PE20020676A1 - Compuestos de mutilina como antibacterianos - Google Patents
Compuestos de mutilina como antibacterianosInfo
- Publication number
- PE20020676A1 PE20020676A1 PE2001000905A PE2001000905A PE20020676A1 PE 20020676 A1 PE20020676 A1 PE 20020676A1 PE 2001000905 A PE2001000905 A PE 2001000905A PE 2001000905 A PE2001000905 A PE 2001000905A PE 20020676 A1 PE20020676 A1 PE 20020676A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- mutilin
- amino
- alkyl
- antibacterial
- Prior art date
Links
- STZYTFJPGGDRJD-NHUWBDDWSA-N retapamulin Chemical class C([C@H]([C@@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CS[C@@H]3C[C@H]4CC[C@H](N4C)C3)C)C[C@]32[C@H]1C(=O)CC3 STZYTFJPGGDRJD-NHUWBDDWSA-N 0.000 title abstract 3
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- -1 PYRROLIDINYL Chemical class 0.000 abstract 4
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052805 deuterium Inorganic materials 0.000 abstract 2
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 1
- OBUUFWIMEGVAQS-UHFFFAOYSA-N Pleuromutenol Natural products CC1C(O)C(C)(C=C)CC(O)C2(C)C(C)CCC31C2C(=O)CC3 OBUUFWIMEGVAQS-UHFFFAOYSA-N 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229960002771 retapamulin Drugs 0.000 abstract 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE MUTILINA DE FORMULA I DONDE R Y R2 JUNTO CON N FORMAN PIRROLIDINILO, PIPERIDINILO; R1 ES C(=X)(R9); R3 Y R3' SON H, DEUTERIO, HALOGENO; R4, R5, R10 SON H, ALQUILO; R6, R7, R8 SON H, DEUTERIO; R9 ES AMINO, ALQUILO, ARILO, HETEROCICLILO, MERCAPTO; SI X ES O; R9 ES H; X ES S, O, NR10, N+(R10')2; R10' ES ALQUILO; Y ES S, O; m ES 0-2; CUANDO R Y R2 JUNTO A N FORMAN PIPERIDINILO; m ES O, Y ES S; Y ESTA UNIDO EN A LA POSICION 3 DEL ANILLO DE PIPERIDINA. SON COMPUESTOS PREFERIDOS 14-O-[(N)-(3-METIL-2-AMINO-BUTIRIL-PIPERIDIN-3-IL)SULFANIL)-ACETIL]MUTILINA, 14-O-[(N-(3-METIL-2-AMINO-BUTIRIL-PIPERIDIN-4-IL)SULFANIL)-ACETIL]MUTILINA, ENTRE OTROS. LOS COMPUESTOS PUEDEN SER UTILES COMO AGENTES ANTIBACTERIANOS
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0022439A GB0022439D0 (en) | 2000-09-13 | 2000-09-13 | Organic compounds |
| GB0022440A GB0022440D0 (en) | 2000-09-13 | 2000-09-13 | Organic Compounds |
| GB0024674A GB0024674D0 (en) | 2000-10-09 | 2000-10-09 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020676A1 true PE20020676A1 (es) | 2002-08-27 |
Family
ID=27255885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000905A PE20020676A1 (es) | 2000-09-13 | 2001-09-10 | Compuestos de mutilina como antibacterianos |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7169804B2 (es) |
| EP (1) | EP1320525B1 (es) |
| JP (1) | JP5134181B2 (es) |
| CN (1) | CN1288134C (es) |
| AR (1) | AR030651A1 (es) |
| AT (1) | ATE264843T1 (es) |
| AU (1) | AU2001291854A1 (es) |
| BR (1) | BRPI0113837B8 (es) |
| CA (1) | CA2418538C (es) |
| DE (1) | DE60102936T2 (es) |
| ES (1) | ES2220809T3 (es) |
| MY (1) | MY133930A (es) |
| PE (1) | PE20020676A1 (es) |
| PT (1) | PT1320525E (es) |
| TW (1) | TWI306852B (es) |
| WO (1) | WO2002022580A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9918037D0 (en) * | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
| GB0207495D0 (en) * | 2002-03-28 | 2002-05-08 | Biochemie Gmbh | Organic compounds |
| GB0209262D0 (en) | 2002-04-23 | 2002-06-05 | Biochemie Gmbh | Organic compounds |
| MXPA05000984A (es) * | 2002-07-24 | 2005-09-12 | Sandoz Ag | Derivados de pleuromutilina como antimicrobianos. |
| GB0308114D0 (en) * | 2003-04-08 | 2003-05-14 | Glaxo Group Ltd | Novel compounds |
| US7544963B2 (en) * | 2005-04-29 | 2009-06-09 | Cree, Inc. | Binary group III-nitride based high electron mobility transistors |
| GB0513058D0 (en) * | 2005-06-27 | 2005-08-03 | Sandoz Ag | Organic compounds |
| WO2007037518A1 (ja) * | 2005-09-29 | 2007-04-05 | Dainippon Sumitomo Pharma Co., Ltd. | ムチリン誘導体及びそれを含有する医薬組成物 |
| EP1808431A1 (en) * | 2006-01-16 | 2007-07-18 | Nabriva Therapeutics Forschungs GmbH | Mutilin derivatives and their use as pharmaceutical |
| AU2007256844A1 (en) * | 2006-06-05 | 2007-12-13 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted erythromycin analogs |
| EP1908750A1 (en) * | 2006-10-05 | 2008-04-09 | Nabriva Therapeutics Forschungs GmbH | Process for the preparation of pleuromutilins |
| JP5322927B2 (ja) | 2007-05-24 | 2013-10-23 | 杏林製薬株式会社 | １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 |
| WO2010056855A1 (en) * | 2008-11-13 | 2010-05-20 | Teva Pharmaceutical Industries Ltd. | Preparation of retapamulin via its pleuromutilin-thiol precursor |
| CN103709115A (zh) * | 2012-10-09 | 2014-04-09 | 山东亨利医药科技有限责任公司 | 截短侧耳素类抗生素衍生物 |
| TWI762573B (zh) | 2017-02-10 | 2022-05-01 | 奧地利商納畢瓦治療有限責任公司 | 截短側耳素之純化 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE789629A (fr) | 1971-10-05 | 1973-04-03 | Sandoz Sa | Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique |
| DE2811314A1 (de) * | 1978-03-16 | 1979-09-27 | Sandoz Ag | Kokzidiostatisches kombinationspraeparat |
| ZA80175B (en) * | 1979-01-12 | 1981-08-26 | Sandoz Ltd | New pleuromutilin derivatives, their production and use |
| CY1353A (en) | 1979-01-12 | 1987-04-24 | Sandoz Ag | New pleuromutilin derivatives, their production and use |
| EP0153277B1 (de) * | 1984-02-17 | 1987-08-26 | Sandoz Ag | Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| JP3054875B2 (ja) * | 1995-02-13 | 2000-06-19 | 株式会社小松製作所 | プラズマトーチ |
| BR9612426A (pt) * | 1996-01-03 | 1999-07-13 | Smithkline Beecham Plc | Derivados carbomoilóxi e sua aplicação como antibacterianos |
| UY25225A1 (es) * | 1997-10-29 | 2000-12-29 | Smithkline Beecham Plc | Derivados de pleuromutilina utiles como agentes antimicrobianos |
| WO2000027790A1 (en) | 1998-11-11 | 2000-05-18 | Smithkline Beecham P.L.C. | Mutilin compounds |
| AU3036200A (en) | 1998-12-18 | 2000-07-12 | Smithkline Beecham Plc | Mutilin 14-ester derivatives having antibacterial activity |
| GB9918037D0 (en) * | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
| GB0207495D0 (en) * | 2002-03-28 | 2002-05-08 | Biochemie Gmbh | Organic compounds |
| MXPA05000984A (es) * | 2002-07-24 | 2005-09-12 | Sandoz Ag | Derivados de pleuromutilina como antimicrobianos. |
-
2001
- 2001-09-10 PE PE2001000905A patent/PE20020676A1/es not_active Application Discontinuation
- 2001-09-11 US US10/363,840 patent/US7169804B2/en not_active Expired - Lifetime
- 2001-09-11 CN CNB018155766A patent/CN1288134C/zh not_active Expired - Lifetime
- 2001-09-11 EP EP01972046A patent/EP1320525B1/en not_active Expired - Lifetime
- 2001-09-11 AR ARP010104289A patent/AR030651A1/es not_active Application Discontinuation
- 2001-09-11 DE DE60102936T patent/DE60102936T2/de not_active Expired - Lifetime
- 2001-09-11 TW TW090122488A patent/TWI306852B/zh not_active IP Right Cessation
- 2001-09-11 AT AT01972046T patent/ATE264843T1/de active
- 2001-09-11 JP JP2002526833A patent/JP5134181B2/ja not_active Expired - Lifetime
- 2001-09-11 WO PCT/EP2001/010502 patent/WO2002022580A1/en not_active Ceased
- 2001-09-11 BR BRPI0113837 patent/BRPI0113837B8/pt not_active IP Right Cessation
- 2001-09-11 CA CA002418538A patent/CA2418538C/en not_active Expired - Lifetime
- 2001-09-11 AU AU2001291854A patent/AU2001291854A1/en not_active Abandoned
- 2001-09-11 PT PT01972046T patent/PT1320525E/pt unknown
- 2001-09-11 MY MYPI20014254 patent/MY133930A/en unknown
- 2001-09-11 ES ES01972046T patent/ES2220809T3/es not_active Expired - Lifetime
-
2007
- 2007-01-12 US US11/652,812 patent/US7569587B2/en not_active Expired - Lifetime
-
2009
- 2009-04-07 US US12/384,580 patent/US20090209584A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1320525A1 (en) | 2003-06-25 |
| US7169804B2 (en) | 2007-01-30 |
| ES2220809T3 (es) | 2004-12-16 |
| CN1633415A (zh) | 2005-06-29 |
| AU2001291854A1 (en) | 2002-03-26 |
| DE60102936D1 (de) | 2004-05-27 |
| CA2418538A1 (en) | 2002-03-21 |
| BR0113837A (pt) | 2003-06-03 |
| DE60102936T2 (de) | 2005-03-24 |
| ATE264843T1 (de) | 2004-05-15 |
| CA2418538C (en) | 2009-12-22 |
| TWI306852B (en) | 2009-03-01 |
| BRPI0113837B8 (pt) | 2021-05-25 |
| US20070135483A1 (en) | 2007-06-14 |
| US7569587B2 (en) | 2009-08-04 |
| WO2002022580A1 (en) | 2002-03-21 |
| HK1079506A1 (en) | 2006-04-07 |
| MY133930A (en) | 2007-11-30 |
| PT1320525E (pt) | 2004-09-30 |
| AR030651A1 (es) | 2003-08-27 |
| US20040102482A1 (en) | 2004-05-27 |
| CN1288134C (zh) | 2006-12-06 |
| JP2004509107A (ja) | 2004-03-25 |
| JP5134181B2 (ja) | 2013-01-30 |
| BRPI0113837B1 (pt) | 2019-01-29 |
| US20090209584A1 (en) | 2009-08-20 |
| EP1320525B1 (en) | 2004-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |