AR051395A1 - Derivados de imidazo- benzodiazepina, composiciones farmaceuticas que los contienen, metodo de preparacion de los mismos, y usos en terapeutica - Google Patents
Derivados de imidazo- benzodiazepina, composiciones farmaceuticas que los contienen, metodo de preparacion de los mismos, y usos en terapeuticaInfo
- Publication number
- AR051395A1 AR051395A1 ARP050104348A ARP050104348A AR051395A1 AR 051395 A1 AR051395 A1 AR 051395A1 AR P050104348 A ARP050104348 A AR P050104348A AR P050104348 A ARP050104348 A AR P050104348A AR 051395 A1 AR051395 A1 AR 051395A1
- Authority
- AR
- Argentina
- Prior art keywords
- imidazo
- lower alkyl
- derivatives
- benzodiazepina
- therapeutics
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 abstract 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente tiene que ver con derivados imidazo[1,5-a][1,2,4]triazolo[1,5-d]benzodiazepina sustituidos de la formula (1), en donde: R1 es hidrogeno, halogeno, alquilo inferior, alquinilo inferior, cicloalquilo, heterocicloalquilo, bencilo, ciano, alcoxi inferior, OCF3, -NHR, -NHC(O)R o -NSHO2R; R2 es alquil inferior sustituido por un halogeno; R3 es hidrogeno, metilo o arilo; R es alquilo inferior, cicloalquilo o arilo; y con sus sales de adicion farmacéuticamente aceptables. Se ha encontrado que esta clase de compuestos muestran alta afinidad y selectividad para el GABA A alfa5 que se une a sitios y puede ser util como promotor cognitivo o para el tratamiento de trastornos cognitivos, ansiedad, esquizofrenia o la enfermedad de Alzheimer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04105169 | 2004-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051395A1 true AR051395A1 (es) | 2007-01-10 |
Family
ID=36035782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050104348A AR051395A1 (es) | 2004-10-20 | 2005-10-18 | Derivados de imidazo- benzodiazepina, composiciones farmaceuticas que los contienen, metodo de preparacion de los mismos, y usos en terapeutica |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7514426B2 (es) |
| EP (1) | EP1805184B1 (es) |
| JP (1) | JP4783375B2 (es) |
| KR (1) | KR100923399B1 (es) |
| CN (1) | CN101044145B (es) |
| AR (1) | AR051395A1 (es) |
| AU (1) | AU2005299032B2 (es) |
| BR (1) | BRPI0519991A2 (es) |
| CA (1) | CA2584259C (es) |
| ES (1) | ES2399439T3 (es) |
| IL (1) | IL182585A0 (es) |
| MX (1) | MX2007004639A (es) |
| NO (1) | NO20071967L (es) |
| NZ (1) | NZ554439A (es) |
| RU (1) | RU2007112940A (es) |
| TW (1) | TWI303247B (es) |
| WO (1) | WO2006045430A1 (es) |
| ZA (1) | ZA200703172B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0515800A (pt) * | 2004-12-14 | 2008-08-05 | Hoffmann La Roche | imidazo-benzodiazepinas tetracìclicas como moduladores de receptores de gaba |
| EP1937688B1 (en) * | 2005-10-11 | 2010-08-11 | F. Hoffmann-La Roche AG | Imidazo benzodiazepine derivatives |
| FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
| EP2298296A1 (en) | 2009-08-25 | 2011-03-23 | CNRS Centre National De La Recherche Scientifique | Composition and method for treating cognitive impairments in down syndrome subjects |
| US20130150351A1 (en) * | 2010-06-03 | 2013-06-13 | Stanley T. Carmichael | Methods and compositions for treating a subject for central nervous system (cns) injury |
| EP2635277B1 (en) | 2010-11-05 | 2018-12-19 | F.Hoffmann-La Roche Ag | Use of active pharmaceutical compounds for the treatment of central nervous system conditions |
| EP2457569A1 (en) | 2010-11-05 | 2012-05-30 | F. Hoffmann-La Roche AG | Use of active pharmaceutical compounds for the treatment of central nervous system conditions |
| DK3034079T3 (en) | 2010-11-15 | 2018-02-05 | Agenebio Inc | PYRIDAZINE DERIVATIVES, COMPOSITIONS AND PROCEDURES FOR TREATING COGNITIVE WEAKNESS |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| CA3123897C (en) | 2013-12-20 | 2024-02-06 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| CN108026107B (zh) | 2015-06-19 | 2021-07-30 | 艾吉因生物股份有限公司 | 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法 |
| BR112019012821A2 (pt) | 2016-12-19 | 2019-11-26 | Agenebio Inc | derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo |
| US20180170941A1 (en) * | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| BR112020004116A2 (pt) * | 2017-08-28 | 2020-09-01 | University Of Maryland, Baltimore | novos moduladores do receptor de ácido gama aminobutírico tipo a para distúrbios de humor |
| WO2019246300A1 (en) | 2018-06-19 | 2019-12-26 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1143728A (en) | 1979-10-04 | 1983-03-29 | Max Gerecke | Imidazodiazepine derivatives |
| CA1174673A (en) * | 1981-02-27 | 1984-09-18 | Walter Hunkeler | Imidazodiazepines |
| ZW985A1 (en) * | 1984-01-19 | 1985-08-28 | Hoffmann La Roche | Imidazodiazepine derivatives |
| DK174086D0 (da) * | 1986-04-16 | 1986-04-16 | Ferrosan As | Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme |
| ZA881538B (en) * | 1987-03-10 | 1988-09-12 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Imidazodiazepine derivatives |
| US4897392A (en) * | 1989-07-03 | 1990-01-30 | Hoechst-Roussel Pharmaceuticals, Inc. | 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines |
| TW201311B (es) * | 1991-06-17 | 1993-03-01 | Hoffmann La Roche | |
| TWI239333B (en) * | 2000-11-16 | 2005-09-11 | Hoffmann La Roche | Benzodiazepine derivatives as GABA A receptor modulators |
| US6686352B2 (en) * | 2001-05-18 | 2004-02-03 | Hoffmann-La Roche Inc. | Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives |
-
2005
- 2005-10-11 ES ES05796938T patent/ES2399439T3/es not_active Expired - Lifetime
- 2005-10-11 RU RU2007112940/04A patent/RU2007112940A/ru not_active Application Discontinuation
- 2005-10-11 CA CA2584259A patent/CA2584259C/en not_active Expired - Lifetime
- 2005-10-11 MX MX2007004639A patent/MX2007004639A/es active IP Right Grant
- 2005-10-11 WO PCT/EP2005/010908 patent/WO2006045430A1/en not_active Ceased
- 2005-10-11 BR BRPI0519991-3A patent/BRPI0519991A2/pt not_active Application Discontinuation
- 2005-10-11 AU AU2005299032A patent/AU2005299032B2/en not_active Ceased
- 2005-10-11 JP JP2007537162A patent/JP4783375B2/ja not_active Expired - Fee Related
- 2005-10-11 KR KR1020077008928A patent/KR100923399B1/ko not_active Expired - Fee Related
- 2005-10-11 EP EP05796938A patent/EP1805184B1/en not_active Expired - Lifetime
- 2005-10-11 NZ NZ554439A patent/NZ554439A/en not_active IP Right Cessation
- 2005-10-11 CN CN2005800359992A patent/CN101044145B/zh not_active Expired - Fee Related
- 2005-10-17 TW TW094136208A patent/TWI303247B/zh not_active IP Right Cessation
- 2005-10-17 US US11/252,025 patent/US7514426B2/en active Active
- 2005-10-18 AR ARP050104348A patent/AR051395A1/es unknown
-
2007
- 2007-04-16 IL IL182585A patent/IL182585A0/en not_active IP Right Cessation
- 2007-04-17 NO NO20071967A patent/NO20071967L/no not_active Application Discontinuation
- 2007-04-17 ZA ZA200703172A patent/ZA200703172B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006045430A1 (en) | 2006-05-04 |
| MX2007004639A (es) | 2007-06-08 |
| CA2584259C (en) | 2013-04-02 |
| EP1805184B1 (en) | 2013-01-09 |
| ES2399439T3 (es) | 2013-04-01 |
| JP2008517011A (ja) | 2008-05-22 |
| NZ554439A (en) | 2009-09-25 |
| BRPI0519991A2 (pt) | 2009-04-07 |
| EP1805184A1 (en) | 2007-07-11 |
| TWI303247B (en) | 2008-11-21 |
| ZA200703172B (en) | 2008-08-27 |
| JP4783375B2 (ja) | 2011-09-28 |
| AU2005299032B2 (en) | 2011-11-17 |
| IL182585A0 (en) | 2007-07-24 |
| CN101044145A (zh) | 2007-09-26 |
| CN101044145B (zh) | 2010-06-16 |
| US20060084642A1 (en) | 2006-04-20 |
| RU2007112940A (ru) | 2008-11-27 |
| AU2005299032A1 (en) | 2006-05-04 |
| KR20070054731A (ko) | 2007-05-29 |
| CA2584259A1 (en) | 2006-05-04 |
| US7514426B2 (en) | 2009-04-07 |
| TW200630372A (en) | 2006-09-01 |
| KR100923399B1 (ko) | 2009-10-23 |
| NO20071967L (no) | 2007-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |