PE20000337A1 - Pirazolpirimidinas y pirazoltriazinas - Google Patents
Pirazolpirimidinas y pirazoltriazinasInfo
- Publication number
- PE20000337A1 PE20000337A1 PE1999000183A PE00018399A PE20000337A1 PE 20000337 A1 PE20000337 A1 PE 20000337A1 PE 1999000183 A PE1999000183 A PE 1999000183A PE 00018399 A PE00018399 A PE 00018399A PE 20000337 A1 PE20000337 A1 PE 20000337A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- benzenosulfonyl
- methylsulfanil
- ilamine
- alcoxyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 108091005435 5-HT6 receptors Proteins 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- -1 PIPERAZINYL Chemical class 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000003973 alkyl amines Chemical group 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 201000010901 lateral sclerosis Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000005264 motor neuron disease Diseases 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
SE REFIERE A PIRAZOLOPIRIMIDINAS Y PIRAZOLOTRIAZINAS DE FORMULA IA o IB; R1 ES FENILO OPCIONALMENTE SUSTITUIDO CON ALQUILO, HALOGENO, ALCOXILO, ENTRE OTROS; R2 ES H, ALQUILO, TIOALQUILO, HIDROXILO-ALCOXILO; R3 ES AMINO, ALQUILAMINO, DIALQUILAMINO, PIPERAZINILO, ENTRE OTROS; R4 ES H, ALQUILO, HIDROXILO-ALQUILO; R5 ES H, HALOGENO, ALQUILO, CICLOALQUILO DE 3-6 MIEMBROS, ENTRE OTROS; R4 Y R5 SON -(CH2)m, -CH2-S-CH2-; m ES 3-4. SON COMPUESTOS PREFERIDOS 3-(4-ISOPROPIL-BENCENOSULFONIL-5-METIL-2-METILSULFANIL-PIRAZOLO[1,5-a]PIRIMIDIN-7-ILAMINA; 8-BENCENOSULFONIL-7-METILSULFANIL-PIRAZOLO[1,5-a][1,3,5]TRIAZIN-4-ILAMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I TIENE AFINIDAD POR LOS RECEPTORES 5-HT6 Y PUEDE SER UTIL PARA EL TRATAMIENTO DE TRASTORNOS NERVIOSOS CENTRALES TALES COMO PSICOSIS, ESQUIZOFRENIA, DEPRESIONES MANIACAS, DEPRESIONES, TRASTORNOS NEUROLOGICOS, TRASTORNOS DE LA MEMORIA, ENFERMEDAD DE PARKINSON, ESCLEROSIS LATERAL AMIOTROPICA, ENFERMEDAD DE ALZHEIMER Y COREA DE HUNTINGTON
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98104346 | 1998-03-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000337A1 true PE20000337A1 (es) | 2000-05-13 |
Family
ID=8231568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000183A PE20000337A1 (es) | 1998-03-11 | 1999-03-08 | Pirazolpirimidinas y pirazoltriazinas |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US6194410B1 (es) |
| EP (1) | EP0941994B1 (es) |
| JP (1) | JP3231288B2 (es) |
| KR (1) | KR100313181B1 (es) |
| CN (1) | CN1118468C (es) |
| AR (1) | AR016453A1 (es) |
| AT (1) | ATE240332T1 (es) |
| AU (1) | AU752408B2 (es) |
| BR (1) | BR9901095A (es) |
| CA (1) | CA2265095C (es) |
| CZ (1) | CZ291514B6 (es) |
| DE (1) | DE69907784T2 (es) |
| DK (1) | DK0941994T3 (es) |
| ES (1) | ES2198095T3 (es) |
| HR (1) | HRP990077B1 (es) |
| HU (1) | HUP9900589A1 (es) |
| ID (1) | ID23575A (es) |
| IL (1) | IL128869A (es) |
| MA (1) | MA26612A1 (es) |
| MY (1) | MY119536A (es) |
| NO (1) | NO312297B1 (es) |
| NZ (1) | NZ334526A (es) |
| PE (1) | PE20000337A1 (es) |
| PL (1) | PL331875A1 (es) |
| PT (1) | PT941994E (es) |
| RU (1) | RU2218340C2 (es) |
| SG (1) | SG78336A1 (es) |
| SI (1) | SI0941994T1 (es) |
| TR (1) | TR199900531A2 (es) |
| TW (1) | TW585865B (es) |
| UY (1) | UY25419A1 (es) |
| YU (1) | YU12099A (es) |
| ZA (1) | ZA991946B (es) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4331500A (en) * | 1999-04-06 | 2000-10-23 | Du Pont Pharmaceuticals Company | Pyrazolotriazines as crf antagonists |
| DE19956791A1 (de) | 1999-11-25 | 2001-05-31 | Merck Patent Gmbh | Neue Sulfonyloxazolamine |
| PE20020394A1 (es) | 2000-08-18 | 2002-06-21 | Agouron Pharma | Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2 |
| CZ20032481A3 (cs) * | 2001-03-13 | 2007-12-27 | Bristol-Myers Squibb Pharma Company | 4-(2-Butylamino)-2, 7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)pyrazolo[1,5-A]-1, 3, 5-triazin, jeho enantiomery a farmaceuticky prijatelné soli jakoligandy receptoru faktoru uvolnujícího kortikotropin |
| BR0210929A (pt) | 2001-06-07 | 2004-06-08 | Hoffmann La Roche | Derivados de indol com afinidade para o receptor 5-ht6 |
| CA2450245A1 (en) | 2001-06-15 | 2002-12-27 | F. Hoffmann-La Roche Ag | 4-piperazinylindole derivatives with 5-ht6 receptor affinity |
| US20040242589A1 (en) * | 2001-08-07 | 2004-12-02 | Bromidge Steven Mark | 3-arylsulfonyl-7-piperzinyl-indoles-benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders |
| BR0215222A (pt) * | 2001-12-20 | 2005-05-24 | Wyeth Corp | Derivados de indolilalquilamina como ligantes de 5-hidroxitriptamina-6 |
| US6642381B2 (en) * | 2001-12-27 | 2003-11-04 | Hoffman-La Roche Inc. | Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors |
| GB0202679D0 (en) * | 2002-02-05 | 2002-03-20 | Glaxo Group Ltd | Novel compounds |
| UA78999C2 (en) * | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
| US6875771B2 (en) | 2002-07-26 | 2005-04-05 | Bristol-Myers Squibb Company | Pyridopyrimidine derivatives as 5-HT6 antagonists |
| EP2194058B1 (en) * | 2002-09-04 | 2013-11-27 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidines suitable for the treatment of cancer diseases |
| US7196078B2 (en) * | 2002-09-04 | 2007-03-27 | Schering Corpoartion | Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7329658B2 (en) * | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| AU2004213375A1 (en) * | 2003-02-14 | 2004-09-02 | Wyeth | Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-Hydroxytryptamine-6 ligands |
| EP1599482A4 (en) | 2003-02-28 | 2008-10-01 | Teijin Pharma Ltd | PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES |
| GB0305559D0 (en) * | 2003-03-11 | 2003-04-16 | Teijin Ltd | Compounds |
| US7585881B2 (en) * | 2004-02-18 | 2009-09-08 | Astrazeneca Ab | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| US20080287405A1 (en) * | 2004-05-14 | 2008-11-20 | Thannickal Victor J | Compositions and Methods Relating to Protein Kinase Inhibitors |
| MX337817B (es) * | 2004-11-04 | 2011-11-04 | Vertex Pharma | Pirazolo [1,5-a] pirimidinas de utilidad como inhibidores de proteina quinasas. |
| RU2390523C2 (ru) * | 2005-10-21 | 2010-05-27 | Мицубиси Танабе Фарма Корпорейшн | ПРОИЗВОДНОЕ ПИРАЗОЛ[1,5-a]ПИРИМИДИНА |
| RU2330854C2 (ru) * | 2006-03-15 | 2008-08-10 | Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУВПО "ПГФА Росздрава") | Способ получения конденсированных гем-диметилзамещенных амино-1,3,5-триазинов |
| JP5575663B2 (ja) * | 2008-01-24 | 2014-08-20 | アンドレイ・アレクサンドロビッチ・イワシェンコ | 置換された２−アミノ−３−（スルホニル）ピラゾロ［１，５−ａ］ピリミジン−セロトニン５−ＨＴ６受容体アンタゴニスト、その調製のための方法及び使用 |
| RU2369600C1 (ru) | 2008-01-24 | 2009-10-10 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ5-HT6 РЕЦЕПТОРОВ, АКТИВНЫЙ КОМПОНЕНТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННОЕ СРЕДСТВО И СПОСОБЫ ИХ ПОЛУЧЕНИЯ |
| US8629154B2 (en) * | 2008-01-24 | 2014-01-14 | Andrey Alexandrovich Ivashchenko | Substituted cycloalcano[e and d] pyrazolo [1,5-a]pyrimidines/antagonists of serotonin 5-HT6 receptors and methods for production and the use thereof |
| WO2009093209A2 (ru) | 2008-01-24 | 2009-07-30 | Alla Chem, Llc | 2-AЛKИЛAMИHO-3-APИЛCУЛЬФOHИЛ-ЦИKЛOAЛKAHO [e ИЛИ d] ПИPAЗOЛO [1,5-a] ПИPИMИДИHЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
| RU2384581C2 (ru) | 2008-05-07 | 2010-03-20 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 2-АМИНО-3-СУЛЬФОНИЛ-ТЕТРАГИДРО-ПИРАЗОЛО[1,5-a]ПИРИДО-ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
| EP2351756A4 (en) * | 2008-10-06 | 2013-01-02 | Ivashchenko Andrey Alexandrovich | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO [1,5-A] PYRIMIDINES, SEROTONIN-5-HT6 RECEPTOR ANTAGONISTS, AND METHOD FOR THEIR PREPARATION AND USE |
| WO2010060952A1 (en) | 2008-11-27 | 2010-06-03 | Boehringer Ingelheim International Gmbh | 6,7,8,9-tetrahydro-5h-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| US9132129B2 (en) | 2010-11-15 | 2015-09-15 | Katholieke Universiteit Leuven | Antiviral compounds |
| RU2443697C1 (ru) | 2010-12-21 | 2012-02-27 | Александр Васильевич Иващенко | Замещенные метил-амины, антагонисты серотониновых 5-ht6 рецепторов, способы получения и применения |
| AU2012314035B2 (en) | 2011-09-30 | 2016-12-15 | Oncodesign S.A. | Macrocyclic LRRK2 kinase inhibitors |
| EP2834243B1 (en) * | 2012-03-09 | 2018-04-25 | Lexicon Pharmaceuticals, Inc. | PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE |
| TW201542550A (zh) * | 2013-09-06 | 2015-11-16 | Lexicon Pharmaceuticals Inc | 吡唑并［１，５－ａ］嘧啶基化合物、包含彼之組合物以及使用彼之方法 |
| TW201620911A (zh) * | 2014-03-17 | 2016-06-16 | 雷西肯製藥股份有限公司 | 銜接子關聯激酶１之抑制劑、包含其之組成物、及其使用方法 |
| EA032838B1 (ru) | 2014-09-17 | 2019-07-31 | Онкодизайн С.А. | Макроциклические ингибиторы lrrk2-киназы |
| EP3268000B1 (en) * | 2015-03-09 | 2021-08-04 | Aurigene Discovery Technologies Limited | Pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives as cdk inhibitors |
| WO2017052394A1 (en) * | 2015-09-23 | 2017-03-30 | Uniwersytet Jagielloński | Imidazopyridine compounds and their use as 5-ht6 receptor ligands |
| JP6872541B2 (ja) | 2015-11-02 | 2021-05-19 | ヤンセン ファーマシューティカ エヌ．ベー． | ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン−７−イル化合物 |
| JP7018944B2 (ja) | 2016-11-02 | 2022-02-14 | ヤンセン ファーマシューティカ エヌ．ベー． | ＰＤＥ２阻害剤としての［１，２，４］トリアゾロ［１，５－ａ］ピリミジン化合物 |
| EA039102B1 (ru) | 2016-11-02 | 2021-12-03 | Янссен Фармацевтика Нв | Соединения [1,2,4]триазоло[1,5-a]пиримидина в качестве ингибиторов pde2 |
| SG11201903892UA (en) | 2016-11-02 | 2019-05-30 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors |
| TW202521536A (zh) | 2019-05-05 | 2025-06-01 | 美商基尼特奇公司 | Ｃｄｋ抑制劑 |
| CN112142744A (zh) * | 2019-06-28 | 2020-12-29 | 上海瑛派药业有限公司 | 取代的稠合杂芳双环化合物作为激酶抑制剂及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3907799A (en) * | 1971-08-16 | 1975-09-23 | Icn Pharmaceuticals | Xanthine oxidase inhibitors |
| WO1989000994A2 (en) | 1987-07-31 | 1989-02-09 | E.I. Du Pont De Nemours And Company | Herbicidal sulfonamides |
| US4921527A (en) * | 1987-07-31 | 1990-05-01 | E. I. Du Pont De Nemours And Company | Herbicidal sulfonamides |
| DE3825043A1 (de) | 1988-07-20 | 1990-02-15 | Schering Ag | 3-methylsulfonyl-pyrazolo(1,5-a)pyrimidin-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider, pflanzenwuchsregulierender und fungizider wirkung |
| US5571813A (en) * | 1993-06-10 | 1996-11-05 | Beiersdorf-Lilly Gmbh | Fused pyrimidine compounds and their use as pharmaceuticals |
| AU7001396A (en) | 1995-09-22 | 1997-04-09 | Takeda Chemical Industries Ltd. | Triazole compounds, their production and use |
| EP0946551A2 (en) | 1996-12-19 | 1999-10-06 | Smithkline Beecham Plc | N-piperazin-1-ylphenyl-benzamide derivatives |
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| WO1999002502A2 (en) | 1997-07-11 | 1999-01-21 | Smithkline Beecham Plc | Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation |
-
1999
- 1999-02-24 US US09/256,927 patent/US6194410B1/en not_active Expired - Fee Related
- 1999-03-03 DE DE69907784T patent/DE69907784T2/de not_active Expired - Fee Related
- 1999-03-03 AT AT99102872T patent/ATE240332T1/de not_active IP Right Cessation
- 1999-03-03 EP EP99102872A patent/EP0941994B1/en not_active Expired - Lifetime
- 1999-03-03 ES ES99102872T patent/ES2198095T3/es not_active Expired - Lifetime
- 1999-03-03 DK DK99102872T patent/DK0941994T3/da active
- 1999-03-03 SI SI9930320T patent/SI0941994T1/xx unknown
- 1999-03-03 PT PT99102872T patent/PT941994E/pt unknown
- 1999-03-08 YU YU12099A patent/YU12099A/sh unknown
- 1999-03-08 NZ NZ334526A patent/NZ334526A/xx unknown
- 1999-03-08 MA MA25485A patent/MA26612A1/fr unknown
- 1999-03-08 PE PE1999000183A patent/PE20000337A1/es not_active Application Discontinuation
- 1999-03-08 CA CA002265095A patent/CA2265095C/en not_active Expired - Fee Related
- 1999-03-08 IL IL12886999A patent/IL128869A/xx not_active IP Right Cessation
- 1999-03-09 JP JP06114999A patent/JP3231288B2/ja not_active Expired - Fee Related
- 1999-03-09 MY MYPI99000853A patent/MY119536A/en unknown
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