AR027050A1 - Bencimidazoles, su preparacion y su empleo como medicamentos - Google Patents
Bencimidazoles, su preparacion y su empleo como medicamentosInfo
- Publication number
- AR027050A1 AR027050A1 ARP000106819A ARP000106819A AR027050A1 AR 027050 A1 AR027050 A1 AR 027050A1 AR P000106819 A ARP000106819 A AR P000106819A AR P000106819 A ARP000106819 A AR P000106819A AR 027050 A1 AR027050 A1 AR 027050A1
- Authority
- AR
- Argentina
- Prior art keywords
- general formula
- preparation
- group
- valuable
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion se refiere a nuevos bencimidazoles de la formula general (1) en la que Ra a Rc están definidos como en la reivindicacion 1, sustautomeros, sus estereoisomeros, sus mezclas, sus profármacos, sus derivados que, en lugar de un grup o carboxi, contienen un grupo cargado negativamene encondiciones fisiologicas, y sus sales, en particular sus sales fisiologicamente compatibles, con ácidos o bases inorgánicos u orgánicos, que presentan valiosaspropiedades. Los compuestos de la form ula general (1) anterior, en los que Rc representa un grupo amidino, representan valiosos productos intermedios para lapreparacion de compuestos amidino de la formula general I que presentan valiosas propiedades farmacologicas, en particular un efect o antitrombotico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19962329A DE19962329A1 (de) | 1999-12-23 | 1999-12-23 | Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR027050A1 true AR027050A1 (es) | 2003-03-12 |
Family
ID=7934028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000106819A AR027050A1 (es) | 1999-12-23 | 2000-12-21 | Bencimidazoles, su preparacion y su empleo como medicamentos |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1244636A1 (es) |
| JP (1) | JP2003519129A (es) |
| AR (1) | AR027050A1 (es) |
| AU (1) | AU2011501A (es) |
| CA (1) | CA2393916A1 (es) |
| DE (1) | DE19962329A1 (es) |
| MX (1) | MXPA02006299A (es) |
| PE (1) | PE20010954A1 (es) |
| UY (1) | UY26492A1 (es) |
| WO (1) | WO2001047896A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10125478A1 (de) * | 2001-05-25 | 2002-11-28 | Boehringer Ingelheim Pharma | Verwendung bicyclischer Heterocyclen zur Behandlung und Vorbeugung arterieller thrombotischer Erkrankungen |
| DE10227666A1 (de) * | 2002-06-20 | 2004-01-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | (R)-2-(4-Amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)- ethyl]-benzimidazol, dessen Monohydrochlorid, Verfahren zu deren Herstellung sowie Verwendung als Arzneimittel |
| US7169934B2 (en) | 2002-06-20 | 2007-01-30 | Boehringer Ingelheim International Gmbh | (R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition |
| PE20040804A1 (es) * | 2002-12-19 | 2004-12-31 | Boehringer Ingelheim Pharma | DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa |
| US7371743B2 (en) | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
| EP1609784A1 (de) * | 2004-06-25 | 2005-12-28 | Boehringer Ingelheim Pharma GmbH & Co.KG | Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen |
| DE102005061623A1 (de) | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen |
| DE102005061624A1 (de) | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von Salzen von 4-(Benzimidazolylmethylamino)-Benzamidinen |
| US10077251B2 (en) | 2012-10-29 | 2018-09-18 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the synthesis of Dabigatran Etexilate and its intermediates |
| WO2014068587A2 (en) * | 2012-10-29 | 2014-05-08 | Biophore India Pharmaceuticals Pvt. Ltd. | An improved process for the synthesis of dabigatran and its intermediates |
| RU2623439C1 (ru) * | 2016-10-14 | 2017-06-26 | федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет" | Бромиды 1-замещенных-3-{ [2-(3,5-ди-трет-4-гидроксифенил)-2-оксоэтил]} -2-аминобензимидазолия, обладающие антиагрегантными и антиоксидантными свойствами |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4129603A1 (de) * | 1991-09-06 | 1993-03-11 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| JP2002502844A (ja) * | 1998-02-03 | 2002-01-29 | ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト | ５員複素環縮合ベンゾ誘導体、その調製及び医薬品としてのそれらの使用 |
| DE19829964A1 (de) * | 1998-07-04 | 2000-01-05 | Boehringer Ingelheim Pharma | Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel |
| TWI248435B (en) * | 1998-07-04 | 2006-02-01 | Boehringer Ingelheim Pharma | Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions |
-
1999
- 1999-12-23 DE DE19962329A patent/DE19962329A1/de not_active Withdrawn
-
2000
- 2000-12-16 AU AU20115/01A patent/AU2011501A/en not_active Abandoned
- 2000-12-16 EP EP00983342A patent/EP1244636A1/de not_active Withdrawn
- 2000-12-16 CA CA002393916A patent/CA2393916A1/en not_active Abandoned
- 2000-12-16 JP JP2001549368A patent/JP2003519129A/ja active Pending
- 2000-12-16 WO PCT/EP2000/012841 patent/WO2001047896A1/de not_active Ceased
- 2000-12-16 MX MXPA02006299A patent/MXPA02006299A/es unknown
- 2000-12-19 PE PE2000001365A patent/PE20010954A1/es not_active Application Discontinuation
- 2000-12-20 UY UY26492A patent/UY26492A1/es not_active Application Discontinuation
- 2000-12-21 AR ARP000106819A patent/AR027050A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001047896A1 (de) | 2001-07-05 |
| DE19962329A1 (de) | 2001-06-28 |
| PE20010954A1 (es) | 2001-10-09 |
| UY26492A1 (es) | 2001-07-31 |
| MXPA02006299A (es) | 2002-12-09 |
| CA2393916A1 (en) | 2001-07-05 |
| AU2011501A (en) | 2001-07-09 |
| JP2003519129A (ja) | 2003-06-17 |
| EP1244636A1 (de) | 2002-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |