PE20001057A1 - Nuevos bis-benzimidazoles - Google Patents
Nuevos bis-benzimidazolesInfo
- Publication number
- PE20001057A1 PE20001057A1 PE1999000986A PE00098699A PE20001057A1 PE 20001057 A1 PE20001057 A1 PE 20001057A1 PE 1999000986 A PE1999000986 A PE 1999000986A PE 00098699 A PE00098699 A PE 00098699A PE 20001057 A1 PE20001057 A1 PE 20001057A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halogen
- cyane
- nitro
- aryl
- Prior art date
Links
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical class 0.000 abstract 6
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 3
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS BIS-BENZIMIDAZOLES DE FORMULA I DONDE R1, R2, R3 Y R4 SON H, OH o HALOGENO; R5 Y R8 SON H, ALQUILO C1-C4; R6 Y R7 SON H, ALQUILO C1-C6, OH, HALOGENO, ALCOXI C1-C6; R9, R10 Y R11 SON H, HALOGENO, NITRO, CIANO O TRIFLUORMETILO; A ES UN GRUPO a, b, c, d; UN N-HETEROCICLO NO AROMATICO DE 5-7 MIEMBROS OPCIONALMENTE CONTIENE O, NR14, CHR15, NR19R20; R12 Y R13 SON H, HALOGENO, NITRO, CIANO, ALQUILO C1-C6, ALCOXI C1-C6, OH; R14 Y R15 SON H, CICLOALQUILO C3-C8, ALQUILO C1-C4, ARILO C6-C10, HETEROCICLO DE 5-6 MIEMBROS, OPCIONALEMENTE SUSTITUIDO CON HALOGENO, CIANO, OH, NR16R17, ENTRE OTROS; O R14 ES -SO2-R18; R16 Y R17 SON H, ALQUILO C1-C4, ACILO C1-C4, SO2-CF3 O JUNTO CON N FORMAN UN HETEROCICLO AROMATICO DE 5-7 MIEMBROS; R18 ES ARILO C6-C10, ALQUILO C1-C4; R19 ES H, ALQUILO C1-C4; R20 ES D-E-R21; D ES ALQUILO C1-C6; E ES UN ENLACE, O; R21 ES ARILO C6-C10, HETEROCICLO DE 5-6 MIEMBROS OPCIONALMENTE SUSTITUIDO CON NITRO, CIANO, HALOGENO, TETRAZOLILO, NR22R23; R22 Y R23 SON H, ACILO C1-C6, ALQUILO C1-C6; R22 ES H; Y R23 ES SO2-CF3. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO DE FORMULA I INHIBE A LA TRIPTASA POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE ASMA, RINITIS ALERGICA
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10271198P | 1998-10-01 | 1998-10-01 | |
| US11726999P | 1999-01-26 | 1999-01-26 | |
| US12327799P | 1999-03-09 | 1999-03-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001057A1 true PE20001057A1 (es) | 2001-01-03 |
Family
ID=27379394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000986A PE20001057A1 (es) | 1998-10-01 | 1999-09-29 | Nuevos bis-benzimidazoles |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1117651A1 (es) |
| JP (1) | JP2002526537A (es) |
| AR (1) | AR021838A1 (es) |
| AU (1) | AU5998199A (es) |
| CA (1) | CA2346040A1 (es) |
| CO (1) | CO5261509A1 (es) |
| GT (1) | GT199900167A (es) |
| PE (1) | PE20001057A1 (es) |
| WO (1) | WO2000020401A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR024158A1 (es) * | 1999-06-01 | 2002-09-04 | Smithkline Beecham Corp | Compuestos antibacterianos |
| US20050256159A1 (en) * | 2002-10-11 | 2005-11-17 | Astrazeneca Ab | 1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors |
| RU2413722C1 (ru) * | 2009-08-07 | 2011-03-10 | Российская Федерация, От Имени Которой Выступает Министерство Образования И Науки Российской Федерации | Способ получения 2,2'-бисбензимидазола |
| WO2012027495A1 (en) | 2010-08-27 | 2012-03-01 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| AU2013208087B2 (en) * | 2012-01-09 | 2017-11-23 | X-Chem, Inc. | Tryptoline derivatives having kinase inhibitory activity and uses thereof |
| US10273243B2 (en) * | 2013-03-14 | 2019-04-30 | The Trustees Of Columbia University In The City Of New York | 4-phenylpiperidines, their preparation and use |
| WO2016086060A1 (en) * | 2014-11-26 | 2016-06-02 | The J. David Gladstone Institutes | Methods for treating a cytomegalovirus infection |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09506335A (ja) * | 1993-09-22 | 1997-06-24 | ザ、ウェルカム、ファンデーション、リミテッド | 抗ウイルス剤としてのビス（アミノベンズイミダゾリル）アルカン |
| US5693515A (en) * | 1995-04-28 | 1997-12-02 | Arris Pharmaceutical Corporation | Metal complexed serine protease inhibitors |
| NZ500029A (en) * | 1997-04-07 | 2001-02-23 | Axys Pharm Inc | Compounds and compositions of carboxamide derivatives associated with the treatment of rheumatoid arthritis, conjunctivitis and/ or syncytial virus infections |
| WO1999026932A1 (en) * | 1997-11-26 | 1999-06-03 | Axys Pharmaceuticals, Inc. | By amidino group substituted heterocyclic derivatives and their use as anticoagulants |
-
1999
- 1999-09-28 GT GT199900167A patent/GT199900167A/es unknown
- 1999-09-29 WO PCT/JP1999/005319 patent/WO2000020401A1/en not_active Ceased
- 1999-09-29 EP EP99969935A patent/EP1117651A1/en not_active Withdrawn
- 1999-09-29 CA CA002346040A patent/CA2346040A1/en not_active Abandoned
- 1999-09-29 AR ARP990104911A patent/AR021838A1/es unknown
- 1999-09-29 AU AU59981/99A patent/AU5998199A/en not_active Abandoned
- 1999-09-29 JP JP2000574518A patent/JP2002526537A/ja active Pending
- 1999-09-29 PE PE1999000986A patent/PE20001057A1/es not_active Application Discontinuation
- 1999-09-30 CO CO99062024A patent/CO5261509A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000020401A1 (en) | 2000-04-13 |
| EP1117651A1 (en) | 2001-07-25 |
| AR021838A1 (es) | 2002-08-07 |
| CA2346040A1 (en) | 2000-04-13 |
| JP2002526537A (ja) | 2002-08-20 |
| GT199900167A (es) | 2001-03-21 |
| CO5261509A1 (es) | 2003-03-31 |
| AU5998199A (en) | 2000-04-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR040031A1 (es) | Compuestos de pirazol-pirimidina anilina utiles como inhibidores de cinasa y composiciones farmaceuticas que los contienen | |
| AR006720A1 (es) | Un compuesto derivado de azahexano heterociclico, su uso para la preparacion de una composicion farmaceutica, procedimiento para prepararlo y una composicion farmaceutica que lo comprende | |
| PE20090116A1 (es) | Mezclas fungicidas que comprenden 1-metilpirazol-4-ilcarboxanilidas sustituidas | |
| ES2221440T3 (es) | Derivados de acido aminofenoxiacetico como neuroprotectores. | |
| MX9405286A (es) | Nuevos herbicidas. | |
| AR036041A1 (es) | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen | |
| PE20021002A1 (es) | Compuestos heterociclicos condensados | |
| PE20051058A1 (es) | Fenilalanina-amidas sustituidas por benzoilo | |
| PE20020720A1 (es) | Derivados benzimidazol y piridilimidazol como ligandos para receptores gabaa | |
| CO5080782A1 (es) | Compuestos heterociclicos como inhibidores de enzimas de rotamasa | |
| CO5721002A2 (es) | Derivados de acido 3-(4-benciloxifenil) propanoico | |
| NO954072L (no) | Vannopplöselige camptotecinderivater, fremgangsmåte for deres fremstilling og deres anvendelse som antitumormidler | |
| PE20001543A1 (es) | Derivados de piridopiranoacepinas, su preparacion y su aplicacion en terapeutica | |
| CO5660289A2 (es) | Derivados de 4-piridinilmetilsulfonamida como agentes fungicidas para proteccion de plantas | |
| PE20080136A1 (es) | Arilsulfonamidas sustituidas como agentes antivirales | |
| NO983493L (no) | Nye benzimidazol-, benzoksazol- og benzotiazolforbindelser, fremgangsmÕte ved fremstilling derav og farmas°ytiske sammensetninger inneholdende slike | |
| PE20001057A1 (es) | Nuevos bis-benzimidazoles | |
| BR0210170A (pt) | Agente herbicida contendo benzoilpirazol e protetores | |
| PE20021018A1 (es) | DERIVADOS DE ß - CARBOLINA | |
| PE20071324A1 (es) | Metodos de usar derivados de 3-piridilo como pesticidas | |
| ES2039221T3 (es) | Procedimiento para producir derivados de piridazinona. | |
| PE51499A1 (es) | Derivados de 5-aroilnaftaleno | |
| PE20020687A1 (es) | Imidazoles y tiazoles sustituidos como inhibidores de la farnesil transferasa | |
| ES2037011T3 (es) | Procedimiento para la preparacion de nuevos derivados de benzofuran-2-il-imidazol. | |
| BR8600171A (pt) | Processo para a preparacao de 1-aril-4-nitropirazois,composicoes herbicidas,processos para combater ervas daninhas e para a preparacao de composicoes e processo para a preparacao de 1-arilpirazois |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AE | Restoration of lapsed or forfeited application | ||
| FC | Refusal |