PE20030728A1 - Compuestos de isocromano - Google Patents
Compuestos de isocromanoInfo
- Publication number
- PE20030728A1 PE20030728A1 PE2002001229A PE2002001229A PE20030728A1 PE 20030728 A1 PE20030728 A1 PE 20030728A1 PE 2002001229 A PE2002001229 A PE 2002001229A PE 2002001229 A PE2002001229 A PE 2002001229A PE 20030728 A1 PE20030728 A1 PE 20030728A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- dihydro
- compounds
- benzopyran
- carboxamide
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- -1 PYRROLYL Chemical class 0.000 abstract 3
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 239000000164 antipsychotic agent Substances 0.000 abstract 1
- 229940005529 antipsychotics Drugs 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE ISOCROMANO DE FORMULA I DONDE R1 ES CN, CONR13R14, SO2NR13R14, (CH2)tR21, ENTRE OTROS; R21 ES NR13R14, NR13COR22, ENTRE OTROS; R13, R14, R22 SON H, ALQUILO O JUNTO A N FORMAN MORFOLINO, PIRROLILO, PIPERIDINILO; A ES O, S, t ES 0-2; r ES 0-3; v ES 0-2; R2 ES H, ALQUILO, ALCOXI, HALO; R3, R4, R5, R6, R7, R8 SON H, ALQUILO; R9, R10, R11, R12 SON H, ALQUILO, (CH2)q-OR20; R20 ES ALQUILO; n ES 1-2; p ES 0-2; q ES 1-2; W-V ES CH2-CR25-, O-C(R25), S-C(R25), ENTRE OTROS; R25 ES H, ALQUILO, X-Y ES N(Z)CH2, C(Q)(Z)CH2, C(Z)=CH; Z ES UN GRUPO i, xxi, ENTRE OTROS; T ES CH2, O, S, CO, HC=CH; m Y s SON 0-1; R15, R16, R19 SON H, HALO, ALQUILO, ALCOXI, ENTRE OTROS; Q ES H, HALO, NITRILO, CARBOXI-ALQUILO, HIDROXI, ALQUILO; CUANDO T ES CH2, O, S, CO; (m+s) ES 1-2; R1 ES (CH2)t-R21. SON COMPUESTOS PREFERIDOS (1S)-1-{2-[(2R)-4-(1,2-DIHIDRO-5-ACENAFTILENIL)-2-METILPIPERAZINIL]ETIL}-3,4-DIHIDRO-1H-2-BENZOPIRAN-6-CARBOXAMIDA; (1S)-1-{2-[4-(1,2-DIHIDRO-5-ACENAFTILENIL)-2-METILPIPERAZINIL]ETIL}-3,4-DIHIDRO-1H-2-BENZOPIRAN-6-CARBOXAMIDA; (1S)-1-{2-[(2R)-2-METIL-4-(1H,3H-NAFTO[1,8-cd]PIRAN-6-IL)PIPERAZINIL]ETIL}-3,4-DIHIDRO-1H-2-BENZOPIRAN-6-CARBOXAMIDA, ENTRE OTROS. LOS COMPUESTOS SON UTILES COMO ANTIPSICOTICOS Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE UN TRASTORNO ASOCIADO CON DISFUNCION DE SEROTONINA, SISTEMA NERVIOSO CENTRAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0130339.5A GB0130339D0 (en) | 2001-12-19 | 2001-12-19 | Isochroman compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030728A1 true PE20030728A1 (es) | 2003-08-29 |
Family
ID=9927920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002001229A PE20030728A1 (es) | 2001-12-19 | 2002-12-13 | Compuestos de isocromano |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1458703B1 (es) |
| JP (1) | JP2005516952A (es) |
| CN (1) | CN1312148C (es) |
| AR (1) | AR038662A1 (es) |
| AT (1) | ATE355283T1 (es) |
| AU (1) | AU2002359378B8 (es) |
| BR (1) | BR0214859A (es) |
| CA (1) | CA2469278A1 (es) |
| CY (1) | CY1106552T1 (es) |
| DE (1) | DE60218529T2 (es) |
| DK (1) | DK1458703T3 (es) |
| ES (1) | ES2280606T3 (es) |
| GB (1) | GB0130339D0 (es) |
| MX (1) | MXPA04006085A (es) |
| PE (1) | PE20030728A1 (es) |
| PT (1) | PT1458703E (es) |
| SI (1) | SI1458703T1 (es) |
| SV (1) | SV2004001441A (es) |
| TW (1) | TW200301116A (es) |
| WO (1) | WO2003053948A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7538113B2 (en) | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
| US7582636B2 (en) | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
| NL2000351C2 (nl) | 2005-12-22 | 2007-09-11 | Pfizer Prod Inc | Estrogeen-modulatoren. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247553A (en) * | 1977-10-31 | 1981-01-27 | The Upjohn Company | Methods of treating psychosis |
| DE69419778T2 (de) * | 1993-12-28 | 1999-12-09 | Pharmacia & Upjohn Co., Kalamazoo | Heterozyklische verbindungen für die behandlung von kardiovaskular- und zentralnervensystem störungen |
| MX9710260A (es) * | 1995-06-30 | 1998-03-29 | Upjohn Co | Isocromanos 1, 6-disustituidos para el tratamiento de migrañas. |
| GB2370270A (en) * | 2000-12-20 | 2002-06-26 | Lilly Co Eli | Pharmaceutical compounds |
-
2001
- 2001-12-19 GB GBGB0130339.5A patent/GB0130339D0/en not_active Ceased
-
2002
- 2002-11-18 TW TW091133608A patent/TW200301116A/zh unknown
- 2002-12-06 CA CA002469278A patent/CA2469278A1/en not_active Abandoned
- 2002-12-06 PT PT02793911T patent/PT1458703E/pt unknown
- 2002-12-06 JP JP2003554664A patent/JP2005516952A/ja not_active Ceased
- 2002-12-06 CN CNB028281209A patent/CN1312148C/zh not_active Expired - Fee Related
- 2002-12-06 BR BR0214859-5A patent/BR0214859A/pt not_active IP Right Cessation
- 2002-12-06 DE DE60218529T patent/DE60218529T2/de not_active Expired - Lifetime
- 2002-12-06 MX MXPA04006085A patent/MXPA04006085A/es active IP Right Grant
- 2002-12-06 ES ES02793911T patent/ES2280606T3/es not_active Expired - Lifetime
- 2002-12-06 SI SI200230528T patent/SI1458703T1/sl unknown
- 2002-12-06 AU AU2002359378A patent/AU2002359378B8/en not_active Ceased
- 2002-12-06 WO PCT/US2002/036148 patent/WO2003053948A1/en not_active Ceased
- 2002-12-06 AT AT02793911T patent/ATE355283T1/de not_active IP Right Cessation
- 2002-12-06 EP EP02793911A patent/EP1458703B1/en not_active Expired - Lifetime
- 2002-12-06 DK DK02793911T patent/DK1458703T3/da active
- 2002-12-13 PE PE2002001229A patent/PE20030728A1/es not_active Application Discontinuation
- 2002-12-18 AR ARP020104961A patent/AR038662A1/es unknown
- 2002-12-19 SV SV2002001441A patent/SV2004001441A/es not_active Application Discontinuation
-
2007
- 2007-04-26 CY CY20071100573T patent/CY1106552T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04006085A (es) | 2004-09-27 |
| SI1458703T1 (sl) | 2007-08-31 |
| GB0130339D0 (en) | 2002-02-06 |
| ES2280606T3 (es) | 2007-09-16 |
| SV2004001441A (es) | 2004-05-07 |
| AU2002359378B2 (en) | 2008-08-21 |
| WO2003053948A1 (en) | 2003-07-03 |
| AU2002359378B8 (en) | 2008-09-11 |
| AU2002359378A1 (en) | 2003-07-09 |
| CA2469278A1 (en) | 2003-07-03 |
| EP1458703A1 (en) | 2004-09-22 |
| PT1458703E (pt) | 2007-05-31 |
| JP2005516952A (ja) | 2005-06-09 |
| TW200301116A (en) | 2003-07-01 |
| CY1106552T1 (el) | 2012-01-25 |
| CN1620447A (zh) | 2005-05-25 |
| AR038662A1 (es) | 2005-01-26 |
| DK1458703T3 (da) | 2007-06-11 |
| DE60218529T2 (de) | 2007-11-22 |
| DE60218529D1 (de) | 2007-04-12 |
| ATE355283T1 (de) | 2006-03-15 |
| BR0214859A (pt) | 2004-11-03 |
| CN1312148C (zh) | 2007-04-25 |
| EP1458703B1 (en) | 2007-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |