PE20030713A1 - Derivados benzotiazol de nicotina o isonicotina - Google Patents
Derivados benzotiazol de nicotina o isonicotinaInfo
- Publication number
- PE20030713A1 PE20030713A1 PE2002001104A PE2002001104A PE20030713A1 PE 20030713 A1 PE20030713 A1 PE 20030713A1 PE 2002001104 A PE2002001104 A PE 2002001104A PE 2002001104 A PE2002001104 A PE 2002001104A PE 20030713 A1 PE20030713 A1 PE 20030713A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- isonicotine
- nicotine
- metoxi
- isonicotinamide
- Prior art date
Links
- 229960002715 nicotine Drugs 0.000 title abstract 2
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title abstract 2
- UEIZUEWXLJOVLD-UHFFFAOYSA-N 3-(1-methylpyrrolidin-3-yl)pyridine Chemical compound C1N(C)CCC1C1=CC=CN=C1 UEIZUEWXLJOVLD-UHFFFAOYSA-N 0.000 title 1
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 1
- -1 ISONICOTINE BENZOTHIAZOLE DERIVATIVES Chemical class 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
- 102000007471 Adenosine A2A receptor Human genes 0.000 abstract 1
- 108010085277 Adenosine A2A receptor Proteins 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DERIVADOS BENZOTIAZOL DE NICOTINA O ISONICOTINA DE FORMULA IA O IB DONDE R1 ES FENILO, PIPERIDIN-1-ILO, MORFOLINILO; A ES O; R ES -(CH2)n-N(R'')-C(O)-ALQUILO, -(CH2)n-O-ALQUILO-, -(CH2)n-O-(CH2)n-O-ALQUILO, (CH2)n-MORFOLINILO, ENTRE OTROS; A ES -N(R')-; R ES ALQUILO, CICLOALQUILO C4-C6; -(CH2)n-O-ALQUILO, -(CH2)n-PIRIDINILO, -(CH2)n-PIPERIDINILO, -(CH2)n-FENILO, ENTRE OTROS; R' Y R'' SON H, ALQUILO; n ES 1-2; A ES -CH2-; R ES -N(R´´)-(C2)m-O-ALQUILO, -N(R'')2, -S-ALQUILO, ENTRE OTROS; R'' ES H, ALQUILO; m ES 1-3; A Y R JUNTOS SON PIPERAZINILO CON ALQUILO, -C(O)-ALQUILO, PIPERIDINILO, MORFOLINILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 2-(2-METOXI-ETOXI)-N-(4-METOXI-7-MORFOLIN-4-IL-BENZOTIAZOL-2-IL)-ISONICOTINAMIDA, 2-ETOXI-N-(4-METOXI-7-MORFOLIN-4-IL-BENZOTIAZOL-2-IL)-ISONICOTINAMIDA, 2-METOXI-N-(4-METOXI-7-MORFOLIN-4-IL-BENZOTIAZOL-2-IL)-ISONICOTINAMIDA, 2-ISOPROPOXI-N-(4-METOXI-7-MORFOLIN-4-IL-BENZOTIAZOL-2-IL)-ISONICOTINAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCESO PARA LA PREPARACION. LOS COMPUESTOS MENCIONADOS TIENEN AFINIDAD POR EL RECEPTOR DE ADENOSINA A2A Y SON UTILES COMO AGENTES NEUROPROTECTORES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01127312 | 2001-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030713A1 true PE20030713A1 (es) | 2003-08-23 |
Family
ID=8179263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002001104A PE20030713A1 (es) | 2001-11-19 | 2002-11-15 | Derivados benzotiazol de nicotina o isonicotina |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US6620811B2 (es) |
| EP (1) | EP1448198B1 (es) |
| JP (1) | JP4226474B2 (es) |
| KR (1) | KR100577110B1 (es) |
| CN (1) | CN100546580C (es) |
| AR (1) | AR039367A1 (es) |
| AT (1) | ATE376831T1 (es) |
| AU (1) | AU2002351955B2 (es) |
| BR (1) | BR0214245A (es) |
| CA (1) | CA2467552C (es) |
| DE (1) | DE60223278T2 (es) |
| DK (1) | DK1448198T3 (es) |
| EA (1) | EA007502B1 (es) |
| EC (1) | ECSP045109A (es) |
| ES (1) | ES2294187T3 (es) |
| GT (1) | GT200200232A (es) |
| HR (1) | HRP20040396A2 (es) |
| HU (1) | HUP0402161A3 (es) |
| IL (2) | IL161623A0 (es) |
| JO (1) | JO2290B1 (es) |
| MA (1) | MA27083A1 (es) |
| MX (1) | MXPA04004684A (es) |
| MY (1) | MY126176A (es) |
| NO (1) | NO20042576L (es) |
| NZ (1) | NZ532802A (es) |
| PA (1) | PA8558001A1 (es) |
| PE (1) | PE20030713A1 (es) |
| PL (1) | PL369517A1 (es) |
| PT (1) | PT1448198E (es) |
| RS (1) | RS39904A (es) |
| RU (1) | RU2294933C2 (es) |
| SI (1) | SI1448198T1 (es) |
| TN (1) | TNSN04087A1 (es) |
| TW (1) | TW200407134A (es) |
| UA (1) | UA77462C2 (es) |
| UY (1) | UY27542A1 (es) |
| WO (1) | WO2003043636A1 (es) |
| ZA (1) | ZA200403817B (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100526487B1 (ko) * | 2000-06-21 | 2005-11-08 | 에프. 호프만-라 로슈 아게 | 벤조티아졸 유도체 |
| PT2266558T (pt) * | 2001-06-07 | 2017-07-21 | Analgesic Neuropharmaceuticals Llc | Tratamento da dor neuropática com o antagonista dos recetores de n-metil-d-aspartato (nmda) dextrometorfano |
| US6734179B2 (en) * | 2001-12-12 | 2004-05-11 | Hoffmann-La Roche Inc. | Benzothiazoles |
| US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| US6872833B2 (en) * | 2003-04-14 | 2005-03-29 | Hoffmann-La Roche Inc. | Adenosine receptor ligands |
| CA2533598C (en) * | 2003-07-23 | 2012-09-11 | Synta Pharmaceuticals, Corp. | Method for modulating calcium ion-release-activated calcium ion channels |
| US7335658B2 (en) | 2003-07-30 | 2008-02-26 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| AU2004274154A1 (en) * | 2003-09-19 | 2005-03-31 | F. Hoffmann-La Roche Ag | Thiazolopyridine derivatives as adenosine receptor ligands |
| WO2005044793A2 (en) * | 2003-10-31 | 2005-05-19 | Takeda Pharmaceutical Company Limited | Nitrogen-containing fused heterocyclic compounds |
| SI3002283T1 (en) | 2003-12-26 | 2018-06-29 | Kyowa Hakko Kirin Co., Ltd. | Thiazole derivatives |
| BRPI0418939A (pt) * | 2004-07-06 | 2008-04-08 | Xenon Pharmaceuticals Inc | derivados de nicotinamida e sua utilização como agentes terapêuticos |
| KR100823799B1 (ko) * | 2004-07-22 | 2008-04-21 | 에프. 호프만-라 로슈 아게 | 벤조티아졸 유도체 |
| BRPI0513510A (pt) * | 2004-07-22 | 2008-05-06 | Hoffmann La Roche | benzotiazóis substituìdos |
| RU2382782C2 (ru) * | 2004-07-22 | 2010-02-27 | Ф. Хоффманн-Ля Рош Аг | Производные бензотиазола |
| AU2005286728A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| MX2007003321A (es) * | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| AR051026A1 (es) | 2004-09-20 | 2006-12-13 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| AU2005286648A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| AU2005286653A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridine derivatives for inhibiting human stearoyl-CoA-desaturase |
| WO2006034341A2 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| BRPI0515505A (pt) * | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e sua utilização como inibidores da estearoil-coa desaturase |
| EP1804792A1 (en) * | 2004-09-20 | 2007-07-11 | Xenon Pharmaceuticals Inc. | Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coa-desaturase (scd) |
| CA2580857A1 (en) * | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| US7459563B2 (en) * | 2004-11-05 | 2008-12-02 | Hoffmann-La Roche Inc. | Process for the preparation of isonicotinic acid derivatives |
| MX2007011234A (es) * | 2005-03-14 | 2007-11-12 | Transtech Pharma Inc | Derivados de benzazol, composiciones y metodos de uso en la forma de inhibidores de b-secretasa. |
| MX2007015216A (es) * | 2005-06-03 | 2008-02-22 | Xenon Pharmaceuticals Inc | Derivados de aminotiazol y sus usos como agentes terapeuticos. |
| JP2010509392A (ja) * | 2006-11-13 | 2010-03-25 | ファイザー・プロダクツ・インク | ジアリール、ジピリジニルおよびアリール−ピリジニル誘導体ならびにその使用 |
| WO2010126743A1 (en) | 2009-04-27 | 2010-11-04 | High Point Pharmaceuticals, Llc | SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS β-SECRETASE INHIBITORS |
| TWI548411B (zh) | 2009-04-28 | 2016-09-11 | Kyowa Hakko Kirin Co Ltd | Exercise disorder treatment |
| UA113383C2 (xx) | 2009-09-02 | 2017-01-25 | Терапевтичний агент для лікування тривожних розладів | |
| UA110097C2 (uk) | 2009-09-02 | 2015-11-25 | Терапевтичний агент для лікування розладів настрою | |
| JP2013522364A (ja) * | 2010-03-23 | 2013-06-13 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | 置換イミダゾ［１，２−ｂ］ピリダジン誘導体、医薬組成物、及びβ−セクレターゼ阻害剤としての使用の方法 |
| JP5248585B2 (ja) * | 2010-12-15 | 2013-07-31 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 治療薬としてのニコチンアミド誘導体およびそれらの使用 |
| DE102011005232A1 (de) | 2011-03-08 | 2012-09-13 | AristoCon GmbH & Co. KG | Adenosin und seine Derivate zur Verwendung in der Schmerztherapie |
| SI3023415T1 (en) | 2012-10-02 | 2018-01-31 | Gilead Sciences, Inc. | Histone demethylase inhibitors |
| WO2020103930A1 (zh) * | 2018-11-22 | 2020-05-28 | 上海科技大学 | 噻唑并环类化合物、其制备方法、中间体和应用 |
| DE102019110904B4 (de) * | 2019-04-26 | 2022-01-20 | Helmholtz-Zentrum Dresden - Rossendorf E. V. | N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-acetamid-Derivate und deren Verwendung |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3374550D1 (en) | 1982-12-21 | 1987-12-23 | Johnsen Jorgensen Plastics Ltd | Dispensing container |
| FI91859C (fi) | 1987-06-17 | 1994-08-25 | Eisai Co Ltd | Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi |
| IL90337A0 (en) * | 1988-05-24 | 1989-12-15 | Pfizer | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents |
| KR100526487B1 (ko) | 2000-06-21 | 2005-11-08 | 에프. 호프만-라 로슈 아게 | 벤조티아졸 유도체 |
-
2002
- 2002-11-05 US US10/288,100 patent/US6620811B2/en not_active Expired - Lifetime
- 2002-11-11 MX MXPA04004684A patent/MXPA04004684A/es active IP Right Grant
- 2002-11-11 RS YU39904A patent/RS39904A/sr unknown
- 2002-11-11 KR KR1020047007638A patent/KR100577110B1/ko not_active Expired - Fee Related
- 2002-11-11 PL PL02369517A patent/PL369517A1/xx not_active Application Discontinuation
- 2002-11-11 AU AU2002351955A patent/AU2002351955B2/en not_active Ceased
- 2002-11-11 JP JP2003545317A patent/JP4226474B2/ja not_active Expired - Fee Related
- 2002-11-11 ES ES02787632T patent/ES2294187T3/es not_active Expired - Lifetime
- 2002-11-11 CN CNB028228391A patent/CN100546580C/zh not_active Expired - Fee Related
- 2002-11-11 DK DK02787632T patent/DK1448198T3/da active
- 2002-11-11 WO PCT/EP2002/012562 patent/WO2003043636A1/en not_active Ceased
- 2002-11-11 EP EP02787632A patent/EP1448198B1/en not_active Expired - Lifetime
- 2002-11-11 UA UA20040604552A patent/UA77462C2/uk unknown
- 2002-11-11 RU RU2004118425/04A patent/RU2294933C2/ru not_active IP Right Cessation
- 2002-11-11 IL IL16162302A patent/IL161623A0/xx unknown
- 2002-11-11 EA EA200400598A patent/EA007502B1/ru not_active IP Right Cessation
- 2002-11-11 BR BR0214245-7A patent/BR0214245A/pt not_active IP Right Cessation
- 2002-11-11 HR HR20040396A patent/HRP20040396A2/hr not_active Application Discontinuation
- 2002-11-11 SI SI200230637T patent/SI1448198T1/sl unknown
- 2002-11-11 HU HU0402161A patent/HUP0402161A3/hu not_active Application Discontinuation
- 2002-11-11 PT PT02787632T patent/PT1448198E/pt unknown
- 2002-11-11 CA CA2467552A patent/CA2467552C/en not_active Expired - Fee Related
- 2002-11-11 NZ NZ532802A patent/NZ532802A/en unknown
- 2002-11-11 AT AT02787632T patent/ATE376831T1/de active
- 2002-11-11 DE DE60223278T patent/DE60223278T2/de not_active Expired - Lifetime
- 2002-11-14 PA PA20028558001A patent/PA8558001A1/es unknown
- 2002-11-14 TW TW091133371A patent/TW200407134A/zh unknown
- 2002-11-15 PE PE2002001104A patent/PE20030713A1/es not_active Application Discontinuation
- 2002-11-18 JO JO2002114A patent/JO2290B1/en active
- 2002-11-18 UY UY27542A patent/UY27542A1/es not_active Application Discontinuation
- 2002-11-18 MY MYPI20024303A patent/MY126176A/en unknown
- 2002-11-18 AR ARP020104416A patent/AR039367A1/es unknown
- 2002-11-18 GT GT200200232A patent/GT200200232A/es unknown
-
2004
- 2004-04-26 IL IL161623A patent/IL161623A/en not_active IP Right Cessation
- 2004-05-17 EC EC2004005109A patent/ECSP045109A/es unknown
- 2004-05-18 ZA ZA200403817A patent/ZA200403817B/en unknown
- 2004-05-18 TN TNP2004000087A patent/TNSN04087A1/en unknown
- 2004-05-18 MA MA27681A patent/MA27083A1/fr unknown
- 2004-06-18 NO NO20042576A patent/NO20042576L/no not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20030713A1 (es) | Derivados benzotiazol de nicotina o isonicotina | |
| NL300927I1 (nl) | tivozanib of een zout of hydraat ervan, in het bijzonder het hydrochloride-monohydraat | |
| PE20020104A1 (es) | Derivados de benzotiazol | |
| PE20060693A1 (es) | Nuevos derivados de trifluorometansulfonanilida oxamida eter | |
| MY124864A (en) | Adenosine a2a receptor antagonists | |
| HUP0300693A2 (hu) | Eljárás epotilon-analógok és -intermedierek előállítására | |
| MXPA04000532A (es) | Derivados de 8-metoxi-(1,2,4)-triazolo(1,5-a)piridina y su uso como ligandos receptores de adenosina. | |
| TR200400541T4 (tr) | Terapide faydalı tropan türevleri. | |
| PE20030601A1 (es) | Derivados de 1,8-naftiridina y su uso para el tratamiento de la diabetes y transtornos relacionados | |
| PE20020506A1 (es) | Derivados de pirazol fusionados como inhibidores de la proteina cinasa | |
| AR063240A1 (es) | Derivados de n-aril pirazol,composiciones farmaceuticas que los contienen y usos para el tratamiento de la diabetes tipo2,y enfermedades relacionadas. | |
| NZ231983A (en) | Substituted 1,3-diazoles and 1,2,4-triazoles; fungicidal compositions, methods for preparation and combating fungal disease | |
| SE0104332D0 (sv) | Therapeutic agents | |
| TNSN04165A1 (en) | Substituted hydroxyethylamines | |
| PT1003725E (pt) | Fungicidas de fluoropirazoldifenilamidas | |
| NO20065184L (no) | 1-amino-ftalazinderivater, deres fremstilling og terapeutiske anvendelse derav | |
| AR032466A1 (es) | Ciclilamina sulfonamidas, utilizacion de las mismas para la manufactura de un medicamento y composiciones farmaceuticas utiles como agonistas de los receptores beta-3 adrenergicos | |
| PE20081662A1 (es) | DERIVADOS DE 6-OXO-6,7-DIHIDRO-5H-DIBENZO[b,d]AZEPIN-7-ILO | |
| NO20033145L (no) | Purinderivater som purinergiske reseptorantagonister | |
| SE0301446D0 (sv) | New Compounds | |
| PE20030761A1 (es) | Derivados del 7-amino-benzotiazol | |
| DE69204041D1 (de) | Thiazolidinverbindeungen, deren Herstellung und therapeutische Verwendung. | |
| AR037221A1 (es) | Compuestos derivados de piridina, uso de los mismos, un procedimiento para su preparacion y un medicamento que contiene uno o mas de dichos compuestos | |
| NO20012965L (no) | Sulfonyloksazolaminer som terapeutisk aktive forbindelser | |
| AR056574A1 (es) | Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |