NO20100579L - Fremgangsmater for behandling av reumatoid artritt ved anvendelse av opploselig mutant CTLA4 molekyl - Google Patents
Fremgangsmater for behandling av reumatoid artritt ved anvendelse av opploselig mutant CTLA4 molekylInfo
- Publication number
- NO20100579L NO20100579L NO20100579A NO20100579A NO20100579L NO 20100579 L NO20100579 L NO 20100579L NO 20100579 A NO20100579 A NO 20100579A NO 20100579 A NO20100579 A NO 20100579A NO 20100579 L NO20100579 L NO 20100579L
- Authority
- NO
- Norway
- Prior art keywords
- methods
- rheumatoid arthritis
- soluble ctla4
- treating rheumatoid
- mutant molecule
- Prior art date
Links
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 title abstract 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 title abstract 2
- 206010039073 rheumatoid arthritis Diseases 0.000 title 1
- 102000005738 B7 Antigens Human genes 0.000 abstract 1
- 108010045634 B7 Antigens Proteins 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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-
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
Abstract
Den foreliggende oppfinnelsen angår sammensetninger og fremgangsmåter for behandling av revmatisk sykdom, ved å administrere til et individ løselige CTLA4-molekyler som blokkerer endogene B7-molekyler fra å binde deres ligander.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21591300P | 2000-07-03 | 2000-07-03 | |
| PCT/US2001/021204 WO2002002638A2 (en) | 2000-07-03 | 2001-07-02 | Methods for treating rheumatic diseases using a soluble ctla4 molecule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20100579L true NO20100579L (no) | 2003-02-19 |
Family
ID=22804919
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20026264A NO20026264L (no) | 2000-07-03 | 2002-12-27 | Fremgangsmater for behandling av revmatiske sykdommer ved anvendelse av et loselig CTLA4-molekyl |
| NO20100580A NO20100580L (no) | 2000-07-03 | 2010-04-22 | Fremgangsmater for behandling av reumatoid artritt ved anvendelse av opploselig mutant CTLA4 molekyl |
| NO20100579A NO20100579L (no) | 2000-07-03 | 2010-04-22 | Fremgangsmater for behandling av reumatoid artritt ved anvendelse av opploselig mutant CTLA4 molekyl |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20026264A NO20026264L (no) | 2000-07-03 | 2002-12-27 | Fremgangsmater for behandling av revmatiske sykdommer ved anvendelse av et loselig CTLA4-molekyl |
| NO20100580A NO20100580L (no) | 2000-07-03 | 2010-04-22 | Fremgangsmater for behandling av reumatoid artritt ved anvendelse av opploselig mutant CTLA4 molekyl |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US7455835B2 (no) |
| EP (4) | EP3384924A1 (no) |
| JP (1) | JP2004517806A (no) |
| KR (3) | KR20030017606A (no) |
| CN (1) | CN1318086C (no) |
| AR (2) | AR035037A1 (no) |
| AT (1) | ATE401909T1 (no) |
| AU (2) | AU2001273174B2 (no) |
| BG (2) | BG66024B1 (no) |
| BR (1) | BR0112104A (no) |
| CA (2) | CA2630062C (no) |
| CY (3) | CY1109786T1 (no) |
| CZ (1) | CZ303959B6 (no) |
| DE (1) | DE60135029D1 (no) |
| DK (2) | DK1372696T3 (no) |
| EE (1) | EE05378B1 (no) |
| ES (2) | ES2667203T3 (no) |
| HR (1) | HRP20030071B1 (no) |
| HU (3) | HU227669B1 (no) |
| IL (2) | IL153593A0 (no) |
| IS (1) | IS2834B (no) |
| LT (2) | LT1935427T (no) |
| LV (1) | LV12993B (no) |
| MX (1) | MXPA02012603A (no) |
| MY (1) | MY137552A (no) |
| NO (3) | NO20026264L (no) |
| PE (1) | PE20020772A1 (no) |
| PL (2) | PL207534B1 (no) |
| PT (2) | PT1372696E (no) |
| RS (1) | RS50811B (no) |
| RU (1) | RU2287340C2 (no) |
| SI (3) | SI21078A (no) |
| SK (1) | SK287940B6 (no) |
| TR (1) | TR201807700T4 (no) |
| TW (2) | TWI322153B (no) |
| UY (1) | UY26815A1 (no) |
| WO (1) | WO2002002638A2 (no) |
| ZA (1) | ZA200210058B (no) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
| US6887471B1 (en) * | 1991-06-27 | 2005-05-03 | Bristol-Myers Squibb Company | Method to inhibit T cell interactions with soluble B7 |
| DE69713499T3 (de) * | 1996-03-20 | 2010-05-06 | Bristol-Myers Squibb Co., Seattle | Verfahren zur inhibierung der immunreaktion durch blockierung der gp39/cd40 und ctla4/cd28/b7 routen und zusammensetzung zu deren verwendung |
| ZA98533B (en) * | 1997-01-31 | 1999-07-22 | Bristol Myers Squibb Co | Soluble CTLA4 mutant molecules and uses thereof. |
| US20030219863A1 (en) * | 1997-01-31 | 2003-11-27 | Bristol-Myers Squibb Company | Soluble CTLA4 mutant molecules and uses thereof |
| EG24459A (en) * | 2000-05-26 | 2009-07-16 | Bristol Myers Squibb Co | Soluble CTLA4 mutant molecules and uses thereof |
| US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
| US20020039577A1 (en) * | 2000-06-09 | 2002-04-04 | Townsend Robert M. | Methods for regulating a lymphocyte-mediated immune response by blocking costimulatory signals and blocking LFA-1 mediated adhesion in lymphocytes |
| RU2287340C2 (ru) | 2000-07-03 | 2006-11-20 | Бристол-Маерс Сквибб Компани | Способы лечения ревматических заболеваний с применением растворимого ctla4 |
| US20040022787A1 (en) | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
| PL375139A1 (en) * | 2001-01-26 | 2005-11-28 | Emory University | Methods of inducing organ transplant tolerance and correcting hemoglobinopathies |
| HU229680B1 (hu) * | 2001-05-23 | 2014-04-28 | Bristol Myers Squibb Co | Eljárások allogén sziget átültetés védelmére oldható CTLA4 mutáns molekulák alkalmazásával |
| EP1496931A4 (en) * | 2002-04-19 | 2009-07-01 | Bristol Myers Squibb Co | METHODS OF TREATING AUTOIMMUNE DISEASE USING SOLUBLE CTLA4 MOLECULE AND ARMM OR NSAID |
| TWI328614B (en) * | 2002-12-23 | 2010-08-11 | Bristol Myers Squibb Co | Product quality enhancement in mammalian cell culture processes for protein production |
| CA2511520A1 (en) * | 2002-12-23 | 2004-07-15 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
| AU2003299971A1 (en) | 2002-12-30 | 2004-07-29 | Amgen Inc. | Combination therapy with co-stimulatory factors |
| WO2005016266A2 (en) * | 2003-08-04 | 2005-02-24 | Bristol-Myers Squibb Company | Methods for treating cardiovascular disease using a soluble ctla4 molecule |
| WO2005044188A2 (en) | 2003-10-27 | 2005-05-19 | Amgen Inc. | Compositions and methods to modulate an immune response to an immunogenic therapeutic agent |
| US7815765B2 (en) * | 2004-04-01 | 2010-10-19 | Swei Mu Wang | Method for forming laminated synthetic leather |
| US9309316B2 (en) | 2005-12-20 | 2016-04-12 | Bristol-Myers Squibb Company | Stable subcutaneous protein formulations and uses thereof |
| PE20071063A1 (es) * | 2005-12-20 | 2007-10-24 | Bristol Myers Squibb Co | Formulaciones de proteinas estables |
| ES2439641T3 (es) | 2005-12-20 | 2014-01-24 | Bristol-Myers Squibb Company | Composiciones y procedimientos de producción de una composición |
| AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
| US7528111B2 (en) * | 2006-05-12 | 2009-05-05 | Bristol-Myers Squibb Company | Method of vaccinating subjects receiving immune modulating therapy |
| GB0620934D0 (en) | 2006-10-20 | 2006-11-29 | Cambridge Antibody Tech | Protein variants |
| AU2012202324B2 (en) * | 2007-11-01 | 2014-08-28 | Astellas Pharma Inc. | Immunosuppressive polypeptides and nucleic acids |
| AU2014250683B2 (en) * | 2007-11-01 | 2015-11-26 | Astellas Pharma Inc. | Immunosuppressive polypeptides and nucleic acids |
| AU2008319053B2 (en) * | 2007-11-01 | 2012-04-26 | Astellas Pharma Inc. | Immunosuppressive polypeptides and nucleic acids |
| US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
| US7915222B2 (en) | 2008-05-05 | 2011-03-29 | Bristol-Myers Squibb Company | Method of preventing the development of rheumatoid arthritis in subjects with undifferentiated arthritis |
| US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
| AU2009293019A1 (en) | 2008-09-19 | 2010-03-25 | Tandem Diabetes Care Inc. | Solute concentration measurement device and related methods |
| WO2010042433A1 (en) | 2008-10-06 | 2010-04-15 | Bristol-Myers Squibb Company | Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases |
| ES2615861T3 (es) * | 2008-10-30 | 2017-06-08 | Yeda Research And Development Company Ltd. | Células T de memoria central anti-terceros, métodos de producción de las mismas y uso de las mismas en trasplante y tratamiento de enfermedades |
| US20110152770A1 (en) | 2009-07-30 | 2011-06-23 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
| CN102030828B (zh) * | 2009-09-25 | 2014-10-29 | 上海抗体药物国家工程研究中心有限公司 | 一种高亲和力的CTLA4-Ig融合蛋白突变体 |
| LT2536745T (lt) | 2010-02-19 | 2016-09-26 | Xencor, Inc. | Nauji ctla4-ig imunoadhezinai |
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