en) | 1999-06-18 | 2001-01-02 | Inst Farmaceutyczny | Crystalline forms of lansoprozole and method of obtaining lansoprazole in pharmacologically advanthageous crystalline form |
-
2001
- 2001-08-17 DE DE10140492A patent/DE10140492A1/de not_active Withdrawn
-
2002
- 2002-08-08 PT PT02758447T patent/PT1421076E/pt unknown
- 2002-08-08 AT AT02758447T patent/ATE375337T1/de active
- 2002-08-08 WO PCT/EP2002/008867 patent/WO2003016301A1/de not_active Ceased
- 2002-08-08 EP EP02758447A patent/EP1421076B1/de not_active Expired - Lifetime
- 2002-08-08 DE DE50211061T patent/DE50211061D1/de not_active Expired - Lifetime
- 2002-08-08 CA CA2457576A patent/CA2457576C/en not_active Expired - Fee Related
- 2002-08-08 ES ES02758447T patent/ES2295389T3/es not_active Expired - Lifetime
- 2002-08-08 IL IL16025202A patent/IL160252A0/xx unknown
- 2002-08-15 PE PE2002000736A patent/PE20030357A1/es not_active Application Discontinuation
- 2002-08-15 AR ARP020103095A patent/AR036263A1/es unknown
-
2004
- 2004-02-04 US US10/772,033 patent/US7435825B2/en not_active Expired - Fee Related
- 2004-02-05 IL IL160252A patent/IL160252A/en not_active IP Right Cessation
-
2008
- 2008-07-09 US US12/169,813 patent/US7557218B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE50211061D1 (de) | 2007-11-22 |
| DE10140492A1 (de) | 2003-08-14 |
| EP1421076B1 (de) | 2007-10-10 |
| CA2457576A1 (en) | 2003-02-27 |
| EP1421076A1 (de) | 2004-05-26 |
| AR036263A1 (es) | 2004-08-25 |
| US20080269497A1 (en) | 2008-10-30 |
| IL160252A (en) | 2009-06-15 |
| IL160252A0 (en) | 2004-07-25 |
| US20040158072A1 (en) | 2004-08-12 |
| CA2457576C (en) | 2010-05-25 |
| ATE375337T1 (de) | 2007-10-15 |
| WO2003016301A1 (de) | 2003-02-27 |
| PT1421076E (pt) | 2007-11-28 |
| US7435825B2 (en) | 2008-10-14 |
| US7557218B2 (en) | 2009-07-07 |
| ES2295389T3 (es) | 2008-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |