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AR027050A1 - BENCIMIDAZOLES, ITS PREPARATION AND ITS EMPLOYMENT AS MEDICATIONS - Google Patents

BENCIMIDAZOLES, ITS PREPARATION AND ITS EMPLOYMENT AS MEDICATIONS

Info

Publication number
AR027050A1
AR027050A1 ARP000106819A ARP000106819A AR027050A1 AR 027050 A1 AR027050 A1 AR 027050A1 AR P000106819 A ARP000106819 A AR P000106819A AR P000106819 A ARP000106819 A AR P000106819A AR 027050 A1 AR027050 A1 AR 027050A1
Authority
AR
Argentina
Prior art keywords
general formula
preparation
group
valuable
compounds
Prior art date
Application number
ARP000106819A
Other languages
Spanish (es)
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of AR027050A1 publication Critical patent/AR027050A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a nuevos bencimidazoles de la formula general (1) en la que Ra a Rc están definidos como en la reivindicacion 1, sustautomeros, sus estereoisomeros, sus mezclas, sus profármacos, sus derivados que, en lugar de un grup o carboxi, contienen un grupo cargado negativamene encondiciones fisiologicas, y sus sales, en particular sus sales fisiologicamente compatibles, con ácidos o bases inorgánicos u orgánicos, que presentan valiosaspropiedades. Los compuestos de la form ula general (1) anterior, en los que Rc representa un grupo amidino, representan valiosos productos intermedios para lapreparacion de compuestos amidino de la formula general I que presentan valiosas propiedades farmacologicas, en particular un efect o antitrombotico.The present invention relates to new benzimidazoles of the general formula (1) in which Ra to Rc are defined as in claim 1, sustautomers, their stereoisomers, their mixtures, their prodrugs, their derivatives that, instead of a group or carboxy, they contain a negatively charged group with physiological conditions, and their salts, in particular their physiologically compatible salts, with inorganic or organic acids or bases, which have valuable properties. The compounds of the above general formula (1), in which Rc represents an amidino group, represent valuable intermediates for the preparation of amidino compounds of the general formula I which present valuable pharmacological properties, in particular an effective or antithrombotic.

ARP000106819A 1999-12-23 2000-12-21 BENCIMIDAZOLES, ITS PREPARATION AND ITS EMPLOYMENT AS MEDICATIONS AR027050A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19962329A DE19962329A1 (en) 1999-12-23 1999-12-23 New substituted 2-(phenylaminomethyl)-benzimidazoles, used as thrombin inhibitors, serine protease inhibitors, antithrombotic agents and intermediates

Publications (1)

Publication Number Publication Date
AR027050A1 true AR027050A1 (en) 2003-03-12

Family

ID=7934028

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000106819A AR027050A1 (en) 1999-12-23 2000-12-21 BENCIMIDAZOLES, ITS PREPARATION AND ITS EMPLOYMENT AS MEDICATIONS

Country Status (10)

Country Link
EP (1) EP1244636A1 (en)
JP (1) JP2003519129A (en)
AR (1) AR027050A1 (en)
AU (1) AU2011501A (en)
CA (1) CA2393916A1 (en)
DE (1) DE19962329A1 (en)
MX (1) MXPA02006299A (en)
PE (1) PE20010954A1 (en)
UY (1) UY26492A1 (en)
WO (1) WO2001047896A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10125478A1 (en) * 2001-05-25 2002-11-28 Boehringer Ingelheim Pharma Treatment or prophylaxis of arterial thrombosis, using 5-quinolinesulfonylamino-benzimidazole derivatives having combined thrombin inhibiting and fibrinogen receptor inhibiting action
DE10227666A1 (en) * 2002-06-20 2004-01-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg (R) -2- (4-amidinophenylaminomethyl) -1-methyl-5- [1- (carboxymethylamino) -1- (pyrrolidinocarbonyl) ethyl] benzimidazole, its monohydrochloride, process for its preparation and use as a medicament
US7169934B2 (en) 2002-06-20 2007-01-30 Boehringer Ingelheim International Gmbh (R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
PE20040804A1 (en) * 2002-12-19 2004-12-31 Boehringer Ingelheim Pharma CARBOXAMID DERIVATIVES AS INHIBITORS OF THE Xa FACTOR
US7371743B2 (en) 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
EP1609784A1 (en) * 2004-06-25 2005-12-28 Boehringer Ingelheim Pharma GmbH & Co.KG Process for the preparation of 4-(benzimidazolylmethylamino)-benzamidines
DE102005061623A1 (en) 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Improved process for the preparation of 4- (benzimidazolylmethylamino) -benzamidines and their salts
DE102005061624A1 (en) 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Improved process for the preparation of salts of 4- (benzimidazolylmethylamino) -benzamidines
US10077251B2 (en) 2012-10-29 2018-09-18 Biophore India Pharmaceuticals Pvt. Ltd. Process for the synthesis of Dabigatran Etexilate and its intermediates
WO2014068587A2 (en) * 2012-10-29 2014-05-08 Biophore India Pharmaceuticals Pvt. Ltd. An improved process for the synthesis of dabigatran and its intermediates
RU2623439C1 (en) * 2016-10-14 2017-06-26 федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет" 1-substituted-3-{[2-(3,5-di-tret-4-hydroxyphenyl)-2-oxoethyl]}-2aminobenzimidazolium bromides with antiplatelet and antioxidant properties

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4129603A1 (en) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K CONDENSED 5-LOW HETEROCYCLES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICAMENTS CONTAINING THESE COMPOUNDS
JP2002502844A (en) * 1998-02-03 2002-01-29 ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト 5-membered heterocyclic fused benzo derivatives, their preparation and their use as pharmaceuticals
DE19829964A1 (en) * 1998-07-04 2000-01-05 Boehringer Ingelheim Pharma New benzimidazolyl amidine or nitrile compounds, used as thrombin inhibitors, antithrombotic agents or intermediates
TWI248435B (en) * 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions

Also Published As

Publication number Publication date
WO2001047896A1 (en) 2001-07-05
DE19962329A1 (en) 2001-06-28
PE20010954A1 (en) 2001-10-09
UY26492A1 (en) 2001-07-31
MXPA02006299A (en) 2002-12-09
CA2393916A1 (en) 2001-07-05
AU2011501A (en) 2001-07-09
JP2003519129A (en) 2003-06-17
EP1244636A1 (en) 2002-10-02

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