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PE20010954A1 - Bencimidazoles, su preparacion y su empleo como medicamentos - Google Patents

Bencimidazoles, su preparacion y su empleo como medicamentos

Info

Publication number
PE20010954A1
PE20010954A1 PE2000001365A PE0013652000A PE20010954A1 PE 20010954 A1 PE20010954 A1 PE 20010954A1 PE 2000001365 A PE2000001365 A PE 2000001365A PE 0013652000 A PE0013652000 A PE 0013652000A PE 20010954 A1 PE20010954 A1 PE 20010954A1
Authority
PE
Peru
Prior art keywords
alkyl
preparation
benzhimidazoles
medicines
amidine
Prior art date
Application number
PE2000001365A
Other languages
English (en)
Inventor
Wolfgang Wienen
Norbert Hauel
Henning Priepke
Uwe Ries
Jean Marie Stassen
Herbert Nar
Iris Kauffmann-Hefner
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20010954A1 publication Critical patent/PE20010954A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A BENCIMIDAZOLES DE FORMULA I, DONDE Ra ES ALQUILO C1-C3 SUSTITUIDO CON FLUOR, PIRROLIDINOCARBONILO, AMINO, ALQUILO C1-C3, ENTRE OTROS; Rb ES ALQUILO C1-C3; Rc ES AMIDINO, CIANO, 1,2,4-OXADIZOL-3-ILO SUSTITUIDO EN POSICION 5 POR ALQUILO C1-C3, FENILO; SON COMPUESTOS PREFERIDOS 2-[4-(N-FENILCARBONIL-AMIDINO)-FENILAMINOMETIL]-1-METIL-5-[1-(n-BUTILOXICARBONILMETILAMINO)-1-(PIRROLIDINOCARBONIL)-ETIL]BENCIMIDAZOL, 2-(4-AMIDINOFENILAMINOMETIL)-1-METIL-5-[1-(TETRAZOL-5-IL-METILAMINO)-1-(PIRROLIDINOCARBONIL)-ETIL]BENCIMIDAZOL, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS I PUEDEN SER UTILES COMO ANTITROMBOTICOS
PE2000001365A 1999-12-23 2000-12-19 Bencimidazoles, su preparacion y su empleo como medicamentos PE20010954A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19962329A DE19962329A1 (de) 1999-12-23 1999-12-23 Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
PE20010954A1 true PE20010954A1 (es) 2001-10-09

Family

ID=7934028

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001365A PE20010954A1 (es) 1999-12-23 2000-12-19 Bencimidazoles, su preparacion y su empleo como medicamentos

Country Status (10)

Country Link
EP (1) EP1244636A1 (es)
JP (1) JP2003519129A (es)
AR (1) AR027050A1 (es)
AU (1) AU2011501A (es)
CA (1) CA2393916A1 (es)
DE (1) DE19962329A1 (es)
MX (1) MXPA02006299A (es)
PE (1) PE20010954A1 (es)
UY (1) UY26492A1 (es)
WO (1) WO2001047896A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10125478A1 (de) * 2001-05-25 2002-11-28 Boehringer Ingelheim Pharma Verwendung bicyclischer Heterocyclen zur Behandlung und Vorbeugung arterieller thrombotischer Erkrankungen
DE10227666A1 (de) * 2002-06-20 2004-01-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg (R)-2-(4-Amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)- ethyl]-benzimidazol, dessen Monohydrochlorid, Verfahren zu deren Herstellung sowie Verwendung als Arzneimittel
US7169934B2 (en) 2002-06-20 2007-01-30 Boehringer Ingelheim International Gmbh (R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
PE20040804A1 (es) * 2002-12-19 2004-12-31 Boehringer Ingelheim Pharma DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa
US7371743B2 (en) 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
EP1609784A1 (de) * 2004-06-25 2005-12-28 Boehringer Ingelheim Pharma GmbH & Co.KG Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen
DE102005061624A1 (de) 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von Salzen von 4-(Benzimidazolylmethylamino)-Benzamidinen
DE102005061623A1 (de) 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen
US10077251B2 (en) 2012-10-29 2018-09-18 Biophore India Pharmaceuticals Pvt. Ltd. Process for the synthesis of Dabigatran Etexilate and its intermediates
WO2014068587A2 (en) * 2012-10-29 2014-05-08 Biophore India Pharmaceuticals Pvt. Ltd. An improved process for the synthesis of dabigatran and its intermediates
RU2623439C1 (ru) * 2016-10-14 2017-06-26 федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет" Бромиды 1-замещенных-3-{ [2-(3,5-ди-трет-4-гидроксифенил)-2-оксоэтил]} -2-аминобензимидазолия, обладающие антиагрегантными и антиоксидантными свойствами

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4129603A1 (de) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP1060166A1 (de) * 1998-02-03 2000-12-20 Boehringer Ingelheim Pharma KG 5-gliedrige benzokondensierte heterocyclen als antithrombotika
DE19829964A1 (de) * 1998-07-04 2000-01-05 Boehringer Ingelheim Pharma Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel
TWI248435B (en) * 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions

Also Published As

Publication number Publication date
CA2393916A1 (en) 2001-07-05
JP2003519129A (ja) 2003-06-17
AR027050A1 (es) 2003-03-12
WO2001047896A1 (de) 2001-07-05
MXPA02006299A (es) 2002-12-09
UY26492A1 (es) 2001-07-31
EP1244636A1 (de) 2002-10-02
DE19962329A1 (de) 2001-06-28
AU2011501A (en) 2001-07-09

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Legal Events

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