AR053587A1 - Derivados de pirazol - Google Patents
Derivados de pirazolInfo
- Publication number
- AR053587A1 AR053587A1 ARP060101529A ARP060101529A AR053587A1 AR 053587 A1 AR053587 A1 AR 053587A1 AR P060101529 A ARP060101529 A AR P060101529A AR P060101529 A ARP060101529 A AR P060101529A AR 053587 A1 AR053587 A1 AR 053587A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heteroatom
- optionally substituted
- halo
- cycloalkyl
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 2
- 208000000450 Pelvic Pain Diseases 0.000 abstract 2
- 208000005641 Adenomyosis Diseases 0.000 abstract 1
- 208000004483 Dyspareunia Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010046798 Uterine leiomyoma Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000009274 endometriosis of uterus Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 201000010260 leiomyoma Diseases 0.000 abstract 1
- 208000007106 menorrhagia Diseases 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/28—Two oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos de formula (1) o derivados farmacéuticamente aceptables de los mismos, en la que R1 representa H, alquilo C1-6, alquilC1-6-oxi, cicloalquilo C3-8 o halo; R2 representa H, alquilo C1-6 (opcionalmente sustituido con R3), fenilo (opcionalmente sustituido con CN) o het; R3 representa OH, CN, Het, -R4-alquilo C1-6 o CONR5R6; R4 representa -CO2- o -O-; R5 y R6 representan independientemente H, alquilo C1-6 (opcionalmente sustituido con OR7) cicloalquilo C3-8; R7 representa H o alquilo C1-6; Het representa un grupo heterocíclico aromático de 5 o 6 miembros que contiene (i) de 1 a 4 heteroátomo(s) de N o (ii) 1 o 2 heteroátomo(s) de N y un heteroátomo de O o uno de S o (ii) 1 o 2 heteroátomo(s) de O o S, estando dicho grupo heterocíclico opcionalmente sustituido con 1 o más grupos seleccionados entre CN y alquilo C1-6; R8 representa alquilo C1-6, alquil C1-6-oxi, cicloalquilo C3-8 o halo; R9 y R10 representan independientemente H, alquilo C1-6, alquil C1-6-oxi, CN, CF3 o halo; pueden ser utiles para tratar endometriosis, fibroides uterinos (leiomiomata), menorragia, adenomiosis, dismenorrea primaria y secundaria (incluyendo síntomas de dispareunia, disquexia y dolor pélvico cronico), o síndrome de dolor pélvico cronico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67354405P | 2005-04-20 | 2005-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR053587A1 true AR053587A1 (es) | 2007-05-09 |
Family
ID=35044974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060101529A AR053587A1 (es) | 2005-04-20 | 2006-04-18 | Derivados de pirazol |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7482375B2 (es) |
| EP (1) | EP1874732A1 (es) |
| JP (1) | JP2008536910A (es) |
| AR (1) | AR053587A1 (es) |
| CA (1) | CA2604218A1 (es) |
| DO (1) | DOP2006000088A (es) |
| GT (1) | GT200600155A (es) |
| NL (1) | NL1031626C2 (es) |
| PE (1) | PE20061316A1 (es) |
| TW (1) | TW200716609A (es) |
| UY (1) | UY29486A1 (es) |
| WO (1) | WO2006111856A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU714980B2 (en) | 1996-07-24 | 2000-01-13 | Warner-Lambert Company Llc | Isobutylgaba and its derivatives for the treatment of pain |
| US20100087407A1 (en) * | 2006-08-04 | 2010-04-08 | James Symons | use of aromatase inhibitors |
| US20080096950A1 (en) * | 2006-10-19 | 2008-04-24 | Karl Richard Gibson | Compounds Useful In Therapy |
| PE20081803A1 (es) * | 2007-03-09 | 2008-12-11 | Wyeth Corp | Sintesis y caracterizacion de la forma ii polimorfica de 4-(2-(4,4-dimetil-2-oxooxazolidin-3-il)tiazol-4-il)benzonitrilo |
| WO2008135824A1 (en) * | 2007-05-02 | 2008-11-13 | Pfizer Limited | Oxyalkylpyrazole compounds useful in therapy |
| WO2009075838A2 (en) * | 2007-12-10 | 2009-06-18 | Meditrina Pharmaceuticals, Inc. | Treatment of menorrhagia with aromatase inhibitor |
| US20090270361A1 (en) * | 2008-03-26 | 2009-10-29 | Takeda Pharmaceutical Company Limited | Substituted pyrazole derivatives and use thereof |
| JP2010043063A (ja) | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
| EP2350017A1 (en) * | 2008-09-18 | 2011-08-03 | Pfizer Limited | Amide compounds useful in therapy |
| US20150272622A1 (en) * | 2011-12-22 | 2015-10-01 | Previvo Genetics, Llc | Recovery and processing of human embryos formed in vivo |
| BR112014029131B1 (pt) | 2012-05-31 | 2021-03-09 | Allergan Pharmaceuticals International Limited | cápsula de mucoadesivo |
| HK1211852A1 (en) | 2012-11-02 | 2016-06-03 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
| EP2929883A1 (en) | 2014-04-08 | 2015-10-14 | Institut Pasteur | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors |
| US20170037014A1 (en) * | 2014-05-06 | 2017-02-09 | E. I. Du Pont De Nemours And Company | Fungicidal pyrazoles |
| RU2017112748A (ru) | 2014-11-17 | 2018-12-19 | Арно Терапьютикс, Инк. | Композиции онапристона пролонгированного действия и способы |
| US10308676B2 (en) | 2015-09-25 | 2019-06-04 | Context Biopharma Inc. | Methods of making onapristone intermediates |
| CN108883067B (zh) | 2015-12-15 | 2021-03-09 | 康特斯生物制药公司 | 非晶奥那司酮组合物及其制备方法 |
| WO2018102369A1 (en) | 2016-11-30 | 2018-06-07 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
| US20230414492A1 (en) * | 2019-04-02 | 2023-12-28 | Nose To Brain Therapeutics Llc | Intranasal delivery of cannabidiol to treat central nervous system disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3621024C2 (de) * | 1986-06-20 | 1999-10-28 | Schering Ag | 11beta-Phenylestradiene, deren Herstellung und diese enthaltende pharmazeutische Präparate |
| BRPI0208811B8 (pt) | 2001-04-10 | 2021-05-25 | Pfizer | derivados de pirazol, seu uso e processo de preparação, bem como composição farmacêutica compreendendo os mesmos |
| US6933312B2 (en) * | 2002-10-07 | 2005-08-23 | Agouron Pharmaceuticals, Inc. | Pyrazole derivatives |
-
2006
- 2006-04-10 WO PCT/IB2006/001096 patent/WO2006111856A1/en not_active Ceased
- 2006-04-10 EP EP06744619A patent/EP1874732A1/en not_active Withdrawn
- 2006-04-10 CA CA002604218A patent/CA2604218A1/en not_active Abandoned
- 2006-04-10 JP JP2008507193A patent/JP2008536910A/ja active Pending
- 2006-04-11 DO DO2006000088A patent/DOP2006000088A/es unknown
- 2006-04-18 US US11/408,286 patent/US7482375B2/en not_active Expired - Fee Related
- 2006-04-18 AR ARP060101529A patent/AR053587A1/es unknown
- 2006-04-19 NL NL1031626A patent/NL1031626C2/nl not_active IP Right Cessation
- 2006-04-19 UY UY29486A patent/UY29486A1/es not_active Application Discontinuation
- 2006-04-19 GT GT200600155A patent/GT200600155A/es unknown
- 2006-04-19 PE PE2006000409A patent/PE20061316A1/es not_active Application Discontinuation
- 2006-04-19 TW TW095113963A patent/TW200716609A/zh unknown
-
2008
- 2008-12-12 US US12/333,533 patent/US20090099209A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008536910A (ja) | 2008-09-11 |
| US20090099209A1 (en) | 2009-04-16 |
| NL1031626C2 (nl) | 2007-03-19 |
| TW200716609A (en) | 2007-05-01 |
| CA2604218A1 (en) | 2006-10-26 |
| US20060241125A1 (en) | 2006-10-26 |
| NL1031626A1 (nl) | 2006-10-23 |
| WO2006111856A1 (en) | 2006-10-26 |
| DOP2006000088A (es) | 2006-10-31 |
| EP1874732A1 (en) | 2008-01-09 |
| PE20061316A1 (es) | 2007-01-13 |
| GT200600155A (es) | 2007-04-18 |
| UY29486A1 (es) | 2006-11-30 |
| US7482375B2 (en) | 2009-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |