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PE20001484A1 - Derivados de naftalen-1-ilo urea y acido carbamico - Google Patents

Derivados de naftalen-1-ilo urea y acido carbamico

Info

Publication number
PE20001484A1
PE20001484A1 PE2000000212A PE0002122000A PE20001484A1 PE 20001484 A1 PE20001484 A1 PE 20001484A1 PE 2000000212 A PE2000000212 A PE 2000000212A PE 0002122000 A PE0002122000 A PE 0002122000A PE 20001484 A1 PE20001484 A1 PE 20001484A1
Authority
PE
Peru
Prior art keywords
phenyl
alkyl
urea
tolil
morfolin
Prior art date
Application number
PE2000000212A
Other languages
English (en)
Inventor
Rajashekhar Betageri
Hidenori Takahashi
Pier Francesco Cirillo
Thomas Gilmore
Eugene Richard Hickey
Thomas Kirrane Jr
Monica Helen Moriak
Neil Moss
Usha Patel
John Robert Proudfoot
John Robinson Regan
Raijv Sharma
Sanxing Sun
Alan David Swinamer
Steffen Breitfelder
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20001484A1 publication Critical patent/PE20001484A1/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • A61P17/06—Antipsoriatics
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
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Abstract

SE REFIERE A UN COMPUESTO AROMATICO DE FORMULA I, Ar1-NH-C(=W)-NH-Ar2-X-Y-Z: Ar1 ES PIRROL, PIRROLIDINA, PIRAZOL, IMIDAZOL, OXAZOL, TIAZOL, FURANO, TIOFENO OPCIONALMENTE SUSTITUIDO CON R1, R2, R3; Ar2 ES FENILO, NAFTILO, QUINOLINA, ISOQUINOLINA, TETRAHIDRONAFTILO, ENTRE OTROS; X ES CICLOALQUILO, CICLOALQUENILO C5-C8 OPCIONALMENTE SUSTITUIDO CON OXO, ALQUILO C1-C4, ENTRE OTROS; Y ES UN ENLACE, CADENA DE CARBONOS LOS GRUPOS METILO ESTAN OPCIONALMENTE REEMPLAZADOS POR O, NH, SO, SO2, S Y SUSTITUIDO CON OXO, ALQUILO C1-C4, ENTRE OTROS; Z ES FENILO, PIRIDINA, PIRIMIDINA, PIRIDAZINA, IMIDAZOL, ENTRE OTROS; R1 ES ALQUILO C3-C10, ALQUENILO C3-C10, CICLOALQUENILO C5-C7, ENTRE OTROS; R2 ES ALQUILO C1-C6, R3 ES FENILO, NAFTILO, HETEROCICLO O R1 Y R2 JUNTOS FORMAN FENILO, PIRIDINILO CONDENSADO; W ES O, S. SON COMPUESTOS PREFERIDOS 1-[5-TERC-BUTIL-2-p-TOLIL-2H-PIRAZOL-3-IL]-3-[4-(4-MORFOLIN-4-IL-METIL)FENIL)NAFTALEN-1-IL]UREA; 1-[5-TERC-BUTIL-2-p-TOLIL-2H-PIRAZOL-3-IL]-3-[4-(4-(2-(MORFOLIN-4-IL)ETIL)FENIL)NAFTALEN-1-IL]UREA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN INHIBIDOR DE LA LIBERACION DE CITOQUINAS INFLAMATORIAS TAL COMO INTERLEUQUINA 1 Y FACTOR DE NECROSIS TUMORAL Y PUEDE SER UTIL PARA EL TRATAMIENTO DE LA ARTRITIS REUMATOIDE, OSTEOARTRITIS, ENFERMEDAD DE CROHN, COLITIS ULCEROSA
PE2000000212A 1999-03-12 2000-03-10 Derivados de naftalen-1-ilo urea y acido carbamico PE20001484A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12414899P 1999-03-12 1999-03-12
US16586799P 1999-11-16 1999-11-16

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PE20001484A1 true PE20001484A1 (es) 2001-01-22

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PE2000000212A PE20001484A1 (es) 1999-03-12 2000-03-10 Derivados de naftalen-1-ilo urea y acido carbamico

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EP (1) EP1165516B1 (es)
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AR (1) AR028473A1 (es)
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US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
EP1140840B1 (en) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ES2384160T3 (es) 1999-01-13 2012-07-02 Bayer Healthcare Llc Difenil ureas sustituidas con omega-carboxi arilo como agentes inhibidores de la cinasa p38
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