PE20020772A1 - Composicion farmaceutica que comprende una molecula ctla4 soluble - Google Patents
Composicion farmaceutica que comprende una molecula ctla4 solubleInfo
- Publication number
- PE20020772A1 PE20020772A1 PE2001001131A PE2001001131A PE20020772A1 PE 20020772 A1 PE20020772 A1 PE 20020772A1 PE 2001001131 A PE2001001131 A PE 2001001131A PE 2001001131 A PE2001001131 A PE 2001001131A PE 20020772 A1 PE20020772 A1 PE 20020772A1
- Authority
- PE
- Peru
- Prior art keywords
- ctla4
- pharmaceutical composition
- soluble
- sulfasal
- molecula
- Prior art date
Links
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 title abstract 4
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical group NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 abstract 1
- DHMQDGOQFOQNFH-CNRUNOGKSA-N 2-amino-2-tritioacetic acid Chemical compound [3H]C(N)C(O)=O DHMQDGOQFOQNFH-CNRUNOGKSA-N 0.000 abstract 1
- 102100039496 Choline transporter-like protein 4 Human genes 0.000 abstract 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
- 229930105110 Cyclosporin A Natural products 0.000 abstract 1
- 108010036949 Cyclosporine Proteins 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 101000889282 Homo sapiens Choline transporter-like protein 4 Proteins 0.000 abstract 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 abstract 1
- 125000003412 L-alanyl group Chemical group [H]N([H])[C@@](C([H])([H])[H])(C(=O)[*])[H] 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 108700012920 TNF Proteins 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical compound [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 abstract 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 abstract 1
- 229940063655 aluminum stearate Drugs 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 abstract 1
- 229960002170 azathioprine Drugs 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960001265 ciclosporin Drugs 0.000 abstract 1
- 239000008119 colloidal silica Substances 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 229960001334 corticosteroids Drugs 0.000 abstract 1
- 229930182912 cyclosporin Natural products 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 229960000598 infliximab Drugs 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 239000004302 potassium sorbate Substances 0.000 abstract 1
- 235000010241 potassium sorbate Nutrition 0.000 abstract 1
- 229940069338 potassium sorbate Drugs 0.000 abstract 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 abstract 1
- 229960004618 prednisone Drugs 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A61K38/13—Cyclosporins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
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- Animal Behavior & Ethology (AREA)
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Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: i)DE 0,5mg/Kg A 100mg/Kg DE UNA MOLECULA MUTADA DE LA PROTEINA CTL4 EN LA POSICION +104, QUE CAMBIA LA LEUCINA POR OTRO AMINOACIDO SIENDO LA MOLECULA SOLUBLE DE CTLA4 1)L104EIg DE 357 AMINOACIDOS; 2)UNA MUTACION EN LA POSICION 104 DE CTLA4 (LEUCINA POR ACIDO GLUTAMICO); UNA SEGUNDA MUTACION POR CUALQUIER OTRO AMINOACIDO DE a)ALANINA EN LA POSICION 29; b)GLICINA EN LA POSICION 105; c)SERINA EN LA POSICION 25; d)TREONINA EN LA POSICION 32; 3)L104EA29YIg; 4)L104EA29LIg; 5)L104EA29TIg; 6)L104EA29WIg; Y ii)UN AGENTE INMUNOSUPRESOR COMO CORTICOSTEROIDES, ANTIINFLAMATORIOS NO ESTEROIDALES, CICLOSPORINA, PREDNISONA, AZATIOPRINA, METOTREXATO, BLOQUEADORES O ANTAGONISTAS DE TNFa, INFLIXIMAB, SULFASALOZOPRINA, SALES DE ORO, ETANERCEPT, ANAKINRA; iii)PORTADOR FARMACEUTICAMENTE ACEPTABLE COMO INTERCAMBIADORES DE IONES, ALUMINA, ESTEARATO DE ALUMINIO, LECITINA, PROTEINAS SERICAS, , SUSTANCIAS AMORTIGUADORAS, GLICINA, ACIDO ASCORBICO, SORBATO DE POTASIO, SILICE COLOIDAL. LAS MOLECULAS MUTADAS CTLA4 SOLUBLES BLOQUEAN QUE LAS MOLECULAS B7 ENDOGENAS SE ENLACEN A SUS LIGANDOS CD28 EN LAS CELULAS T Y PUEDEN SER UTIL PARA EL TRATAMIENTO DE ENFERMEDADES REUMATICAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21591300P | 2000-07-03 | 2000-07-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020772A1 true PE20020772A1 (es) | 2002-09-06 |
Family
ID=22804919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001001131A PE20020772A1 (es) | 2000-07-03 | 2001-11-14 | Composicion farmaceutica que comprende una molecula ctla4 soluble |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US7455835B2 (es) |
| EP (4) | EP1372696B1 (es) |
| JP (1) | JP2004517806A (es) |
| KR (3) | KR100895552B1 (es) |
| CN (1) | CN1318086C (es) |
| AR (2) | AR035037A1 (es) |
| AT (1) | ATE401909T1 (es) |
| AU (2) | AU2001273174B2 (es) |
| BG (2) | BG66024B1 (es) |
| BR (1) | BR0112104A (es) |
| CA (2) | CA2413190C (es) |
| CY (3) | CY1109786T1 (es) |
| CZ (1) | CZ303959B6 (es) |
| DE (1) | DE60135029D1 (es) |
| DK (2) | DK1935427T3 (es) |
| EE (1) | EE05378B1 (es) |
| ES (2) | ES2310557T3 (es) |
| HR (1) | HRP20030071B1 (es) |
| HU (3) | HU227669B1 (es) |
| IL (2) | IL153593A0 (es) |
| IS (1) | IS2834B (es) |
| LT (2) | LT1935427T (es) |
| LV (1) | LV12993B (es) |
| MX (1) | MXPA02012603A (es) |
| MY (1) | MY137552A (es) |
| NO (3) | NO20026264L (es) |
| PE (1) | PE20020772A1 (es) |
| PL (2) | PL212205B1 (es) |
| PT (2) | PT1935427T (es) |
| RS (1) | RS50811B (es) |
| RU (1) | RU2287340C2 (es) |
| SI (3) | SI1935427T1 (es) |
| SK (1) | SK287940B6 (es) |
| TR (1) | TR201807700T4 (es) |
| TW (2) | TWI311564B (es) |
| UY (1) | UY26815A1 (es) |
| WO (1) | WO2002002638A2 (es) |
| ZA (1) | ZA200210058B (es) |
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- 2001-07-02 ES ES08001340.2T patent/ES2667203T3/es not_active Expired - Lifetime
- 2001-07-02 JP JP2002507889A patent/JP2004517806A/ja active Pending
- 2001-07-02 LT LTEP08001340.2T patent/LT1935427T/lt unknown
- 2001-07-02 AT AT01952420T patent/ATE401909T1/de active
- 2001-07-02 PT PT01952420T patent/PT1372696E/pt unknown
- 2001-07-02 SK SK1774-2002A patent/SK287940B6/sk not_active IP Right Cessation
- 2001-07-02 RU RU2003103098/14A patent/RU2287340C2/ru active
- 2001-07-02 DE DE60135029T patent/DE60135029D1/de not_active Expired - Lifetime
- 2001-11-14 PE PE2001001131A patent/PE20020772A1/es not_active Application Discontinuation
-
2002
- 2002-12-06 BG BG107362A patent/BG66024B1/bg unknown
- 2002-12-11 ZA ZA2002/10058A patent/ZA200210058B/en unknown
- 2002-12-23 IL IL153593A patent/IL153593A/en active IP Right Grant
- 2002-12-27 NO NO20026264A patent/NO20026264L/no not_active Application Discontinuation
-
2003
- 2003-01-02 IS IS6667A patent/IS2834B/is unknown
- 2003-01-07 LT LT2003002A patent/LT5063B/lt not_active IP Right Cessation
- 2003-02-03 LV LVP-03-08A patent/LV12993B/en unknown
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2008
- 2008-05-09 AR ARP080101975A patent/AR066511A2/es unknown
- 2008-10-21 CY CY20081101167T patent/CY1109786T1/el unknown
- 2008-11-05 CY CY2008017C patent/CY2008017I2/el unknown
-
2010
- 2010-03-05 BG BG110611A patent/BG66454B1/bg unknown
- 2010-04-22 NO NO20100579A patent/NO20100579L/no unknown
- 2010-04-22 NO NO20100580A patent/NO20100580L/no not_active Application Discontinuation
- 2010-04-27 HU HUS1000008C patent/HUS1000008I1/hu unknown
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2018
- 2018-05-23 CY CY20181100546T patent/CY1120577T1/el unknown
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