PE20001049A1 - Complejos estables de compuestos escasamente solubles - Google Patents
Complejos estables de compuestos escasamente solublesInfo
- Publication number
- PE20001049A1 PE20001049A1 PE1999000947A PE00094799A PE20001049A1 PE 20001049 A1 PE20001049 A1 PE 20001049A1 PE 1999000947 A PE1999000947 A PE 1999000947A PE 00094799 A PE00094799 A PE 00094799A PE 20001049 A1 PE20001049 A1 PE 20001049A1
- Authority
- PE
- Peru
- Prior art keywords
- polymer
- poorly soluble
- weight
- drying
- refers
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 229920000831 ionic polymer Polymers 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Natural products CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- -1 METHACRYL ESTER Chemical class 0.000 abstract 1
- 229920006318 anionic polymer Polymers 0.000 abstract 1
- 229920006317 cationic polymer Polymers 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 230000009477 glass transition Effects 0.000 abstract 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 abstract 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000013557 residual solvent Substances 0.000 abstract 1
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 abstract 1
- 229960001852 saquinavir Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- MIQPIUSUKVNLNT-UHFFFAOYSA-N tolcapone Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 abstract 1
- 229960004603 tolcapone Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UN COMPLEJO INSOLUBLE EN AGUA DE a)DE 0,1% A 80% EN PESO DE UN COMPUESTO ACTIVO ESTABLE, AMORFO; ESCASAMENTE SOLUBLE CUANDO ESTA EN LA FORMA CRISTALINA, CON UNA SOLUBILIDAD INFERIOR A 1 mg/ml EN SOLUCION ACUOSA; DE FORMULA I, TOLCAPONE, ACIDO 1,3-CISRETINOICO, SAQUINAVIR, ENTRE OTROS; b)NO MENOS DE 20% DE PESO DE UN POLIMERO IONICO INSOLUBLE EN AGUA QUE TIENE UN PESO MOLECULAR SUPERIOR A 80 000 D Y UNA TEMPERATURA DE TRANSICION VITREA IGUAL O SUPERIOR A 50°C; DE PREFERENCIA ES UN POLIMERO CATIONICO TAL COMO COPOLIMERO DE DIMETILAMINOETILMETACRILATO, ESTER METACRILICO NEUTRO; POLIMERO ANIONICO TAL COMO COPOLIMERO DE ACIDO METACRILICO, ENTRE OTROS; LA SOLUBILIDAD DEPENDE DEL pH; c)UN SOPORTE. TAMBIEN SE REFIERE A PROCEDIMIENTOS PARA LA PREPARACION QUE COMPRENDE a)DISOLUCION DE LA FORMA CRISTALINA DEL COMPUESTO Y DEL POLIMERO IONICO EN UN SOLVENTE ORGANICO COMO ALCOHOL ETILICO O METILICO, SULFOXIDO DE DIMETILO, ENTRE OTROS; b)PONER EN CONTACTO CON UN SOLUCION ACUOSA A UN pH EN EL QUE EL POLIMERO IONICO ES ESCASAMENTE SOLUBLE, MICROPRECIPITANDOSE EL COMPUESTO ACTIVO Y EL POLIMERO EN FORMA DE UN COMPLEJO COMPUESTO/POLIMERO, ELIMINANDOSE EL SOLVENTE MEDIANTE EL SECADO POR PULVERIZACION O LIOFILIZACION, EL DISOLVENTE RESIDUAL SE ELIMINA MEDIANTE EVAPORACION O SECADO
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10133698P | 1998-09-22 | 1998-09-22 | |
| US13653199P | 1999-05-28 | 1999-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001049A1 true PE20001049A1 (es) | 2000-10-17 |
Family
ID=26798138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000947A PE20001049A1 (es) | 1998-09-22 | 1999-09-17 | Complejos estables de compuestos escasamente solubles |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6350786B1 (es) |
| EP (1) | EP0988863B2 (es) |
| JP (5) | JP2000095708A (es) |
| KR (1) | KR100362019B1 (es) |
| CN (1) | CN1201821C (es) |
| AR (2) | AR022096A1 (es) |
| AT (1) | ATE265232T1 (es) |
| AU (1) | AU770745B2 (es) |
| BR (1) | BR9904283A (es) |
| CA (1) | CA2282906C (es) |
| CO (1) | CO5140077A1 (es) |
| CZ (1) | CZ300215B6 (es) |
| DE (1) | DE69916733T3 (es) |
| DK (1) | DK0988863T4 (es) |
| ES (1) | ES2218918T5 (es) |
| HR (1) | HRP990287B1 (es) |
| HU (1) | HU228341B1 (es) |
| ID (1) | ID24034A (es) |
| IL (1) | IL131957A (es) |
| MA (1) | MA26692A1 (es) |
| MY (1) | MY124377A (es) |
| NO (1) | NO326928B1 (es) |
| NZ (1) | NZ337884A (es) |
| PE (1) | PE20001049A1 (es) |
| PL (1) | PL202757B1 (es) |
| PT (1) | PT988863E (es) |
| RS (1) | RS50193B (es) |
| RU (1) | RU2240827C2 (es) |
| SG (1) | SG97131A1 (es) |
| SI (1) | SI0988863T2 (es) |
| TR (1) | TR199902324A3 (es) |
| TW (1) | TWI234465B (es) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2307482T3 (es) | 1999-02-10 | 2008-12-01 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas. |
| US6440959B1 (en) | 1999-04-21 | 2002-08-27 | Hoffman-La Roche Inc. | Pyrazolobenzodiazepines |
| AR033651A1 (es) * | 1999-10-01 | 2004-01-07 | Hoffmann La Roche | Derivados de pirimidina-2,4,6-triona, composiciones farmaceuticas que contienen dichos compuestos y el empleo de los mismos para la manufactura de un medicamento |
| US6313143B1 (en) * | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| CA2409003C (en) * | 2000-05-16 | 2010-10-19 | Ortho-Mcneil Pharmaceutical, Inc. | Process for coating medical devices using super-critical carbon dioxide |
| US6482847B2 (en) * | 2000-10-03 | 2002-11-19 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
| US6469179B1 (en) | 2000-10-03 | 2002-10-22 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
| US6607784B2 (en) | 2000-12-22 | 2003-08-19 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US20050048126A1 (en) | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US6951656B2 (en) | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US6548531B2 (en) | 2001-02-09 | 2003-04-15 | Hoffmann-La Roche Inc. | Method for cancer therapy |
| US6716845B2 (en) | 2001-03-30 | 2004-04-06 | Hoffmann-La Roche Inc. | Barbituric acid derivatives |
| BR0210000A (pt) * | 2001-05-30 | 2004-05-04 | Csir | Método de encapsular uma substância ativa |
| US20030044514A1 (en) * | 2001-06-13 | 2003-03-06 | Richard Robert E. | Using supercritical fluids to infuse therapeutic on a medical device |
| WO2002102373A1 (en) * | 2001-06-15 | 2002-12-27 | F. Hoffmann-La Roche Ag | Method for administration of cancer therapeutic |
| HUP0400264A2 (hu) | 2001-06-22 | 2004-08-30 | Pfizer Products Inc. | Alacsony oldékonyságú és/vagy savra érzékeny hatóanyagokat és semlegesített savas polimereket tartalmazó gyógyszerkészítmények és eljárás az előállításukra |
| WO2003000235A1 (en) | 2001-06-22 | 2003-01-03 | Pfizer Products Inc. | Pharmaceutical compositions of dispersions of drugs and neutral polymers |
| CN1558755A (zh) | 2001-09-26 | 2004-12-29 | ���ع��ʹ�˾ | 通过分散和除去溶剂或液相制备亚微米大小的纳米颗粒 |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| US20030139373A1 (en) * | 2001-11-20 | 2003-07-24 | Breimer Lars Holger | Method for cancer therapy |
| WO2003063822A2 (en) | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus |
| CN1681479A (zh) | 2002-08-12 | 2005-10-12 | 辉瑞产品公司 | 半有序药物和聚合物的药物组合物 |
| DE10351087A1 (de) * | 2003-10-31 | 2005-05-25 | Bayer Technology Services Gmbh | Feste Wirkstoff-Formulierung |
| CN100563658C (zh) | 2003-11-14 | 2009-12-02 | 味之素株式会社 | 苯丙氨酸衍生物的固体分散体或固体分散体医药制剂 |
| EP3216449A1 (en) * | 2003-11-14 | 2017-09-13 | EA Pharma Co., Ltd. | Oral administration preparation of phenylalanine derivatives |
| BRPI0509583A (pt) * | 2004-04-01 | 2007-10-09 | Hoffmann La Roche | composições farmacêuticas de pirimidina-2,4,6-trionas |
| AR049915A1 (es) * | 2004-06-14 | 2006-09-13 | Anacor Pharmaceuticals Inc | Compuestos con contenido de boro y metodos de uso de los mismos |
| WO2006062980A2 (en) * | 2004-12-07 | 2006-06-15 | Nektar Therapeutics | Stable non-crystalline formulation comprising tiagabine |
| EP1839650A1 (en) * | 2004-12-28 | 2007-10-03 | Eisai R&D Management Co., Ltd. | Quick disintegration tablet and method of producing the same |
| US9040558B2 (en) | 2004-12-31 | 2015-05-26 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| US20060182788A1 (en) * | 2005-01-27 | 2006-08-17 | Parminder Singh | Hydrophilic biocompatible adhesive formulations and uses |
| EP1690528A1 (de) * | 2005-02-11 | 2006-08-16 | Abbott GmbH & Co. KG | Herstellung von Dosierungsformen mit einer festen Dispersion eines mikrokristallinen Wirkstoffs |
| EP1885338A1 (en) * | 2005-05-19 | 2008-02-13 | Pfizer, Inc. | Pharmaceutical compostions comprising an amorphous form of a vegf-r inhibitor |
| EP1767194A1 (de) * | 2005-06-09 | 2007-03-28 | Helm AG | Verfahren zur Herstellung von Adsorbaten des Drospirenons |
| WO2007002433A1 (en) * | 2005-06-22 | 2007-01-04 | Plexxikon, Inc. | Pyrrolo [2, 3-b] pyridine derivatives as protein kinase inhibitors |
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| CL2007002331A1 (es) * | 2006-08-10 | 2008-04-18 | Cipla Ltd | Composicion oral solida que comprede uno o mas farmacos antirretrovirales y al menos un polimero insoluble en agua, en relacion aproximadamente 1:1 hasta 1:6; proceso de elaboracion; y uso para el tratamiento del vih. |
| US20080107725A1 (en) * | 2006-10-13 | 2008-05-08 | Albano Antonio A | Pharmaceutical Solid Dosage Forms Comprising Amorphous Compounds Micro-Embedded in Ionic Water-Insoluble Polymers |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| PE20121126A1 (es) * | 2006-12-21 | 2012-08-24 | Plexxikon Inc | Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa |
| WO2008079909A1 (en) * | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| WO2008081829A1 (ja) | 2006-12-27 | 2008-07-10 | Astellas Pharma Inc. | 難水溶性薬物の溶解性維持用アミノアルキルメタアクリレートコポリマーｅ |
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| US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
| US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
| EP1997479A1 (en) * | 2007-05-31 | 2008-12-03 | Helm AG | Stabilized amorphous candesartan cilexetil compositions for oral administration |
| BRPI0814423B1 (pt) | 2007-07-17 | 2022-04-19 | Plexxikon, Inc | Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos |
| MX2010004222A (es) * | 2007-10-19 | 2010-09-14 | Purdue Research Foundation | Formulaciones solidas de compuestos cristalinos. |
| US7794750B2 (en) * | 2008-06-20 | 2010-09-14 | Mutual Pharmaceutical Company, Inc. | Controlled-release formulations, method of manufacture, and use thereof |
| US8632805B2 (en) * | 2008-06-20 | 2014-01-21 | Mutual Pharmaceutical Company, Inc. | Controlled-release formulations, method of manufacture, and use thereof |
| WO2010044842A1 (en) * | 2008-10-16 | 2010-04-22 | University Of Tennessee Research Foundation | Tamper resistant oral dosage forms containing an embolizing agent |
| KR20100073454A (ko) * | 2008-12-23 | 2010-07-01 | 국립암센터 | 트란스글루타미나제 억제제로 사용되는 신규한 피라졸로디아제핀계 화합물, 이의 제조방법 및 이를 포함하는 조성물 |
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| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| ES2719145T3 (es) | 2011-06-20 | 2019-07-08 | H Lundbeck As | 1-Piperazino-3-fenil-indanos deuterados para el tratamiento de la esquizofrenia |
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| EP2649989B1 (en) | 2012-04-13 | 2017-10-18 | King Saud University | Method for preparing a solid dispersion, solid dispersion obtained thereby and use thereof |
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1999
- 1999-09-07 US US09/391,060 patent/US6350786B1/en not_active Expired - Lifetime
- 1999-09-13 SI SI9930573T patent/SI0988863T2/sl unknown
- 1999-09-13 DE DE69916733T patent/DE69916733T3/de not_active Expired - Lifetime
- 1999-09-13 PT PT99117908T patent/PT988863E/pt unknown
- 1999-09-13 EP EP99117908A patent/EP0988863B2/en not_active Expired - Lifetime
- 1999-09-13 AT AT99117908T patent/ATE265232T1/de active
- 1999-09-13 ES ES99117908T patent/ES2218918T5/es not_active Expired - Lifetime
- 1999-09-13 DK DK99117908T patent/DK0988863T4/da active
- 1999-09-16 IL IL13195799A patent/IL131957A/xx not_active IP Right Cessation
- 1999-09-17 CO CO99059117A patent/CO5140077A1/es unknown
- 1999-09-17 NZ NZ337884A patent/NZ337884A/xx not_active IP Right Cessation
- 1999-09-17 CZ CZ0330499A patent/CZ300215B6/cs not_active IP Right Cessation
- 1999-09-17 SG SG9904570A patent/SG97131A1/en unknown
- 1999-09-17 PE PE1999000947A patent/PE20001049A1/es not_active IP Right Cessation
- 1999-09-20 CA CA2282906A patent/CA2282906C/en not_active Expired - Lifetime
- 1999-09-20 MY MYPI99004065A patent/MY124377A/en unknown
- 1999-09-20 AU AU48807/99A patent/AU770745B2/en not_active Expired
- 1999-09-20 HR HR990287 patent/HRP990287B1/xx not_active IP Right Cessation
- 1999-09-20 ID IDP990878D patent/ID24034A/id unknown
- 1999-09-20 AR ARP990104725A patent/AR022096A1/es not_active Application Discontinuation
- 1999-09-20 HU HU9903189A patent/HU228341B1/hu unknown
- 1999-09-20 TW TW088116184A patent/TWI234465B/zh not_active IP Right Cessation
- 1999-09-21 NO NO19994583A patent/NO326928B1/no not_active IP Right Cessation
- 1999-09-21 MA MA25778A patent/MA26692A1/fr unknown
- 1999-09-21 JP JP11267142A patent/JP2000095708A/ja not_active Withdrawn
- 1999-09-21 TR TR1999/02324A patent/TR199902324A3/tr unknown
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- 1999-09-21 BR BR9904283-5A patent/BR9904283A/pt not_active Application Discontinuation
- 1999-09-21 CN CNB991194063A patent/CN1201821C/zh not_active Expired - Lifetime
- 1999-09-21 RU RU99120377/15A patent/RU2240827C2/ru active
- 1999-09-22 PL PL335592A patent/PL202757B1/pl unknown
- 1999-09-22 KR KR1019990041130A patent/KR100362019B1/ko not_active Expired - Lifetime
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2007
- 2007-06-06 JP JP2007150911A patent/JP2007224048A/ja active Pending
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