AR036263A1 - Cristal de 2-(2-piridinil)metiltio-1h-bencimidazol opcionalmente sustituido y metodo para aislarlo - Google Patents
Cristal de 2-(2-piridinil)metiltio-1h-bencimidazol opcionalmente sustituido y metodo para aislarloInfo
- Publication number
- AR036263A1 AR036263A1 ARP020103095A ARP020103095A AR036263A1 AR 036263 A1 AR036263 A1 AR 036263A1 AR P020103095 A ARP020103095 A AR P020103095A AR P020103095 A ARP020103095 A AR P020103095A AR 036263 A1 AR036263 A1 AR 036263A1
- Authority
- AR
- Argentina
- Prior art keywords
- crystal
- cycloalkyl
- alkyl
- hydrogen
- methylti
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- -1 C1-8 alkyl radical Chemical class 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- XECLLKBXBCBFKX-UHFFFAOYSA-N O.N=1C2=CC=CC=C2N(SC)C=1C1=CC=CC=N1 Chemical class O.N=1C2=CC=CC=C2N(SC)C=1C1=CC=CC=N1 XECLLKBXBCBFKX-UHFFFAOYSA-N 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 abstract 1
- SBQLYHNEIUGQKH-UHFFFAOYSA-N omeprazole Chemical compound N1=C2[CH]C(OC)=CC=C2N=C1S(=O)CC1=NC=C(C)C(OC)=C1C SBQLYHNEIUGQKH-UHFFFAOYSA-N 0.000 abstract 1
- 229960000381 omeprazole Drugs 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cristales de hidratos de 2-(2-piridinil)metiltio-1H-bencimidazol opcionalmente sustituidos de fórmula estructural (1), donde: R1, R2 y R3, que son iguales o diferentes, representan hidrógeno, un radical alquilo C1-8, cicloalquilo C3-8, fluoralquilo C2-8 o alcoxi C1-8; R4 y R5, representan de manera iguales o diferentes hidrógeno, un radical alquilo C1-8, cicloalquilo C3-8, CH2-cicloalquilo C3-8, alcoxicarbonilo C1-8, alcoxi C1-8 fluoralcoxi C1-8, CF3, fluoralquilo C2-8 ó -C(O)O-alquilo C1-8; y R6 es hidrógeno o un radical alquilo C1-2; y x es 0,5-2. También se describe un método para aislar dicho cristal de un medio de reacción en el que se encuentra la base libre. Estos compuestos son la última etapa de partida para la obtención de productos terapéuticos contra úlceras, especialmente omeprazol o lanzoprazol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10140492A DE10140492A1 (de) | 2001-08-17 | 2001-08-17 | Hydrate von gegebenenfalls substituierten 2-(2-Pyridinyl)methylthio-1H-benzimidazolen und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036263A1 true AR036263A1 (es) | 2004-08-25 |
Family
ID=7695825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103095A AR036263A1 (es) | 2001-08-17 | 2002-08-15 | Cristal de 2-(2-piridinil)metiltio-1h-bencimidazol opcionalmente sustituido y metodo para aislarlo |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7435825B2 (es) |
| EP (1) | EP1421076B1 (es) |
| AR (1) | AR036263A1 (es) |
| AT (1) | ATE375337T1 (es) |
| CA (1) | CA2457576C (es) |
| DE (2) | DE10140492A1 (es) |
| ES (1) | ES2295389T3 (es) |
| IL (2) | IL160252A0 (es) |
| PE (1) | PE20030357A1 (es) |
| PT (1) | PT1421076E (es) |
| WO (1) | WO2003016301A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2510849A1 (en) * | 2002-12-19 | 2004-07-08 | Teva Pharmaceutical Industries Ltd | Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates |
| MXPA05013316A (es) * | 2003-06-10 | 2006-03-17 | Teva Pharma | Proceso para preparar bencimidazoles 2[-(piridinil)metil]sulfinil-sustituidos y derivados clorados novedosos de pantoprazol. |
| TN2019000082A1 (en) | 2016-09-14 | 2020-07-15 | Beijing hanmi pharm co ltd | Antibody specifically binding to il-17a and functional fragment thereof |
| CN116253716A (zh) * | 2023-02-08 | 2023-06-13 | 苏州东瑞制药有限公司 | 一种乌非拉唑的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| IL66340A (en) | 1981-08-13 | 1986-08-31 | Haessle Ab | Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation |
| IE53249B1 (en) * | 1981-09-04 | 1988-09-14 | Anderson Cook Inc | Method for making a composite metal-plastic gear |
| JPH0643426B2 (ja) | 1986-07-25 | 1994-06-08 | 東京田辺製薬株式会社 | イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤 |
| AU1538397A (en) | 1996-02-06 | 1997-08-28 | Pdi-Research Laboratories, Inc. | Synthesis of omeprazole-type pyridine derivatives and intermediates thereof |
| TW385306B (en) | 1996-11-14 | 2000-03-21 | Takeda Chemical Industries Ltd | Method for producing crystals of benzimidazole derivatives |
| CA2204580A1 (en) | 1997-05-06 | 1998-11-06 | Michel Zoghbi | Synthesis of pharmaceutically useful pyridine derivatives |
| GB9717107D0 (en) * | 1997-08-12 | 1997-10-15 | Univ Oxford | Organic compound synthesis |
| US6166213A (en) | 1998-08-11 | 2000-12-26 | Merck & Co., Inc. | Omeprazole process and compositions thereof |
| PL333847A1 (en) | 1999-06-18 | 2001-01-02 | Inst Farmaceutyczny | Crystalline forms of lansoprozole and method of obtaining lansoprazole in pharmacologically advanthageous crystalline form |
-
2001
- 2001-08-17 DE DE10140492A patent/DE10140492A1/de not_active Withdrawn
-
2002
- 2002-08-08 IL IL16025202A patent/IL160252A0/xx unknown
- 2002-08-08 AT AT02758447T patent/ATE375337T1/de active
- 2002-08-08 WO PCT/EP2002/008867 patent/WO2003016301A1/de not_active Ceased
- 2002-08-08 CA CA2457576A patent/CA2457576C/en not_active Expired - Fee Related
- 2002-08-08 ES ES02758447T patent/ES2295389T3/es not_active Expired - Lifetime
- 2002-08-08 EP EP02758447A patent/EP1421076B1/de not_active Expired - Lifetime
- 2002-08-08 PT PT02758447T patent/PT1421076E/pt unknown
- 2002-08-08 DE DE50211061T patent/DE50211061D1/de not_active Expired - Lifetime
- 2002-08-15 AR ARP020103095A patent/AR036263A1/es unknown
- 2002-08-15 PE PE2002000736A patent/PE20030357A1/es not_active Application Discontinuation
-
2004
- 2004-02-04 US US10/772,033 patent/US7435825B2/en not_active Expired - Fee Related
- 2004-02-05 IL IL160252A patent/IL160252A/en not_active IP Right Cessation
-
2008
- 2008-07-09 US US12/169,813 patent/US7557218B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20080269497A1 (en) | 2008-10-30 |
| US7435825B2 (en) | 2008-10-14 |
| DE10140492A1 (de) | 2003-08-14 |
| CA2457576A1 (en) | 2003-02-27 |
| IL160252A (en) | 2009-06-15 |
| US7557218B2 (en) | 2009-07-07 |
| EP1421076A1 (de) | 2004-05-26 |
| PT1421076E (pt) | 2007-11-28 |
| IL160252A0 (en) | 2004-07-25 |
| ES2295389T3 (es) | 2008-04-16 |
| WO2003016301A1 (de) | 2003-02-27 |
| US20040158072A1 (en) | 2004-08-12 |
| DE50211061D1 (de) | 2007-11-22 |
| CA2457576C (en) | 2010-05-25 |
| PE20030357A1 (es) | 2003-04-26 |
| EP1421076B1 (de) | 2007-10-10 |
| ATE375337T1 (de) | 2007-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |