AR021970A1 - Inhibidores de proteasas - Google Patents
Inhibidores de proteasasInfo
- Publication number
- AR021970A1 AR021970A1 ARP990106647A ARP990106647A AR021970A1 AR 021970 A1 AR021970 A1 AR 021970A1 AR P990106647 A ARP990106647 A AR P990106647A AR P990106647 A ARP990106647 A AR P990106647A AR 021970 A1 AR021970 A1 AR 021970A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- het
- cycloalkyl
- independently selected
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 25
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 11
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 102200160920 rs35304565 Human genes 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
El presente proporciona compuestos de Formula (1) en la que: A se selecciona entre el grupo que consta de C(O) y CH(OH); R1 se selecciona entre el grupoque consta de las formulas (2), (3), (4) y (5); R2 se selecciona entre el grupo que consta de H, alquilo C1-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6,het-alquilo C0-6, R9C(O)-, R9C(S)-, R9SO2-, R9OC(O)-, R9R12NC(O)-, R9R12NC(S)-, R12HNCH(R12)C(O)-, R9OC(O)NR12CH(R12)C(O)-, adamantil-C(O)-, o un grupo deformula (6); R se selecciona entre el grupo que consta de H, alquilo C1-6, Ar-alquilo C0-6, y Het-alquilo C0-6; R se selecciona entre el grupo que constade H, alquilo 1-6, cicloalquil C3-6-alquilo C1-6, Ar-alquilo C0-6, y Het-alquilo C0-6; R3 y R8 se seleccionan independientemente entre el grupo que consta deH, alquenilo C2-6, alquinilo C2-6, Het, Ar o alquilo C1-6 opcionalmente sustituido con OR13, SR13, NR132, R13NC(O)OR5, CO2R13, CO2NR132, N(C=NH)NH2, Het y Ar;R4 se selecciona entre el grupo que consta de H, alquilo C1-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6, Het-alquilo C0-6, R5C(O)-, R5C(S)-, R5SO2-,R5OC(O)-, R5R14NC(O)-, R5R14NC(S)-, R14HNCH(R14)C(O)- y R5OC(O)NR14CH(R14)C(O)-; R5, R9 y R10 se seleccionan independientemente entre el grupo que consta dealquiloC1-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6, y Het-alquilo C0-6; R6 se selecciona entre el grupo que consta de H, alquilo C1-6, Ar-alquiloC0-6 y Het-alquilo C0-6; R7 se selecciona entre el grupo que consta de H, alquilo C1-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6, Het-alquilo C0-6,R10C(O)-, R10C(S)-, R10SO2-, R10OC(O)-, R10R15NC(O)-, R10R15NC(S)-, R15HNCH(R15)C(O)-, y R10OC(O)NR15CH(R15)C(O)-; o R6 y R7 se conectan para formar un anillode pirrolidina, piperidina o morfolina; cada R se selecciona independientemente entre el grupo que consta de H, alquilo C1-6, Ar-alquilo C0-6 y Het-alquiloC0-6; R11 es Ar; R12, R13, R14 y R15 se seleccionan independientemente entre el grupo que consta de H, alquilo C1-6, Ar-alquilo C0-6 y Het-alquilo C0-6; R* seselecciona entre el grupo que consta de H, alquilo C1-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6 y Het-alquilo C0-6; Z se selecciona entre el grupo que
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11414398P | 1998-12-23 | 1998-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021970A1 true AR021970A1 (es) | 2002-09-04 |
Family
ID=22353596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106647A AR021970A1 (es) | 1998-12-23 | 1999-12-21 | Inhibidores de proteasas |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1140897A4 (es) |
| JP (1) | JP2002533452A (es) |
| AR (1) | AR021970A1 (es) |
| AU (1) | AU2713100A (es) |
| CO (1) | CO5180541A1 (es) |
| DZ (1) | DZ2976A1 (es) |
| HK (1) | HK1041690A1 (es) |
| PE (1) | PE20001355A1 (es) |
| WO (1) | WO2000039115A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
| EP1232154A4 (en) | 1999-11-10 | 2004-06-23 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
| AU1474801A (en) | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
| AU1588901A (en) | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
| AU4344101A (en) | 2000-03-21 | 2001-10-03 | Smithkline Beecham Corp | Protease inhibitors |
| US6982263B2 (en) | 2001-06-08 | 2006-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitriles useful as reversible inhibitors of cysteine proteases |
| US7087604B2 (en) | 2002-03-08 | 2006-08-08 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| JP2008512461A (ja) * | 2004-09-07 | 2008-04-24 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
| JP5236293B2 (ja) * | 2005-01-13 | 2013-07-17 | ブリストル−マイヤーズ スクイブ カンパニー | Ｘｉａ因子阻害剤としての置換ビアリール化合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ2285A1 (fr) * | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
| KR20010012316A (ko) * | 1997-05-08 | 2001-02-15 | 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 | 프로테아제 억제제 |
-
1999
- 1999-12-16 CO CO99078651A patent/CO5180541A1/es not_active Application Discontinuation
- 1999-12-21 EP EP99968936A patent/EP1140897A4/en not_active Withdrawn
- 1999-12-21 AR ARP990106647A patent/AR021970A1/es unknown
- 1999-12-21 AU AU27131/00A patent/AU2713100A/en not_active Abandoned
- 1999-12-21 WO PCT/US1999/030602 patent/WO2000039115A1/en not_active Ceased
- 1999-12-21 JP JP2000591026A patent/JP2002533452A/ja not_active Withdrawn
- 1999-12-21 HK HK02101209.3A patent/HK1041690A1/zh unknown
- 1999-12-22 DZ DZ990276A patent/DZ2976A1/xx active
- 1999-12-23 PE PE1999001311A patent/PE20001355A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20001355A1 (es) | 2001-01-28 |
| AU2713100A (en) | 2000-07-31 |
| CO5180541A1 (es) | 2002-07-30 |
| WO2000039115A1 (en) | 2000-07-06 |
| HK1041690A1 (zh) | 2002-07-19 |
| EP1140897A1 (en) | 2001-10-10 |
| JP2002533452A (ja) | 2002-10-08 |
| EP1140897A4 (en) | 2002-04-03 |
| DZ2976A1 (fr) | 2004-03-15 |
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