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PE20020692A1 - Compuestos derivados de benzotiofeno y su procedimiento de obtencion - Google Patents

Compuestos derivados de benzotiofeno y su procedimiento de obtencion

Info

Publication number
PE20020692A1
PE20020692A1 PE2001001181A PE2001001181A PE20020692A1 PE 20020692 A1 PE20020692 A1 PE 20020692A1 PE 2001001181 A PE2001001181 A PE 2001001181A PE 2001001181 A PE2001001181 A PE 2001001181A PE 20020692 A1 PE20020692 A1 PE 20020692A1
Authority
PE
Peru
Prior art keywords
alkyl
benzothiophene
thiofen
piperazin
propan
Prior art date
Application number
PE2001001181A
Other languages
English (en)
Inventor
Castillo Nieto Juan Carlos Del
Aldaz Berta Lasheras
Vega Antonio Monge
Mancini Marisabel Mourelle
Rio Zambrana Joaquin Del
Original Assignee
Vita Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Lab filed Critical Vita Lab
Publication of PE20020692A1 publication Critical patent/PE20020692A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Thin Film Transistor (AREA)

Abstract

SE REFIERE A DERIVADOS DE BENZOTIOFENO DE FORMULA I; DONDE n ES 1-3; Z ES CO, CHOH, R1 ES H, ALQUILO C1-C6, HALOGENO, OR2, NITRO, CIANO, NR3R4, COR2, COOR2, OCOR2, SO2NR3R4, SO2R2, SR2, CONR3R4; R2 ES H, ALQUILO C1-C6, FENILO; R3 Y R4 SON H, ALQUILO C1-C6, FENILO, R3 Y R4 FORMAN JUNTOS MORFOLINA, TIOMORFOLINA, PIPERAZINA; Ar ES UN SISTEMA BICICLICO OPCIONALMENTE SUSTITUIDO POR UN ANILLO HETEROCICLICO BENZOCONDENSADO DE 5 A 7 MIEMBROS. SON COMPUESTOS PREFERIDOS 1-(5-NITROBENZO[b]TIOFEN-3-IL)-3-[4-(2,3-DIHIDRO-1,4-BENZODIOXIN-5-IL)PIPERAZIN-1-IL]PROPAN-1-ONA; 1-(5-FLUOROBENZO[b]TIOFEN-3-IL)-3-[4-(QUINOL-8-IL)PIPERAZIN-1-IL]PROPAN-1-OL, ENTRE OTROS. LOS COMPUESTOS SON INHIBIDORES DE LA RECEPTACION DE SEROTONINA Y MUESTRAN AFINIDAD POR EL RECEPTOR 5-HT1 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE TRASTORNOS NEUROLOGICOS COMO DEPRESION, PSICOSIS, TRASTORNOS DE ANSIEDAD, PANICO, OBSESIVOS COMPULSIVOS, ALIMENTARIOS
PE2001001181A 2000-11-29 2001-11-26 Compuestos derivados de benzotiofeno y su procedimiento de obtencion PE20020692A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002914A ES2188344B1 (es) 2000-11-29 2000-11-29 Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.

Publications (1)

Publication Number Publication Date
PE20020692A1 true PE20020692A1 (es) 2002-09-02

Family

ID=8495887

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001181A PE20020692A1 (es) 2000-11-29 2001-11-26 Compuestos derivados de benzotiofeno y su procedimiento de obtencion

Country Status (35)

Country Link
US (1) US20040034219A1 (es)
EP (1) EP1337528B1 (es)
JP (1) JP2004514719A (es)
KR (1) KR20030066689A (es)
CN (1) CN1478088A (es)
AP (1) AP2003002801A0 (es)
AR (1) AR034009A1 (es)
AT (1) ATE272634T1 (es)
AU (1) AU2002215157A1 (es)
BG (1) BG107851A (es)
BR (1) BR0115708A (es)
CA (1) CA2429892A1 (es)
CZ (1) CZ20031398A3 (es)
DE (1) DE60104717T2 (es)
EA (1) EA200300519A1 (es)
EE (1) EE200300245A (es)
ES (2) ES2188344B1 (es)
GE (1) GEP20043366B (es)
HR (1) HRP20030407A2 (es)
HU (1) HUP0303568A3 (es)
IL (1) IL155966A0 (es)
IS (1) IS6824A (es)
MA (1) MA26963A1 (es)
MX (1) MXPA03004875A (es)
NO (1) NO20032332L (es)
NZ (1) NZ525950A (es)
OA (1) OA12536A (es)
PE (1) PE20020692A1 (es)
PL (1) PL362982A1 (es)
PT (1) PT1337528E (es)
SI (1) SI1337528T1 (es)
SK (1) SK6202003A3 (es)
TR (1) TR200402779T4 (es)
WO (1) WO2002044170A2 (es)
ZA (1) ZA200303858B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1408976T5 (da) 2001-07-20 2011-01-10 Psychogenics Inc Behandling af ADHD (Attention deficit hyperactivity disorder)
AR039127A1 (es) 2002-03-27 2005-02-09 Glaxo Group Ltd Compuesto de quinolina, procedimiento para su preparacion, composicion farmaceutica que lo comprende y uso del mismo para la fabricacion de un medicamento
CA2512022A1 (en) 2003-01-13 2004-07-29 Dynogen Pharmaceuticals, Inc. Method of treating nausea, vomiting, retching or any combination thereof
US7276603B2 (en) * 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
MXPA06000795A (es) 2003-07-22 2006-08-23 Arena Pharm Inc Derivados de diaril y arilheteroaril urea como moduladores del receptor 5-ht2a de serotonina utiles para la profilaxis y tratamiento de desordenes relacionados con el mismo.
DE102004023635A1 (de) * 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023506A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023508A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Säurederivate substituierter Cyclohexyl-1,4-diamine
DE102004023501A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023507A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexylessigsäure-Derivate
DE102004023632A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Substituierte Cyclohexylcarbonsäure-Derivate
DE102004023522A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexyl-1,4-diamin-Derivate
US7881267B2 (en) * 2004-06-04 2011-02-01 Hewlett-Packard Development Company, L.P. Portable computing device for wireless communications and method of operation
DE102004063797A1 (de) * 2004-12-30 2006-07-13 Schwarz Pharma Ag Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
EP2508177A1 (en) 2007-12-12 2012-10-10 Glaxo Group Limited Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
CN101619056B (zh) 2008-07-02 2013-07-17 石药集团中奇制药技术（石家庄）有限公司 苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁症药物的应用
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
EP3027607B1 (en) 2013-07-29 2020-08-26 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
WO2016192657A1 (en) 2015-06-03 2016-12-08 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
MX388281B (es) 2015-06-12 2025-03-11 Axovant Sciences Gmbh Derivados de diaril y arilheteroaril urea como moduladores del receptor 5ht2a de serotonina útiles para la profilaxis y el tratamiento de un trastorno conductual del sueño rem.
HK1247555A1 (zh) 2015-07-15 2018-09-28 Axovant Sciences Gmbh 用於预防和治疗与神经变性疾病相关的幻觉的作为5-ht2a血清素受体的调节剂的二芳基脲和芳基杂芳基脲衍生物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
ZA929008B (en) * 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5693804A (en) * 1994-11-17 1997-12-02 Molecular Geriatrics Corporation Substituted 1-aryl-3-piperazin-1'-yl propanones
US5658909A (en) * 1994-11-17 1997-08-19 Molecular Geriatrics Corporation Certain substituted 1-aryl-3-piperazin-1'-yl propanones to treat Alzheimer's Disease
ES2128266B1 (es) * 1997-07-08 2000-01-16 Vita Invest Sa Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.

Also Published As

Publication number Publication date
ZA200303858B (en) 2004-05-19
SK6202003A3 (en) 2004-05-04
CA2429892A1 (en) 2002-06-06
SI1337528T1 (en) 2005-02-28
PL362982A1 (en) 2004-11-02
PT1337528E (pt) 2004-11-30
MA26963A1 (fr) 2004-12-20
AR034009A1 (es) 2004-01-21
AP2003002801A0 (en) 2003-06-30
IS6824A (is) 2003-05-22
HUP0303568A2 (hu) 2004-03-01
GEP20043366B (en) 2004-04-13
CZ20031398A3 (cs) 2004-01-14
WO2002044170A3 (en) 2002-09-06
MXPA03004875A (es) 2005-02-14
HRP20030407A2 (en) 2004-08-31
EP1337528A2 (en) 2003-08-27
ES2225623T3 (es) 2005-03-16
DE60104717D1 (de) 2004-09-09
AU2002215157A1 (en) 2002-06-11
ES2188344A1 (es) 2003-06-16
TR200402779T4 (tr) 2004-11-22
BR0115708A (pt) 2004-02-03
DE60104717T2 (de) 2006-04-06
CN1478088A (zh) 2004-02-25
OA12536A (en) 2006-06-05
US20040034219A1 (en) 2004-02-19
ES2188344B1 (es) 2004-09-16
NZ525950A (en) 2004-11-26
KR20030066689A (ko) 2003-08-09
JP2004514719A (ja) 2004-05-20
NO20032332D0 (no) 2003-05-22
EP1337528B1 (en) 2004-08-04
EE200300245A (et) 2003-08-15
BG107851A (bg) 2004-06-30
NO20032332L (no) 2003-05-22
WO2002044170A2 (en) 2002-06-06
HUP0303568A3 (en) 2005-02-28
IL155966A0 (en) 2003-12-23
ATE272634T1 (de) 2004-08-15
EA200300519A1 (ru) 2003-12-25

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