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MA26612A1 - Pyrazolopyrimidines et pyrazolotriazines - Google Patents

Pyrazolopyrimidines et pyrazolotriazines

Info

Publication number
MA26612A1
MA26612A1 MA25485A MA25485A MA26612A1 MA 26612 A1 MA26612 A1 MA 26612A1 MA 25485 A MA25485 A MA 25485A MA 25485 A MA25485 A MA 25485A MA 26612 A1 MA26612 A1 MA 26612A1
Authority
MA
Morocco
Prior art keywords
pyrazolotriazines
pyrazolopyrimidines
Prior art date
Application number
MA25485A
Other languages
English (en)
Inventor
Michael Boes
Claus Riemer
Heinz Stadler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA26612A1 publication Critical patent/MA26612A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
MA25485A 1998-03-11 1999-03-08 Pyrazolopyrimidines et pyrazolotriazines MA26612A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98104346 1998-03-11

Publications (1)

Publication Number Publication Date
MA26612A1 true MA26612A1 (fr) 2004-12-20

Family

ID=8231568

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25485A MA26612A1 (fr) 1998-03-11 1999-03-08 Pyrazolopyrimidines et pyrazolotriazines

Country Status (33)

Country Link
US (1) US6194410B1 (fr)
EP (1) EP0941994B1 (fr)
JP (1) JP3231288B2 (fr)
KR (1) KR100313181B1 (fr)
CN (1) CN1118468C (fr)
AR (1) AR016453A1 (fr)
AT (1) ATE240332T1 (fr)
AU (1) AU752408B2 (fr)
BR (1) BR9901095A (fr)
CA (1) CA2265095C (fr)
CZ (1) CZ291514B6 (fr)
DE (1) DE69907784T2 (fr)
DK (1) DK0941994T3 (fr)
ES (1) ES2198095T3 (fr)
HR (1) HRP990077B1 (fr)
HU (1) HUP9900589A1 (fr)
ID (1) ID23575A (fr)
IL (1) IL128869A (fr)
MA (1) MA26612A1 (fr)
MY (1) MY119536A (fr)
NO (1) NO312297B1 (fr)
NZ (1) NZ334526A (fr)
PE (1) PE20000337A1 (fr)
PL (1) PL331875A1 (fr)
PT (1) PT941994E (fr)
RU (1) RU2218340C2 (fr)
SG (1) SG78336A1 (fr)
SI (1) SI0941994T1 (fr)
TR (1) TR199900531A2 (fr)
TW (1) TW585865B (fr)
UY (1) UY25419A1 (fr)
YU (1) YU12099A (fr)
ZA (1) ZA991946B (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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WO2000059907A2 (fr) * 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines antagonistes de corticoliberine (crf)
DE19956791A1 (de) * 1999-11-25 2001-05-31 Merck Patent Gmbh Neue Sulfonyloxazolamine
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
ATE355102T1 (de) * 2001-03-13 2006-03-15 Bristol Myers Squibb Pharma Co 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6- methoxypyrid-3-yl) pyrazolo- 1,5-aö-1,3,5-triazin,seine enantiomeren und pharmazeutisch annehmbare salze als corticotropin-releasing-factor-rezeptor-ligande
SK16052003A3 (en) 2001-06-07 2004-10-05 Hoffmann La Roche New indole derivatives with 5-HT6 receptor affinity
MXPA03011638A (es) 2001-06-15 2004-04-02 Hoffmann La Roche Nuevos derivados de 4-piperazinil indol con afinidad por el receptor 5-ht6.
JP2005527463A (ja) * 2001-08-07 2005-09-15 スミスクライン ビーチャム パブリック リミテッド カンパニー Cns疾患を治療するための5−ht6受容体アフィニティーを有する3−アリールスルホニル−7−ピペラジニル−インドール、−ベンゾフランおよび−ベンゾチオフェン
PL210413B1 (pl) * 2001-12-20 2012-01-31 Wyeth Corp Pochodne indoliloalkiloaminy
US6642381B2 (en) * 2001-12-27 2003-11-04 Hoffman-La Roche Inc. Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
GB0202679D0 (en) * 2002-02-05 2002-03-20 Glaxo Group Ltd Novel compounds
UA78999C2 (en) * 2002-06-04 2007-05-10 Wyeth Corp 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
US6875771B2 (en) 2002-07-26 2005-04-05 Bristol-Myers Squibb Company Pyridopyrimidine derivatives as 5-HT6 antagonists
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
PT1537116E (pt) * 2002-09-04 2010-09-03 Schering Corp Pirazolopirimidinas adequadas para o tratamento de doenças cancerosas
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
MXPA05008441A (es) * 2003-02-14 2005-10-19 Wyeth Corp Derivados de heterociclil-3-sulfonilindazol o azaindazol como ligandos de 5-hidroxitriptamina-6.
AU2004215481B2 (en) 2003-02-28 2010-11-11 Teijin Pharma Limited Pyrazolo(1,5-A)pyrimidine derivatives
GB0305559D0 (en) * 2003-03-11 2003-04-16 Teijin Ltd Compounds
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
WO2005112936A1 (fr) * 2004-05-14 2005-12-01 The Regents Of The University Of Michigan Compositions et methodes associees aux inhibiteurs de la proteine kinase
US7528138B2 (en) * 2004-11-04 2009-05-05 Vertex Pharmaceuticals Incorporated Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
RU2390523C2 (ru) * 2005-10-21 2010-05-27 Мицубиси Танабе Фарма Корпорейшн ПРОИЗВОДНОЕ ПИРАЗОЛ[1,5-a]ПИРИМИДИНА
RU2330854C2 (ru) * 2006-03-15 2008-08-10 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУВПО "ПГФА Росздрава") Способ получения конденсированных гем-диметилзамещенных амино-1,3,5-триазинов
RU2369600C1 (ru) * 2008-01-24 2009-10-10 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ5-HT6 РЕЦЕПТОРОВ, АКТИВНЫЙ КОМПОНЕНТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННОЕ СРЕДСТВО И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
EP2248816B1 (fr) * 2008-01-24 2014-10-22 Alla Chem, LLC. 2-alkylamino-3-arylsulfonyl-cyclo-alcano [e ou d]pyrazolo[1,5-a]pyrimidines substituées fonctionnant comme des antagonistes des récepteurs 5-ht6 de sérotonine, procédés de fabrication et d'utilisation
EA017818B1 (ru) * 2008-01-24 2013-03-29 Андрей Александрович ИВАЩЕНКО ЗАМЕЩЕННЫЕ ЦИКЛОАЛКАНО[e ИЛИ d]ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-НТРЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
US8309559B2 (en) * 2008-01-24 2012-11-13 Nikolay Filippovich Savchuk (EN) substituted 2-amino-3-sulfonyl-pyrazolo[1,5-A] pyrimidines/antagonists of serotonin 5-HT6 receptors, methods for the production and the use thereof
RU2384581C2 (ru) 2008-05-07 2010-03-20 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2-АМИНО-3-СУЛЬФОНИЛ-ТЕТРАГИДРО-ПИРАЗОЛО[1,5-a]ПИРИДО-ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
EP3020719B1 (fr) 2008-10-06 2017-09-20 Alla Chem, LLC. 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines substituées, antagonistes du récepteur 5-ht6 de sérotonine, procédés de production et d'utilisation associés
EP2384328B1 (fr) 2008-11-27 2013-02-13 Boehringer Ingelheim International GmbH Derives de 6,7,8,9-tetrahydro-5h-1,4,7,10a-tetraaza-cyclohept[f]indene, compositions pharmaceutiques contenant ces composes, leur utilisation et procede pour leur preaparation
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
KR20140003438A (ko) 2010-11-15 2014-01-09 카톨리에케 유니버시테이트 루벤 항바이러스성 축합 헤테로사이클릭 화합물
RU2443697C1 (ru) 2010-12-21 2012-02-27 Александр Васильевич Иващенко Замещенные метил-амины, антагонисты серотониновых 5-ht6 рецепторов, способы получения и применения
EP2760453B1 (fr) 2011-09-30 2016-05-25 Ipsen Pharma S.A.S. Inhibiteurs macrocycliques de la kinase lrrk2
PL2834243T3 (pl) * 2012-03-09 2018-09-28 Lexicon Pharmaceuticals, Inc. Związki na bazie pirazolo[1,5-a]pirymidyny, zawierające je kompozycje i sposoby ich zastosowania
TW201542550A (zh) * 2013-09-06 2015-11-16 Lexicon Pharmaceuticals Inc 吡唑并[1,5-a]嘧啶基化合物、包含彼之組合物以及使用彼之方法
TW201620911A (zh) * 2014-03-17 2016-06-16 雷西肯製藥股份有限公司 銜接子關聯激酶1之抑制劑、包含其之組成物、及其使用方法
TR201904514T4 (tr) 2014-09-17 2019-04-22 Oncodesign Sa Makrosiklik LRRK2 kinaz inhibitörleri.
ES2899196T3 (es) 2015-03-09 2022-03-10 Aurigene Discovery Tech Ltd Derivados de pirazolo[1,5-a][1,3,5]triazina y de pirazolo[1,5-a]pirimidina como inhibidores de CDK
WO2017052394A1 (fr) * 2015-09-23 2017-03-30 Uniwersytet Jagielloński Composés d'imidazopyridine et leur utilisation comme ligands du récepteur 5-ht6
HK1256751A1 (zh) 2015-11-02 2019-10-04 Janssen Pharmaceutica Nv [1,2,4]三唑并[1,5-a]嘧啶-7-基化合物
CN109937202B (zh) 2016-11-02 2022-12-30 詹森药业有限公司 作为pde2抑制剂的[1,2,4]三唑并[1,5-a]嘧啶化合物
MA46690A (fr) 2016-11-02 2019-09-11 Janssen Pharmaceutica Nv Composés de [1,2,4]triazolo [1,5-a]pyrimidine en tant qu'inhibiteurs de pde2
MY193511A (en) 2016-11-02 2022-10-17 Janssen Pharmaceutica Nv [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors
TW202521536A (zh) 2019-05-05 2025-06-01 美商基尼特奇公司 Cdk抑制劑
CN112142744A (zh) 2019-06-28 2020-12-29 上海瑛派药业有限公司 取代的稠合杂芳双环化合物作为激酶抑制剂及其应用
MX2022008627A (es) 2020-01-13 2022-11-08 Verge Analytics Inc Pirazolo-pirimidinas sustituidas y usos de las mismas.

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WO1989000994A2 (fr) 1987-07-31 1989-02-09 E.I. Du Pont De Nemours And Company Sulfonamides herbicides
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CA2274055A1 (fr) 1996-12-19 1998-06-25 Smithkline Beecham P.L.C. Derives du n-piperazine-1-ylphenyl-benzamide
DZ2376A1 (fr) 1996-12-19 2002-12-28 Smithkline Beecham Plc Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
TR200000073T2 (tr) 1997-07-11 2000-06-21 Smithkline Beecham P.L.C. 5-HT6 Reseptör antagonistleri olan sülfonamid türevleri ve bunların hazırlanma prosesi

Also Published As

Publication number Publication date
TW585865B (en) 2004-05-01
PL331875A1 (en) 1999-09-13
ES2198095T3 (es) 2004-01-16
AU752408B2 (en) 2002-09-19
ZA991946B (en) 1999-09-13
AR016453A1 (es) 2001-07-04
IL128869A (en) 2003-09-17
JP3231288B2 (ja) 2001-11-19
US6194410B1 (en) 2001-02-27
CN1236780A (zh) 1999-12-01
PE20000337A1 (es) 2000-05-13
DK0941994T3 (da) 2003-09-08
HRP990077A2 (en) 2000-02-29
CZ291514B6 (cs) 2003-03-12
CZ82599A3 (cs) 1999-09-15
HUP9900589A1 (hu) 2000-03-28
HK1023343A1 (en) 2000-09-08
SI0941994T1 (en) 2003-10-31
EP0941994B1 (fr) 2003-05-14
DE69907784T2 (de) 2004-03-25
NO312297B1 (no) 2002-04-22
JP2000186090A (ja) 2000-07-04
HU9900589D0 (en) 1999-05-28
NZ334526A (en) 2000-07-28
NO991150D0 (no) 1999-03-10
TR199900531A3 (tr) 1999-10-21
CN1118468C (zh) 2003-08-20
RU2218340C2 (ru) 2003-12-10
UY25419A1 (es) 2001-11-30
MY119536A (en) 2005-06-30
IL128869A0 (en) 2000-01-31
KR19990077741A (ko) 1999-10-25
KR100313181B1 (ko) 2001-11-05
BR9901095A (pt) 2000-05-02
HRP990077B1 (en) 2003-08-31
DE69907784D1 (de) 2003-06-18
SG78336A1 (en) 2001-02-20
TR199900531A2 (xx) 1999-10-21
NO991150L (no) 1999-09-13
CA2265095C (fr) 2008-07-22
YU12099A (sh) 2000-10-30
AU2038399A (en) 1999-09-23
ID23575A (id) 2000-05-04
CA2265095A1 (fr) 1999-09-11
ATE240332T1 (de) 2003-05-15
EP0941994A1 (fr) 1999-09-15
PT941994E (pt) 2003-09-30

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