PE20020708A1 - 2-piridonas antimicrobianas, sus composiciones y usos - Google Patents
2-piridonas antimicrobianas, sus composiciones y usosInfo
- Publication number
- PE20020708A1 PE20020708A1 PE2001001249A PE2001001249A PE20020708A1 PE 20020708 A1 PE20020708 A1 PE 20020708A1 PE 2001001249 A PE2001001249 A PE 2001001249A PE 2001001249 A PE2001001249 A PE 2001001249A PE 20020708 A1 PE20020708 A1 PE 20020708A1
- Authority
- PE
- Peru
- Prior art keywords
- alkene
- ethyl
- alkyl
- cycloalkyl
- pyridones
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 150000001336 alkenes Chemical class 0.000 abstract 5
- -1 AMINO Chemical class 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical class CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A 2-PIRIDONAS DE FORMULA I DONDE R1 ES CICLOALQUILO C3-C6, HETEROCICLOALQUILO C4-C6, ALQUILO C1-C6, ALQUENO C2-C6, ARILO, HETEROARILO; R2 ES H; R3 ES H, OH; R5 ES H, OH, AMINO, HALO, ALQUILO C1-C6, ALQUENO C2-C6, ALCOXI C1-C6; R6 ES H, OH, AMINOCARBONILO, CIANO, ALQUILO C1-C4, ALQUENO C2-C4; R7 ES UN RADICAL DE PIPERIDINA, PIRROLIDINA, CICLO DE 4 MIEMBROS CON UN N SUSTITUIDOS CON R9 Y R10; R9 ES AMINO UNIDO A UN CARBONO NO ADYACENTE AL N, AMINOALQUILO C1-C3; R10 ES H, ALQUILO C1-C4, ALQUENO C2-C6, CICLOALQUILO C3-C6 FUSIONADO O ESPIROCICLO, R8 ES H, HALO, ALCOXI C1-C6, ALQUILTIO C1-C6, ALQUENO C2-C6; O R8 Y R1 JUNTOS FORMAN UN HETEROCICLO DE 6 MIEMBROS. SON COMPUESTOS PREFERIDOS ESTER ETILICO DEL ACIDO 8-[3-(N-BOC-AMINOETIL)PIRROLIDINIL]-1-ETIL-9-METOXI-4-OXO-4H-QUINOLIZIN-3-CARBOXILICO; ESTER ETILICO DEL ACIDO 8-#-AMINOPIPERIDINIL)-1-ETIL-9-METOXI-4-OXO-4H-QUINOLIZIN-3-CARBOXILICO, ENTRE OTROS. LOS COMPUESTOS I SON AGENTES ANTIMICROBIANOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25562800P | 2000-12-14 | 2000-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020708A1 true PE20020708A1 (es) | 2002-09-26 |
Family
ID=22969188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001001249A PE20020708A1 (es) | 2000-12-14 | 2001-12-13 | 2-piridonas antimicrobianas, sus composiciones y usos |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6509349B1 (es) |
| EP (1) | EP1341787A2 (es) |
| JP (1) | JP2004515549A (es) |
| AR (1) | AR031808A1 (es) |
| AU (2) | AU2002230893B2 (es) |
| BR (1) | BR0116205A (es) |
| CA (1) | CA2427872A1 (es) |
| HU (1) | HUP0303457A3 (es) |
| IL (1) | IL155678A0 (es) |
| NO (1) | NO20032666L (es) |
| NZ (1) | NZ525570A (es) |
| PE (1) | PE20020708A1 (es) |
| PL (1) | PL363301A1 (es) |
| WO (1) | WO2002048143A2 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011515403A (ja) * | 2008-03-21 | 2011-05-19 | メルク・シャープ・エンド・ドーム・コーポレイション | キノリジジノンｍ１受容体ポジティブアロステリックモジュレータ |
| JP2011519856A (ja) | 2008-05-01 | 2011-07-14 | メルク・シャープ・エンド・ドーム・コーポレイション | ４−オキソ−１，４−ジヒドロキノリンｍ１受容体ポジティブアロステリックモジュレーター |
| FR2936798B1 (fr) * | 2008-10-03 | 2012-09-28 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens. |
| FR2936951B1 (fr) * | 2008-10-10 | 2010-12-03 | Novexel | Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments |
| FR2937034B1 (fr) * | 2008-10-10 | 2012-11-23 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens |
| WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
| EP3034078A1 (en) | 2010-09-27 | 2016-06-22 | Emergent Product Development Gaithersburg Inc. | 2-pyridone antimicrobial compositions |
| EP3312176A1 (en) | 2011-02-01 | 2018-04-25 | Emergent Product Development Gaithersburg Inc. | Antimicrobial 4-oxoquinolizines |
| CN103483248B (zh) * | 2013-09-09 | 2016-01-20 | 江苏宇翔化工有限公司 | 一种4-氯-3-甲氧基-2-甲基-4-吡啶的合成方法 |
| ITBO20150177A1 (it) * | 2015-04-14 | 2016-10-14 | Fornaciari Miriam | Sistema per somministrazione orale per il rilascio controllato di sostanze attive |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0717608B2 (ja) | 1986-04-25 | 1995-03-01 | 杏林製薬株式会社 | ６−アルコキシキノロンカルボン酸誘導体 |
| DE3704907A1 (de) | 1987-02-17 | 1988-08-25 | Bayer Ag | Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden |
| US4921857A (en) | 1987-09-18 | 1990-05-01 | Merck & Co., Inc. | 4-Oxo-4h-quinolizine-3-carboxylic acids and derivatives thereof |
| US5328908A (en) | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
| US5164402A (en) | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
| RU2049777C1 (ru) | 1989-08-16 | 1995-12-10 | Пфайзер Инк. | Азабицикло-хинолон-карбоновые кислоты или их фармацевтически приемлемые кислотно-аддитивные соли и промежуточные продукты для их получения |
| JPH03115277A (ja) | 1989-09-28 | 1991-05-16 | Banyu Pharmaceut Co Ltd | ピリドンカルボン酸誘導体 |
| FR2656611B1 (fr) | 1990-01-04 | 1992-05-07 | Hoechst France | Nouvelles quinolones, leurs sels, utiles comme agents antimicrobiens, procede de preparation et leur application a titre de medicaments et compositions les renfermant. |
| US5726182A (en) | 1990-05-02 | 1998-03-10 | Abbott Laboratories | Quinolizinone type compounds |
| DE69132348T2 (de) * | 1990-05-02 | 2001-03-15 | Abbott Laboratories, Abbott Park | Verbindungen vom chinolizinon-typ |
| US5580872A (en) * | 1990-05-02 | 1996-12-03 | Abbott Laboratories | Quinolizinone type compounds |
| US5072001A (en) | 1990-11-30 | 1991-12-10 | Warner-Lambert Company | Certain optically active substituted 3-pyrraidine acetic acid derivatives useful as intermediates |
| KR930703292A (ko) | 1991-12-27 | 1993-11-29 | 쿠사이 요시히로 | 신규 퀴놀론 유도체 또는 그의 염 및 이 화합물을 함유하는 항균제 |
| NO304832B1 (no) | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
| DE4230804A1 (de) | 1992-09-15 | 1994-03-17 | Bayer Ag | 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate |
| DE4301246A1 (de) | 1993-01-19 | 1994-07-21 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäurederivate |
| AU689809B2 (en) | 1993-10-14 | 1998-04-09 | Abbott Laboratories | Quinolizinone type compounds |
| WO1996005192A1 (en) | 1994-08-12 | 1996-02-22 | Toyama Chemical Co., Ltd. | Novel quinolone- or naphthyridonecarboxylic acid derivative or salt thereof |
| JPH092953A (ja) | 1995-06-16 | 1997-01-07 | Chugai Pharmaceut Co Ltd | バルフロキサシン製剤 |
| JP3833738B2 (ja) | 1995-11-15 | 2006-10-18 | 第一製薬株式会社 | 置換アミノメチルピロリジン誘導体 |
| AU4723197A (en) | 1996-10-25 | 1998-05-22 | Daiichi Pharmaceutical Co., Ltd. | Tricyclic amine derivatives |
| JPH10287669A (ja) | 1997-04-10 | 1998-10-27 | Dai Ichi Seiyaku Co Ltd | 置換アミノメチルピロリジン誘導体 |
| AU7449398A (en) | 1997-05-21 | 1998-12-11 | Daiichi Pharmaceutical Co., Ltd. | Cis-disubstituted aminocycloalkyl-pyrrolidine derivatives |
| MY119816A (en) | 1997-05-30 | 2005-07-29 | Daiichi Seiyaku Co | Substituted cyclobutylamine derivatives |
| KR100241673B1 (ko) | 1997-08-09 | 2000-03-02 | 김충섭 | 퀴놀리진 카르복실산 유도체 |
-
2001
- 2001-12-07 BR BR0116205-5A patent/BR0116205A/pt not_active IP Right Cessation
- 2001-12-07 JP JP2002549674A patent/JP2004515549A/ja not_active Withdrawn
- 2001-12-07 IL IL15567801A patent/IL155678A0/xx unknown
- 2001-12-07 AU AU2002230893A patent/AU2002230893B2/en not_active Ceased
- 2001-12-07 HU HU0303457A patent/HUP0303457A3/hu unknown
- 2001-12-07 CA CA002427872A patent/CA2427872A1/en not_active Abandoned
- 2001-12-07 AU AU3089302A patent/AU3089302A/xx active Pending
- 2001-12-07 PL PL01363301A patent/PL363301A1/xx not_active Application Discontinuation
- 2001-12-07 EP EP01991150A patent/EP1341787A2/en not_active Withdrawn
- 2001-12-07 NZ NZ525570A patent/NZ525570A/en unknown
- 2001-12-07 WO PCT/US2001/048535 patent/WO2002048143A2/en not_active Ceased
- 2001-12-13 PE PE2001001249A patent/PE20020708A1/es not_active Application Discontinuation
- 2001-12-14 US US10/020,709 patent/US6509349B1/en not_active Expired - Fee Related
- 2001-12-14 AR ARP010105793A patent/AR031808A1/es unknown
-
2002
- 2002-11-22 US US10/302,247 patent/US20030171587A1/en not_active Abandoned
-
2003
- 2003-06-12 NO NO20032666A patent/NO20032666L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0303457A3 (en) | 2008-05-28 |
| HUP0303457A2 (hu) | 2004-01-28 |
| BR0116205A (pt) | 2003-12-23 |
| WO2002048143A3 (en) | 2003-03-13 |
| WO2002048143A2 (en) | 2002-06-20 |
| CA2427872A1 (en) | 2002-06-20 |
| AU3089302A (en) | 2002-06-24 |
| IL155678A0 (en) | 2003-11-23 |
| JP2004515549A (ja) | 2004-05-27 |
| AU2002230893B2 (en) | 2005-06-09 |
| NO20032666D0 (no) | 2003-06-12 |
| US6509349B1 (en) | 2003-01-21 |
| US20030171587A1 (en) | 2003-09-11 |
| NO20032666L (no) | 2003-08-14 |
| NZ525570A (en) | 2005-04-29 |
| AR031808A1 (es) | 2003-10-01 |
| PL363301A1 (en) | 2004-11-15 |
| EP1341787A2 (en) | 2003-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |